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1. 发明专利

AU2269892A NEURAL IMPLANT SYSTEM 未知
公开(公告)号：AU2269892A
公开(公告)日：1993-01-25
申请号：AU2269892
申请日：1992-06-25
申请人： BROWN UNIVERSITY RESEARCH FOUNDATION
发明人： PATRICK AEBISCHER , MOSES GODDARD , JOHN G MOLDAUER , PAUL J MULHAUSER , M. ANNE RATHBUN , PAUL R SANBERG , ALFRED V. VASCONCELLOS
IPC分类号： A61M37/00 , A61F2/02 , A61K9/00 , A61M31/00
摘要： A composition comprises encapsulated cells that provide a biologically active factor such as an anti-nociceptive agent and is formulated for insertion into the human spinal region of the central nervous system. Use of encapsulated cells to prepare a medicament for insertion into the human spinal region for provision of the biologically active factor to a patient.

2. 发明专利

AU2302892A CAPSULE EXTRUSION SYSTEMS 未知
公开(公告)号：AU2302892A
公开(公告)日：1993-01-25
申请号：AU2302892
申请日：1992-06-25
申请人： BROWN UNIVERSITY RESEARCH FOUNDATION
发明人： PATRICK AEBISCHER , JOHN F MILLS , LARS WAHLBERG , EDWARD J DOHERTY , PATRICK A. TRESCO
IPC分类号： B01J13/14 , A61J20060101 , A61J3/06 , A61J3/07 , A61K9/00 , A61K9/50 , B01J13/02 , B01J13/04 , C12M1/00 , C12N5/00 , C12N5/02 , C12N5/071 , C12N11/04
摘要： Methods for producing cell capsules are disclosed in which a coagulant (22), which can include a cell suspension or other biologically active factor, and a polymeric casting solution (26) are extruded through a common extrusion port (14) having at least two concentric bores, such that the coagulant is extruded through the inner bore (16) and the polymeric casting solution is extruded through the outer bore (18). The method involves initiating extrusion of the coagulant within a temporal range of about 10 msecs to about one second from initiating delivery of the casting solution through the respective bores. Delivery of the coagulant is then shut off, and extrusion of the casting solution is terminated either immediately or after some predetermined time.

3. 发明专利

AU632827B2 NEUROLOGICAL THERAPY SYSTEM 未知
公开(公告)号：AU632827B2
公开(公告)日：1993-01-14
申请号：AU5856590
申请日：1990-06-20
申请人： BROWN UNIVERSITY RESEARCH FOUNDATION
发明人： PATRICK AEBISCHER , SHELLEY R. WINN
IPC分类号： A61F2/02 , A61K9/00 , A61K9/20 , A61K9/22 , A61M31/00

4. 发明专利

AU2305492A RENEWABLE NEURAL IMPLANT DEVICE AND METHOD 未知
公开(公告)号：AU2305492A
公开(公告)日：1993-01-25
申请号：AU2305492
申请日：1992-06-25
申请人： BROWN UNIVERSITY RESEARCH FOUNDATION
发明人： PATRICK AEBISCHER , PAUL C. DICESARE , MOSES GODDARD , PAUL J MULHAUSER
IPC分类号： A61M25/00 , A61F2/02 , A61K9/00 , A61M31/00 , A61M37/00
摘要： Refillable immunoisolatory neurological therapy devices for local and controlled delivery of a biologically active factor to the brain of a patient. The devices include a cell chamber (20) adapted for infusion with secretory cells and having at least one semipermeable or permselective surface across which biologically active factors secreted by the cells can be delivered to the brain. The devices also include means (38) for introducing secretory cells into the cell chamber, and means for renewing the cells or cell medium.

