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1. 发明公开

EP1794120A2 PEPTIDASE INHIBITORS 有权
标题翻译：肽
公开(公告)号：EP1794120A2
公开(公告)日：2007-06-13
申请号：EP05783778.3
申请日：2005-07-21
申请人： Royalty, Susan Marie , Burns, James Ford , Scicinski, Jan Jozef , Jagdmann Jr., Gunnar Erik , Foglesong, Robert James , Griffin, Kellee Renee , Dyakonov, Tatyana , Middlemiss, David
发明人： Royalty, Susan Marie , Burns, James Ford , Scicinski, Jan Jozef , Jagdmann Jr., Gunnar Erik , Foglesong, Robert James , Griffin, Kellee Renee , Dyakonov, Tatyana , Middlemiss, David
IPC分类号： C07D207/09 , C07D207/10 , A61K31/4025
CPC分类号： C07D207/10 , C07D207/16 , C07D277/04 , C07D401/12 , C07D403/12 , C07D405/12
摘要： The present invention relates to a series of novel compounds having the formula (I) wherein: X is NR3 or O; n is 1 or 2; A is a bicyclic carbocycle and R1 and R2 are as described herein. The compounds are useful as DPP-IV inhibitors, such as for the treatment of diabetes.

2. 发明申请

WO2006012395A3 PEPTIDASE INHIBITORS 审中-公开
公开(公告)号：WO2006012395A3
公开(公告)日：2006-02-02
申请号：PCT/US2005/025837
申请日：2005-07-21
申请人： ROYALTY, Susan Marie , BURNS, James Ford , SCICINSKI, Jan Jozef , JAGDMANN, JR., Gunnar Erik , FOGLESONG, Robert James , GRIFFIN, Kellee Renee , DYAKONOV, Tatyana , MIDDLEMISS, David
发明人： ROYALTY, Susan Marie , BURNS, James Ford , SCICINSKI, Jan Jozef , JAGDMANN, JR., Gunnar Erik , FOGLESONG, Robert James , GRIFFIN, Kellee Renee , DYAKONOV, Tatyana , MIDDLEMISS, David
IPC分类号： C07D207/09 , C07D207/10 , A61K31/4025
摘要： The present invention relates to a series of novel compounds having the formula (I) wherein: X is NR 3 or O; n is 1 or 2; A is a bicyclic carbocycle and R1 and R2 are as described herein. The compounds are useful as DPP-IV inhibitors, such as for the treatment of diabetes.

3. 发明申请

WO2010108052A3 AMIDE DERIVATIVES AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS 审中-公开
标题翻译：作为神经元Y5受体配体的酰胺衍生物
公开(公告)号：WO2010108052A3
公开(公告)日：2011-02-24
申请号：PCT/US2010027892
申请日：2010-03-19
申请人： LUNDBECK & CO AS H , CHEN BIN , BURNS JAMES FORD , DOLLER DARIO
发明人： CHEN BIN , BURNS JAMES FORD , DOLLER DARIO
IPC分类号： C07D413/12 , A61K31/535 , A61P25/28 , C07D413/06 , C07D413/10
CPC分类号： C07D401/12 , C07D403/12 , C07D413/12
摘要： Disclosed are a series of neuropeptide Y Y5 receptor ligands, and as such are useful to treat disorders related to mood, stress, ADHD, cognition, stress and dementia.
摘要翻译：公开了一系列神经肽Y Y5受体配体，因此可用于治疗与情绪，压力，ADHD，认知，压力和痴呆相关的疾病。

4. 发明申请

WO2006012441A1 PEPTIDASE INHIBITORS 审中-公开
标题翻译：肽抑制剂
公开(公告)号：WO2006012441A1
公开(公告)日：2006-02-02
申请号：PCT/US2005/025918
申请日：2005-07-21
申请人： ROYALTY, Susan Marie , BURNS, James Ford , SCICINSKI, Jan Jozef , FOGLESONG, Robert James , JAGDMANN, JR., Gunnar Erik , GRIFFIN, Kellee Renee , DYAKONOV, Tatyana , MIDDLEMISS, David
发明人： ROYALTY, Susan Marie , BURNS, James Ford , SCICINSKI, Jan Jozef , FOGLESONG, Robert James , JAGDMANN, JR., Gunnar Erik , GRIFFIN, Kellee Renee , DYAKONOV, Tatyana , MIDDLEMISS, David
IPC分类号： A61K31/4025
CPC分类号： C07D207/16 , C07D207/10 , C07D277/04 , C07D401/12 , C07D417/12
摘要： The present invention relates to a series of novel compounds having the formula: [INSERT FORMULA I] wherein A is a bicyclic carbocycle and R¿1? and R¿2? are independently [INSERT MOLECULE FROM CLAIM 1] The compounds are useful as DPP-IV inhibitors and for treating diabetes.
摘要翻译：本发明涉及一系列具有下式的新颖化合物：其中A是双环碳环，R 1〜和R？独立地[来自权利要求1的分子]该化合物可用作DPP-IV抑制剂和治疗糖尿病。

