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1. 发明申请

WO2012175434A1 PHARMACEUTICAL FORMULATIONS COMPRISING VESTIPITANT 审中-公开
标题翻译：包括VESTIPITANT的药物制剂
公开(公告)号：WO2012175434A1
公开(公告)日：2012-12-27
申请号：PCT/EP2012/061550
申请日：2012-06-18
申请人： GLAXO GROUP LIMITED , BEATO, Stefania , BRESCIANI, Massimo , CROY, Scott, R , MULLER, Francis, Xavier
发明人： BEATO, Stefania , BRESCIANI, Massimo , CROY, Scott, R , MULLER, Francis, Xavier
IPC分类号： A61K31/496 , A61K47/40 , A61K9/00 , A61P1/08 , A61P25/20 , A61K47/48
CPC分类号： A61K9/0019 , A61K9/08 , A61K31/495 , A61K47/12 , A61K47/6951 , B82Y5/00
摘要： A pharmaceutical formulation for intravenous (IV) administration comprising 2-(S)-(4-Fluoro-2- methyl-phenyl)-piperazine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methyl-amide or a pharmaceutically acceptable salt thereof and a process for its preparation and its use in medical therapy.
摘要翻译：用于静脉内（IV）给药的药物制剂包含2-（S） - （4-氟-2-甲基 - 苯基） - 哌嗪-1-甲酸[1-（R） - （3,5-双 - 苯基） - 乙基] - 甲基 - 酰胺或其药学上可接受的盐及其制备方法及其在药物治疗中的应用。

2. 发明申请

WO2005049306A1 ULTRASOUND-ASSISTED COMPACTION PROCESS WITH A COMPACTION DEVICE MADE OF COUPLED PLASTIC-METAL MATERIALS 审中-公开
标题翻译：超声波辅助压缩工艺与压接装置的耦合塑料 - 金属材料
公开(公告)号：WO2005049306A1
公开(公告)日：2005-06-02
申请号：PCT/EP2004/052990
申请日：2004-11-17
申请人： EURAND PHARMACEUTICALS LIMITED , KIRCHMAYER, Stefano , BRESCIANI, Massimo , DOBETTI, Luca
发明人： KIRCHMAYER, Stefano , BRESCIANI, Massimo , DOBETTI, Luca
IPC分类号： B30B11/02
CPC分类号： B30B11/022 , B30B15/024
摘要： An ultrasound-assisted compaction device for carrying out a compaction process of a powder mixture characterised in that the die chamber and the punch of said device are made of a different material one from the other, said material being chosen from plastic and metal material.
摘要翻译：一种用于进行粉末混合物的压实过程的超声辅助压实装置，其特征在于，所述模具室和所述装置的冲头由彼此不同的材料制成，所述材料选自塑料和金属材料。

3. 发明申请

WO2003074028A1 PROCESS FOR LOADING AND THERMODYNAMICALLY ACTIVATING DRUGS ON POLYMERS BY MEANS OF SUPERCRITICAL FLUIDS 审中-公开
标题翻译：通过超临界流体的聚合物装载和热力学活化药物的方法
公开(公告)号：WO2003074028A1
公开(公告)日：2003-09-12
申请号：PCT/EP2003/002204
申请日：2003-03-07
申请人： EURAND PHARMACEUTICALS LTD. , BRESCIANI, Massimo , DOBETTI, Luca , KIRCHMAYER, Stefano
发明人： BRESCIANI, Massimo , DOBETTI, Luca , KIRCHMAYER, Stefano
IPC分类号： A61K9/14
CPC分类号： A61K9/1694 , A61K9/14 , A61K9/146 , A61K9/1635
摘要： The present invention refers to a process of loading drugs in a thermodynamic activated form into polymers by means of supercritical fluids. The process includes a pre-treatment step of the cross-linked polymer with pure supercritical fluid to allow a higher degree and a more rapid kinetic of drug loading into cross-linked polymers and also a higher thermodynamic activation of the drugs.
摘要翻译：本发明涉及通过超临界流体将热力学活性形式的药物装入聚合物的方法。该方法包括交联聚合物与纯超临界流体的预处理步骤，以允许药物负载到交联聚合物中的更高程度和更快速的动力学以及药物的较高的热力学活化。

