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1. 发明申请

WO2005040794A2 VISUAL INDICATING DEVICE FOR BAD BREATH 审中-公开
标题翻译：视觉指示装置不良呼吸
公开(公告)号：WO2005040794A2
公开(公告)日：2005-05-06
申请号：PCT/US2004/027626
申请日：2004-08-23
申请人： KIMBERLY-CLARK WORLDWIDE, INC. , MACDONALD, John, Gavin , HUANG, Yanbin , MCGRATH, Kevin, Peter , BOGA, RameshBabu
发明人： MACDONALD, John, Gavin , HUANG, Yanbin , MCGRATH, Kevin, Peter , BOGA, RameshBabu
IPC分类号： G01N33/497
CPC分类号： G01N33/497 , B41M5/30 , G01N31/223 , G01N33/52 , G01N33/54346
摘要： The invention provides a breath testing device which includes a visual indicating agent which changes color in the presence of an odor associated with bad breath, such as sulfur and ammonia odors. An example of the visual indicating agent is 4,4'-bis(dimethylamino)-benzhydrol (Michler's hydrol or BDMB) and related dyes having a similar chemical structure. The indicating agent is applied to a substrate which is then inserted into a tube or straw, or which covers one end of a straw. When a user with bad breath blows into the tube or straw, the indicating agent will change color. The breath testing devices provide a quick and affordable means for a user to test their breath, and they may be packaged in discreet, pocket-sized dispensers which can be carried in a pocket or purse.
摘要翻译：本发明提供了一种呼吸测试装置，其包括视觉指示剂，其在存在与口臭相关的气味（例如硫和氨气味）的情况下改变颜色。视觉指示剂的实例是具有类似化学结构的4,4'-双（二甲基氨基） - 苯偶姻（米氏（Michler's hydrol）或BDMB）和相关染料。将指示剂施加到基底上，然后将基底插入管子或吸管中，或者覆盖吸管的一端。当呼吸不畅的使用者吹入管或吸管时，指示剂将改变颜色。呼气测试装置为用户测试呼吸提供了快速且经济的手段，并且它们可以被包装在可以携带在口袋或钱包中的谨慎的口袋大小的分配器中。

2. 发明申请

WO2007122523A2 METHOD FOR DETECTING THE ONSET OF OVULATION 审中-公开
标题翻译：检测渗透过程的方法
公开(公告)号：WO2007122523A2
公开(公告)日：2007-11-01
申请号：PCT/IB2007/050974
申请日：2007-03-20
申请人： KIMBERLY-CLARK WORLDWIDE, INC. , MARTIN, Stephanie, M. , BOGA, RameshBabu , MACDONALD, John, Gavin
发明人： MARTIN, Stephanie, M. , BOGA, RameshBabu , MACDONALD, John, Gavin
IPC分类号： A61B10/00 , A61D17/00 , G01N31/22
CPC分类号： A61B10/0012 , A61B2010/0006 , A61B2010/0087 , A61D17/002 , G01N31/223 , Y10T436/18 , Y10T436/182 , Y10T436/25875
摘要： A method for detecting the onset of ovulation in a female mammal is provided. The method comprises contacting mouth air of the female mammal with an arylmethane test chromogen in an amount effective to undergo a rapid and detectable color change in the presence of one or more volatile sulfur compounds. The color of the test chromogen is compared to a control color that corresponds to a pre-ovulatory sulfur content. The difference in color between the test chromogen and the control color is correlated to the onset of ovulation.
摘要翻译：提供了一种用于检测雌性哺乳动物排卵发作的方法。该方法包括使一种或多种挥发性硫化合物存在下有效地经历快速和可检测的颜色变化的量使该雌性哺乳动物的口腔空气与芳基甲烷测试的色原体接触。将测试色原体的颜色与对应于排卵前的硫含量的对照颜色进行比较。测试色原体和对照色之间的颜色差异与排卵的发生相关。

