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1. 发明授权

US06844451B2 Method for isolating terpene trilactones (ginkgolides, bilobalide) from leaves and pharmaceutical powders of Ginkgo biloba 失效
标题翻译：银杏叶片和药用粉末分离萜三烯内酯（银杏内酯，银杏内酯）的方法
公开(公告)号：US06844451B2
公开(公告)日：2005-01-18
申请号：US10615346
申请日：2003-07-07
申请人： Dirk Lichtblau , Nina Berova , John Berger , Koji Nakanishi
发明人： Dirk Lichtblau , Nina Berova , John Berger , Koji Nakanishi
IPC分类号： A61K31/365 , A61K36/00 , A61K36/16 , C07D307/77 , C07D493/14 , C07D307/93
CPC分类号： C07D307/77 , A61K31/365 , A61K36/16
摘要： A method of isolating terpene trilactones from Ginkgo biloba plant material or extract comprising the steps of suspending the plant material or extract in either water or an aqueous solution of an oxidation reagent; extracting the terpene trilactones using an acceptable extraction agent; separating the organic layer from the aqueous layer; washing the organic layer with an acceptable aqueous salt or hydroxide solution, which may be an alkaline solution; and drying the organic layer to form a dried extract containing terpene trilactones. Further purification by treatment with or filtration over activated charcoal, by treatment with or filtration over alumina and by recrystallization with an acceptable solvent or solvent mixture leads to extracts with a content of terpene trilactones higher than 50%. Unwanted levels of ginkgolic acids are reduced to acceptable levels by reversed phase chromatography.
摘要翻译：从银杏植物材料或提取物中分离萜品三内酯的方法，包括将植物材料或提取物悬浮在水或氧化试剂的水溶液中的步骤; 使用可接受的提取剂萃取萜烯三内酯; 从水层分离有机层; 用可接受的盐或氢氧化物溶液洗涤有机层，其可以是碱性溶液; 并干燥有机层以形成含有萜烯三内酯的干燥提取物。通过用活性炭处理或过滤进一步纯化，通过在氧化铝上处理或过滤，并用可接受的溶剂或溶剂混合物重结晶，得到萜烯三内酯的含量高于50％的提取物。不需要的银杏酸水平通过反相色谱法降至可接受的水平。

2. 发明申请

WO2006083366A2 PREPARATION OF GINKGOLIDE AND F-SECO-GINKGOLIDE LACTOLS 审中-公开
标题翻译：银杏内酯和F-SECO-GINKGOLIDE LACTOL的制备
公开(公告)号：WO2006083366A2
公开(公告)日：2006-08-10
申请号：PCT/US2005/042647
申请日：2005-11-23
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , NAKANISHI, Koji , BEROVA, Nina , TANAKA, Katsunori
发明人： NAKANISHI, Koji , BEROVA, Nina , TANAKA, Katsunori
IPC分类号： A61K31/365
CPC分类号： C07D493/22
摘要： The present invention relates to synthesis of C 11 natural ginkgolide derivatives and C 11 f-seco-gingkolide derivatives from the corresponding lactols which are selectively obtained using NaBH 4 .
摘要翻译：本发明涉及从相应的乳液中合成天然银杏内酰胺衍生物和C 11-11-顺式 - 起始化合物衍生物，所述衍生物使用NaBH 4 / SUB>。

3. 发明申请

WO2006083366A3 PREPARATION OF GINKGOLIDE AND F-SECO-GINKGOLIDE LACTOLS 审中-公开
标题翻译：银杏内酯和F-SECO-GINKGOLIDE LACTOL的制备
公开(公告)号：WO2006083366A3
公开(公告)日：2007-08-02
申请号：PCT/US2005042647
申请日：2005-11-23
申请人： UNIV COLUMBIA , NAKANISHI KOJI , BEROVA NINA , TANAKA KATSUNORI
发明人： NAKANISHI KOJI , BEROVA NINA , TANAKA KATSUNORI
IPC分类号： A61K31/33 , A61K31/34 , C07D307/77 , C07D407/00
CPC分类号： C07D493/22
摘要： The present invention relates to synthesis of C 11 natural ginkgolide derivatives and C 11 f-seco-gingkolide derivatives from the corresponding lactols which are selectively obtained using NaBH 4 .
摘要翻译：本发明涉及从相应的乳液中合成天然银杏内酰胺衍生物和C 11-11-顺式 - 起始化合物衍生物，所述衍生物使用NaBH 4 / SUB>。

