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1. 发明申请

WO2004084938A1 IMPROVED VACCINES 审中-公开
标题翻译：改进的疫苗
公开(公告)号：WO2004084938A1
公开(公告)日：2004-10-07
申请号：PCT/EP2004/003002
申请日：2004-03-22
申请人： INTERCELL AG , BUSCHLE, Michael , HABEL, André , FRITZ, Jörg , PRINZ, Karin , LINGNAU, Karen
发明人： BUSCHLE, Michael , HABEL, André , FRITZ, Jörg , PRINZ, Karin , LINGNAU, Karen
IPC分类号： A61K39/39
CPC分类号： A61K39/39 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/29 , A61K39/292 , A61K2039/55505 , A61K2039/55516 , A61K2039/55561 , A61K2039/57 , C07K14/005 , C12N7/00 , C12N2730/10122 , C12N2730/10134 , C12N2760/16034 , C12N2760/16122 , C12N2760/16134 , C12N2760/16222 , C12N2760/16234 , C12N2770/24222 , C12N2770/24234 , Y02A50/39
摘要： The invention refers to an improved vaccine against infections with pathogens, especially viral pathogens, comprising an antigen, a peptide of the formula R 1 -XZXZ N -XZX-R 2 and an immunostimulatory deoxynucleic acid containing deoxyinosine and/or deoxyuridine residues.
摘要翻译：本发明涉及针对包含抗原，式R1-XZXZN-XZX-R2的肽和含有脱氧肌氨酸和/或脱氧尿苷残基的免疫刺激性脱氧核酸的病原体，特别是病毒病原体感染的改良疫苗。

2. 发明申请

WO2004024182A2 METHOD FOR ISOLATING HEPATITIS C VIRUS PEPTIDES 审中-公开
标题翻译：分离丙型肝炎病毒多肽的方法
公开(公告)号：WO2004024182A2
公开(公告)日：2004-03-25
申请号：PCT/EP2003/009482
申请日：2003-08-27
申请人： INTERCELL AG , BUSCHLE, Michael , HABEL, Andre , KLADE, Christoph , MATTNER, Frank , OTAVA, Oleksandr , VYTVYTSKA, Oresta , ZAUNER, Wolfgang , ZINKE, Sandra , KIRLAPPOS, Helen
发明人： BUSCHLE, Michael , HABEL, Andre , KLADE, Christoph , MATTNER, Frank , OTAVA, Oleksandr , VYTVYTSKA, Oresta , ZAUNER, Wolfgang , ZINKE, Sandra , KIRLAPPOS, Helen
IPC分类号： A61K39/00
CPC分类号： C07K7/06 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/292 , A61K2039/525 , A61K2039/57 , C07K7/08 , C07K14/005 , C07K2319/00 , C12N2710/16122 , C12N2760/16122 , C12N2770/24222 , C12N2770/24234 , G01N2500/04 , Y10S930/223
摘要： Described is a method for isolating Hepatitis C Virus peptides (HPs) which have a binding capacity to a MHC/HLA molecule or a complex comprising said HCV-peptide and said MHC/HLA molecule characterized by the following steps: - providing a pool of HCV-peptide, said pool containing HCV-peptides which bind to said MHC/HLA molecule and HCV-peptides which do not bind to said MHC/HLA molecule, -contacting said MHC/HLA molecule with said pool of HCV-peptides whereby a HCV-peptide which has a binding capacity to said MHC/HLA molecule binds to said MHC/HLA molecule and a complex comprising said HCV-peptide and said MHC/HLA molecule is formed, -detecting and optionally separating said complex from the HCV-peptide which do not bind to said MHC/HLA molecule and optionally isolating and characterising the HCV-peptide from said complex.
摘要翻译：描述了用于分离对MHC / HLA分子或包含所述HCV-肽和所述MHC / HLA分子的复合物具有结合能力的丙型肝炎病毒肽（HP）的方法，其特征在于以下步骤： - 提供HCV-肽库，所述库包含结合所述MHC / HLA分子的HCV-肽和不结合所述MHC / HLA分子的HCV-肽 - 接触所述MHC / HLA分子与所述库由此具有与所述MHC / HLA分子的结合能力的HCV-肽与所述MHC / HLA分子结合并形成包含所述HCV-肽和所述MHC / HLA分子的复合物， - 检测并任选地分离所述HCV-肽来自不与所述MHC / HLA分子结合的HCV-肽复合物，并且任选地从所述复合物分离和表征HCV-肽。

