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1. 发明申请

US20140343865A1 Biomarkers for Kidney Cancer and Methods Using the Same 审中-公开
标题翻译：肾癌生物标志物及其使用方法
公开(公告)号：US20140343865A1
公开(公告)日：2014-11-20
申请号：US14362943
申请日：2012-12-07
申请人： Meredith V. Brown , Kay A. Lawton , Bruce Neri , Yang Chen
发明人： Meredith V. Brown , Kay A. Lawton , Bruce Neri , Yang Chen
IPC分类号： G01N33/574 , G06F19/12
CPC分类号： G01N33/57438 , G01N33/5011 , G01N2800/52 , G01N2800/56 , G01N2800/60 , G16B5/00
摘要： Methods for identifying and evaluating biochemical entities useful as biomarkers for kidney cancer, target identification/validation, and monitoring of drug efficacy are provided. Also provided are suites of small molecule entities as biomarkers for kidney cancer.
摘要翻译：提供了用于鉴定和评估可用作肾癌生物标志物的生物化学实体的方法，靶标鉴定/验证和药物疗效监测。还提供了小分子实体的套件作为肾癌的生物标志物。

2. 发明申请

US20070254295A1 METHODS OF PREDICTING AND MONITORING TYROSINE KINASE INHIBITOR THERAPY 有权
标题翻译：预测和监测酪氨酸激酶抑制剂治疗方法
公开(公告)号：US20070254295A1
公开(公告)日：2007-11-01
申请号：US11687254
申请日：2007-03-16
申请人： Jeanne Harvey , Bruce Neri , Sharat Singh
发明人： Jeanne Harvey , Bruce Neri , Sharat Singh
IPC分类号： G01N33/53 , A61P35/00 , C12Q1/68
CPC分类号： G06F19/18 , C12Q1/6886 , C12Q2600/106 , C12Q2600/154 , G01N33/57484 , G01N2333/91215 , G01N2500/04 , G01N2800/52 , G06F19/24
摘要： The present invention provides methods for analyzing a combination of biomarkers to individualize tyrosine kinase inhibitor therapy in patients who have been diagnosed with cancer. In particular, the assay methods of the present invention are useful for predicting, identifying, or monitoring the response of a tumor, tumor cell, or patient to treatment with a tyrosine kinase inhibitor using an algorithm based upon biomarker profiling. The assay methods of the present invention are also useful for predicting whether a patient has a risk of developing toxicity or resistance to treatment with a tyrosine kinase inhibitor. In addition, the assay methods of the present invention are useful for monitoring tyrosine kinase inhibitor therapy in a patient receiving the drug to evaluate whether the patient will develop resistance to the drug. Furthermore, the assay methods of the present invention are useful for optimizing the dose of a tyrosine kinase inhibitor in a patient receiving the drug to achieve therapeutic efficacy and/or reduce toxic side-effects.
摘要翻译：本发明提供了用于分析已经被诊断患有癌症的患者中的酪氨酸激酶抑制剂治疗的生物标志物的组合的方法。特别地，本发明的测定方法可用于使用基于生物标志物分析的算法预测，鉴定或监测肿瘤，肿瘤细胞或患者用酪氨酸激酶抑制剂治疗的应答。本发明的测定方法也可用于预测患者是否具有产生毒性或抗酪氨酸激酶抑制剂治疗的风险。此外，本发明的测定方法可用于监测接受药物的患者中的酪氨酸激酶抑制剂治疗，以评估患者是否会产生对药物的抗药性。此外，本发明的测定方法可用于优化接受该药物的患者中的酪氨酸激酶抑制剂的剂量以达到治疗功效和/或减少毒副作用。

