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1. 发明申请

WO2003025002A3 METHOD AND COMPOSITIONS OF DEFENSIN-ANTIGEN FUSION PROTEINS AND CHEMOKINE-ANTIGEN FUSION PROTEINS AS VACCINES FOR TUMORS AND VIRAL INFECTION 审中-公开
公开(公告)号：WO2003025002A3
公开(公告)日：2003-03-27
申请号：PCT/US2001/043830
申请日：2001-11-19
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , BIRAGYN, Arya , KWAK, Larry, W.
发明人： BIRAGYN, Arya , KWAK, Larry, W.
IPC分类号： C07K14/52
摘要： The present invention relates to a vaccine for increasing the immunogenicity of a tumor antigen thus allowing treatment of cancer, as well as a vaccine that increases the immunogenicity of a viral antigen, thus allowing treatment of viral infection, including immunodeficiency virus (HIV) infection. In particualar, the present invention provides a fusion protein compirsing a defensin or chemokine fused to either a tumor antigen or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune response effective in treating cancer or effective in treating or preventing viral infection.

2. 发明申请

WO2007041364A2 METHODS AND COMPOSITIONS FOR MODULATING IMMUNE TOLERANCE 审中-公开
标题翻译：调节免疫耐受的方法和组合物
公开(公告)号：WO2007041364A2
公开(公告)日：2007-04-12
申请号：PCT/US2006/038195
申请日：2006-09-28
申请人： GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY , BIRAGYN, Arya , MATSUSHIMA, Kouji , BATAAR, Dolgor
发明人： BIRAGYN, Arya , MATSUSHIMA, Kouji , BATAAR, Dolgor
IPC分类号： A61K47/48
CPC分类号： A61K38/465 , A61K38/195 , A61K38/45 , A61K45/06 , A61K47/6415 , A61K47/642 , C07K14/521 , C07K14/523 , C07K14/7158 , C07K2319/55 , C12N9/1077 , C12N9/22 , C12Y204/02036 , C12Y301/27 , C12Y301/27005
摘要： The instant invention provides methods and compositions for modulation of the immune system. Specifically, the invention provides methods and compositions for increasing T cell mediated immune response useful in the treatment of cancer and chronic infection.
摘要翻译：本发明提供了调节免疫系统的方法和组合物。具体而言，本发明提供了用于增加用于治疗癌症和慢性感染的T细胞介导的免疫应答的方法和组合物。

3. 发明申请

WO2010099472A2 SPANX-B POLYPEPTIDES AND THEIR USE 审中-公开
标题翻译： SPANX-B多肽及其用途
公开(公告)号：WO2010099472A2
公开(公告)日：2010-09-02
申请号：PCT/US2010/025633
申请日：2010-02-26
申请人： THE U.S.A. OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , BIRAGYN, Arya , LARIONOV, Vladimir, L.
发明人： BIRAGYN, Arya , LARIONOV, Vladimir, L.
IPC分类号： A61K39/00 , C07K7/06 , C07K7/08 , C07K14/82 , C12N15/12 , C12N15/86 , A61P35/00
CPC分类号： C07K14/4748 , A61K39/0011 , A61K45/06 , A61K2039/5158 , A61K2039/53 , C07K14/82
摘要： It is disclosed herein that SPANX-B is uniquely expressed in a number of human tumors and that SPANX-B is an immunogenic antigen that is recognized by human T cells inducing helper CD4 + and cytolytic CD8 + T cell responses. Specific SPANX-B polypeptides and polynucleotides are disclosed that can be used to generate an immune response. In several embodiments, these polypeptides can be used for the treatment of a variety of cancers, including melanoma, colon carcinoma, ovarian cancer, breast cancer, myeloma, lung carcinoma and renal cancer.
摘要翻译：本文公开了SPANX-B在许多人类肿瘤中独特表达，并且SPANX-B是由诱导辅助性CD4 + T细胞的人类T细胞识别的免疫原性抗原，和细胞溶解CD8 + T细胞应答。公开了可用于产生免疫应答的特定SPANX-B多肽和多核苷酸。在几个实施方案中，这些多肽可用于治疗多种癌症，包括黑素瘤，结肠癌，卵巢癌，乳腺癌，骨髓瘤，肺癌和肾癌。

