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1. 发明申请

WO2005087799A2 MVL, AN ANTIVIRAL PROTEIN FROM A CYANOBACTERIUM 审中-公开
标题翻译： MVL，来自CYANOBACTERIUM的抗病毒蛋白质
公开(公告)号：WO2005087799A2
公开(公告)日：2005-09-22
申请号：PCT/US2005/007703
申请日：2005-03-09
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , BEWLEY, Carole, A.
发明人： BEWLEY, Carole, A.
IPC分类号： C07K9/00
CPC分类号： C07K14/195 , Y10S530/825
摘要： The present invention relates, e.g., to an isolated polypeptide from a cyanobacterium, Microcystis viridis, which binds specifically to an oligosaccharide comprising the tetrasaccharide Man-alpha-(1→6)Man-beta (1→4) G1cNAc-beta(1→4)G1cNAc. The polypeptide can be obtained, for example, from a cell that expresses a recombinant nucleic acid that encodes a MVL-like polypeptide. The invention also relates to an isolated polypeptide comprising one or more copies of the sequence GPLWSNXEAQXXGPX (SEQ ID NO: 1) and/or one or more copies of the sequence FTGQWXTXVEXXMSV (SEQ ID NO: 2), wherein the polypeptide binds specifically to the above-mentioned oligosaccharide. Conjugates comprising such polypeptides and an effector molecule are also disclosed, as are methods of using such polypeptides or conjugates, e.g., for inhibiting infection by a virus, such as HIV, or for removing a virus, such as HIV, from a sample, such as a bodily fluid or an inanimate object.
摘要翻译：本发明涉及例如与来自蓝细菌的微囊藻（Microcystis viridis）分离的多肽，其与包含四糖Man-α-（1-> 6）Man-β（1-> 4）G1cNAc-β（ 1-> 4）G1cNAc。多肽可以例如从表达编码MVL样多肽的重组核酸的细胞获得。本发明还涉及包含序列GPLWSNXEAQXXGPX（SEQ ID NO：1）和/或序列FTGQWXTXVEXXMSV（SEQ ID NO：2）的一个或多个拷贝的一个或多个拷贝的分离的多肽，其中所述多肽特异性结合于上述寡糖。还公开了包含此类多肽和效应分子的缀合物，以及使用此类多肽或缀合物的方法，例如用于抑制病毒如HIV的感染或从样品中除去病毒如HIV。作为体液或无生命物体。

2. 发明申请

WO2002081483A3 INHIBITORS OF ACYL GLUCOSAMINYL INOSITOL AMIDASE AND METHODS OF USE 审中-公开
公开(公告)号：WO2002081483A3
公开(公告)日：2002-10-17
申请号：PCT/US2002/011117
申请日：2002-04-08
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , FAHEY, Robert, C. , NEWTON, Gerald, L. , BEWLEY, Carole, A. , NICHOLAS, Gillian
发明人： FAHEY, Robert, C. , NEWTON, Gerald, L. , BEWLEY, Carole, A. , NICHOLAS, Gillian
IPC分类号： A61K31/165
摘要： The present invention provides compounds with activity as inhibitors of acyl glucosaminylinositol amidases with amidase activity against S-conjugate amides, particularly mycothiol-derived S-conjugate amides. Certain of the invention compounds are naturally occurring compounds obtained from marine sponges and other organisms. The invention further provides methods for using the compounds to inhibit virulence and reduce antibiotic resistance of mycothiol-producing bacteria.