5. 发明申请

WO2005032511A2 NANOPARTICULATE THERAPEUTIC BIOLOGICALLY ACTIVE AGENTS 审中-公开
标题翻译：纳米颗粒治疗生物活性剂
公开(公告)号：WO2005032511A2
公开(公告)日：2005-04-14
申请号：PCT/US2004/032271
申请日：2004-09-30
申请人： SPHERICS, INC. , BROWN UNIVERSITY RESEARCH FOUNDATION , JACOB, Jules, S. , JONG, Yong, S. , ABRAMSON, Danielle, T. , MATHIOWITZ, Edith , SANTOS, Camilla, A. , BASSETT, Michael, J. , FURTADO, Stacia
发明人： JACOB, Jules, S. , JONG, Yong, S. , ABRAMSON, Danielle, T. , MATHIOWITZ, Edith , SANTOS, Camilla, A. , BASSETT, Michael, J. , FURTADO, Stacia
IPC分类号： A61K9/00
CPC分类号： A61K38/208 , A61K9/14 , A61K9/146 , A61K9/1688 , A61K9/5026 , A61K9/5031 , A61K9/5089 , A61K31/7105 , A61K38/168 , A61K38/27 , A61K38/28
摘要： Compositions containing particles of biologically active agents with sizes in the micron and submicron range and methods for making and using such particles are described herein. In the preferred embodiment the biologically active agents are peptides, proteins, nucleic acid molecules, or hydrophilic synthetic molecules. The particles have a size ranging from an average diameter of about 100 nm to about 2000 nm, preferably about 200 nm to 600 nm. Optionally the biologically active agents contain a polymeric coating. The particles are formed by adding a biologically active agent to an aqueous solution, mixing a nonsolvent that is miscible with water with the aqueous solution, and precipitating particles of the biologically active agents out of the nonsolvent: aqueous solution combination. The nonsolvent is typically a C1 to C6 alcohol, preferably a C2 to a C5 alcohol. In the preferred embodiment, the nonsolvent is tert -butyl alcohol.
摘要翻译：本文描述了包含具有微米和亚微米范围尺寸的生物活性剂颗粒的组合物以及制备和使用此类颗粒的方法。在优选的实施方案中，生物活性剂是肽，蛋白质，核酸分子或亲水性合成分子。颗粒具有范围从约100nm至约2000nm的平均直径，优选约200nm至600nm的尺寸。任选地，生物活性剂含有聚合物涂层。通过将生物活性剂加入到水溶液中，将与水混溶的非溶剂与水溶液混合，并将生物活性剂的颗粒从非溶剂：水溶液组合物中沉淀出来而形成颗粒。非溶剂通常是C1至C6醇，优选C2至C5醇。在优选的实施方案中，非溶剂是叔丁醇。

6. 发明申请

WO2004080392A2 KINASE INHIBITORS AND METHODS OF USE IN SCREENING ASSAYS AND MODULATION OF CELL PROLIFERATION AND GROWTH 审中-公开
标题翻译：激酶抑制剂和筛选测定中使用的方法和细胞增殖和生长的调节
公开(公告)号：WO2004080392A2
公开(公告)日：2004-09-23
申请号：PCT/US2004/006670
申请日：2004-03-04
申请人： BROWN UNIVERSITY RESEARCH FOUNDATION , SEDIVY, John, M. , KOLCH, Walter , KAM, Yeung, Chi
发明人： SEDIVY, John, M. , KOLCH, Walter , KAM, Yeung, Chi
IPC分类号： A61K
CPC分类号： C12Q1/6876 , A61K38/00 , C12Q1/485 , C12Q2600/158 , G01N33/566 , G01N33/574 , G01N33/6872 , G01N2510/00
摘要： The invention relates to the discovery of a novel amino acid sequence motif, herein termed the RKIP motif, and to the family of proteins defined by the presence of that motif. Proteins comprising the RKIP motif modulate kinases involved in signal transduction pathways. The RKIP motif forms the basis for screening assays for the identification of agents useful for modulating signal transduction pathways subject to RKIP family mediated regulation, and for the diagnosis and treatment of disorders involving inappropriate activities of pathways subject to RKIP family mediated regulation.
摘要翻译：本发明涉及新颖的氨基酸序列基序（这里称为RKIP基序）以及由该基序的存在定义的蛋白家族的发现。包含RKIP基序的蛋白调节参与信号转导途径的激酶。 RKIP基序构成了用于鉴定可用于调节受RKIP家族调节的信号转导途径的药剂的筛选测定的基础，以及用于诊断和治疗涉及RKIP家族调节的途径的不适当活性的疾病。