4. 发明申请

WO2004038002A2 MODULATION OF DENDRITIC CELL FUNCTION AND OTHER CELLULAR RESPONSES MEDIATED BY DEFENSIN COMPOSITIONS 审中-公开
标题翻译：抑制剂组合物介导的细胞功能调节和其他细胞因子的调节
公开(公告)号：WO2004038002A2
公开(公告)日：2004-05-06
申请号：PCT/US2003/033940
申请日：2003-10-24
申请人： THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , BIRAGYN, Arya , KWAK, Larry, W.
发明人： BIRAGYN, Arya , KWAK, Larry, W.
IPC分类号： C12N
CPC分类号： C07K16/00 , C07K2317/622 , C07K2319/00
摘要： Methods are provided to reduce inflammation and to treat abnormal physiological conditions or diseases by modulating a robust, type 1 adaptive immune response in vivo . The present invention also provides proteins and the nucleotides encoding them, compositions, vectors (including vaccine vectors) and delivery vehicles, cells capable of expressing the proteins, and kits for practicing the invention.
摘要翻译：提供了减少炎症并通过在体内调节健壮的1型适应性免疫应答来治疗异常生理状况或疾病的方法。本发明还提供蛋白质和编码它们的组合物，组合物，载体（包括疫苗载体）和递送载体，能够表达蛋白质的细胞，以及用于实施本发明的试剂盒。

5. 发明申请

WO0222687A3 VIRAL CHEMOKINE-TUMUR ANTIGEN FUSION PROTEINS 审中-公开
标题翻译： VIRAL CHEMOKINE-TUMUR抗原蛋白融合蛋白
公开(公告)号：WO0222687A3
公开(公告)日：2003-07-24
申请号：PCT/US0129075
申请日：2001-09-17
申请人： US GOV HEALTH & HUMAN SERV , KWAK LARRY W , BIRAGYN ARYA
发明人： KWAK LARRY W , BIRAGYN ARYA
IPC分类号： A61K39/395 , A61P31/12 , A61P35/00 , C07K14/03 , C07K14/16 , C07K14/47 , C07K14/52 , C07K16/00 , C07K16/28 , C12N1/21 , C07K19/00 , A61K31/7088 , A61K39/00 , A61K48/00 , C12N15/62 , C12N15/70
CPC分类号： C07K14/521 , A61K39/39541 , A61K2039/505 , C07K14/005 , C07K14/4727 , C07K14/4748 , C07K14/523 , C07K16/00 , C07K16/2875 , C07K16/2896 , C07K2319/00 , C12N2710/16422 , C12N2740/16122 , Y10S514/885
摘要： The present invention relates to a vaccine for increasing the immunogenicity of a tumor antigen thus allowing treatment of cancer, as well as a vaccine that increases the immunogenicity of a viral antigen, thus allowing treatment of viral infection, including immunodeficiency virus (HIV) infection. In particular, the present invention provides a fusion protein comprising a viral chemokine fused to either a tumor antigen or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune response effective in treating cancer or effective in treating or preventing viral infection.
摘要翻译：本发明涉及用于增加肿瘤抗原的免疫原性的疫苗，从而允许治疗癌症，以及增加病毒抗原的免疫原性的疫苗，从而允许治疗包括免疫缺陷病毒（HIV）感染在内的病毒感染。特别地，本发明提供了融合蛋白，其包含与肿瘤抗原或病毒抗原融合的病毒趋化因子，其作为蛋白质或核酸疫苗施用以引发有效治疗癌症或有效治疗或预防病毒的免疫应答感染。