3. 发明申请

WO02081483A2 INHIBITORS OF ACYL GLUCOSAMINYL INOSITOL AMIDASE AND METHODS OF USE 审中-公开
标题翻译： ACYL GLUCOSAMINYL INOSITOL AMIDASE的抑制剂及其使用方法
公开(公告)号：WO02081483A2
公开(公告)日：2002-10-17
申请号：PCT/US0211117
申请日：2002-04-08
申请人： UNIV CALIFORNIA , FAHEY ROBERT C , NEWTON GERALD L , BEWLEY CAROLE A , NICHOLAS GILLIAN
发明人： FAHEY ROBERT C , NEWTON GERALD L , BEWLEY CAROLE A , NICHOLAS GILLIAN
IPC分类号： A61P31/04 , C07C225/06 , C07C279/12 , C07D213/16 , C07D213/36 , C07D233/88 , C07D413/12 , C07D413/14 , C07H15/12 , C07F
CPC分类号： C07D213/06 , C07C225/06 , C07C279/12 , C07D213/36 , C07D233/88 , C07D413/12 , C07D413/14 , C07H15/12
摘要： The present invention provides compounds with activity as inhibitors of acyl glucosaminylinositol amidases with amidase activity against S-conjugate amides, particularly mycothiol-derived S-conjugate amides. Certain of the invention compounds are naturally occurring compounds obtained from marine sponges and other organisms. The invention further provides methods for using the compounds to inhibit virulence and reduce antibiotic resistance of mycothiol-producing bacteria.
摘要翻译：本发明提供了作为具有针对S-缀合物酰胺的酰胺酶活性的酰基葡糖胺基肌醇酰胺酶抑制剂的活性的化合物，特别是由咪唑硫醇衍生的S-缀合物酰胺。某些本发明化合物是从海洋海绵和其他生物得到的天然存在的化合物。本发明进一步提供了使用该化合物来抑制产毒霉菌产生细菌的毒力并减少抗生素抗性的方法。

4. 发明申请

WO2012116254A2 CHRYSOPHAENTIN ANALOGS THAT INHIBIT FTSZ PROTEIN 审中-公开
标题翻译：抑制FTSZ蛋白的CHRYSOPHAENTIN模拟物
公开(公告)号：WO2012116254A2
公开(公告)日：2012-08-30
申请号：PCT/US2012026438
申请日：2012-02-24
申请人： US HEALTH , UNIV PITTSBURGH , BEWLEY CAROLE A , WIPF PETER
发明人： BEWLEY CAROLE A , WIPF PETER
IPC分类号： C07C15/50 , A61K31/085 , C07C17/266 , C07C25/24 , C07C41/05 , C07C43/275 , C07C43/285 , C07C43/295
CPC分类号： C07C37/14 , A61K31/055 , A61K31/085 , A61K45/06 , C07C39/373 , C07C43/23 , C07D321/00
摘要： Embodiments of antimicrobial chrysophaentin compounds, pharmaceutical compositions including the chrysophaentin compounds, methods for using the chrysophaentin compounds, and methods for synthesizing the chrysophaentin compounds are disclosed. Certain embodiments of the chrysophaentin compounds inhibit FtsZ protein, thereby inhibiting the growth of clinically relevant bacteria, including drug-resistant strains.
摘要翻译：公开了抗微生物菌素化合物的实施方案，包括辣椒素化合物的药物组合物，使用辣椒素化合物的方法，以及合成辣椒素化合物的方法。辣椒素化合物的某些实施方案抑制FtsZ蛋白，从而抑制临床相关细菌（包括耐药菌株）的生长。

5. 发明申请

WO2004004659A3 ALKALOID DERIVATIVES AND METHODS OF THEIR USE 审中-公开
标题翻译：生物碱衍生物及其使用方法
公开(公告)号：WO2004004659A3
公开(公告)日：2004-05-13
申请号：PCT/US0321456
申请日：2003-07-09
申请人： US HEALTH , BEWLEY CAROLE , NICHOLAS GILLIAN , NICOLAOU K C , BARLUENGA SOFIA , PFEFFERKORN JEFFREY , HUGHES ROBERT
发明人： BEWLEY CAROLE , NICHOLAS GILLIAN , NICOLAOU K C , BARLUENGA SOFIA , PFEFFERKORN JEFFREY , HUGHES ROBERT
IPC分类号： C07C323/41 , A61K31/165 , C07C233/05
CPC分类号： C07C323/41
摘要： Synthetic alkaloid derivatives useful as inhibitors of acyl gluc osaminyl inositol amidase activity, including mycothiol-S-conjugate amidase, are disclosed. In addition, methods of using the inhibitors of acyl glucosaminyl inositol amidase in the treatment of bacterial infections, including those caused by Mycobacterium tuberculosis, are also disclosed.
摘要翻译：公开了用作酰基葡糖苷奥沙米林肌醇酰胺酶活性抑制剂的合成生物碱衍生物，包括mycothiol-S-共轭酰胺酶。另外，还公开了使用酰基葡糖胺基肌醇酰胺酶抑制剂治疗细菌感染（包括由结核分枝杆菌引起的那些）的方法。