3. 发明申请

WO2007070105A1 IDENTIFICATION OF COMPOUNDS FOR INHIBITING COMPLEXATION OF C-REACTIVE PROTEIN WITH FIBRONECTIN 审中-公开
标题翻译：鉴定化合物抑制C反应蛋白与纤维蛋白复合物的化合物
公开(公告)号：WO2007070105A1
公开(公告)日：2007-06-21
申请号：PCT/US2006/026454
申请日：2006-06-30
申请人： KIMBERLY-CLARK WORLDWIDE, INC. , BOGA, RameshBabu , MALIK, Sohail , QUIRK, Stephen
发明人： BOGA, RameshBabu , MALIK, Sohail , QUIRK, Stephen
IPC分类号： G01N33/68
CPC分类号： G01N33/558 , G01N33/68 , G01N2333/4737 , G01N2333/78 , G01N2500/02 , Y10S436/815
摘要： Disclosed are screening processes for identification of compounds that may inhibit complex formation between C-reactive protein and fibronectin. Compounds identified by the disclosed methods may be utilized to inhibit the target analytes that are known to occur during skin aging as well as during the course of several diseases. Accordingly, inhibitory compounds identified by the disclosed methods may be utilized to prevent and treat damaged tissue, inflammatory conditions, cardiovascular conditions, renal conditions, periodontal conditions and obesity, among other conditions. For example, the compounds identified by the disclosed methods may be utilized to treat tissue that has suffered trauma, e.g., burns or wounds, as well as tissue that is inflamed due to any of several causes. The disclosed compounds may also be utilized to improve the accuracy of assays designed to assess CRP or Fn levels in a sample, for instance in a plasma sample, as a risk assessment tool in certain medical conditions and to discover new treatments.
摘要翻译：公开了用于鉴定可能抑制C-反应蛋白和纤连蛋白之间的复合物形成的化合物的筛选方法。通过公开的方法鉴定的化合物可以用于抑制已知在皮肤老化期间以及在几种疾病过程中发生的目标分析物。因此，通过所公开的方法鉴定的抑制性化合物可以用于预防和治疗受损组织，炎性病症，心血管病，肾病，牙周病和肥胖等疾病。例如，通过公开的方法鉴定的化合物可用于治疗已经遭受创伤的组织，例如烧伤或伤口，以及由于几种原因中的任何一种而发炎的组织。所公开的化合物还可以用于提高设计用于评估样品中的CRP或Fn水平的测定的准确度，例如在血浆样品中，作为某些医疗条件下的风险评估工具并发现新的治疗。

4. 发明申请

WO2005039656A1 ODOR CONTROLLING ARTICLE INCLUDING A VISUAL INDICATING DEVICE FOR MONITORING ODOR ABSORPTION 审中-公开
标题翻译：气味控制文章，包括用于监测气味吸收的视觉指示装置
公开(公告)号：WO2005039656A1
公开(公告)日：2005-05-06
申请号：PCT/US2004/027624
申请日：2004-08-23
申请人： KIMBERLY-CLARK WORLDWIDE, INC. , MACDONALD, John, Gavin , BOGA, RameshBabu , KIM, Jaeho , DO, Bao, Trong , KUZNETSOV, Irene
发明人： MACDONALD, John, Gavin , BOGA, RameshBabu , KIM, Jaeho , DO, Bao, Trong , KUZNETSOV, Irene
IPC分类号： A61L9/01
CPC分类号： B01J20/28014 , A61F13/42 , A61F13/8405 , A61L9/01 , A61L9/014 , A61L15/46 , A61L15/56 , A61L2300/102 , A61L2300/442 , A61L2300/624 , B01J20/0233 , B01J20/041 , B01J20/06 , B01J20/08 , B01J20/103 , B01J20/28007 , B01J20/28033 , B01J20/3204 , B01J20/3236 , B01J2220/49 , B82Y30/00 , G01N31/22 , Y10S604/904 , Y10S977/707
摘要： The present invention relates to a visual indicating device and an article for controlling odors, in particular foot, garbage, basement, cooking, pet, tobacco, feces and urine odors. The article comprises a visual indicating agent that is color sensitive to the odor, and optionally, an odor absorbing agent. The visual indicating agent changes color when the article has been exposed to a sufficient amount of odor to saturate the article. The indicating agent may be applied in differing concentrations to two or more zones so as to indicate to a user of the article how much of the odor absorbing capacity has been used, or conversely, how much of the odor absorbing capacity remains. Suitable visual indicating agents that change color in response to odors are also described. The article for controlling odors may be a disposable odor absorbing sheet, air freshening product, diaper, undergarment pad, face mask, air filtration device, sanitary napkin, tampon, panty shield or incontinence pad.
摘要翻译：本发明涉及视觉指示装置和用于控制气味，特别是脚，垃圾，地下室，烹饪，宠物，烟草，粪便和尿气的气味物品。该物品包括对气味具有颜色敏感性的视觉指示剂，以及任选的气味吸收剂。当物品暴露于足够的气味以使物品饱和时，视觉指示剂改变颜色。指示剂可以以不同的浓度施用于两个或更多个区域，以便向用户指示已经使用了多少气味吸收能力，或相反地，残留了多少气味吸收能力。还描述了响应于气味改变颜色的合适的视觉指示剂。用于控制气味的物品可以是一次性气味吸收片，空气清新产品，尿布，内衣垫，面罩，空气过滤装置，卫生巾，卫生棉条，内裤护罩或失禁垫。