3. 发明申请

US20130217647A1 Biomarkers for Prostate Cancer and Methods Using the Same 审中-公开
标题翻译：前列腺癌生物标志物及其使用方法
公开(公告)号：US20130217647A1
公开(公告)日：2013-08-22
申请号：US13812183
申请日：2011-07-27
申请人： Jeffrey R. Shuster , Matthew W. Mitchell , Jonathan E. McDunn , Bruce Neri
发明人： Jeffrey R. Shuster , Matthew W. Mitchell , Jonathan E. McDunn , Bruce Neri
IPC分类号： G01N33/574 , A61K31/7072 , A61K31/685
CPC分类号： G01N33/57434 , A61K31/685 , A61K31/7072 , G01N2800/52 , G01N2800/56
摘要： Biomarkers (and suites of biomarkers) relating to prostate cancer are provided, as well as methods for using such biomarkers (ans suites thereof), including early prediction of prostate cancer, disease grading, target identification/validation, and monitoring of drug efficacy.
摘要翻译：提供了与前列腺癌相关的生物标志物（以及生物标志物的套件），以及使用这些生物标志物（及其适用于其）的方法，包括对前列腺癌的早期预测，疾病分级，靶标鉴定/验证和药物功效的监测。

4. 发明授权

US07873479B2 Methods of diagnosing inflammatory bowel disease 有权
标题翻译：炎症性肠病诊断方法
公开(公告)号：US07873479B2
公开(公告)日：2011-01-18
申请号：US11565544
申请日：2006-11-30
申请人： Augusto Lois , Bruce Neri
发明人： Augusto Lois , Bruce Neri
IPC分类号： G06F7/00
CPC分类号： G01N33/56972 , A61K31/00 , A61K31/24 , A61K31/4985 , A61K31/52 , A61K31/56 , G01N2469/20 , G01N2800/065 , G01N2800/52 , G16H50/70 , Y02A90/26
摘要： The present invention provides methods, systems, and code for accurately classifying whether a sample from an individual is associated with inflammatory bowel disease (IBD) or a clinical subtype thereof. In particular, the present invention is useful for classifying a sample from an individual as an IBD sample using a statistical algorithm and/or empirical data. The present invention is also useful for differentiating between a clinical subtype of IBD such as Crohn's disease (CD) and ulcerative colitis (UC) using a statistical algorithm and/or empirical data. Thus, the present invention provides an accurate diagnostic prediction of IBD or a clinical subtype thereof and prognostic information useful for guiding treatment decisions.
摘要翻译：本发明提供了用于准确地分类来自个体的样品是否与炎症性肠病（IBD）或其临床亚型相关联的方法，系统和代码。特别地，本发明可用于使用统计学算法和/或经验数据将来自个人的样本作为IBD样本进行分类。本发明还可用于使用统计学算法和/或经验数据来区分诸如克罗恩病（CD）和溃疡性结肠炎（UC）的IBD的临床亚型。因此，本发明提供IBD或其临床亚型的准确诊断预测和用于指导治疗决定的预后信息。

5. 发明申请

US20100094560A1 METHODS FOR DIAGNOSING IRRITABLE BOWEL SYNDROME 审中-公开
标题翻译：用于诊断可刺激性牙刷综合征的方法
公开(公告)号：US20100094560A1
公开(公告)日：2010-04-15
申请号：US12253177
申请日：2008-10-16
申请人： AUGUSTO LOIS , BRUCE NERI
发明人： AUGUSTO LOIS , BRUCE NERI
IPC分类号： G06F17/18 , C12Q1/37 , C12Q1/68 , G01N33/53 , G06F19/00
CPC分类号： G01N33/564 , G01N33/6893 , G01N2800/065 , G01N2800/52
摘要： The present invention provides methods, systems, and code for accurately classifying whether a sample from an individual is associated with irritable bowel syndrome (IBS). In particular, the present invention is useful for classifying a sample from an individual as an IBS sample using a statistical algorithm and/or empirical data. The present invention is also useful for ruling out one or more diseases or disorders that present with IBS-like symptoms and ruling in IBS using a combination of statistical algorithms and/or empirical data. Thus, the present invention provides an accurate diagnostic prediction of IBS and prognostic information useful for guiding treatment decisions.
摘要翻译：本发明提供了用于准确分类来自个体的样品是否与肠易激综合征（IBS）相关联的方法，系统和代码。特别地，本发明可用于使用统计算法和/或经验数据将来自个体的样品作为IBS样品进行分类。本发明也可用于排除使用统计学算法和/或经验数据的组合在IBS中呈现IBS样症状和统治的一种或多种疾病或障碍。因此，本发明提供了IBS的准确诊断预测和用于指导治疗决定的预后信息。