4. 发明申请

WO2003002258A1 DRUG ACTIVATION PROCESS AND VIBRATIONAL MILL THEREFOR 审中-公开
标题翻译：药物活化过程和振动磨房
公开(公告)号：WO2003002258A1
公开(公告)日：2003-01-09
申请号：PCT/EP2002/006050
申请日：2002-06-03
申请人： EURAND PHARMACEUTICALS LTD , DOBETTI, Luca , RABAGLIA, Leonardo , BRESCIANI, Massimo
发明人： DOBETTI, Luca , RABAGLIA, Leonardo , BRESCIANI, Massimo
IPC分类号： B02C17/14
CPC分类号： B02C17/14 , A61K9/14 , A61K9/146
摘要： The invention comprises a process for activating drugs by means of high-energy co-grinding of the drug with a pharmaceutical carrier, characterised by the use of a vibrational mill equipped with means that regulate the vibration frequency. The process, performed by modifying the frequency of vibration and keeping its amplitude constant, produces drug/carrier composites with a constant particle size in which the degree of drug activation increases in proportion to the frequency applied. The invention also includes a vibrational mill suitably modified to perform the process described.
摘要翻译：本发明包括通过药物与药物载体的高能量共研磨来激活药物的方法，其特征在于使用具有调节振动频率的装置的振动磨。通过改变振动频率并保持其振幅恒定而进行的该过程产生具有恒定粒径的药物/载体复合物，其中药物活化程度与施加的频率成比例地增加。本发明还包括适当修改以执行所述方法的振动磨。

5. 发明申请

WO2003002259A1 PROCESS FOR ACTIVATION OF DRUGS IN A VIBRATIONAL MILL 审中-公开
标题翻译：在振动磨机中激活药物的过程
公开(公告)号：WO2003002259A1
公开(公告)日：2003-01-09
申请号：PCT/EP2002/007117
申请日：2002-06-27
申请人： EURAND PHARMACEUTICALS LTD , DOBETTI, Luca , BRESCIANI, Massimo
发明人： DOBETTI, Luca , BRESCIANI, Massimo
IPC分类号： B02C17/14
CPC分类号： B02C17/20 , A61K9/14 , A61K9/146 , B02C17/14
摘要： A process is described for the activation (increase in solubility and bioavailability) of drugs. The process, carried out in a vibrational mill, is characterised by the use of given proportions between the physical mixture made up of drug and pharmaceutical carrier and the empty volume among the grinding means contained inside the mill. The process leads to obtaining powders for pharmaceutical use in which the drug has a high and constant degree of activation; this result is obtainable irrespective of the nature of the drug and carrier used, and of their weight ratio.
摘要翻译：描述了用于药物的活化（溶解度和生物利用度的增加）的方法。在振动研磨机中进行的方法的特征在于在由药物和药物载体组成的物理混合物之间使用给定的比例，以及在磨机内部包含的研磨装置中的空体积。该方法导致获得药物使用的粉末，其中药物具有高且恒定的活化程度; 无论使用的药物和载体的性质以及它们的重量比如何，均可获得该结果。

6. 发明申请

WO2003002097A1 PROCESS OF THERMODYNAMICAL ACTIVATION OF WATER-INSOLUBLE DRUGS LOADED INTO CROSS-LINKED POLYMERS 审中-公开
标题翻译：加载到交联聚合物中的水不溶性药物的热力学活化方法
公开(公告)号：WO2003002097A1
公开(公告)日：2003-01-09
申请号：PCT/EP2002/006052
申请日：2002-06-03
申请人： EURAND PHARMACEUTICALS LTD , BRESCIANI, Massimo , MAGAROTTO, Lorenzo , DOBETTI, Luca
发明人： BRESCIANI, Massimo , MAGAROTTO, Lorenzo , DOBETTI, Luca
IPC分类号： A61K9/16
CPC分类号： A61K9/146
摘要： The present invention refers to a process to prepare a highly activated composite of one or more water-insoluble drugs, said process comprising the steps of: (a) subjecting said water-insoluble drug and a cross-linked polymer to co-grinding; (b) exposing the ground product of step a. to contact with water or water vapours. The resulting composite contains large amounts of drug in the easily soluble amorphous form, reduced amounts of drug in the nanocrystalline form, and is substantially free from practically insoluble drug crystals.
摘要翻译：本发明涉及一种制备一种或多种水不溶性药物的高活性复合物的方法，所述方法包括以下步骤：（a）使所述水不溶性药物和交联聚合物共磨; （b）暴露步骤a的研磨产物。与水或水蒸汽接触。所得到的复合物含有大量容易溶解的无定形形式的药物，减少了纳米晶体形式的药物，基本上不含几乎不溶的药物晶体。