5. 发明申请

WO2008134228A1 BENZOXAZOLE COMPOUNDS 审中-公开
标题翻译：苯并噻唑化合物
公开(公告)号：WO2008134228A1
公开(公告)日：2008-11-06
申请号：PCT/US2008/060183
申请日：2008-04-14
申请人： H. LUNDBECK A/S , BURNS, James, Ford , DELEON, John
发明人： BURNS, James, Ford , DELEON, John
IPC分类号： A61P1/00 , A61K31/55 , C07D243/08
CPC分类号： C07D263/58
摘要： The present invention is directed to benzoxazole compounds which are ltgands at the NPY Y5 receptor. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression, anxiety or obesity which comprises administering to the subject an amount of a compound of the subject invention. Furthermore, this invention also provides uses of a compound of the invention for the manufacture of a medicament for treating a subject suffering from depression, anxiety or obesity.
摘要翻译：本发明涉及作为NPY Y5受体的化合物的苯并恶唑化合物。本发明还提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供了治疗患有抑郁，焦虑或肥胖症的受试者的方法，其包括给予受试者一定量的本发明化合物。此外，本发明还提供本发明化合物在制备用于治疗患有抑郁症，焦虑症或肥胖症的受试者的药物中的用途。

6. 发明申请

WO2010108052A2 AMIDE DERIVATIVES AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS 审中-公开
标题翻译：作为神经元Y5受体配体的酰胺衍生物
公开(公告)号：WO2010108052A2
公开(公告)日：2010-09-23
申请号：PCT/US2010/027892
申请日：2010-03-19
申请人： H. LUNDBECK A/S , CHEN, Bin , BURNS, James, Ford , DOLLER, Dario
发明人： CHEN, Bin , BURNS, James, Ford , DOLLER, Dario
IPC分类号： C07D413/12 , C07D413/10 , C07D413/06 , A61P25/28 , A61K31/535
CPC分类号： C07D401/12 , C07D403/12 , C07D413/12
摘要： Disclosed are a series of neuropeptide Y Y5 receptor ligands, and as such are useful to treat disorders related to mood, stress, ADHD, cognition, stress and dementia.
摘要翻译：公开了一系列神经肽Y Y5受体配体，因此可用于治疗与情绪，压力，ADHD，认知，压力和痴呆相关的疾病。

7. 发明申请

WO2006012395A2 PEPTIDASE INHIBITORS 审中-公开
标题翻译：肽抑制剂
公开(公告)号：WO2006012395A2
公开(公告)日：2006-02-02
申请号：PCT/US2005025837
申请日：2005-07-21
申请人： ROYALTY SUSAN MARIE , BURNS JAMES FORD , SCICINSKI JAN JOZEF , JAGDMANN JR GUNNAR ERIK , FOGLESONG ROBERT JAMES , GRIFFIN KELLEE RENEE , DYAKONOV TATYANA , MIDDLEMISS DAVID
发明人： ROYALTY SUSAN MARIE , BURNS JAMES FORD , SCICINSKI JAN JOZEF , JAGDMANN JR GUNNAR ERIK , FOGLESONG ROBERT JAMES , GRIFFIN KELLEE RENEE , DYAKONOV TATYANA , MIDDLEMISS DAVID
IPC分类号： A61K31/497 , C07D403/02
CPC分类号： C07D207/10 , C07D207/16 , C07D277/04 , C07D401/12 , C07D403/12 , C07D405/12
摘要： The present invention relates to a series of novel compounds having the formula (I) wherein: X is NR 3 or O; n is 1 or 2; A is a bicyclic carbocycle and R1 and R1 are as described herein. The compounds are useful as DPP-IV inhibitors, such as for the treatment of diabetes.
摘要翻译：本发明涉及一系列具有式（I）的新化合物，其中：X为NR 3或O; n为1或2; A是双环碳环，R1和R1如本文所述。该化合物可用作DPP-IV抑制剂，例如治疗糖尿病。

8. 发明专利

CA2574418A1 PEPTIDASE INHIBITORS 未知
公开(公告)号：CA2574418A1
公开(公告)日：2006-02-02
申请号：CA2574418
申请日：2005-07-21
申请人： BURNS JAMES FORD , MIDDLEMISS DAVID , JAGDMANN JR GUNNAR ERIK , ROYALTY SUSAN MARIE , DYAKONOV TATYANA , SCICINSKI JAN JOZEF , GRIFFIN KELLEE RENEE , FOGLESONG ROBERT JAMES
发明人： BURNS JAMES FORD , MIDDLEMISS DAVID , JAGDMANN GUNNAR ERIK JR , ROYALTY SUSAN MARIE , DYAKONOV TATYANA , SCICINSKI JAN JOZEF , GRIFFIN KELLEE RENEE , FOGLESONG ROBERT JAMES
IPC分类号： C07D207/09 , A61K31/4025 , C07D207/10
摘要： The present invention relates to a series of novel compounds having the formula (I) wherein: X is NR3 or O; n is 1 or 2; A is a bicyclic carbocycle and R1 and R2 are as described herein. The compounds are useful as DPP-IV inhibitors, such as for the treatment of diabetes.

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