7. 发明申请

WO2004017102A2 SCANNING MAGNETIC MICROSCOPE HAVING IMPROVED MAGNETIC SENSOR 审中-公开
标题翻译：具有改进磁传感器的扫描磁性显微镜
公开(公告)号：WO2004017102A2
公开(公告)日：2004-02-26
申请号：PCT/US2003/025390
申请日：2003-08-14
申请人： BROWN UNIVERSITY RESEARCH FOUNDATION , XIAO, Gang
发明人： XIAO, Gang
IPC分类号： G02B
CPC分类号： G01Q60/54 , G01Q10/04 , G01Q30/04 , G01R33/0385
摘要： A scanning magnetic microscope SMM (20) includes a sensor (10) for sensing a magnetic field generated by a specimen (78), the sensor including one of a MTJ, a GMR, or an EHE sensor; translation apparatus (22A-C, 52) for translating the sensor relative to a surface of sad specimen; and a data processor (50), having an input coupled to an output of said sensor, for constructing an image of said magnetic field. The sensor preferably includes one to three sensing units each defining a sensing axis for sensing a component of a magnetic field from a specimen, the sensing units disposed such that the sensing axes are orthogonal to one another. Pluralities of such sensors can be disposed in two or three dimensional arrays. The SMM can be used for examining the current flow in ICs, electromigration, magnetic data storage media, biomagnetic systems and magnetic ink used to print currency.
摘要翻译：扫描磁显微镜SMM（20）包括用于感测由试样（78）产生的磁场的传感器（10），所述传感器包括MTJ，GMR或EHE传感器之一; 用于将传感器相对于悲伤样本的表面平移的翻译装置（22A-C，52）以及数据处理器（50），其具有耦合到所述传感器的输出的输入，用于构造所述磁场的图像。传感器优选地包括一至三个感测单元，每个感测单元限定用于感测来自样本的磁场分量的感测轴，所述感测单元设置成使得感测轴彼此正交。多个这样的传感器可以设置在二维或三维阵列中。 SMM可用于检查IC中的电流，电迁移，磁数据存储介质，生物磁系统和用于打印货币的磁性墨水。

8. 发明申请

WO2003013683A1 METHODS FOR MICRONIZATION OF HYDROPHOBIC DRUGS 审中-公开
标题翻译：疏水药物微量化方法
公开(公告)号：WO2003013683A1
公开(公告)日：2003-02-20
申请号：PCT/US2002/025134
申请日：2002-08-08
申请人： BROWN UNIVERSITY RESEARCH FOUNDATION
发明人： MATHIOWITZ, Edith , THANOS, Christopher , LIU, Zhi
IPC分类号： B01D9/00
CPC分类号： A61K9/5138 , A61K9/14 , A61K9/146 , A61K9/1688 , A61K9/1694 , A61K9/5146 , A61K9/5192 , B01D9/00 , B01J13/06 , Y10T428/2982 , Y10T428/2985 , Y10T428/2989 , Y10T428/31685 , Y10T428/31696
摘要： The invention involves methods and products related to the micronization of hydrophobic drugs. A method of micronizing hydrophobic drugs using a set of solutions including an aqueous solution is provided. The invention also relates to products of micronized hydrophobic drugs and related methods of use.
摘要翻译：本发明涉及与疏水性药物的微粉化相关的方法和产品。提供了使用一组包括水溶液的溶液来微粉化疏水性药物的方法。本发明还涉及微粉化疏水药物的产品和相关使用方法。