6. 发明申请

US20060154276A1 Methods of diagnosing inflammatory bowel disease 审中-公开
标题翻译：炎症性肠病诊断方法
公开(公告)号：US20060154276A1
公开(公告)日：2006-07-13
申请号：US11293616
申请日：2005-12-01
申请人： Augusto Lois , Bruce Neri , Esther Oh , John Marcelletti , Susan Carroll , Katie Smith
发明人： Augusto Lois , Bruce Neri , Esther Oh , John Marcelletti , Susan Carroll , Katie Smith
IPC分类号： C12Q1/68 , G01N33/569 , G01N33/53
CPC分类号： G01N33/6854 , G01N33/6893 , G01N2800/065 , G01N2800/52
摘要： The present invention provides methods for diagnosing inflammatory bowel disease (IBD) or for differentiating between Crohn's disease (CD), ulcerative colitis (UC), and indeterminate colitis (IC) in an individual by using a combination of learning statistical classifiers based upon the presence or level of one or more IBD markers in a sample from the individual. The present invention also provides methods for diagnosing the presence or severity of IBD and for stratifying IBD in an individual by determining the level of one or more IBD markers in a sample from the individual and calculating an index value using an algorithm based upon the level of the IBD markers. Methods for monitoring the efficacy of IBD therapy, monitoring the progression or regression of IBD, and optimizing therapy in an individual having IBD are also provided.
摘要翻译：本发明提供了通过使用基于存在的学习统计分类器的组合来诊断炎症性肠病（IBD）或用于区分个体中的克罗恩病（CD），溃疡性结肠炎（UC）和不确定性结肠炎（IC）或来自个体的样品中的一种或多种IBD标记物的水平。本发明还提供了用于诊断IBD的存在或严重性以及通过确定来自个体的样本中的一种或多种IBD标记的水平来计算个体中IBD的分级的方法，并且使用基于 IBD标记。还提供了用于监测IBD治疗的功效，监测IBD的进展或消退以及优化IBD个体治疗的方法。

7. 发明申请

US20160123984A1 DRUG SELECTION FOR BREAST CANCER THERAPY USING ANTIBODY-BASED ARRAYS 审中-公开
公开(公告)号：US20160123984A1
公开(公告)日：2016-05-05
申请号：US14993813
申请日：2016-01-12
申请人： SHARAT SINGH , JEANNE HARVEY , PHILLIP KIM , XINJUN LIU , LIMIN LIU , ROBERT BARHAM , BRUCE NERI
发明人： SHARAT SINGH , JEANNE HARVEY , PHILLIP KIM , XINJUN LIU , LIMIN LIU , ROBERT BARHAM , BRUCE NERI
IPC分类号： G01N33/574
CPC分类号： G01N33/57415 , G01N33/5011 , G01N2800/52 , G01N2800/60
摘要： The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of components of signal transduction pathways derived from use of the invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.

8. 发明申请

US20130045880A1 DRUG SELECTION FOR BREAST CANCER THERAPY USING ANTIBODY-BASED ARRAYS 有权
标题翻译：使用基于抗体的阵列进行乳腺癌治疗的药物选择
公开(公告)号：US20130045880A1
公开(公告)日：2013-02-21
申请号：US13439737
申请日：2012-04-04
申请人： Sharat Singh , Jeanne Harvey , Phillip Kim , Xinjun Liu , Limin Liu , Robert Barham , Bruce Neri
发明人： Sharat Singh , Jeanne Harvey , Phillip Kim , Xinjun Liu , Limin Liu , Robert Barham , Bruce Neri
IPC分类号： C40B30/04
CPC分类号： G01N33/57415 , G01N33/5011 , G01N2800/52 , G01N2800/60
摘要： The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of components of signal transduction pathways derived from use of the invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.
摘要翻译：本发明提供用于检测肿瘤细胞中信号转导途径的组分的激活状态的组合物和方法。关于使用本发明的信号转导途径的组分的激活状态的信息可用于癌症诊断，预后和癌症治疗的设计。