3. 发明申请

WO0045839A3 A METHOD FOR SELECTING AND PRODUCING VACCINE AND DIAGNOSTIC PREPARATIONS 审中-公开
标题翻译：选择和生产疫苗和诊断准备的方法
公开(公告)号：WO0045839A3
公开(公告)日：2001-10-04
申请号：PCT/EP0000661
申请日：2000-01-28
申请人： CISTEM BIOTECHNOLOGIES GMBH , VON GABAIN ALEXANDER , BUSCHLE MICHAEL
发明人： VON GABAIN ALEXANDER , BUSCHLE MICHAEL
IPC分类号： C12N15/10 , C40B40/02 , A61K39/00 , G01N33/50 , G01N33/68
CPC分类号： C40B40/02 , C12N15/1037
摘要： There is disclosed a method for selecting and producing vaccine and diagnostic preparations against a specific pathogenic organism, wherein a non-human vertebrate is immunized with a preparation of the pathogenic organism, samples containing the antibodies to the pathogen-preparation are taken from immunized vertebrates, a gene library of the genome of the pathogenic organism is produced, which gene library is capable of being expressed in host cells, the pathogen polypeptide sequences-expessing gene library-host cells being selectable as regards their binding to an antibody, antigenic polypeptides are identified by contacting the gene library with the antibody-containing sample taken, and those clones of the gene library are selected whose expressed polypeptides bind to an antibody, and the identified antigenic polypeptides are finished to a vaccine or diagnostic preparation.
摘要翻译：公开了一种用于选择和产生针对特定致病生物体的疫苗和诊断制剂的方法，其中非病人脊椎动物用病原体生物体的制备物免疫，含有病原体制剂抗体的样品取自免疫的脊椎动物，产生病原生物基因组的基因文库，该基因文库能够在宿主细胞中表达，鉴定出与抗体结合可选择的病原体多肽序列表达基因文库宿主细胞，鉴定抗原多肽通过使所述基因文库与所采集的含抗体的样品接触，并选择其表达的多肽与抗体结合的基因文库的克隆，并将所鉴定的抗原性多肽完成为疫苗或诊断制剂。

4. 发明申请

WO9938528A3 VACCINE FORMULATIONS 审中-公开
标题翻译：疫苗制剂
公开(公告)号：WO9938528A3
公开(公告)日：1999-12-09
申请号：PCT/EP9900524
申请日：1999-01-27
申请人： BOEHRINGER INGELHEIM INT , BUSCHLE MICHAEL , BIRNSTIEL MAX , SCHMIDT WALTER
发明人： BUSCHLE MICHAEL , BIRNSTIEL MAX , SCHMIDT WALTER
IPC分类号： A61K9/08 , A61K9/107 , A61K39/00 , A61K39/39 , A61K47/10 , A61K47/18 , A61K47/26 , A61K47/44 , A61P35/00 , A61P37/02
CPC分类号： A61K39/39 , A61K39/00 , A61K2039/55511
摘要： The invention relates to a vaccine containing one or more synthetic or highly purified natural peptides or proteins as antigen(s) as well as one or more adjuvants. The vaccine is presented as a solution or emulsion which is free from inorganic salt ions or has a low concentration of salt ions. Said vaccine preferably contains substances able to make it isotonic, especially sorbitol.
摘要翻译：将含有一种或多种合成或高度纯化的天然肽或蛋白质作为抗原（S）和一种或多种佐剂的疫苗，存在作为溶液或乳液，其不含无机盐离子或具有盐离子的低浓度。优选地，它包含了使疫苗等渗，尤其是山梨糖醇的能力的物质。