9. 发明申请

WO2003007412A1 POLYMER ELECTROLYTE MEMBRANE FOR ELECTROCHEMICAL AND OTHER APPLICATIONS 审中-公开
标题翻译：聚合物电解质膜用于电化学和其他应用
公开(公告)号：WO2003007412A1
公开(公告)日：2003-01-23
申请号：PCT/US2002/022535
申请日：2002-07-15
申请人： BROWN UNIVERSITY RESEARCH FOUNDATION , RISEN, William, M., Jr. , ZHANG, Pu
发明人： RISEN, William, M., Jr. , ZHANG, Pu
IPC分类号： H01M8/10
CPC分类号： C08J5/2268 , C08J5/2293 , C08J2327/18 , H01M4/8605 , H01M4/881 , H01M4/8817 , H01M4/8853 , H01M4/8882 , H01M4/921 , H01M8/1004 , H01M8/1016 , H01M8/1018 , H01M8/1023 , H01M8/1039 , H01M8/1086 , Y02P70/56
摘要： Modified ion-conducting membranes (10), and a method for making the same, which increases the membrane (10) surface area, and, optionally, incorporates mono- and multi-metal ion-containing catalysts for both fuel consumption catalysis in fuel cells as well as catalysis of reactions to ameliorate the effects of CO and other impurities in fuel cells. The membranes (10) modified by these methods can fin application in catalysis and transport applications.
摘要翻译：改进的离子导电膜（10）及其制备方法，其增加膜（10）表面积，并且任选地包含用于燃料电池中的燃料消耗催化剂的单金属和多金属离子的催化剂以及催化反应，以改善燃料电池中CO和其他杂质的影响。通过这些方法改性的膜（10）可以在催化和运输应用中应用。

10. 发明申请

WO1997041418A1 OPTICAL METHOD FOR DETERMINING THE MECHANICAL PROPERTIES OF A MATERIAL 审中-公开
标题翻译：用于确定材料的机械性能的光学方法
公开(公告)号：WO1997041418A1
公开(公告)日：1997-11-06
申请号：PCT/US1997005956
申请日：1997-04-10
申请人： BROWN UNIVERSITY RESEARCH FOUNDATION
发明人： BROWN UNIVERSITY RESEARCH FOUNDATION , MARIS, Humphrey, J. , STONER, Robert, J.
IPC分类号： G01N21/00
CPC分类号： G01N29/0681 , G01N21/17 , G01N29/2418 , G01N2291/011 , G01N2291/0237 , G01N2291/02854 , G01N2291/02881 , G01N2291/0427
摘要： Disclosed is a method for characterizing a sample, comprising the steps of: (a) acquiring data from the sample using at least one probe beam wavelength to measure, for times less than a few nanoseconds, a change in the reflectivity of the sample induced by a pump beams; (b) analyzing the data to determine at least one material property by comparing a background signal component of the data with data obtained for a similar delay time range from one or more samples prepared under conditions known to give rise to certain physical and chemical material properties; and (c) analyzing a component of the measured time dependent reflectivity caused by ultrasonic waves generated by the pump beam using the at least one determined material property. The first step of analyzing may include a step of interpolating between reference samples to obtain an intermediate set of material properties. The material properties may include sound velocity, density, and optical constants. In one embodiment, only a correlation is made with the background signal, and at least one of the structural phase, grain orientation, and stoichiometry is determined.
摘要翻译：公开了一种用于表征样品的方法，包括以下步骤：（a）使用至少一个探针光束波长从样品获取数据，对于小于几纳秒的时间，测量样品的反射率的变化，由泵梁; （b）通过将数据的背景信号分量与在已知产生某些物理和化学材料性质的条件下制备的一种或多种样品相似的延迟时间范围获得的数据进行比较来分析数据以确定至少一种材料性质 ; 以及（c）使用所述至少一个确定的材料特性来分析由所述泵浦光束产生的超声波引起的测量的与时间相关的反射率的分量。分析的第一步可以包括在参考样本之间插值以获得中间的材料特性集的步骤。材料特性可包括声速，密度和光学常数。在一个实施例中，仅与背景信号进行相关，并且确定结构相位，晶粒取向和化学计量中的至少一个。

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