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1. 发明专利

CA181668A DIE 未知
公开(公告)号：CA181668A
公开(公告)日：1918-01-11
申请号：CA181668D
申请日：1917-03-22
申请人： EVANS GARFIELD I , BOYLE WILLIAM J
发明人： EVANS GARFIELD I , BOYLE WILLIAM J

2. 发明专利

CA459191A ADJUSTABLE MOTOR BASE 未知
公开(公告)号：CA459191A
公开(公告)日：1949-08-30
申请号：CA459191D
申请人： BOYLE WILLIAM J
发明人： BOYLE WILLIAM J

3. 发明申请

WO2008088594A3 ISOLATION OF ANTIBODIES THAT CROSS-REACT AND NEUTRALIZE RANKL ORGINATING FROM MULTIPLE SPECIES 审中-公开
公开(公告)号：WO2008088594A3
公开(公告)日：2008-07-24
申请号：PCT/US2007/079938
申请日：2007-09-28
申请人： ANAPTYS BIOSCIENCES, INC. , BOYLE, William, J.
发明人： BOYLE, William, J.
IPC分类号： A61K39/395
摘要： The invention provides specific binding members (e g, antibodies or antigen-binding fragments thereof) which bind to RANKL originating from multiple species. An epitope recognized by the specific binding members can be selected from surface exposed loop domains that bind to and activate its cognate receptor, RANK (Receptor Activator of NFkB), on the surface of osteoclast precursors and other cell types. The invention provides peptides for generating such anti-RANKL antibodies, including murine sequences, other non-human sequences and cross- reactive peptides. The specific binding members are useful m the diagnosis and treatment of lytic bone diseases, including osteoporosis, rheumatoid arthritis, bone metastasis and hypercalcemia of malignancy, glucocorticoid- mduced bone loss, a periodontal disease or condition, a cancer and Juvenile Paget's Disease. The binding members can also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or antigen-bmding fragments thereof.

4. 发明申请

WO0047740A9 TNF-RELATED PROTEINS 审中-公开
标题翻译：与TNF相关的蛋白质
公开(公告)号：WO0047740A9
公开(公告)日：2002-04-04
申请号：PCT/US0003653
申请日：2000-02-11
申请人： AMGEN INC , BOYLE WILLIAM J , HSU HAILING
发明人： BOYLE WILLIAM J , HSU HAILING
IPC分类号： C07K14/705 , C12N15/12 , A61K38/19 , A61K48/00 , C07K16/22 , C07K16/46 , C07K19/00 , C12N15/62 , C12N15/70
CPC分类号： C07K14/70575 , C12N2799/021
摘要： A member of the tumor necrosis factor family and associated antibodies and uses are described. This member is primarily expressed in B cells and its expression correlates to increases in the number of B cells and immunoglobulins produced. The human ortholog contains 285 amino acids; the mouse ortholog, 309 amino acids. The protein is a type II transmembrane protein and has an amino terminal cytoplasmic domain, a transmembrane domain, and a carboxy terminal extracellular domain. TNF-related proteins of the invention may be membrane-associated or in soluble form, recombinantly produced or isolated after natural production. The invention provides for nucleic acids encoding such TNF-related proteins, vectors and host cells expressing the polypeptides, and methods for producting recombinant porteins. Antibodies, fragments, and related fusion proteins and derivatives may be used as agonists or antagonists of AGP-3 related activity.
摘要翻译：描述了肿瘤坏死因子家族的成员以及相关抗体和用途。该成员主要在B细胞中表达，其表达与产生的B细胞和免疫球蛋白的数量增加相关。人类直向同源物含有285个氨基酸; 小鼠直向同源物，309个氨基酸。蛋白质是II型跨膜蛋白，具有氨基末端胞质结构域，跨膜结构域和羧基末端胞外结构域。本发明的TNF相关蛋白可以是膜相关的或可溶形式，在天然生产后重组产生或分离。本发明提供了编码这种TNF相关蛋白的核酸，表达多肽的载体和宿主细胞，以及用于产生重组蛋白的方法。抗体，片段和相关的融合蛋白和衍生物可以用作AGP-3相关活性的激动剂或拮抗剂。

