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1. 发明申请

WO2005016262A2 METHODS FOR ADMINISTERING ARIPIPRAZOLE 审中-公开
标题翻译：管理阿维哌唑的方法
公开(公告)号：WO2005016262A2
公开(公告)日：2005-02-24
申请号：PCT/US2004/024345
申请日：2004-07-29
申请人： ALKERMES CONTROLLED THERAPEUTIC. II , BROWN, Josiah
发明人： BROWN, Josiah
IPC分类号： A61K
CPC分类号： A61K9/0019 , A61K9/10 , A61K31/496 , A61K47/02 , A61K47/26 , A61K47/38
摘要： The present invention relates, in part, to the discovery that a pharmaceutical composition comprising aripiprazole and a carrier administered in a bolus injection resulted in an extended release profile similar to that obtained by the injection of a poly lactide-co-glycolide microsphere formulation containing the active agent. This surprising result suggests that pharmacologically beneficial extended release formulations without the complexities and expense associated with the manufacture microspheres.
摘要翻译：本发明部分地涉及包含阿立哌唑和以推注给药的载体的药物组合物的发现，导致延长的释放曲线类似于通过注射含有丙交酯 - 共 - 乙交酯微球制剂而获得的释放曲线活性剂。令人惊奇的结果表明药理学有益的延长释放制剂没有与制造微球有关的复杂性和费用。

2. 发明申请

WO2005025543A3 POLYMER-BASED SUSTAINED RELEASE DEVICE AND METHOD FOR PREPARATION 审中-公开
公开(公告)号：WO2005025543A3
公开(公告)日：2005-03-24
申请号：PCT/US2004/029645
申请日：2004-09-08
申请人： ALKERMES CONTROLLED THERAPEUTICS, INC. , TROIANO, Gregory, C. , PASZYC, Tina , JAWOROWICZ, Warren, E. , BROWN, Josiah
发明人： TROIANO, Gregory, C. , PASZYC, Tina , JAWOROWICZ, Warren, E. , BROWN, Josiah
IPC分类号： A61K9/16 , A61K38/00
摘要： Methods for preparing a polymer-based sustained release device including a biocompatible polymer having incorporated therein a biologically active agent are described. In one embodiment, the method of preparing a polymer-based sustained release device comprises the steps of (a) exchanging a continuous medium component of a disperse system, the disperse system including a biologically active agent as a dispersed entity, with an organic liquid, thereby forming a first mixture that includes the biologically active agent and the organic liquid; (b) combining a biocompatible polymer with the first mixture, thereby forming a second mixture that includes the biologically active agent, the organic liquid, and the biocompatible polymer; and (c) separating the organic liquid from the second mixture, thereby forming the polymer-based sustained release device. In one embodiment, the continuous medium component of the disperse system is exchanged with the organic liquid using diafiltration, for example, diafiltration using tangential flow filtration.

3. 发明申请

WO2005025543A2 POLYMER-BASED SUSTAINED RELEASE DEVICE AND METHOD FOR PREPARATION 审中-公开
标题翻译：基于聚合物的持续释放装置及其制备方法
公开(公告)号：WO2005025543A2
公开(公告)日：2005-03-24
申请号：PCT/US2004029645
申请日：2004-09-08
申请人： ALKERMES INC , TROIANO GREGORY C , PASZYC TINA , JAWOROWICZ WARREN E , BROWN JOSIAH
发明人： TROIANO GREGORY C , PASZYC TINA , JAWOROWICZ WARREN E , BROWN JOSIAH
IPC分类号： A61K9/16 , A61K38/00
CPC分类号： A61K9/1694 , A61K9/1647
摘要： Methods for preparing a polymer-based sustained release device including a biocompatible polymer having incorporated therein a biologically active agent are described. In one embodiment, the method of preparing a polymer-based sustained release device comprises the steps of (a) exchanging a continuous medium component of a disperse system, the disperse system including a biologically active agent as a dispersed entity, with an organic liquid, thereby forming a first mixture that includes the biologically active agent and the organic liquid; (b) combining a biocompatible polymer with the first mixture, thereby forming a second mixture that includes the biologically active agent, the organic liquid, and the biocompatible polymer; and (c) separating the organic liquid from the second mixture, thereby forming the polymer-based sustained release device. In one embodiment, the continuous medium component of the disperse system is exchanged with the organic liquid using diafiltration, for example, diafiltration using tangential flow filtration.
摘要翻译：描述了制备包含其中并入生物活性剂的生物相容性聚合物的基于聚合物的持续释放装置的方法。在一个实施方案中，制备基于聚合物的持续释放装置的方法包括以下步骤：（a）将分散系统的连续介质组分（包括分散体的生物活性剂）与有机液体交换，从而形成包含生物活性剂和有机液体的第一混合物; （b）将生物相容性聚合物与第一混合物结合，从而形成包含生物活性剂，有机液体和生物相容性聚合物的第二混合物; 和（c）从第二混合物中分离有机液体，从而形成基于聚合物的持续释放装置。在一个实施方案中，使用渗滤将有机液体与分散系统的连续介质组分进行交换，例如使用切向流过滤进行渗滤。