6. 发明申请

WO2003072594A3 AN OBLIGATE DOMAIN-SWAPPED DIMER OF CYANOVIRIN WITH ENHANCED ANTI-VIRAL ACTIVITY 审中-公开
公开(公告)号：WO2003072594A3
公开(公告)日：2003-09-04
申请号：PCT/US2003/006115
申请日：2003-02-25
申请人： GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICE , BEWLEY, Carole, A.
发明人： BEWLEY, Carole, A.
IPC分类号： A61K39/21
摘要： A purified or isolated obligate domain-swapped dimer of CVN; an isolated or purified nucleic acid encoding at least one obligate domain-swapped dimer of CVN, optionally in the form of a vector; a host cell comprising such an isolated or purified nucleic acid; a composition comprising (i) the obligate domain-swapped dimer of CVN or the isolated or purified nucleic acid encoding at least one obligate domain-swapped dimer of CVN, optionally in the form of a vector, and (ii) a carrier therefor; a method of inhibiting a viral infection of a mammal, which method comprises administering to the mammal an antiviral effective amount of the aforementioned composition, whereupon the viral infection of the mammal is inhibited; and a method of making an obligate domain-swapped dimer of CVN, which method comprises introducing at least one mutation in the linker region of wild-type CVN, whereupon an obligate domain-swapped dimer of CVN is obtained.

7. 发明申请

WO2012116254A3 CHRYSOPHAENTIN ANALOGS THAT INHIBIT FTSZ PROTEIN 审中-公开
公开(公告)号：WO2012116254A3
公开(公告)日：2012-08-30
申请号：PCT/US2012/026438
申请日：2012-02-24
申请人： THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , BEWLEY, Carole A. , WIPF, Peter
发明人： BEWLEY, Carole A. , WIPF, Peter
IPC分类号： C07C15/50 , C07C17/266 , C07C25/24 , C07C41/05 , C07C43/275 , C07C43/285 , C07C43/295 , A61K31/085
摘要： Embodiments of antimicrobial chrysophaentin compounds, pharmaceutical compositions including the chrysophaentin compounds, methods for using the chrysophaentin compounds, and methods for synthesizing the chrysophaentin compounds are disclosed. Certain embodiments of the chrysophaentin compounds inhibit FtsZ protein, thereby inhibiting the growth of clinically relevant bacteria, including drug-resistant strains.

8. 发明申请

WO2003072594A2 AN OBLIGATE DOMAIN-SWAPPED DIMER OF CYANOVIRIN WITH ENHANCED ANTI-VIRAL ACTIVITY 审中-公开
标题翻译：具有增强抗病毒活性的CYANOVIRIN的寡核苷酸转换二聚体
公开(公告)号：WO2003072594A2
公开(公告)日：2003-09-04
申请号：PCT/US2003/006115
申请日：2003-02-25
申请人： GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICE , BEWLEY, Carole, A.
发明人： BEWLEY, Carole, A.
IPC分类号： C07K
CPC分类号： C07K14/195 , A61K38/00 , A61K39/00 , A61K2039/53
摘要： A purified or isolated obligate domain-swapped dimer of CVN; an isolated or purified nucleic acid encoding at least one obligate domain-swapped dimer of CVN, optionally in the form of a vector; a host cell comprising such an isolated or purified nucleic acid; a composition comprising (i) the obligate domain-swapped dimer of CVN or the isolated or purified nucleic acid encoding at least one obligate domain-swapped dimer of CVN, optionally in the form of a vector, and (ii) a carrier therefor; a method of inhibiting a viral infection of a mammal, which method comprises administering to the mammal an antiviral effective amount of the aforementioned composition, whereupon the viral infection of the mammal is inhibited; and a method of making an obligate domain-swapped dimer of CVN, which method comprises introducing at least one mutation in the linker region of wild-type CVN, whereupon an obligate domain-swapped dimer of CVN is obtained.
摘要翻译：纯化或分离的CVN的专一性域交换的二聚体，其是编码CVN的至少一个专性域交换的二聚体的分离或纯化的核酸，任选以载体的形式，包含这种分离或纯化的核酸的宿主细胞包含我是CVN的专有域交换的二聚体或编码CVN的至少一个专性域交换的二聚体的分离的或纯化的核酸，任选地以载体的形式，和ii的载体用于抑制病毒感染的方法哺乳动物，该方法包括向哺乳动物施用抗病毒有效量的上述组合物，由此抑制哺乳动物的病毒感染，以及制备CVN的专性域交换的二聚体的方法，该方法包括将至少一种突变引入野生型CVN的接头区域，得到CVN的专有域交换的二聚体。