5. 发明申请

WO2009053867A2 VIRTUAL REALITY SIMULATIONS FOR HEALTH CARE CUSTOMER MANAGEMENT 审中-公开
标题翻译：医疗客户管理的虚拟现实模拟
公开(公告)号：WO2009053867A2
公开(公告)日：2009-04-30
申请号：PCT/IB2008/053955
申请日：2008-09-29
申请人： KIMBERLY-CLARK WORLDWIDE, INC. , ANDERSON, Joel , BOGA, Rameshbabu , BOWMAN, Daniel , CANSLER, Valerie , CLEMENT, Gary , GAKHAR, Sudhanshu , HASTINGS, Patrick , LYNCH, William , PHILLIPS, Erica , RANGANATHAN, Sridhar , TIMMERS, Richard
发明人： ANDERSON, Joel , BOGA, Rameshbabu , BOWMAN, Daniel , CANSLER, Valerie , CLEMENT, Gary , GAKHAR, Sudhanshu , HASTINGS, Patrick , LYNCH, William , PHILLIPS, Erica , RANGANATHAN, Sridhar , TIMMERS, Richard
IPC分类号： G06Q50/00 , G09B9/00
CPC分类号： G09B19/0076 , G06F19/00 , G06Q10/06 , G06Q50/22 , G09B23/28
摘要： Embodiments of the invention provide virtual reality tools and simulations used for improved health care customer management. The virtual reality tools may be used by a product manufacturer or seller to assist in relationship management with health care partners including identifying improved solutions for a variety of problems, strengthening infection prevention processes and systems, improving order and flow in the operating room and other care-delivery environments, identifying benefits from new products, providing techniques for evaluating new health care systems and processes, etc.
摘要翻译：本发明的实施例提供了用于改善健康护理客户管理的虚拟现实工具和模拟。产品制造商或销售商可以使用虚拟现实工具来协助与医疗保健合作伙伴的关系管理，包括识别各种问题的改进解决方案，加强感染预防流程和系统，改善手术室的秩序和流动以及其他护理 - 交付环境，识别新产品带来的好处，提供评估新医疗保健系统和流程的技术等。

