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1. 发明申请

WO1998000231A1 HIGH-THROUGHPUT SCREENING ASSAY SYSTEMS IN MICROSCALE FLUIDIC DEVICES 审中-公开
标题翻译：微型流体装置中的高通量筛选分析系统
公开(公告)号：WO1998000231A1
公开(公告)日：1998-01-08
申请号：PCT/US1997010894
申请日：1997-06-24
申请人： CALIPER TECHNOLOGIES CORPORATION , PARCE, John, Wallace , KOPF-SILL, Anne, R. , BOUSSE, Luc, J.
发明人： CALIPER TECHNOLOGIES CORPORATION
IPC分类号： B01J19/00
CPC分类号： G01N33/502 , B01J19/0093 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/00952 , B01J2219/00961 , B01J2219/0097 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L3/502784 , B01L2200/027 , B01L2200/0605 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B01L2400/0418 , B01L2400/0487 , G01N27/44791 , G01N33/5008 , G01N33/5011 , G01N33/5064 , G01N33/5091 , G01N33/5097 , G01N33/5304 , G01N33/57415 , G01N35/08 , Y10S366/02 , Y10S435/81 , Y10S435/817 , Y10S436/804 , Y10S436/805 , Y10S436/806 , Y10T436/11 , Y10T436/110833 , Y10T436/113332 , Y10T436/117497 , Y10T436/25
摘要： The present invention provides microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems. The device includes a series of channels (110, 112), and optional reagent channel (114), fabricated into the surface of the substrate. At least one of these channels will typically have very small cross-sectional dimensions, e.g. in the range of from about 0.1 mu m to about 500 mu m. The device also includes reservoirs (104, 106 and 108), disposed and fluidly connected at the ends of the channels (110 and 114). As shown, sample channel (112) is used to introduce the plurality of different test compounds into the device. As such, this channel will generally be fluidly connected to a source of large numbers of separate test compounds that will be individually introduced into the sample channel (112) and subsequently into channel (110).
摘要翻译：本发明提供了用于进行高通量筛选测定的微流体装置和方法。特别地，本发明的装置和方法可用于筛选大量不同的化合物，因为它们对多种化学品，优选生物化学体系的影响。该装置包括一系列通道（110,112）和可选的试剂通道（114），其制造在基板的表面中。这些通道中的至少一个通常具有非常小的横截面尺寸，例如，在约0.1μm至约500μm的范围内。装置还包括在通道（110和114）的端部处设置并流体连接的储存器（104,106和108）。如图所示，使用样品通道（112）将多种不同的测试化合物引入装置。因此，该通道通常将流体地连接到将分别引入样品通道（112）并随后进入通道（110）的大量单独测试化合物的源。

2. 发明申请

WO2003084629A3 METHODS AND APPARATUS FOR SEPARATION AND ISOLATION OF COMPONENTS FROM A BIOLOGICAL SAMPLE 审中-公开
公开(公告)号：WO2003084629A3
公开(公告)日：2003-10-16
申请号：PCT/US2003/009628
申请日：2003-03-27
申请人： CALIPER TECHNOLOGIES CORP. , DUBROW, Robert, S. , BOUSSE, Luc, J. , PHAN, Huan, L.
发明人： DUBROW, Robert, S. , BOUSSE, Luc, J. , PHAN, Huan, L.
IPC分类号： G01N33/558
摘要： Devices, systems and methods for use in separating sample materials into different sample components and then isolating one or more of the sample components for further processing or analysis are disclosed. Devices employ configurations that optionally allow a sample material to be electrophoretically separated into sample components in a separation matrix within a separation conduit. The sample components may then be detected in a detection zone in the separation conduit and then selected components shunted to a component collection conduit within the device downstream of the detection zone for further processing or analysis based on information received at the detection zone. Methods of using these devices, and systems that incorporate these devices are also envisioned.

