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1. 发明申请

WO2010111443A2 OMENTUM AS A SOURCE OF STROMAL/STEM CELLS AND MEDICAL TREATMENTS USING OMENTUM STROMAL/STEM CELLS 审中-公开
标题翻译：作为使用光纤/干细胞的结构/干细胞和医疗治疗的来源
公开(公告)号：WO2010111443A2
公开(公告)日：2010-09-30
申请号：PCT/US2010028577
申请日：2010-03-25
申请人： UNIV LOYOLA CHICAGO , IWASHIMA MAKIO , LOVE ROBERT , BRAUN RUDOLF KARL , SETHUPATHI PERIANNA , KNIGHT KATHERINE LATHROP
发明人： IWASHIMA MAKIO , LOVE ROBERT , BRAUN RUDOLF KARL , SETHUPATHI PERIANNA , KNIGHT KATHERINE LATHROP
IPC分类号： A61K35/12
CPC分类号： C12N5/0667 , A61K35/12
摘要： Methods for generating and using omentum cells, particularly stromal cells and/or omentum stem cells, in medical treatments such as tissue repair and regeneration to facilitate healing from traumatic injury to an abdominal organ, immune modulation treatments such as suppression of immune responses and inflammation/prevention of tissue fibrosis. A medical procedure is performed on a patient involving harvesting omental tissue from the patient, then transferring the omental tissue to an organ of the patient. A portion of the harvested omental tissue may be activated prior to transferring the omental tissue to the organ. The transferred omental tissue may comprise non-lymphoid cells isolated from the omentum tissue and obtained by homogenizing a portion of the harvested omental tissue. The invention also encompasses a medical procedure comprising the transfer of omental stem cells to a patient, and a procedure comprising in vitro activation of omental stem cells by T cells to enhance immunomodulatory functions of the omental stem cells.
摘要翻译：用于在诸如组织修复和再生的医学治疗中产生和使用网膜细胞，特别是基质细胞和/或网膜干细胞的方法，以促进从创伤性损伤到腹部器官的愈合，免疫调节治疗如抑制免疫应答和炎症/ 预防组织纤维化。对患者进行医疗手术，涉及从患者收集网膜组织，然后将网膜组织转移到患者的器官。在将网膜组织转移到器官之前，一部分收获的网状组织可以被活化。转移的网膜组织可以包括从网膜组织分离并通过使收获的网膜组织的一部分均质获得的非淋巴细胞。本发明还包括包括将网膜干细胞转移到患者的医学过程，以及包括T细胞体外激活网膜干细胞以增强网膜干细胞的免疫调节功能的方法。

2. 发明申请

WO2010111443A3 OMENTUM AS A SOURCE OF STROMAL/STEM CELLS AND MEDICAL TREATMENTS USING OMENTUM STROMAL/STEM CELLS 审中-公开
公开(公告)号：WO2010111443A3
公开(公告)日：2010-09-30
申请号：PCT/US2010/028577
申请日：2010-03-25
申请人： LOYOLA UNIVERSITY CHICAGO , IWASHIMA, Makio , LOVE, Robert , BRAUN, Rudolf Karl , SETHUPATHI, Perianna , KNIGHT, Katherine Lathrop
发明人： IWASHIMA, Makio , LOVE, Robert , BRAUN, Rudolf Karl , SETHUPATHI, Perianna , KNIGHT, Katherine Lathrop
IPC分类号： A61K38/18 , A61K35/00 , A61K38/16 , C12N5/0735 , C12N5/071 , A61P1/16 , A61P1/18
摘要： Methods for generating and using omentum cells, particularly stromal cells and/or omentum stem cells, in medical treatments such as tissue repair and regeneration to facilitate healing from traumatic injury to an abdominal organ, immune modulation treatments such as suppression of immune responses and inflammation/prevention of tissue fibrosis. A medical procedure is performed on a patient involving harvesting omental tissue from the patient, then transferring the omental tissue to an organ of the patient. A portion of the harvested omental tissue may be activated prior to transferring the omental tissue to the organ. The transferred omental tissue may comprise non-lymphoid cells isolated from the omentum tissue and obtained by homogenizing a portion of the harvested omental tissue. The invention also encompasses a medical procedure comprising the transfer of omental stem cells to a patient, and a procedure comprising in vitro activation of omental stem cells by T cells to enhance immunomodulatory functions of the omental stem cells.

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