9. 发明申请

WO2005087799A3 MVL, AN ANTIVIRAL PROTEIN FROM A CYANOBACTERIUM 审中-公开
标题翻译： MVL，一种来自CYANOBACTERIUM的抗病毒蛋白
公开(公告)号：WO2005087799A3
公开(公告)日：2005-11-24
申请号：PCT/US2005007703
申请日：2005-03-09
申请人： US GOV HEALTH & HUMAN SERV , BEWLEY CAROLE A
发明人： BEWLEY CAROLE A
IPC分类号： C07K14/195 , A61K38/16 , A61P31/12
CPC分类号： C07K14/195 , Y10S530/825
摘要： The present invention relates, e.g., to an isolated polypeptide from a cyanobacterium, Microcystis viridis, which binds specifically to an oligosaccharide comprising the tetrasaccharide Man-alpha-(1->6)Man-beta (1->4) G1cNAc-beta(1->4)G1cNAc. The polypeptide can be obtained, for example, from a cell that expresses a recombinant nucleic acid that encodes a MVL-like polypeptide. The invention also relates to an isolated polypeptide comprising one or more copies of the sequence GPLWSNXEAQXXGPX (SEQ ID NO: 1) and/or one or more copies of the sequence FTGQWXTXVEXXMSV (SEQ ID NO: 2), wherein the polypeptide binds specifically to the above-mentioned oligosaccharide. Conjugates comprising such polypeptides and an effector molecule are also disclosed, as are methods of using such polypeptides or conjugates, e.g., for inhibiting infection by a virus, such as HIV, or for removing a virus, such as HIV, from a sample, such as a bodily fluid or an inanimate object.
摘要翻译：本发明涉及例如来自蓝细菌微绿囊藻的分离的多肽，其特异性结合包含四糖Man-α-（1→6）Man-β（1→4）GlcNAc-β（ 1-> 4）G1cNAc。多肽可以例如从表达编码MVL样多肽的重组核酸的细胞中获得。本发明还涉及包含序列GPLWSNXEAQXXGPX（SEQ ID NO：1）的一个或多个拷贝和/或序列FTGQWXTXVEXXMSV（SEQ ID NO：2）的一个或多个拷贝的分离的多肽，其中所述多肽特异性结合上述寡糖。还公开了包含此类多肽和效应分子的缀合物，以及使用这些多肽或缀合物的方法，例如用于抑制病毒如HIV的感染或从样品中除去病毒如HIV的方法作为体液或无生命的物体。

10. 发明申请

WO2004004659A2 ALKALOID DERIVATIVES AND METHODS OF THEIR USE 审中-公开
标题翻译： ALKALOID衍生物及其使用方法
公开(公告)号：WO2004004659A2
公开(公告)日：2004-01-15
申请号：PCT/US2003/021456
申请日：2003-07-09
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , BEWLEY, Carole , NICHOLAS, Gillian , NICOLAOU, K., C. , BARLUENGA, Sofia , PFEFFERKORN, Jeffrey , HUGHES, Robert
发明人： BEWLEY, Carole , NICHOLAS, Gillian , NICOLAOU, K., C. , BARLUENGA, Sofia , PFEFFERKORN, Jeffrey , HUGHES, Robert
IPC分类号： A61K
CPC分类号： C07C323/41
摘要： Synthetic alkaloid derivatives useful as inhibitors of acyl gluc osaminyl inositol amidase activity, including mycothiol-S-conjugate amidase, are disclosed. In addition, methods of using the inhibitors of acyl glucosaminyl inositol amidase in the treatment of bacterial infections, including those caused by Mycobacterium tuberculosis , are also disclosed.
摘要翻译：公开了可用作酰基葡糖胺基甲酰肌醇酰胺酶活性抑制剂的合成生物碱衍生物，包括咪唑硫醇-S-共轭酰胺酶。此外，还公开了使用酰基葡糖胺基肌醇酰胺酶抑制剂治疗细菌感染的方法，包括由结核分枝杆菌引起的那些。

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