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1. 发明申请

WO2011143274A1 POLYPEPTIDE INHIBITORS OF VLA4 审中-公开
标题翻译： VLA4多肽抑制剂
公开(公告)号：WO2011143274A1
公开(公告)日：2011-11-17
申请号：PCT/US2011/035995
申请日：2011-05-10
申请人： PERSEID THERAPEUTICS , PAIDHUNGAT, Madan , NANISETTI, Amulya , BOUQUIN, Thomas , ANDERSEN, Kim , PATRICK, Sarah , CHAPIN, Steven , YOUEL, Dan , KREBBER, Claus , FAN, Rong , MALASHOCK, Daniel , BRIDEAU-ANDERSEN, Amy , KARRER, Erik , DEVENS, Bruce , BASS, Steven , DETRINIDAD, Myriam
发明人： PAIDHUNGAT, Madan , NANISETTI, Amulya , BOUQUIN, Thomas , ANDERSEN, Kim , PATRICK, Sarah , CHAPIN, Steven , YOUEL, Dan , KREBBER, Claus , FAN, Rong , MALASHOCK, Daniel , BRIDEAU-ANDERSEN, Amy , KARRER, Erik , DEVENS, Bruce , BASS, Steven , DETRINIDAD, Myriam
IPC分类号： C07K14/54
CPC分类号： C07K14/70542
摘要： The invention provides novel 2D-VCAM-1 variant polypeptides and conjugates thereof that bind human VLA4. The invention also provides related polynucleotides, compositions, vectors, host cells, and methods.
摘要翻译：本发明提供了结合人VLA4的新型2D-VCAM-1变体多肽及其缀合物。本发明还提供了相关的多核苷酸，组合物，载体，宿主细胞和方法。

2. 发明申请

WO2007044083A2 EVOLVED INTERFERON-ALPHA POLYPEPTIDES 审中-公开
公开(公告)号：WO2007044083A2
公开(公告)日：2007-04-19
申请号：PCT/US2006019088
申请日：2006-05-17
申请人： MAXYGEN INC , PAIDHUNGAT MADAN M , SAS IAN , BOUQUIN THOMAS , LIN DAVID , CHEN TEDDY , GUPTILL DOUGLAS , BRIDEAU-ANDERSEN AMY , BASS STEVEN H , PATTEN PHILLIP A
发明人： PAIDHUNGAT MADAN M , SAS IAN , BOUQUIN THOMAS , LIN DAVID , CHEN TEDDY , GUPTILL DOUGLAS , BRIDEAU-ANDERSEN AMY , BASS STEVEN H , PATTEN PHILLIP A
IPC分类号： C07K14/56
CPC分类号： C07K14/56 , A61K38/00
摘要： The present invention provides evolved interferon-alpha polypeptides, and conjugates thereof, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
摘要翻译：本发明提供了进化型干扰素-α多肽及其缀合物，以及编码多肽的核酸。本发明还包括包含这些多肽，缀合物和核酸的组合物; 含有或表达多肽，缀合物和核酸的细胞; 制备多肽，缀合物和核酸的方法; 以及使用多肽，缀合物和核酸的方法。

3. 发明申请

WO2007044083A3 EVOLVED INTERFERON-ALPHA POLYPEPTIDES 审中-公开
公开(公告)号：WO2007044083A3
公开(公告)日：2007-04-19
申请号：PCT/US2006/019088
申请日：2006-05-17
申请人： MAXYGEN, INC. , PAIDHUNGAT, Madan, M. , SAS, Ian , BOUQUIN, Thomas , LIN, David , CHEN, Teddy , GUPTILL, Douglas , BRIDEAU-ANDERSEN, Amy , BASS, Steven, H. , PATTEN, Phillip, A.
发明人： PAIDHUNGAT, Madan, M. , SAS, Ian , BOUQUIN, Thomas , LIN, David , CHEN, Teddy , GUPTILL, Douglas , BRIDEAU-ANDERSEN, Amy , BASS, Steven, H. , PATTEN, Phillip, A.
IPC分类号： C07K14/56
摘要： The present invention provides evolved interferon-alpha polypeptides, and conjugates thereof, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.

4. 发明申请

WO2005073375A1 REGULATED STOP CODON READTHROUGH 审中-公开
标题翻译：调节停止CODON READTHROUGH
公开(公告)号：WO2005073375A1
公开(公告)日：2005-08-11
申请号：PCT/DK2005/000070
申请日：2005-01-28
申请人： MAXYGEN HOLDINGS LTD. , MAXYGEN APS , BOUQUIN, Thomas
发明人： BOUQUIN, Thomas
IPC分类号： C12N15/10
CPC分类号： C12N15/1086 , C07K2319/035 , C07K2319/40 , C07K2319/60 , C12N15/62 , C12N15/67 , G01N33/502
摘要： Methods for screening or selecting cells expressing a polypeptide of interest, e.g. for selecting cells expressing a desired level of a polypeptidé of interest, for evaluating recombinant polypeptide expression in a population of cells, or for selecting cells expressing a polypeptide with a desired binding affinity to a ligand, as well as for producing a polypeptide of interest from a selected cell, where the cells comprise an expression cassette comprising a first polynucleotide encoding the polypeptide of interest, at least one stop codon downstream of the first polynucleotide, and a second polynucleotide encoding a cell membrane anchoring peptide, a reporter peptide or an epitope tag downstream of the stop codon, and where the cells are cultured in the presence of a termination suppression agent, in particular an aminoglycoside antibiotic, that results in regulated stop codon readthrough.
摘要翻译：用于筛选或选择表达目的多肽的细胞的方法，例如用于选择表达期望水平的感兴趣多肽的细胞，用于评估细胞群体中的重组多肽表达，或用于选择表达具有对配体的所需结合亲和力的多肽的细胞，以及用于产生感兴趣的多肽选择的细胞，其中细胞包含表达盒，其包含编码目标多肽的第一多核苷酸，第一多核苷酸下游的至少一个终止密码子，以及编码细胞膜锚定肽，报告肽或表位标签的第二多核苷酸在终止密码子的下游，并且其中细胞在终止抑制剂（特别是氨基糖苷类抗生素）存在下培养，导致调节的终止密码子读取。

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