4. 发明申请

WO0160334A3 METHOD AND APPARATUS FOR UNIFORM SORBATE EQUILIBRATION OF SOLID SAMPLES 审中-公开
标题翻译：固体样品均匀等离子体的方法和装置
公开(公告)号：WO0160334A3
公开(公告)日：2002-03-14
申请号：PCT/US0104586
申请日：2001-02-13
申请人： ALKERMES INC , COSTANTINO HENRY R , BROWN JOSIAH
发明人： COSTANTINO HENRY R , BROWN JOSIAH
IPC分类号： G01N1/28 , G01N15/08 , G01N35/00 , G01N5/04 , G05D22/00
CPC分类号： G01N15/0893 , G01N1/28 , G01N2035/00455
摘要： Solid samples having a uniform sorbate content are produced by directing a gas having a constant sorbate pressure through a plurality of containers, each container enclosing a solid sample. The sorbate content of the solid samples equilibrates with the sorbatepressure in the gas, thereby causing the solid samples to have a uniform sorbate content. An apparatus that can be employed to generate solid samples having a uniform sorbate content includes a relative humidity generator, and a manifold which connects the relative humidity generator to a plurality of solid sample containers.
摘要翻译：具有均匀山梨酸盐含量的固体样品通过将具有恒定的山梨酸盐压力的气体引导通过多个容器来产生，每个容器包围固体样品。固体样品的山梨酸盐含量与气体中的山梨酸盐压力平衡，从而使固体样品具有均匀的山梨酸盐含量。可用于产生具有均匀山梨酸含量的固体样品的装置包括相对湿度发生器和将相对湿度发生器连接到多个固体样品容器的歧管。

5. 发明申请

WO2012154483A1 DRY POWDER FOSFOMYCIN/TOBRAMYCIN FORMULATION FOR INHALATION 审中-公开
标题翻译：干粉FOSFOMYCIN / TOBRAMYCIN制剂用于吸入
公开(公告)号：WO2012154483A1
公开(公告)日：2012-11-15
申请号：PCT/US2012/036260
申请日：2012-05-03
申请人： GILEAD SCIENCES, INC. , LAI, Johnny , BROWN, Josiah , STAPLETON, Kevin, Walter
发明人： LAI, Johnny , BROWN, Josiah , STAPLETON, Kevin, Walter
IPC分类号： A61K31/198 , A61K31/665 , A61K31/7036 , A61P11/00 , A61K9/00
CPC分类号： A61K9/0073 , A61K9/0075 , A61K31/198 , A61K31/665 , A61K31/7036 , A61K45/06 , Y02A50/473 , A61K2300/00
摘要： The present invention provides an inhaled dry powder formulation containing a combination of fosfomycin salt and tobramycin-leucine compound particles. The use of such formulation for the treatment of patients who have Chronic Obstructive Pulmonary Disease (COPD) and who are experiencing or at risk of experiencing acute exacerbation, as well as patients who have other bacterial infections of the respiratory tract, particularly the lower respiratory tract, and methods for treating the same are also provided.
摘要翻译：本发明提供含有磷霉素盐和妥布霉素 - 亮氨酸复合物颗粒的组合的吸入干粉制剂。使用这种制剂治疗患有慢性阻塞性肺疾病（COPD）并且正在经历或正在经历急性加重的患者的患者，以及患有其它呼吸道细菌感染的患者，特别是下呼吸道，还提供了其处理方法。

6. 发明申请

WO2005016262A3 METHODS FOR ADMINISTERING ARIPIPRAZOLE 审中-公开
标题翻译：治疗ARIPIPRAZOLE的方法
公开(公告)号：WO2005016262A3
公开(公告)日：2005-09-09
申请号：PCT/US2004024345
申请日：2004-07-29
申请人： ALKERMES INC , BROWN JOSIAH
发明人： BROWN JOSIAH
IPC分类号： A61K31/496 , A61K47/02 , A61K47/26 , A61K47/38 , A61K9/08 , A61K9/10
CPC分类号： A61K9/0019 , A61K9/10 , A61K31/496 , A61K47/02 , A61K47/26 , A61K47/38
摘要： The present invention relates, in part, to the discovery that a pharmaceutical composition comprising aripiprazole and a carrier administered in a bolus injection resulted in an extended release profile similar to that obtained by the injection of a poly lactide-co-glycolide microsphere formulation containing the active agent. This surprising result suggests that pharmacologically beneficial extended release formulations without the complexities and expense associated with the manufacture microspheres.
摘要翻译：本发明部分涉及这样的发现，即包含阿立哌唑和以推注方式给药的载体的药物组合物导致延长的释放曲线，其类似于通过注射包含阿拉伯糖醇的聚丙交酯 - 共 - 乙交酯微球制剂活性剂。这一令人惊讶的结果表明，药理学上有益的缓释制剂没有与制造微球相关的复杂性和费用。