9. 发明授权

US08315818B2 Methods of diagnosing inflammatory bowel disease 有权
标题翻译：炎症性肠病诊断方法
公开(公告)号：US08315818B2
公开(公告)日：2012-11-20
申请号：US12965512
申请日：2010-12-10
申请人： Augusto Lois , Bruce Neri
发明人： Augusto Lois , Bruce Neri
IPC分类号： G06F7/00
CPC分类号： G01N33/56972 , A61K31/00 , A61K31/24 , A61K31/4985 , A61K31/52 , A61K31/56 , G01N2469/20 , G01N2800/065 , G01N2800/52 , G16H50/70 , Y02A90/26
摘要： The present invention provides methods, systems, and code for accurately classifying whether a sample from an individual is associated with inflammatory bowel disease (IBD) or a clinical subtype thereof. In particular, the present invention is useful for classifying a sample from an individual as an IBD sample using a statistical algorithm and/or empirical data. The present invention is also useful for differentiating between a clinical subtype of IBD such as Crohn's disease (CD) and ulcerative colitis (UC) using a statistical algorithm and/or empirical data. Thus, the present invention provides an accurate diagnostic prediction of IBD or a clinical subtype thereof and prognostic information useful for guiding treatment decisions.
摘要翻译：本发明提供了用于准确地分类来自个体的样品是否与炎症性肠病（IBD）或其临床亚型相关联的方法，系统和代码。特别地，本发明可用于使用统计学算法和/或经验数据将来自个人的样本作为IBD样本进行分类。本发明还可用于使用统计学算法和/或经验数据来区分诸如克罗恩病（CD）和溃疡性结肠炎（UC）的IBD的临床亚型。因此，本发明提供IBD或其临床亚型的准确诊断预测和用于指导治疗决定的预后信息。

10. 发明授权

US07908091B2 Methods of predicting and monitoring tyrosine kinase inhibitor therapy 有权
标题翻译：预测和监测酪氨酸激酶抑制剂治疗方法
公开(公告)号：US07908091B2
公开(公告)日：2011-03-15
申请号：US11687254
申请日：2007-03-16
申请人： Jeanne Harvey , Bruce Neri , Sharat Singh
发明人： Jeanne Harvey , Bruce Neri , Sharat Singh
IPC分类号： G06F7/00
CPC分类号： G06F19/18 , C12Q1/6886 , C12Q2600/106 , C12Q2600/154 , G01N33/57484 , G01N2333/91215 , G01N2500/04 , G01N2800/52 , G06F19/24
摘要： The present invention provides methods for analyzing a combination of biomarkers to individualize tyrosine kinase inhibitor therapy in patients who have been diagnosed with cancer. In particular, the assay methods of the present invention are useful for predicting, identifying, or monitoring the response of a tumor, tumor cell, or patient to treatment with a tyrosine kinase inhibitor using an algorithm based upon biomarker profiling. The assay methods of the present invention are also useful for predicting whether a patient has a risk of developing toxicity or resistance to treatment with a tyrosine kinase inhibitor. In addition, the assay methods of the present invention are useful for monitoring tyrosine kinase inhibitor therapy in a patient receiving the drug to evaluate whether the patient will develop resistance to the drug. Furthermore, the assay methods of the present invention are useful for optimizing the dose of a tyrosine kinase inhibitor in a patient receiving the drug to achieve therapeutic efficacy and/or reduce toxic side-effects.
摘要翻译：本发明提供了用于分析已经被诊断患有癌症的患者中的酪氨酸激酶抑制剂治疗的生物标志物的组合的方法。特别地，本发明的测定方法可用于使用基于生物标志物分析的算法预测，鉴定或监测肿瘤，肿瘤细胞或患者用酪氨酸激酶抑制剂治疗的应答。本发明的测定方法也可用于预测患者是否具有产生毒性或抗酪氨酸激酶抑制剂治疗的风险。此外，本发明的测定方法可用于监测接受药物的患者中的酪氨酸激酶抑制剂治疗，以评估患者是否会产生对药物的抗药性。此外，本发明的测定方法可用于优化接受该药物的患者中的酪氨酸激酶抑制剂的剂量以达到治疗功效和/或减少毒副作用。

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