5. 发明申请

WO1995025808A1 PROCESS FOR TREATING EUCARYOTIC CELLS 审中-公开
标题翻译：方法的真核细胞进行的处理
公开(公告)号：WO1995025808A1
公开(公告)日：1995-09-28
申请号：PCT/EP1995000995
申请日：1995-03-17
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , COTTEN, Matthew , BAKER, Adam , BUSCHLE, Michael , WAGNER, Ernst
发明人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH
IPC分类号： C12N15/87
CPC分类号： A61K48/00 , C12N15/10 , C12N15/87
摘要： In a process for treating eucaryotic cells, in applications in which the toxicity of lipopolysaccharides has an adverse effect, substances are used during transfection or to clean the foreign material which bond lipopolysaccharides and neutralise their toxicity. The process is of particular advantage when foreign material is to be inserted in the cells, especially in gene transfer methods. Compositions containing a lipopolysaccharide-bonding substance are used in cell culture applications as a medium and in therapeutic applications as medicaments.
摘要翻译：在转染过程中处理的真核细胞，或用于清洁异物使用的物质中，其中脂多糖的毒性不利了结合脂多糖和中和其毒性应用的方法。如果异物被引入到细胞中，特别是在基因转移方法的方法是特别有利的。含有脂多糖结合物质的组合物，在细胞培养应用和治疗应用中作为用作药物的培养基中使用。

6. 发明申请

WO2005004910A3 HCV VACCINES 审中-公开
公开(公告)号：WO2005004910A3
公开(公告)日：2005-01-20
申请号：PCT/EP2004/007540
申请日：2004-07-09
申请人： INTERCELL AG , BUSCHLE, Michael , FRISCH, Jürgen , KLADE, Christoph , LINGNAU, Karen , ZAUNER, Wolfgang , ZETTLMEISSL, Gerd
发明人： BUSCHLE, Michael , FRISCH, Jürgen , KLADE, Christoph , LINGNAU, Karen , ZAUNER, Wolfgang , ZETTLMEISSL, Gerd
IPC分类号： A61K39/29
摘要： Disclosed is a Hepatitis C virus (HCV) vaccine comprising at least two epitopes, each from a different hotspot epitope, wherein a hotspot epitope is defined as an epitope containing peptide selected from the group consisting of KFPGGGQIVGGVYLLPRRGPRLGVRATRK, GYKVLVLNPSVAAT, AYAAQGYKVLVLNPSVAAT, DLMGYIP(A/L)VGAPL, GEVQVVSTATQSFLATCINGVCWTV, HMWNFISGIQYLAGLSTLPGNPA, VDYPYRLWHYPCT(V/I)N(F/Y)TIFK(V/I)RMYVGGVEHRL, AAWYELTPAETTVRLR, GQGWRLLAPITAYSQQTRGLLGCIV, IGLGKVLVDILAGYGAGVAGALVAFK, FTDNSSPPAVPQTFQV, LEDRDRSELSPLLLSTTEW, YLVAYQATVCARAQAPPPSWD, MSTNPKPQRKTKRNTNR, LINTNGSWHINRTALNCNDSL, TTILGIGTVLDQAET, FDS(S/V)VLCECYDAG(A/C)AWYE, ARLIVFPDLGVRVCEKMALY, AFCSAMYVGDLCGSV, GVLFGLAYFSMVGNW, VVCCSMSYTWTGALITPC, TRVPYFVRAQGLIRA and TTLLFNILGGWVAAQ.