7. 发明申请

WO2004064752A3 METHOD OF PREPARING SUSTAINED RELEASE MICROPARTICLES 审中-公开
标题翻译：制备持续释放微生物的方法
公开(公告)号：WO2004064752A3
公开(公告)日：2005-05-12
申请号：PCT/US2004001501
申请日：2004-01-21
申请人： ALKERMES INC , BROWN JOSIAH , JAWOROWICZ WARREN E , TROIANO GREGORY C
发明人： BROWN JOSIAH , JAWOROWICZ WARREN E , TROIANO GREGORY C
IPC分类号： A61K9/00 , A61K9/16 , A61K9/50
CPC分类号： A61K9/1694 , A61K9/0024 , A61K9/1647 , A61K9/5031 , Y10T428/2982 , Y10T428/2991 , Y10T428/2998
摘要： The present invention relates to a method for preparing an injectable composition of microparticles for the sustained release of a biologically active agent. The microparticles include a biocompatible polymer and a biologically active agent. The invention provides an improved process for the preparation of microparticles, wherein the physical characteristics of the microparticles, for example, the morphology, density and size, are independent of the process used to prepare the initially formed polymer/drug matrix. The method includes the steps of (a) providing a polymer/biologically active agent matrix; (b) compressing the polymer/biologically active agent matrix, thereby forming a compressed matrix; and (c) fragmenting the compressed matrix, thereby forming an injectable microparticle composition. The polymer/drug matrix can be provided by any suitable method.
摘要翻译：本发明涉及制备用于持续释放生物活性剂的微粒的可注射组合物的方法。微粒包括生物相容性聚合物和生物活性剂。本发明提供了一种制备微粒的改进方法，其中微粒的物理特性，例如形态，密度和尺寸，与用于制备初始形成的聚合物/药物基质的方法无关。该方法包括以下步骤：（a）提供聚合物/生物活性剂基质; （b）压缩聚合物/生物活性剂基质，从而形成压缩基质; 和（c）将压缩的基质分段，从而形成可注射的微粒组合物。聚合物/药物基质可以通过任何合适的方法提供。

8. 发明申请

WO2004064752A2 METHOD OF PREPARING SUSTAINED RELEASE MICROPARTICLES 审中-公开
标题翻译：制备持续释放微生物的方法
公开(公告)号：WO2004064752A2
公开(公告)日：2004-08-05
申请号：PCT/US2004/001501
申请日：2004-01-21
申请人： ALKERMES CONTROLLED THERAPEUTICS, INC. , BROWN, Josiah , JAWOROWICZ, Warren, E. , TROIANO, Gregory, C.
发明人： BROWN, Josiah , JAWOROWICZ, Warren, E. , TROIANO, Gregory, C.
IPC分类号： A61K
CPC分类号： A61K9/1694 , A61K9/0024 , A61K9/1647 , A61K9/5031 , Y10T428/2982 , Y10T428/2991 , Y10T428/2998
摘要： The present invention relates to a method for preparing an injectable composition of microparticles for the sustained release of a biologically active agent. The microparticles include a biocompatible polymer and a biologically active agent. The invention provides an improved process for the preparation of microparticles, wherein the physical characteristics of the microparticles, for example, the morphology, density and size, are independent of the process used to prepare the initially formed polymer/drug matrix. The method includes the steps of (a) providing a polymer/biologically active agent matrix; (b) compressing the polymer/biologically active agent matrix, thereby forming a compressed matrix; and (c) fragmenting the compressed matrix, thereby forming an injectable microparticle composition. The polymer/drug matrix can be provided by any suitable method.
摘要翻译：本发明涉及制备用于持续释放生物活性剂的微粒可注射组合物的方法。微粒包括生物相容性聚合物和生物活性剂。本发明提供了一种制备微粒的改进方法，其中微粒的物理特性，例如形态，密度和尺寸，与用于制备初始形成的聚合物/药物基质的方法无关。该方法包括以下步骤：（a）提供聚合物/生物活性剂基质; （b）压缩聚合物/生物活性剂基质，由此形成压缩基质; 和（c）使压缩的基质碎裂，从而形成可注射的微粒组合物。聚合物/药物基质可以通过任何合适的方法提供。

9. 发明授权

US1250133A Car-stopper. 失效
标题翻译：停车
公开(公告)号：US1250133A
公开(公告)日：1917-12-18
申请号：US16757217
申请日：1917-05-09
申请人： BROWN JOSIAH H
发明人： BROWN JOSIAH H
CPC分类号： B61K7/04

10. 发明专利

CA3743A PORTABLE BURGLAR ALARM 未知
公开(公告)号：CA3743A
公开(公告)日：1874-08-13
申请号：CA3743D
申请人： WETHERILL R N , BROWN JOSIAH B
发明人： WETHERILL R N

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