5. 发明申请

WO2008088594A2 ISOLATION OF ANTIBODIES THAT CROSS-REACT AND NEUTRALIZE RANKL ORGINATING FROM MULTIPLE SPECIES 审中-公开
标题翻译：分离多个物种的交叉反应和中和RANKL的抗体的分离
公开(公告)号：WO2008088594A2
公开(公告)日：2008-07-24
申请号：PCT/US2007079938
申请日：2007-09-28
申请人： ANAPTYS BIOSCIENCES INC , BOYLE WILLIAM J
发明人： BOYLE WILLIAM J
IPC分类号： C07K7/00 , A61K39/00 , A61K39/395 , A61K51/00 , A61P19/00 , C07K14/00 , C07K16/18
CPC分类号： C07K14/525 , A61K47/646 , A61K47/6845
摘要： The invention provides specific binding members (e g, antibodies or antigen-binding fragments thereof) which bind to RANKL originating from multiple species. An epitope recognized by the specific binding members can be selected from surface exposed loop domains that bind to and activate its cognate receptor, RANK (Receptor Activator of NFkB), on the surface of osteoclast precursors and other cell types. The invention provides peptides for generating such anti-RANKL antibodies, including murine sequences, other non-human sequences and cross- reactive peptides. The specific binding members are useful m the diagnosis and treatment of lytic bone diseases, including osteoporosis, rheumatoid arthritis, bone metastasis and hypercalcemia of malignancy, glucocorticoid- mduced bone loss, a periodontal disease or condition, a cancer and Juvenile Paget's Disease. The binding members can also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or antigen-bmding fragments thereof.
摘要翻译：本发明提供了与多种物种的RANKL结合的特异性结合成员（例如抗体或其抗原结合片段）。由特异性结合成员识别的表位可以选自在破骨细胞前体和其他细胞类型的表面上结合并激活其同源受体RANK（NFkB的受体激活剂）的表面暴露的环结构域。本发明提供产生抗RANKL抗体的肽，包括鼠序列，其他非人序列和交叉反应肽。特异性结合成员可用于诊断和治疗溶骨病，包括骨质疏松症，类风湿性关节炎，骨转移和恶性高钙血症，糖皮质激素性骨丢失，牙周病或病症，癌症和青少年佩吉特病。结合成员也可以与化学治疗剂或抗癌剂和/或与其它抗体或其抗原结合片段组合的治疗中使用。

6. 发明申请

WO0047740A2 TNF-RELATED PROTEINS 审中-公开
标题翻译： TNF相关蛋白
公开(公告)号：WO0047740A2
公开(公告)日：2000-08-17
申请号：PCT/US0003653
申请日：2000-02-11
申请人： AMGEN INC , BOYLE WILLIAM J , HSU HAILING
发明人： BOYLE WILLIAM J , HSU HAILING
IPC分类号： C07K14/705 , C12N15/12 , A61K38/19 , A61K48/00 , C07K16/22 , C07K19/00 , C12N15/62 , C12N15/70
CPC分类号： C07K14/70575 , C12N2799/021
摘要： A member of the tumor necrosis factor family and associated antibodies and uses are described. This member is primarily expressed in B cells and its expression correlates to increases in the number of B cells and immunoglobulins produced. The human ortholog contains 285 amino acids; the mouse ortholog, 309 amino acids. The protein is a type II transmembrane protein and has an amino terminal cytoplasmic domain, a transmembrane domain, and a carboxy terminal extracellular domain. TNF-related proteins of the invention may be membrane-associated or in soluble form, recombinantly produced or isolated after natural production. The invention provides for nucleic acids encoding such TNF-related proteins, vectors and host cells expressing the polypeptides, and methods for producting recombinant porteins. Antibodies, fragments, and related fusion proteins and derivatives may be used as agonists or antagonists of AGP-3 related activity.
摘要翻译：描述了肿瘤坏死因子家族的成员和相关的抗体和用途。该成员主要在B细胞中表达，其表达与产生的B细胞和免疫球蛋白数量的增加相关。人类直向同源物含有285个氨基酸; 小鼠ortholog，309个氨基酸。该蛋白质是II型跨膜蛋白质，并具有氨基末端细胞质结构域，跨膜结构域和羧基末端胞外结构域。本发明的TNF相关蛋白可以是膜结合或可溶形式，在自然生产后重组产生或分离。本发明提供编码此类TNF-相关蛋白的核酸，表达所述多肽的载体和宿主细胞，以及用于产生重组porteins的方法。抗体，片段和相关的融合蛋白和衍生物可用作AGP-3相关活性的激动剂或拮抗剂。

7. 发明申请

WO2003086289A3 HUMAN ANTI-OPGL NEUTRALIZING ANTIBODIES AS SELECTIVE OPGL PATHWAY INHIBITORS 审中-公开
公开(公告)号：WO2003086289A3
公开(公告)日：2003-10-23
申请号：PCT/US2003/010749
申请日：2003-04-07
申请人： AMGEN INC. , BOYLE, William, J. , MEDLOCK, Eugene , SULLIVAN, John, K. , ELLIOTT, Robin, L. , MARTIN, Francis Hall , HUANG, Haichun
发明人： BOYLE, William, J. , MEDLOCK, Eugene , SULLIVAN, John, K. , ELLIOTT, Robin, L. , MARTIN, Francis Hall , HUANG, Haichun
IPC分类号： A61K39/395
摘要： Monoclonal antibodies and hybridomas producing them that interact with osteoprotegerin ligand (OPGL) are provided. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are also provided. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are further provided.