7. 发明申请

WO9939692A3 PHARMACEUTICAL COMPOSITIONS IN FORM OF POLYMERIC MICROPARTICLES OBTAINED BY EXTRUSION AND SPHERONIZATION 审中-公开
标题翻译：通过挤出和球化获得的聚合物微粒形式的药物组合物
公开(公告)号：WO9939692A3
公开(公告)日：1999-09-23
申请号：PCT/EP9900781
申请日：1999-02-05
申请人： VECTORPHARMA S P A , CARLI FABIO , BRESCIANI MASSIMO , CANAL TIZIANA , GAMBINI PAOLO
发明人： CARLI FABIO , BRESCIANI MASSIMO , CANAL TIZIANA , GAMBINI PAOLO
IPC分类号： A61K9/16 , A61K47/02 , A61K47/14 , A61K47/30 , A61K47/36 , A61K47/44
CPC分类号： A61K9/1694 , A61K9/1611 , A61K9/1635 , A61K9/1652
摘要： Process for the preparation of pharmaceutical compositions comprising one or more polymers and one or more drugs by the extrusion and spheronization technique, wherein said polymers belong to the group of the cross-linked amphiphilic polymers.
摘要翻译：通过挤出和滚圆技术制备包含一种或多种聚合物和一种或多种药物的药物组合物的方法，其中所述聚合物属于交联的两亲聚合物的组。

8. 发明申请

WO2009124825A1 MEDIUM VOLTAGE CIRCUIT BREAKER WITH INTEGRATED ELECTRONIC PROTECTION UNIT 审中-公开
标题翻译：具有集成电子保护单元的中压电路断路器
公开(公告)号：WO2009124825A1
公开(公告)日：2009-10-15
申请号：PCT/EP2009/053005
申请日：2009-03-13
申请人： ABB TECHNOLOGY AG , DI MAIO, Luciano , BRESCIANI, Massimo
发明人： DI MAIO, Luciano , BRESCIANI, Massimo
IPC分类号： H01H71/02 , H01H71/12
CPC分类号： H01H71/0228 , H01H9/12 , H01H9/167 , H01H71/123 , H01H71/48 , H01H71/7409
摘要： A Medium Voltage Circuit Breaker (CB) comprising an electronic protection and control unit (1) having: - a base (2), fixed to the CB, comprising a main body (21) having fixing means (210) for fixing to the CB, a first side (22) of said main body comprising a confined space (220) including connections (221) to the CB and internal accessories thereof, a second side (23) of said main body comprising a plurality of first power and/or signal connection means (231); - a removable unit (3) comprising a casing (31), a first part (310) of said casing hosting one or more Intelligent Electronic Devices, a second part (320) of said casing being removably coupled to said base and comprising a plurality of second power and/or signal connection means (321) connected to said first power and/or signal connection means.
摘要翻译：一种包括电子保护和控制单元（1）的中压断路器（CB），其具有： - 固定到所述CB的基座（2），包括主体（21），所述主体（21）具有用于固定到所述CB的固定装置，所述主体的第一侧（22）包括封闭空间（220），该密封空间包括与CB及其内部附件的连接（221），所述主体的第二侧（23）包括多个第一功率和/或信号连接装置（231）; - 可拆卸单元（3），包括壳体（31），所述壳体的托架一个或多个智能电子设备的第一部分（310），所述壳体的第二部分（320）可拆卸地联接到所述基座并且包括多个连接到所述第一电源和/或信号连接装置的第二电源和/或信号连接装置（321）。

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