6. 发明申请

WO2007122523A3 METHOD FOR DETECTING THE ONSET OF OVULATION 审中-公开
标题翻译：检测渗透过程的方法
公开(公告)号：WO2007122523A3
公开(公告)日：2008-01-10
申请号：PCT/IB2007050974
申请日：2007-03-20
申请人： KIMBERLY CLARK CO , MARTIN STEPHANIE M , BOGA RAMESHBABU , MACDONALD JOHN GAVIN
发明人： MARTIN STEPHANIE M , BOGA RAMESHBABU , MACDONALD JOHN GAVIN
IPC分类号： A61B10/00 , A61D17/00 , G01N31/22
CPC分类号： A61B10/0012 , A61B2010/0006 , A61B2010/0087 , A61D17/002 , G01N31/223 , Y10T436/18 , Y10T436/182 , Y10T436/25875
摘要： A method for detecting the onset of ovulation in a female mammal is provided. The method comprises contacting mouth air of the female mammal with an arylmethane test chromogen in an amount effective to undergo a rapid and detectable color change in the presence of one or more volatile sulfur compounds. The color of the test chromogen is compared to a control color that corresponds to a pre-ovulatory sulfur content. The difference in color between the test chromogen and the control color is correlated to the onset of ovulation.
摘要翻译：提供了一种用于检测雌性哺乳动物排卵发作的方法。该方法包括使一种或多种挥发性硫化合物存在下有效地经历快速和可检测的颜色变化的量使该雌性哺乳动物的口腔空气与芳基甲烷测试的色原体接触。将测试色原体的颜色与对应于排卵前的硫含量的对照颜色进行比较。测试色原体和对照色之间的颜色差异与排卵的发生相关。

7. 发明申请

WO2009077883A1 URINE VOLUME HYDRATION TEST DEVICES 审中-公开
标题翻译：尿液体积测试装置
公开(公告)号：WO2009077883A1
公开(公告)日：2009-06-25
申请号：PCT/IB2008/053658
申请日：2008-09-10
申请人： KIMBERLY-CLARK WORLDWIDE, INC. , SONG, Xuedong , BOGA, RameshBabu , WEI, Ning
发明人： SONG, Xuedong , BOGA, RameshBabu , WEI, Ning
IPC分类号： G01N33/493 , G01N33/48
CPC分类号： G01N21/80 , A61F13/42 , A61F13/84 , A61F2013/427 , A61F2013/8473 , G01N33/521 , G01N33/84
摘要： In accordance with one embodiment of the present disclosure, a method for quantitatively or semi-quantitatively determining the volume of a test sample of urine is provided. The method includes contacting the test sample with a fluidic medium of a lateral flow device having a volume indicator disposed thereon and determining the volume of urine in the test sample based on the distance traveled by the volume indicator along the fluidic medium, the distance traveled by the volume indicator corresponding to the volume of urine in the test sample.
摘要翻译：根据本公开的一个实施例，提供了一种用于定量或半定量地测定尿液测试样本的体积的方法。该方法包括使测试样品与具有设置在其上的体积指示器的侧向流动装置的流体介质接触，并且基于沿着流体介质的体积指示器行进的距离来确定测试样本中的尿液体积，体积指示符对应于测试样品中的尿液体积。

8. 发明申请

WO2007133261A1 MUCOSAL FORMULATION 审中-公开
标题翻译：粘膜制剂
公开(公告)号：WO2007133261A1
公开(公告)日：2007-11-22
申请号：PCT/US2006/046497
申请日：2006-12-06
申请人： KIMBERLY-CLARK WORLDWIDE, INC. , BOGA, RameshBabu , JOHNSON, Robert, B.
发明人： BOGA, RameshBabu , JOHNSON, Robert, B.
IPC分类号： A61K31/565 , A61K31/685 , A61P31/00
CPC分类号： A61K9/127 , A61K31/565 , A61K31/685 , A61K2300/00
摘要： A mucosal formulation for administration to mucosal membranes, such as in the mouth, nasal passage, stomach, vagina, etc., is disclosed. The mucosal formulation contains a lipid-pharmaceutical agent complex formed from phospholipids possessing a hydrophobic moiety that orients into a hydrophobic phase and a polar head moiety that orients towards the aqueous phase (i.e., "amphipathic" lipids). When placed in an aqueous medium (e.g., vaginal fluid), the phospholipids form liposomes or other small lipid vesicles (e.g., micelles) that may then be used to deliver pharmaceutical agents into a living organism.
摘要翻译：公开了用于施用于粘膜的粘膜制剂，例如在口腔，鼻腔，胃，阴道等中。粘膜制剂包含由具有疏水部分的磷脂形成的脂质 - 药剂复合物，所述疏水部分定位成疏水相，并且朝向水相定向的极性头部分（即“两亲性”脂质）。当放置在水性介质（例如阴道液）中时，磷脂形成脂质体或其它小脂质囊泡（例如胶束），然后可以将其用于将药剂递送到生物体内。