8. 发明申请

WO2003086289A2 HUMAN ANTI-OPGL NEUTRALIZING ANTIBODIES AS SELECTIVE OPGL PATHWAY INHIBITORS 审中-公开
标题翻译：人类抗OPGL中和作为选择性OPGL途径抑制剂的抗体
公开(公告)号：WO2003086289A2
公开(公告)日：2003-10-23
申请号：PCT/US2003/010749
申请日：2003-04-07
申请人： AMGEN INC. , BOYLE, William, J. , MEDLOCK, Eugene , SULLIVAN, John, K. , ELLIOTT, Robin, L. , MARTIN, Frank , HUANG, Haichun
发明人： BOYLE, William, J. , MEDLOCK, Eugene , SULLIVAN, John, K. , ELLIOTT, Robin, L. , MARTIN, Frank , HUANG, Haichun
IPC分类号： A61K
CPC分类号： C07K16/241 , A61K2039/505 , C07K16/2875 , C07K2317/21 , C07K2317/34 , C07K2317/56
摘要： Monoclonal antibodies and hybridomas producing them that interact with osteoprotegerin ligand (OPGL) are provided. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are also provided. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are further provided.
摘要翻译：提供了与骨保护素配体（OPGL）相互作用的单克隆抗体和产生它们的杂交瘤。还提供了通过向OPGL施用药学有效量的抗体来治疗骨质疏松症的方法。进一步提供使用OPGL抗体检测样品中OPGL量的方法。

9. 发明申请

WO1997023614A1 OSTEOPROTEGERIN 审中-公开
标题翻译：骨
公开(公告)号：WO1997023614A1
公开(公告)日：1997-07-03
申请号：PCT/US1996020621
申请日：1996-12-20
申请人： AMGEN INC. , BOYLE, William, J. , LACEY, David, L. , CALZONE, Frank, J. , CHANG, Ming-Shi
发明人： AMGEN INC.
IPC分类号： C12N15/12
CPC分类号： C07K14/70578 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention discloses a secreted polypeptide, termed osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind OPG, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.
摘要翻译：本发明公开了称为骨保护素的分泌多肽，其是肿瘤坏死因子受体超家族的成员，并且参与骨代谢的调节。还公开了编码骨保护素，多肽，重组载体和表达宿主细胞，结合OPG的抗体和药物组合物的核酸。多肽用于治疗以增加再吸收为特征的骨疾病，例如骨质疏松症。

10. 发明申请

WO2012058302A1 NICKEL-TITANIUM CORE GUIDE WIRE 审中-公开
标题翻译：镍铁芯指导线
公开(公告)号：WO2012058302A1
公开(公告)日：2012-05-03
申请号：PCT/US2011/057873
申请日：2011-10-26
申请人： ABBOTT CARDIOVASCULAR SYSTEMS INC. , BOYLE, William J. , CORNISH, Wayne E. , PUTZER, Raleigh A.
发明人： BOYLE, William J. , CORNISH, Wayne E. , PUTZER, Raleigh A.
IPC分类号： A61M25/09
CPC分类号： A61M25/09 , A61M2025/09175 , Y10T29/49986 , Y10T29/5187
摘要： A guide wire for use in a medical procedure having a shapeable tip integral with and made from the distal end of a superelastic nitinol distal section of the guide wire, wherein the shapeable tip can be finger kinked. Such a guide wire includes an elongated core made from a superelastic nitinol alloy at the distal end, the distal end of the elongated core having a tapered section leading to a shapeable distal tip. The shapeable tip is an extension of the distal end of the nitinol distal section, and includes permanent strain hardening from at least two different radial directions imparting crystallographic texture in the radial directions that eliminate superelasticity so that permanent deformation can be achieved with finger pressure.
摘要翻译：一种用于医疗过程的导丝，其具有与引导线的超弹性镍钛诺远端部分的远端一体并由远端制成的可成形尖端，其中可成形尖端可以被扭曲。这种导丝包括在远端由超弹性镍钛诺合金制成的细长芯，细长芯的远端具有通向可成形远端的锥形部分。可成形尖端是镍钛诺骨远端部分的远端的延伸部，并且包括从至少两个不同径向方向的永久性应变硬化，其赋予径向方向上的结晶学结构，从而消除超弹性，从而可以用手指压力实现永久变形。

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