7. 发明申请

WO2005004910A2 HCV VACCINES 审中-公开
标题翻译： HCV疫苗
公开(公告)号：WO2005004910A2
公开(公告)日：2005-01-20
申请号：PCT/EP2004007540
申请日：2004-07-09
申请人： INTERCELL AG , BUSCHLE MICHAEL , FRISCH JUERGEN , KLADE CHRISTOPH , LINGNAU KAREN , ZAUNER WOLFGANG , ZETTLMEISSL GERD
发明人： BUSCHLE MICHAEL , FRISCH JUERGEN , KLADE CHRISTOPH , LINGNAU KAREN , ZAUNER WOLFGANG , ZETTLMEISSL GERD
IPC分类号： A61K39/00 , A61K39/29 , C07K14/18
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/55516 , A61K2039/55561 , C12N2770/24222 , C12N2770/24234
摘要： Disclosed is a Hepatitis C virus (HCV) vaccine comprising at least two epitopes, each from a different hotspot epitope, wherein a hotspot epitope is defined as an epitope containing peptide selected from the group consisting of KFPGGGQIVGGVYLLPRRGPRLGVRATRK, GYKVLVLNPSVAAT, AYAAQGYKVLVLNPSVAAT, DLMGYIP(A/L)VGAPL, GEVQVVSTATQSFLATCINGVCWTV, HMWNFISGIQYLAGLSTLPGNPA, VDYPYRLWHYPCT(V/I)N(F/Y)TIFK(V/I)RMYVGGVEHRL, AAWYELTPAETTVRLR, GQGWRLLAPITAYSQQTRGLLGCIV, IGLGKVLVDILAGYGAGVAGALVAFK, FTDNSSPPAVPQTFQV, LEDRDRSELSPLLLSTTEW, YLVAYQATVCARAQAPPPSWD, MSTNPKPQRKTKRNTNR, LINTNGSWHINRTALNCNDSL, TTILGIGTVLDQAET, FDS(S/V)VLCECYDAG(A/C)AWYE, ARLIVFPDLGVRVCEKMALY, AFCSAMYVGDLCGSV, GVLFGLAYFSMVGNW, VVCCSMSYTWTGALITPC, TRVPYFVRAQGLIRA and TTLLFNILGGWVAAQ.
摘要翻译：公开了一种丙型肝炎病毒（HCV）疫苗，其包含至少两个表位，每个表位各自为不同的热点表位，其中热点表位定义为选自KFPGGGQIVGGVYLLPRRGPRLGVRATRK，GYKVLVLNPSVAAT，AYAAQGYKVLVLNPSVAAT，DLMGYIP（A / L）VGAPL，GEVQVVSTATQSFLATCINGVCWTV，HMWNFISGIQYLAGLSTLPGNPA，VDYPYRLWHYPCT（V / I）N（F / Y）TIFK（V / I）RMYVGGVEHRL，AAWYELTPAETTVRLR，GQGWRLLAPITAYSQQTRGLLGCIV，IGLGKVLVDILAGYGAGVAGALVAFK，FTDNSSPPAVPQTFQV，LEDRDRSELSPLLLSTTEW，YLVAYQATVCARAQAPPPSWD，MSTNPKPQRKTKRNTNR，LINTNGSWHINRTALNCNDSL，TTILGIGTVLDQAET，FDS（S / VLCECYDAG（A / C）AWYE，ARLIVFPDLGVRVCEKMALY，AFCSAMYVGDLCGSV，GVLFGLAYFSMVGNW，VVCCSMSYTWTGALITPC，TRVPYFVRAQGLIRA和TTLLFNILGGWVAAQ。