9. 发明申请

WO2006065514A1 SYSTEM AND METHOD FOR MEASURING AND MONITORING OVERFLOW OR WETNESS CONDITIONS IN A WASHROOM 审中-公开
标题翻译：用于测量和监测洗手间过流或湿润条件的系统和方法
公开(公告)号：WO2006065514A1
公开(公告)日：2006-06-22
申请号：PCT/US2005/043006
申请日：2005-11-28
申请人： KIMBERLY-CLARK WORLDWIDE, INC. , REDDY, Kiran, K. , MITCHELL, Joseph , YORK, Cheryl, L. , BUTLER, Amanda , WELCHEL, Debra, N. , BOGA, Rameshbabu , DETAMORE, James, J. , PADAK, Ronald, R. , LYE, Jason
发明人： REDDY, Kiran, K. , MITCHELL, Joseph , YORK, Cheryl, L. , BUTLER, Amanda , WELCHEL, Debra, N. , BOGA, Rameshbabu , DETAMORE, James, J. , PADAK, Ronald, R. , LYE, Jason
IPC分类号： A47K13/24 , G01F23/00 , G05B9/02
CPC分类号： A47K13/24 , A47K17/00 , E03D5/10 , G01F23/0069 , G01F23/242 , G01F23/243 , G01F23/2928 , G01F23/2965 , G07F11/68 , G08C2201/42 , Y10S4/03
摘要： A system for detecting an actual or impending overflow condition from a washroom fixture includes an overflow sensor configured with the fixture at a location to detect an abnormal rise in water level within the fixture before water overflows the fixture. A water sensor may also be disposed to detect an abnormal amount of water on the washroom floor. A data communications unit is in communication with the sensors. A washroom monitoring station is provided in wireless communication with the data communications unit and in communication with the sensors through the data communications unit. The washroom monitoring station is configured for indicating the presence of water when detected by the overflow or water sensors.
摘要翻译：一种用于从洗手间夹具检测实际或即将发生的溢出状况的系统包括溢流传感器，该溢流传感器配置有一个位置处的固定装置，以便在水溢出固定装置之前检测固定装置内的水位异常升高。还可以设置水传感器以检测洗手间地板上的异常量的水。数据通信单元与传感器通信。洗手间监控站提供与数据通信单元的无线通信，并通过数据通信单元与传感器通信。洗手间监控站被配置为在溢出或水传感器检测到时指示水的存在。

10. 发明申请

WO2005061013A1 PERSONAL CARE PRODUCTS WITH VISUAL INDICATOR OF VAGINITIS 审中-公开
标题翻译：个人护理产品与VAGITIS的可视指示器
公开(公告)号：WO2005061013A1
公开(公告)日：2005-07-07
申请号：PCT/US2004/039810
申请日：2004-11-23
申请人： KIMBERLY-CLARK WORLDWIDE, INC. , BOGA, RameshBabu , MACDONALD, John, Gavin
发明人： BOGA, RameshBabu , MACDONALD, John, Gavin
IPC分类号： A61L15/56
CPC分类号： A61F13/84 , A61F2013/8473 , A61L15/56 , G01N33/528
摘要： There is provided a personal care product having a body side liner, a baffle and an indicator strip with two ends. The indicator has an amine sensitive dye near at least one end. The indicator extends from the target area just below the liner to just above the baffle such that the dye deposit is visible to an unaided eye. The dye changes color in the presence of amines which are characteristic of infection, thus alerting the user to the possibility of infection. Such an indicator placed in a feminine hygiene pad, for example, may be useful in the diagnosis of vaginits.
摘要翻译：提供了具有身体侧衬里，挡板和带有两端的指示条的个人护理产品。该指示剂在至少一端附近具有胺敏感染料。指示器从正好在衬垫正下方的目标区域延伸到挡板正上方，使得染色剂沉积物对肉眼可见。染料在存在感染特征的胺存在下改变颜色，从而提醒用户感染的可能性。例如，放置在女性卫生垫中的这种指示剂可用于诊断阴道。

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