3. 发明申请

WO2006034432A3 ELECTROSPRAY APPARATUS WITH AN INTEGRATED ELECTRODE 审中-公开
标题翻译：具有集成电极的电绝缘装置
公开(公告)号：WO2006034432A3
公开(公告)日：2006-08-17
申请号：PCT/US2005034093
申请日：2005-09-21
申请人： PREDICANT BIOSCIENCES INC , BOUSSE LUC J , ZHAO MINGQI
发明人： BOUSSE LUC J , ZHAO MINGQI
IPC分类号： H01J49/00 , B01D59/44
CPC分类号： H01J49/167 , B05B5/025 , B05B5/0533 , H01J49/0018 , Y10T29/494
摘要： The invention provides related apparatus and methods of making an integrated electrospray tip (102) by depositing ionic and/or electronic conductor materials onto a planar substrate. The invention also features methods of forming an electrospray apparatus comprising coupling a first planar substrate (104) to the surface of a second planar substrate (105), wherein a surface on at least one of the substrates includes one or more microfluidic channels (109, 112) and/or reservoirs ((108, 113, 114) which are at least partially or totally enclosed therebetween. The conductive regions of the apparatus do not intersect the microfluidic channels (109, 112) within other portions of the apparatus provided preferably. The invention further provides related apparatus and methods for manufacturing and using microfluidic devices (101) with integrated electrodes for electrospray ionization. The electrospray apparatus in some embodiments may include an electronic conductor electrode or an ionic conductor electrode formed from a microfluidic channel (109, 112) containing a conductive material selected from a variety of solutions and gels.
摘要翻译：本发明提供了通过将离子和/或电子导体材料沉积到平面基底上来制造集成电喷雾尖端（102）的相关装置和方法。本发明还具有形成电喷射装置的方法，包括将第一平面基底（104）耦合到第二平面基底（105）的表面，其中至少一个基底上的表面包括一个或多个微流体通道（109， 112）和/或至少部分或完全封闭在其间的储存器（（108,113,114））。设备的导电区域优选地不与装置的其它部分内的微流体通道（109,112）相交。本发明还提供了用于制造和使用具有用于电喷雾离子化的集成电极的微流体装置（101）的相关装置和方法。一些实施例中的电喷射装置可以包括由微流体通道（109,112）形成的电子导体电极或离子导体电极），其含有选自多种溶液和凝胶的导电材料。

4. 发明申请

WO2003006133A3 MICROFLUIDIC DEVICES AND SYSTEMS FOR SEPARATING COMPONENTS OF A MIXTURE 审中-公开
公开(公告)号：WO2003006133A3
公开(公告)日：2003-01-23
申请号：PCT/US2002/022318
申请日：2002-07-12
申请人： CALIPER TECHNOLOGIES CORP. , WADA, H. Garrett, , BOUSSE, Luc, J. , CHOW, Andrea, W.
发明人： WADA, H. Garrett, , BOUSSE, Luc, J. , CHOW, Andrea, W.
IPC分类号： G01N21/00
摘要： The present invention provides systems, devices and methods for performing fast and efficient separation and collection of components of sample mixtures. The present invention provides integrated systems for performing separation using a muilti port control system to sort and collect components of sample mixtures.

5. 发明申请

WO2003006133A2 MICROFLUIDIC DEVICES AND SYSTEMS FOR SEPARATING COMPONENTS OF A MIXTURE 审中-公开
标题翻译：用于分离混合物组分的微流体器件和系统
公开(公告)号：WO2003006133A2
公开(公告)日：2003-01-23
申请号：PCT/US2002/022318
申请日：2002-07-12
申请人： CALIPER TECHNOLOGIES CORP. , WADA, H. Garrett, , BOUSSE, Luc, J. , CHOW, Andrea, W.
发明人： WADA, H. Garrett, , BOUSSE, Luc, J. , CHOW, Andrea, W.
IPC分类号： B01D
CPC分类号： B01L3/50273 , B01L3/502761 , B01L2200/027 , B01L2200/0647 , B01L2200/10 , B01L2400/0415 , B01L2400/0487 , G01N1/34 , G01N27/44717 , G01N27/44791 , G01N2001/4038 , G01N2015/149
摘要： The present invention provides systems, devices and methods for performing fast and efficient separation and collection of components of sample mixtures. The present invention provides integrated systems for performing separation using a muilti port control system to sort and collect components of sample mixtures.
摘要翻译：本发明提供了用于对样品混合物的组分进行快速和有效分离和收集的系统，装置和方法。本发明提供了用于使用muilti端口控制系统执行分离以整理和收集样品混合物的成分的集成系统。

6. 发明申请

WO1998022811A1 IMPROVED MICROFLUIDIC SYSTEMS 审中-公开
标题翻译：改进的微流体系统
公开(公告)号：WO1998022811A1
公开(公告)日：1998-05-28
申请号：PCT/US1997021024
申请日：1997-11-18
申请人： CALIPER TECHNOLOGIES CORPORATION , PARCE, John, Wallace , KOPF-SILL, Anne, R. , BOUSSE, Luc, J.
发明人： CALIPER TECHNOLOGIES CORPORATION
IPC分类号： G01N27/26
CPC分类号： B01L3/50273 , B01L3/5025 , B01L3/502753 , B01L2200/10 , B01L2300/0645 , B01L2300/0809 , B01L2300/0816 , B01L2300/0864 , B01L2400/0418 , B01L2400/0421 , B01L2400/0688 , G01N27/44791 , Y10T436/2575
摘要： The present invention generally provides microfluidic devices (200) and systems that utilize electrokinetic material transport systems to selectively control and direct the transport of materials through and among complex arrangements of integrated microscale channels (for example, 202 and 208 + 2n, where n = 0, 1, ...8) disposed within integrated body structures.
摘要翻译：本发明通常提供微流体装置（200）和利用电动材料输送系统来选择性地控制和指导材料通过综合微量通道（例如，202和208 + 2n，其中n = 0 ，1，... 8）。