4. 发明申请

WO2003006040A1 METHOD FOR ISOLATING TERPENE TRILACTONES (GINKGOLIDES, BILOBALIDE) FROM LEAVES AND PHARMACEUTICAL POWDERS OF GINKGO BILOBA 审中-公开
标题翻译：用于从银杏叶的叶子和药物粉末中分离TERPENE TRILACTONES（银杏，Bilobalide）的方法
公开(公告)号：WO2003006040A1
公开(公告)日：2003-01-23
申请号：PCT/US2002/022101
申请日：2002-07-11
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , LITCHBLAU, Dirk, Andreas , BERGER, John , BEROVA, Nina , NAKANISHI, Koji
发明人： LITCHBLAU, Dirk, Andreas , BERGER, John , BEROVA, Nina , NAKANISHI, Koji
IPC分类号： A61K35/78
CPC分类号： C07D307/77 , A61K31/365 , A61K36/16
摘要： A method of isolating terpene trilactones from Ginkgo biloba plant material or extract comprising the steps of suspending the plant material or extract in either water or an aqueous solution of an oxidation reagent; extracting the terpene trilactones using an acceptable extraction agent; separating the organic layer from the aqueous layer; washing the organic layer with an acceptable aqueous salt or hydroxide solution, which may be an alkaline solution; and drying the organic layer to form a dried extract containing terpene trilactones. Further purification by treatment with or filtration over activated charcoal, by treatment with or filtration over alumina and by recrystallization with an acceptable solvent or solvent mixture leads to extracts with a content of terpene trilactones higher than 50%. Unwanted levels of ginkgolic acids are reduced to acceptable levels by reversed phase chromatography.
摘要翻译：从银杏植物材料或提取物中分离萜烯三内酯的方法，包括将植物材料或提取物悬浮在水或氧化试剂的水溶液中的步骤; 使用可接受的提取剂萃取萜烯三内酯; 从水层分离有机层; 用可接受的盐或氢氧化物溶液洗涤有机层，其可以是碱性溶液; 并干燥有机层以形成含有萜烯三内酯的干燥提取物。通过用活性炭处理或过滤进一步纯化，通过在氧化铝上处理或过滤，并用可接受的溶剂或溶剂混合物重结晶，得到萜烯三内酯的含量高于50％的提取物。不需要的银杏酸水平通过反相色谱法降至可接受的水平。

5. 发明申请

WO2005092324A1 GINKGOLIDE COMPOUNDS, COMPOSITIONS, EXTRACTS, AND USES THEREOF 审中-公开
标题翻译：银杏内酯化合物，组合物，提取物及其用途
公开(公告)号：WO2005092324A1
公开(公告)日：2005-10-06
申请号：PCT/US2005/009417
申请日：2005-03-21
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , VITOLO, Ottavio, V. , NAKANISHI, Koji , SHELANSKI, Michael, L. , KRANE, Sonja , ARANCIO, Ottavio , JARACZ, Stanislav , BEROVA, Nina, D.
发明人： VITOLO, Ottavio, V. , NAKANISHI, Koji , SHELANSKI, Michael, L. , KRANE, Sonja , ARANCIO, Ottavio , JARACZ, Stanislav , BEROVA, Nina, D.
IPC分类号： A61K31/335
CPC分类号： C07D493/18 , C07D493/22
摘要： The present invention relates to Ginkgolide derivatives, compositions and extracts comprising one or more Ginkgolides and/or derivatives thereof and methods of use of the compositions to treat neurological disorders and as imaging agents.
摘要翻译：本发明涉及银杏内酯衍生物，包含一种或多种银杏内酯和/或其衍生物的组合物和提取物以及用于治疗神经障碍和作为成像剂的组合物的使用方法。

6. 发明专利

BG37003A1 METHOD FOR PREPARING 1- PHENYL- 1- CYCLOHEXYL- 3- (1- PYRROLIDINYL)- 1- PROPANOL 未知
公开(公告)号：BG37003A1
公开(公告)日：1985-03-15
申请号：BG6348583
申请日：1983-12-20
申请人： BOJADZHIEV , STANCHEV , BEROVA , KURTEV
发明人： BOJADZHIEV , STANCHEV , BEROVA , KURTEV
IPC分类号： A61K31/045 , C07C33/34 , C07D207/04