8. 发明申请

WO1997019169A1 TUMOUR VACCINE AND PROCESS FOR THE PREPARATION THEREOF 审中-公开
标题翻译：肿瘤疫苗及其制备方法
公开(公告)号：WO1997019169A1
公开(公告)日：1997-05-29
申请号：PCT/EP1996005126
申请日：1996-11-21
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , SCHMIDT, Walter , BIRNSTIEL, Max , SCHWEIGHOFFER, Tamàs , STEINLEIN, Peter , BUSCHLE, Michael
发明人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH
IPC分类号： C12N05/08
CPC分类号： C07K7/06 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K39/145 , A61K39/39 , A61K2039/5154 , A61K2039/55511 , A61K2039/55516 , A61K2039/55522 , A61K2039/55561 , A61K2039/585 , A61K2300/00
摘要： The invention relates to a tumour vaccine and a process for the preparation thereof. The tumour vaccine contains tumour cells, at least a portion of which has at least one MHC-I-haplotype of the patient on the cell surface, and which have been loaded in such a manner with one or a plurality of peptides bonding to the MHC-I-molecule that said tumour cells are recognised as foreign within the context of the peptides by the patient's immune system and trigger a cellular immune response. Loading takes place in the presence of a polycation such as polylysine.
摘要翻译：肿瘤疫苗及其制备方法。含有肿瘤细胞的肿瘤疫苗，其中至少一个部分具有与细胞表面上的患者中的至少一个MHC-I-单倍型，并且已经如此装载有结合至MHC一种或多种肽I分子在该肿瘤细胞中与肽上下文被患者的免疫系统对外的认可，并触发细胞免疫应答。装载在聚阳离子的存在下进行，如聚赖氨酸。

9. 发明申请

WO1994021808A1 PROCESS FOR PREPARING CANCER VACCINES 审中-公开
标题翻译：用于生产癌症疫苗
公开(公告)号：WO1994021808A1
公开(公告)日：1994-09-29
申请号：PCT/EP1994000859
申请日：1994-03-18
申请人： GENENTECH, INC. , BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BIRNSTIEL, Max, L. , BUSCHLE, Michael , COTTEN, Matthew , MAAS, Gerhard , PLANK, Christian , SCHAFFNER, Gotthold , SCHMIDT, Walter , WAGNER, Ernst , ZATLOUKAL, Kurt
发明人： GENENTECH, INC. , BOEHRINGER INGELHEIM INTERNATIONAL GMBH
IPC分类号： C12N15/87
CPC分类号： C12N7/00 , A61K38/00 , A61K39/0011 , A61K47/50 , A61K48/00 , C07K14/005 , C07K14/485 , C07K14/535 , C07K14/55 , C07K14/57 , C07K14/705 , C12N15/87 , C12N2710/10343 , C12N2710/10361 , C12N2760/20122 , C12Q1/701
摘要： Cancer vaccines are prepared by treating tumor cells or fibroblasts with a complex of immunostimulating polypeptide-coding DNA and of DNA-binding substance, for example polylysine, preferably conjugated with transferrine. The complex further contains a conjugate of DNA-binding substance and of an endosomolytic peptide or an adenovirus having at least one E4 defect or one E1a defect associated with other genetic defects.

10. 发明申请

WO2004084937A1 USE OF ALUM AND A TH1 IMMUNE RESPONSE INDUCING ADJUVANT FOR ENHANCING IMMUNE RESPONSES 审中-公开
标题翻译：使用ALUM和TH1免疫反应诱导ADJUVANT增强免疫应答
公开(公告)号：WO2004084937A1
公开(公告)日：2004-10-07
申请号：PCT/EP2004/003029
申请日：2004-03-22
申请人： INTERCELL AG , BUSCHLE, Michael , LINGNAU, Karen
发明人： BUSCHLE, Michael , LINGNAU, Karen
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A61K39/12 , A61K39/292 , A61K39/39 , A61K2039/55505 , A61K2039/55516 , A61K2039/55561 , A61K2039/57 , C12N2730/10122 , C12N2730/10134 , C12N2760/16022 , Y02A50/39 , Y02A50/464
摘要： The invention relates to the use of Alum for the preparation of a drug for enhancing an antigen-specific type 1 immune response against an antigen in the presence of a type 1 inducing adjuvant.
摘要翻译：本发明涉及在1型诱导佐剂存在下，用于制备用于增强针对抗原的抗原特异性1型免疫应答的药物的用途。

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