7. 发明申请

WO2006034432A2 ELECTROSPRAY APPARATUS WITH AN INTEGRATED ELECTRODE 审中-公开
标题翻译：具有集成电极的电绝缘装置
公开(公告)号：WO2006034432A2
公开(公告)日：2006-03-30
申请号：PCT/US2005/034093
申请日：2005-09-21
申请人： PREDICANT BIOSCIENCES, INC. , BOUSSE, Luc, J. , ZHAO, Mingqi
发明人： BOUSSE, Luc, J. , ZHAO, Mingqi
IPC分类号： B01D59/44
CPC分类号： H01J49/167 , B05B5/025 , B05B5/0533 , H01J49/0018 , Y10T29/494
摘要： The invention provides related apparatus and methods of making an integrated electrospray tip by depositing ionic and/or electronic conductor materials onto a planar substrate. The invention also features methods of forming an electrospray apparatus comprising coupling a first planar substrate to the surface of a second planar substrate, wherein a surface on at least one of the substrates includes one or more microfluidic channels and/or reservoirs which are at least partially or totally enclosed therebetween. The conductive regions of the apparatus do not intersect the microfluidic channels within other portions of the apparatus provided preferably. The invention further provides related apparatus and methods for manufacturing and using microfluidic devices with integrated electrodes for electrospray ionization. The electrospray apparatus in some embodiments may include an electronic conductor electrode or an ionic conductor electrode formed from a microfluidic channel containing a conductive material selected from a variety of solutions and gels.
摘要翻译：本发明提供了通过将离子和/或电子导体材料沉积到平面衬底上来制造集成电喷雾尖端的相关装置和方法。本发明还具有形成电喷射装置的方法，其包括将第一平面基底耦合到第二平面基底的表面，其中至少一个基底上的表面包括一个或多个微流体通道和/或至少部分地或完全封闭在其间。设备的导电区域优选地不与装置的其它部分内的微流体通道相交。本发明还提供了用于制造和使用具有用于电喷雾电离的集成电极的微流体装置的相关装置和方法。在一些实施例中，电喷雾装置可以包括由包含选自多种溶液和凝胶的导电材料的微流体通道形成的电子导体电极或离子导体电极。

8. 发明申请

WO03084629A2 METHODS, SYSTEMS AND APPARATUS FOR SEPARATION AND ISOLATION OF ONE OR MORE SAMPLE COMPONENTS OF A SAMPLE BIOLOGICAL MATERIAL 审中-公开
标题翻译：用于分离和分离样品生物材料的一个或多个样品组分的方法，系统和装置
公开(公告)号：WO03084629A2
公开(公告)日：2003-10-16
申请号：PCT/US0309628
申请日：2003-03-27
申请人： CALIPER TECHN CORP , DUBROW ROBERT S , BOUSSE LUC J , PHAN HUAN L
发明人： DUBROW ROBERT S , BOUSSE LUC J , PHAN HUAN L
IPC分类号： B01L3/00 , G01N27/447 , B01D
CPC分类号： B01L3/50273 , B01L3/502715 , B01L3/502753 , B01L3/502784 , B01L2200/0605 , B01L2200/0631 , B01L2200/10 , B01L2300/0816 , B01L2400/0421 , B01L2400/0487 , G01N27/44791 , Y10T436/25
摘要： Devices, systems and methods for use in separating sample materials into different sample components and then isolating one or more of the sample components for further processing or analysis are disclosed. Devices employ configurations that optionally allow a sample material to be electrophoretically separated into sample components in a separation matrix within a separation conduit. The sample components may then be detected in a detection zone in the separation conduit and then selected components shunted to a component collection conduit within the device downstream of the detection zone for further processing or analysis based on information received at the detection zone. Methods of using these devices, and systems that incorporate these devices are also envisioned.
摘要翻译：公开了用于将样品材料分离成不同样品组分，然后分离一个或多个样品组分用于进一步处理或分析的装置，系统和方法。设备采用可选地允许样品材料在分离管道内的分离基质中电泳分离成样品组分的构型。然后可以在分离管道中的检测区域中检测样品组分，然后根据在检测区域接收的信息，将检测区域下游的选定部件分流到设备下游的组件收集管道，以进一步处理或分析。也可以设想使用这些装置的方法，以及并入这些装置的系统。

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