7. 发明申请

US20050136136A1 Method for isolating terpene trilactones (ginkgolides, bilobadide) from leaves and pharmaceutical powders of ginkgo biloba 审中-公开
标题翻译：从叶片和银杏叶药物粉末中分离萜品三内酯（银杏内酯，二溴化物）的方法
公开(公告)号：US20050136136A1
公开(公告)日：2005-06-23
申请号：US11036409
申请日：2005-01-14
申请人： Dirk Lichtblau , Nina Berova , John Berger , Koji Nakanishi
发明人： Dirk Lichtblau , Nina Berova , John Berger , Koji Nakanishi
IPC分类号： A61K31/365 , A61K36/00 , A61K36/16 , C07D307/77 , C07D493/14 , A61K35/78
CPC分类号： C07D307/77 , A61K31/365 , A61K36/16
摘要： A method of isolating terpene trilactones from Ginkgo biloba plant material or extract comprising the steps of suspending the plant material or extract in either water or an aqueous solution of an oxidation reagent; extracting the terpene trilactones using an acceptable extraction agent; separating the organic layer from the aqueous layer; washing the organic layer with an acceptable aqueous salt or hydroxide solution, which may be an alkaline solution; and drying the organic layer to form a dried extract containing terpene trilactones. Further purification by treatment with or filtration over activated charcoal, by treatment with or filtration over alumina and by recrystallization with an acceptable solvent or solvent mixture leads to extracts with a content of terpene trilactones higher than 50%. Unwanted levels of ginkgolic acids are reduced to acceptable levels by reversed phase chromatography.
摘要翻译：从银杏植物材料或提取物中分离萜品三内酯的方法，包括将植物材料或提取物悬浮在水或氧化试剂的水溶液中的步骤; 使用可接受的提取剂萃取萜烯三内酯; 从水层分离有机层; 用可接受的盐或氢氧化物溶液洗涤有机层，其可以是碱性溶液; 并干燥有机层以形成含有萜烯三内酯的干燥提取物。通过用活性炭处理或过滤进一步纯化，通过在氧化铝上处理或过滤，并用可接受的溶剂或溶剂混合物重结晶，得到萜烯三内酯的含量高于50％的提取物。不需要的银杏酸水平通过反相色谱法降至可接受的水平。

8. 发明授权

US06590109B2 Method for isolating terpene trilactones (ginkgolides, bilobalide) from leaves and pharmaceutical powders of ginkgo biloba 失效
标题翻译：从叶片和银杏叶药物粉末中分离萜内三聚物（银杏内酯，银杏内酯）的方法
公开(公告)号：US06590109B2
公开(公告)日：2003-07-08
申请号：US10194089
申请日：2002-07-11
申请人： Dirk Lichtblau , Nina Berova , John Berger , Koji Nakanishi
发明人： Dirk Lichtblau , Nina Berova , John Berger , Koji Nakanishi
IPC分类号： C07D30793
CPC分类号： C07D307/77 , A61K31/365 , A61K36/16
摘要： A method of isolating terpene trilactones from Ginkgo biloba plant material or extract comprising the steps of suspending the plant material or extract in either water or an aqueous solution of an oxidation reagent; extracting the terpene trilactones using an acceptable extraction agent; separating the organic layer from the aqueous layer; washing the organic layer with an acceptable aqueous salt or hydroxide solution, which may be an alkaline solution; and drying the organic layer to form a dried extract containing terpene trilactones. Further purification by treatment with or filtration over activated charcoal, by treatment with or filtration over alumina and by recrystallization with an acceptable solvent or solvent mixture leads to extracts with a content of terpene trilactones higher than 50%. Unwanted levels of ginkgolic acids are reduced to acceptable levels by reversed phase chromatography.
摘要翻译：从银杏植物材料或提取物中分离萜品三内酯的方法，包括将植物材料或提取物悬浮在水或氧化试剂的水溶液中的步骤; 使用可接受的提取剂萃取萜烯三内酯; 从水层分离有机层; 用可接受的盐或氢氧化物溶液洗涤有机层，其可以是碱性溶液; 并干燥有机层以形成含有萜烯三内酯的干燥提取物。通过用活性炭处理或过滤进一步纯化，通过在氧化铝上处理或过滤，并用可接受的溶剂或溶剂混合物重结晶，得到萜烯三内酯的含量高于50％的提取物。不需要的银杏酸水平通过反相色谱法降至可接受的水平。