6. 发明申请

WO1997035008A1 METHODS AND COMPOSITIONS OF CHIMERIC POLYPEPTIDES FOR TUMOR ANTIGEN VACCINES 审中-公开
标题翻译：用于肿瘤抗原疫苗的寡核苷酸的方法和组合物
公开(公告)号：WO1997035008A1
公开(公告)日：1997-09-25
申请号：PCT/US1997004656
申请日：1997-03-21
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by the SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , KWAK, Larry, W. , BIRAGYN, Arya
发明人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by the SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
IPC分类号： C12N15/12
CPC分类号： C07K14/005 , A61K39/00 , C07K14/4727 , C07K14/82 , C07K2319/00 , C12N7/00 , C12N2730/10122 , C12N2730/10123
摘要： The present invention provides a chimeric polypeptide comprising a hepatitis B virus core antigen (HBcAg) region and a region comprising an epitope of a tumor antigen. The present invention further provides a nucleic acid encoding the chimeric polypeptide, a vector comprising the nucleic acid and a cell comprising the vector. Also provided is a method of inhibiting the growth of tumor cells in a subject, comprising administering to the subject a tumor cell growth-inhibiting amount of a chimeric polypeptide comprising a HBcAg region and a region comprising an epitope of a tumor antigen corresponding to a tumor antigen in the subject. A chimeric polypeptide comprising a hepatitis B virus core antigen region and an antigenic polypeptide region comprising greater than 40 amino acids, which assembles into core particles, is also provided, as well as a method for constructing a chimeric polypeptide comprising a hepatitis B virus core antigen region and an antigenic polypeptide region comprising greater than 40 amino acids, which assembles into core particles, comprising cloning into an expression vector a first DNA fragment encoding the hepatitis B core antigen region and a second DNA fragment encoding an antigenic polypeptide region greater than 40 amino acids; and expressing the DNA of the expression vector in an expression system whereby the chimeric polypeptide assembles into core particles.
摘要翻译：本发明提供了包含乙型肝炎病毒核心抗原（HBcAg）区域和包含肿瘤抗原表位的区域的嵌合多肽。本发明还提供了编码嵌合多肽的核酸，包含核酸的载体和包含载体的细胞。还提供了抑制受试者中肿瘤细胞生长的方法，包括向受试者施用肿瘤细胞生长抑制量的包含HBcAg区的嵌合多肽和包含与肿瘤相应的肿瘤抗原表位的区域抗原。还提供了包含乙型肝炎病毒核心抗原区和包含大于40个氨基酸的抗原性多肽区域的嵌合多肽，其组装成核心颗粒，以及构建包含乙型肝炎病毒核心抗原的嵌合多肽的方法区域和包含大于40个氨基酸的抗原多肽区域，其组装成核心颗粒，包括将表达载体克隆到编码所述乙型肝炎核心抗原区域的第一DNA片段和编码大于40个氨基酸的抗原性多肽区域的第二DNA片段酸; 并在表达系统中表达表达载体的DNA，由此嵌合多肽组装成核心颗粒。

7. 发明申请

WO2012074842A3 COMPOSITIONS AND METHODS FOR TREATING NEOPLASIA 审中-公开
标题翻译：用于治疗NEOPLASIA的组合物和方法
公开(公告)号：WO2012074842A3
公开(公告)日：2013-04-04
申请号：PCT/US2011061872
申请日：2011-11-22
申请人： US OF AMERICA AS REPRESENTED BY THE SECRETARY NAT INST OF HEALTH , BIRAGYN ARYA , LEONARD WARREN J
发明人： BIRAGYN ARYA , LEONARD WARREN J
IPC分类号： A61K39/395 , A61K48/00 , A61P35/00
CPC分类号： G01N33/57407 , A61K45/06 , A61K2039/505 , G01N2333/5418 , G01N2800/56
摘要： The invention features compositions comprising agent that inhibits thymic stromal lymphopoietin (TSLP) or TSLP Receptor expression or biological activity, and related methods of using the compositions for treating or preventing cancer progression or metastasis.
摘要翻译：本发明的特征在于包含抑制胸腺基质淋巴细胞生成素（TSLP）或TSLP受体表达或生物活性的试剂的组合物以及使用该组合物治疗或预防癌症进展或转移的相关方法。

