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1. 发明专利

JP2011102306A 3,5,3'-triiodothyronine sulfate as thyroid hormone preparation and pharmaceutical formulation thereof 审中-公开
标题翻译： 3,5,3'-三硫代吗啉硫酸盐作为甲醛激素的制备和药物制剂
公开(公告)号：JP2011102306A
公开(公告)日：2011-05-26
申请号：JP2010288189
申请日：2010-12-24
申请人： Bracco Spa , ブラッコエッセピア
发明人： PINCHERA ALDO , SANTINI FERRUCCIO
IPC分类号： A61K31/198 , A61P5/14 , A61P37/02
CPC分类号： A61K31/198 , A61K9/20 , A61K31/197
摘要： PROBLEM TO BE SOLVED: To provide a drug effective for the treatment of pathologies due to organic deficiency of triiodothyronine (T3), for example, original hypothyroidism from autoimmune thyroid diseases, hormonal production defects, thyroidectomy, congenital hypothyroidism, as well as some disorders due to reduced activity of type I 5'-iodothyronine monodeiodinase (type I MD) which is induced, for example, by hypothyroidism, non thyroidal systemic illnesses, fast, and selenium shortage. SOLUTION: There are provided a method of using triiodothyronine sulfate, as such or in association with thyroxine (T 4 ), as a drug which activates thyroids, and pharmaceutical formulations therefor. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种有效治疗由于三碘甲状腺原氨酸（T3）的有机缺乏引起的病理学的药物，例如，自身免疫性甲状腺疾病，激素产生缺陷，甲状腺切除术，先天性甲状腺功能减退的原发性甲状腺功能减退，以及由于例如由甲状腺功能减退，非甲状腺全身性疾病，快速和硒缺乏引起的I型5'-碘代甲状腺原酸脱氧尿苷酶（I型MD）的活性降低而引起的一些障碍。解决方案：提供了一种使用三碘甲状腺原氨酸硫酸酯的方法，如甲状腺素（T 4 ）或与甲状腺素（T 4 ）相关联，作为激活甲状腺的药物及其药物制剂。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JPH09151966A DISC BRAKE, IN WHICH CALIPER REACTION FOR MOTORCYCLE FRONT WHEEL PREFERABLY HAVING PERIPHERAL-SECTION ANNULAR DISC IS PASSED THROUGH WHEEL FIXING SUPPORT AXLE 失效
公开(公告)号：JPH09151966A
公开(公告)日：1997-06-10
申请号：JP33804795
申请日：1995-12-01
申请人： BRACCO SPA
发明人： EMANUARE TOSON
IPC分类号： F16D55/224
摘要： PROBLEM TO BE SOLVED: To make a caliper be elastically pulled in an initial braking period and give softer braking movement by fixing the caliper of a disc brake in an arm fixed in a center axle which is coaxial with a wheel and whose end part is key-fixed in a fork end. SOLUTION: In a disc brake for a front wheel of a motor cycle, a caliper 9 which fixes a brake disc 2 in the inner face of a wheel rim 3 and sandwiches the brake disc to carry out braking is so installed as to be elastically pulled back. That is, a supporting arm 9 for a caliper 8 is positioned in a spring lower part 5 of a fork 6 through spacers D1, D2 in an axle and a hole is formed in the axle, in which a hydraulic passage B to operate the caliper 8 is communicated, in the axle line direction. As a result, a braking track with an extremely wide surface area is provided and the reaction heat can be lessened and at the same time lifting of a rear side of a motor cycle due to abrupt braking of the front wheel can be moderated.

3. 发明专利

JPH08283189A BIPHENYL IODIDE DERIVATIVE AND ITS DIAGNOSTIC USE 失效
公开(公告)号：JPH08283189A
公开(公告)日：1996-10-29
申请号：JP34655995
申请日：1995-11-30
申请人： BRACCO SPA
发明人： UTSUJIERI FURUBUIO , BUROTSUKETSUTA MARINO , ANETSURI PIEERU RUCHIO , BUISHIGATSURI MATSUSHIMO
IPC分类号： A61K49/04 , C07C39/367 , C07C43/225 , C07C59/70 , C07C69/708 , C07C233/65 , C07C233/69 , C07C235/06 , C07C235/08 , C07C235/16 , C07C235/20 , C07C235/46 , C07C235/48

4. 发明专利

JPH09313462A DEVICE FOR STANDARDIZING FOR SIGNAL STRENGTH IN MAGNETIC RESONANCE FORMING TECHNIQUE 失效
公开(公告)号：JPH09313462A
公开(公告)日：1997-12-09
申请号：JP3416897
申请日：1997-02-19
申请人： BRACCO SPA
发明人： ANJIERO GARUROTSUTEI , KURISUTOFU DE HAEN , AN MARII SUMISU , MAIKERU ENU IIKINZU , JIYURIASU PII ZOTSUDA
IPC分类号： A61B5/055 , G01R33/28 , G01R33/58
摘要： PROBLEM TO BE SOLVED: To provide a highly reliable standard which can be operated simply and safely and is suitable for standardizing the signal strength in the magnetism resonance photographing of a human or animal body. SOLUTION: As a standard pipe a blocked pipe is used, which is made of a diamagnetic material (other than glass) filled with a water solution or gel containing a paramagnetic component, and is fixed to a specified position by base tape A and lateral tapes B and C fitted with a bell cloth fastener.