9. 发明授权

US4923877A Composition and method for treating glaucoma 失效
标题翻译：治疗青光眼的组合物和方法
公开(公告)号：US4923877A
公开(公告)日：1990-05-08
申请号：US163595
申请日：1988-03-03
申请人： Marko T. Markov , Chavdar B. Ivanov , Deltcho G. Jelyazkov , Diana M. Mondeschka , Nikolina D. Berova , Rositza S. Rakovska , Maria G. Todorova , Diana D. Popova , Emiliya D. Slavova , Tatyana S. Zikolova , Viola M. Marinova , Radi G. Ovcharov , Petko D. Uzunov , Jossif N. Nissimov , Dobrinka G. Gentcheva
发明人： Marko T. Markov , Chavdar B. Ivanov , Deltcho G. Jelyazkov , Diana M. Mondeschka , Nikolina D. Berova , Rositza S. Rakovska , Maria G. Todorova , Diana D. Popova , Emiliya D. Slavova , Tatyana S. Zikolova , Viola M. Marinova , Radi G. Ovcharov , Petko D. Uzunov , Jossif N. Nissimov , Dobrinka G. Gentcheva
IPC分类号： A61K31/47
CPC分类号： A61K31/47 , Y10S514/913
摘要： An antiglaucoma composition containing as the active component a s-/-/-2,3 dihydroxy-9,10,11-trimethoxy-5,8,13,13a-tetrahydro-6H-dibenzo (a,f) quinolizine hydrochloride of the general formula: ##STR1## where R.sub.1 .dbd.R.sub.2 .dbd.R.sub.3 .dbd.R.sub.4 .dbd.H.dbd.R.sub.5 .dbd.R.sub.6 .dbd.R.sub.7 .dbd.CH.sub.3 OThe composition is used as an ophthalmic solution in a method for treating glaucoma by administering a therapeutic dose of 2 to 3 drops two to four times daily to a host such as a warm-blooded animal having glaucoma.
摘要翻译：一种抗青光眼组合物，其含有作为活性成分的s - / - / - 2,3-二羟基-9,10,11-三甲氧基-5,8,13,13a-四氢-6H-二苯并（a，f）喹嗪盐酸盐通式：其中R1 = R2 = R3 = R4 = H = R5 = R6 = R7 = CH3O该组合物用作治疗青光眼的方法中的眼用溶液，通过给予治疗剂量2至3滴2至每天四次到诸如具有青光眼的温血动物的宿主。

10. 发明授权

US4678853A 1-(3,4-dimethylbenzyl)-2-(N-alkyl)-carbamoyl tetrahydroiso quinolines 失效
标题翻译： 1-（3,4-二甲基苄基）-2-（N-烷基） - 氨基甲酰基四氢异喹啉
公开(公告)号：US4678853A
公开(公告)日：1987-07-07
申请号：US818489
申请日：1986-01-13
申请人： Chavdar B. Ivanov , Donka M. Mondeshka , Nikolina D. Berova , Rossitza S. Rakovska , Yordanka T. Panova , Marko T. Markov , Radi G. Ovcharov , Petko D. Usunov , Orhideya B. Zabunova
发明人： Chavdar B. Ivanov , Donka M. Mondeshka , Nikolina D. Berova , Rossitza S. Rakovska , Yordanka T. Panova , Marko T. Markov , Radi G. Ovcharov , Petko D. Usunov , Orhideya B. Zabunova
IPC分类号： A61K31/47 , A61K31/472 , A61P27/02 , A61P27/06 , A61P43/00 , C07D217/20 , C07D217/06
CPC分类号： C07D217/20
摘要： Compounds of the Formula (I) ##STR1## wherein R.sub.1 and R.sub.2 are hydroxyl or methoxyl; R.sub.3 is hydrogen or methoxyl; and R.sub.4 is methyl or chloroethyl; are disclosed having the ability to inhibit adenylatecyclase.
摘要翻译：式（I）的化合物其中R 1和R 2是羟基或甲氧基; R3是氢或甲氧基; 并且R 4是甲基或氯乙基; 被公开具有抑制腺苷酸环化酶的能力。

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