8. 发明申请

WO2012074842A2 COMPOSITIONS AND METHODS FOR TREATING NEOPLASIA 审中-公开
标题翻译：用于治疗NEOPLASIA的组合物和方法
公开(公告)号：WO2012074842A2
公开(公告)日：2012-06-07
申请号：PCT/US2011/061872
申请日：2011-11-22
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, NATIONAL INSTITUTE OF HEALTH , BIRAGYN, Arya , LEONARD, Warren, J.
发明人： BIRAGYN, Arya , LEONARD, Warren, J.
CPC分类号： G01N33/57407 , A61K45/06 , A61K2039/505 , G01N2333/5418 , G01N2800/56
摘要： The invention features compositions comprising agent that inhibits thymic stromal lymphopoietin (TSLP) or TSLP Receptor expression or biological activity, and related methods of using the compositions for treating or preventing cancer progression or metastasis.
摘要翻译：本发明的特征在于包含抑制胸腺基质淋巴细胞生成素（TSLP）或TSLP受体表达或生物活性的试剂的组合物以及使用该组合物治疗或预防癌症进展或转移的相关方法。

9. 发明申请

WO2010099472A3 SPANX-B POLYPEPTIDES AND THEIR USE 审中-公开
标题翻译： SPANX-B多糖及其用途
公开(公告)号：WO2010099472A3
公开(公告)日：2010-10-21
申请号：PCT/US2010025633
申请日：2010-02-26
申请人： U S A OF AMERICA AS REPRESENTE , BIRAGYN ARYA , LARIONOV VLADIMIR L
发明人： BIRAGYN ARYA , LARIONOV VLADIMIR L
IPC分类号： A61K39/00 , A61P35/00 , C07K7/06 , C07K7/08 , C07K14/82 , C12N15/12 , C12N15/86
CPC分类号： C07K14/4748 , A61K39/0011 , A61K45/06 , A61K2039/5158 , A61K2039/53 , C07K14/82
摘要： It is disclosed herein that SPANX-B is uniquely expressed in a number of human tumors and that SPANX-B is an immunogenic antigen that is recognized by human T cells inducing helper CD4+ and cytolytic CD8+ T cell responses. Specific SPANX-B polypeptides and polynucleotides are disclosed that can be used to generate an immune response. In several embodiments, these polypeptides can be used for the treatment of a variety of cancers, including melanoma, colon carcinoma, ovarian cancer, breast cancer, myeloma, lung carcinoma and renal cancer.
摘要翻译：本文公开了SPANX-B在许多人肿瘤中独特地表达，并且SPANX-B是被诱导辅助性CD4 +和细胞溶解性CD8 + T细胞应答的人T细胞识别的免疫原性抗原。公开了可用于产生免疫应答的特异性SPANX-B多肽和多核苷酸。在几个实施方案中，这些多肽可用于治疗多种癌症，包括黑素瘤，结肠癌，卵巢癌，乳腺癌，骨髓瘤，肺癌和肾癌。

10. 发明申请

WO2007041364A3 CONJUGATES FOR MODULATING THE IMMUNE TOLERANCE 审中-公开
标题翻译：调整免责条款的协议
公开(公告)号：WO2007041364A3
公开(公告)日：2008-10-09
申请号：PCT/US2006038195
申请日：2006-09-28
申请人： US GOV HEALTH & HUMAN SERV , BIRAGYN ARYA , MATSUSHIMA KOUJI , BATAAR DOLGOR
发明人： BIRAGYN ARYA , MATSUSHIMA KOUJI , BATAAR DOLGOR
IPC分类号： A61K47/48 , A61P37/02
CPC分类号： A61K38/465 , A61K38/195 , A61K38/45 , A61K45/06 , A61K47/48261 , A61K47/48269 , A61K47/6415 , A61K47/642 , C07K14/521 , C07K14/523 , C07K14/7158 , C07K2319/55 , C12N9/1077 , C12N9/22 , C12Y204/02036 , C12Y301/27 , C12Y301/27005
摘要： The instant invention provides methods and compositions for modulation of the immune system. Specifically, the invention provides methods and compositions for increasing T cell mediated immune response useful in the treatment of cancer and chronic infection.
摘要翻译：本发明提供了用于调节免疫系统的方法和组合物。具体地，本发明提供了用于增加可用于治疗癌症和慢性感染的T细胞介导的免疫应答的方法和组合物。

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