5. 发明专利

JPH09100284A METHOD FOR RECOVERING GADOLINIUM AND COMPLEXING AGENT THEREFOR FROM AQUEOUS SOLUTION CONTAINING GADOLINIUM COMPLEX 失效
公开(公告)号：JPH09100284A
公开(公告)日：1997-04-15
申请号：JP15733596
申请日：1996-05-15
申请人： BRACCO SPA
发明人： JIYORUJIO RIPA , PAORO MOROSHI
IPC分类号： C07C51/41 , C01F17/00 , C07C55/07 , C07C227/40 , C07C229/16 , C07F5/00 , C22B59/00
摘要： The invention refers to a novel process for the recovery of gadolinium and its complexing agent from aqueous solutions containing their complexes and/or salts of said complexes.

6. 发明专利

JP2010145416A Method for the determination of prosthetic infections 有权
标题翻译：确定预后感染的方法
公开(公告)号：JP2010145416A
公开(公告)日：2010-07-01
申请号：JP2010018353
申请日：2010-01-29
申请人： Bracco Spa , ブラッコエッセピア
发明人： THALLER MARIA CRISTINA , ROSSOLINI GIANMARIA , SELAN LAURA , PASSARIELLO CLAUDIO
IPC分类号： G01N33/53 , C12N1/20 , C12P19/04 , C12Q1/14 , C12R1/445 , G01N33/569
CPC分类号： C12P19/04 , G01N33/56938
摘要： PROBLEM TO BE SOLVED: To provide a method for the determination of prosthetic infections which includes a step for detecting, from blood samples or other biological fluid samples, antibodies reacting with a polysaccharide produced by virulent staphylococcal strain.
SOLUTION: A method for the laboratory determination of prosthetic infections is described. This method performed on biological fluid isolated from patients, is based on the detection of antibodies specific for the polysaccharides produced by bacterium colonizing prosthetic devices.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于确定假体感染的方法，其包括从血液样本或其他生物流体样品中检测与由毒力葡萄球菌菌株产生的多糖反应的抗体的步骤。
解决方案：描述了用于实验室测定假体感染的方法。对从患者分离的生物液体进行的这种方法是基于对由细菌定植的假体装置产生的多糖特异的抗体的检测。版权所有（C）2010，JPO＆INPIT

7. 发明专利

JPH1129593A BINDING OF CHELATING AGENT TO AMINO GROUP-CONTAINING MOLECULE 失效
公开(公告)号：JPH1129593A
公开(公告)日：1999-02-02
申请号：JP10265698
申请日：1998-04-14
申请人： BRACCO SPA
发明人： MAISANO FEDERICO , GOZZINI LUIGIA
IPC分类号： A61K49/00 , A61K49/12 , A61K49/14 , C07F5/00 , C07K1/13 , C09K3/00
摘要： PROBLEM TO BE SOLVED: To provide a method for affording effective diagnostic images through reducing the toxicity of paramagnetic metallic ions. SOLUTION: This method is to bind a polyaminopolycarboxylic acid chelating agent to the amino group in molecules/macromolecules, comprising (a) chelating agent activation process by forming a reactive ester of the chelating agent; (b) process for binding the reactive ester to the amino group in a molecule intended to have the character of a function group; (c) process for eliminating the unreacted chelating agent, and process for forming a metal complex of the conjugate from the process (b); (d) process for the reaction of the metal complex with the reaction chelating agents in the process (a); and (e) process for eliminating the unreacted chelating agent and, similarly to the process (c), process for the 2nd complex formation with the metallic ion.

8. 发明专利

JPH1121279A LOW-TOXIC PARAMAGNETIC METAL CHELATE COMPLEX 失效
公开(公告)号：JPH1121279A
公开(公告)日：1999-01-26
申请号：JP10609798
申请日：1998-04-16
申请人： BRACCO SPA
发明人： UGGERI FULVIO , FEDELI FRANCO , MAIOCCHI ALESSANDRO , FRANZINI MAURIZIO , VIRTUANI MARIO
IPC分类号： C07D401/06 , A61K49/00 , A61K49/06 , C07D257/02 , C07F5/00
摘要： PROBLEM TO BE SOLVED: To obtain a new compound capable of forming a chelate with a paramagnetic metal ion compound. SOLUTION: This compound is shown by formula I [R is a (O-interrupted or OH-substituted) 1-15C straight-chain or branched-chain alkyl; the chain, as the case may be, is interrupted and/or substituted by a 5- or 6-membered saturated carbocycle, and the cyclic group, in turn, as the case may be, is substituted by X (X is OH, etc.); R1 is H, etc.; however, R is neither a non-substituted alkyl nor a group of formula II, two or more of R1 substitutents being each CH2 OH], e.g. 10 2-[[2-(2-hydroxyethoxy)ethyl]amino]-2-oxoethyl}-α,α',α"-tris(hydroxymethyl)-1,4,7,10-tetrazacyclododecane-1,4,7-triacetic acid. The compound of formula I is obtained, for example, by reaction of a compound of formula III (R1 ' is H, etc.), with a compound of the formula R-X' (R is a group to be substituted at the N-atom on the tetrazacyclododecane; X' is an eliminable group such as Cl) to form a compound of formula IV which, in turn, is deprotected by catalytic hydrogenation.

