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    • 4. 发明申请
    • METHODS FOR SYNTHESIZING METAL MESOPORPHYRINS
    • 合成金属间苯二酚的方法
    • WO2012135686A1
    • 2012-10-04
    • PCT/US2012/031557
    • 2012-03-30
    • INFACARE PHARMACEUTICAL CORPORATIONBOUCHER, Christopher P.ROE, David
    • BOUCHER, Christopher P.ROE, David
    • C07D487/22
    • C07F7/2284C07D487/22
    • Methods of synthesizing metal mesoporphyrin compounds, wherein the compound may be formed by hemin transmetallation and subsequent hydrogenation of the tin protoporphyrin IX to form a metal mesoporphyrin. A method of synthesizing a metal mesoporphyrin compound comprises forming a protoporphyrin methyl ester from hemin and converting the protoporphyrin methyl ester intermediate to a metal mesoporphyrin compound through metal insertion and hydrogenation. A metal mesoporphyrin compound may be formed from hemin by a hydrogen-free hydrogenation method to form a mesoporphyrin IX intermediate followed by metal insertion and hydrogenation. A method of synthesizing a metal mesoporphyrin compound comprises forming a mesoporphyrin IX dihydrochloride intermediate compound and converting the mesoporphyrin IX intermediate to a metal mesoporphyrin compound through metal insertion. A metal mesoporphyrin compound may be formed directly from hemin without isolation of any intermediates.
    • 合成金属中卟啉化合物的方法,其中所述化合物可以通过血红素转移金属化和随后的锡原卟啉IX的氢化形成金属中卟啉而形成。 合成金属中卟啉化合物的方法包括由血红素形成原卟啉甲酯,并通过金属插入和氢化将原卟啉甲酯中间体转化成金属中卟啉化合物。 金属中卟啉化合物可以由氢氧化铵通过无氢氢化方法形成中卟啉IX中间体,随后金属插入和氢化。 合成金属中卟啉化合物的方法包括形成中卟啉IX二盐酸盐中间体化合物,并通过金属插入将中卟啉IX中间体转化成金属中卟啉化合物。 金属中卟啉化合物可直接由血红素形成,而不分离任何中间体。