9. 发明专利

JPH0999074A MANUFACTURE OF INJECTOR IN WHICH INJECTION SOLUTION IS FILLED IN ADVANCE WITHOUT RESIDUAL AIR BUBBLES 失效
公开(公告)号：JPH0999074A
公开(公告)日：1997-04-15
申请号：JP15733496
申请日：1996-05-15
申请人： BRACCO SPA
发明人： KURISUTOFU DE HAEN
IPC分类号： A61M5/178 , A61M5/20 , B65B3/00
摘要： PROBLEM TO BE SOLVED: To obtain a syringe filled with an injection without contg. dangerous residual air bubbles by temporarily sealing a nozzle with a cap, filling a prescribed amt. of the injection into the syringe, inserting a plunger-piston under a reduced pressure therein and filling the remaining amt. through the nozzle and, in some cases, resealing the cap under the reduced pressure. SOLUTION: The method for producing the syringe previously filled with the injection without contg. the dangerous residual air bubbles is executed by first temporarily sealing the nozzle of the syringe by using the suitable removable cap and filling the desired injection of at least 80vol.%, more preferably 95vol.% of the dose into the syringe from the open end on the opposite side. The plunger-piston are thereafter inserted under the reduced pressure into the syringe. The cap is removed by rotating the syringe. The remaining amt. of the injection is then completely filled into the syringe through the nozzle. In some cases, the cap is resealed to the front end of the syringe under the reduced pressure. The syringe previously filled with the injection is sterilized and packaged after these operations.

10. 发明申请

WO2007141325A1 METHOD OF PROCESSING MULTICHANNEL AND MULTIVARIATE SIGNALS AND METHOD OF CLASSIFYING SOURCES OF MULTICHANNEL AND MULTIVARIATE SIGNALS OPERATING ACCORDING TO SUCH PROCESSING METHOD 审中-公开
标题翻译：多通道和多重信号的处理方法以及根据这种处理方法操作的多通道和多重信号分类源的方法
公开(公告)号：WO2007141325A1
公开(公告)日：2007-12-13
申请号：PCT/EP2007/055646
申请日：2007-06-08
申请人： BRACCO SPA , SEMEION , BUSCEMA, Paolo Massimo
发明人： BUSCEMA, Paolo Massimo
IPC分类号： G06K9/62
CPC分类号： G06K9/6247 , G06K9/6273
摘要： A method of processing multichannel and multivariate signals as described hereinbefore, wherein the signals from each channel are subjected to a first processing step by a recirculation artificial neural network being trained to generate the recorded multichannel and multivariate signals; and a second processing step in which the weights of the connections between the knots of the recirculation neural network determined in the first processing step are processed by an artificial neural network, the recirculation neural network being preferably of the non supervised kind. A particular family of recirculation neural network which can be used according to the present invention is a so called auto-associative neural network. The method further provides, in combination, the use of a predictive and/or classification and/or clustering algorithm for determining the qualities or features of objects from the multichannel multivariate signals generated by said object, the weight matrix obtained by processing said multichannel and multivariate signals with a self-associated neural network being used as records for representing said multichannel and multivariate signals. The method is used for patients suffering from neurological disorders for analysing and evaluating the EEG patterns of these patients.
摘要翻译：一种如上文所述处理多通道和多变量信号的方法，其中来自每个通道的信号经受正在被训练以产生所记录的多通道和多变量信号的再循环人造神经网络的第一处理步骤; 以及第二处理步骤，其中在第一处理步骤中确定的再循环神经网络的节点之间的连接的权重由人造神经网络处理，再循环神经网络优选地是非监督类型。可以根据本发明使用的特定的再循环神经网络族是所谓的自相关神经网络。该方法组合地进一步提供使用预测和/或分类和/或聚类算法来从所述对象产生的多通道多变量信号中确定对象的质量或特征，通过处理所述多通道和多变量获得的权重矩阵具有自相关神经网络的信号被用作表示所述多通道和多变量信号的记录。该方法用于患有神经障碍的患者，用于分析和评估这些患者的EEG模式。

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