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1. 发明申请

WO2021168345A1 MICROSTRUCTURE SYSTEMS AND METHODS FOR PAIN TREATMENT 审中-公开
公开(公告)号：WO2021168345A1
公开(公告)日：2021-08-26
申请号：PCT/US2021/018901
申请日：2021-02-19
申请人： KITOTECH MEDICAL, INC. , AUDELL, Robert Arman , BERENSON, Ronald J. , LEUNG, Cheuk Yin Paul
发明人： AUDELL, Robert Arman , BERENSON, Ronald J. , LEUNG, Cheuk Yin Paul
IPC分类号： A61M37/00 , A61F2/10 , A61M5/00
摘要： The present invention relates generally to devices comprising one or more microstructures that are used to relieve, treat or prevent pain. The devices are designed such that they are inserted into the superficial layers of the skin to achieve pain relief. The devices are designed such that the microstructures are able to grasp and secure to the skin. The devices may consist of microstructures in arrays that are attached to a backing to enable the devices to adhere to the skin. Also provided are wound closure systems that comprise one or more microstructure devices along with other components, such as protective covers and therapeutics. A variety of packaging specifications are disclosed, as is a dispenser apparatus configured to enable simple one-handed application of the devices. Methods described herein provide for treatment of pain.

2. 发明申请

WO2010105112A1 DETECTION OF SHORT-CHAIN FATTY ACIDS IN BIOLOGICAL SAMPLES 审中-公开
标题翻译：检测生物样品中短链脂肪酸
公开(公告)号：WO2010105112A1
公开(公告)日：2010-09-16
申请号：PCT/US2010/027063
申请日：2010-03-11
申请人： HEMAQUEST PHARMACEUTICALS, INC. , BERENSON, Ronald, J. , BOBBITT, Patrick , LIN, Zhongping
发明人： BERENSON, Ronald, J. , BOBBITT, Patrick , LIN, Zhongping
IPC分类号： G01N30/00 , G01N30/72
CPC分类号： G01N30/88 , G01N2030/8822 , Y10T436/201666
摘要： Described herein is a method of detecting and/or quantifying analytes, such as short-chain fatty acids. Analysis for the presence and/or quantity of the small molecule can be performed on a biological sample from a subject. In some embodiments, a liquid chromatography/mass spectrometry (LC-MS/MS) instrumentation is combined with a solid-phase extraction (SPE). Methods of derivatization can also be incorporated with LC-MS/MS and SPE instrumentation to detect and quantify target analytes. In addition to derivation, methods of reconstituting derivatized molecules can also be incorporated with LC-MS/MS and SPE instrumentation to detect and quantify target analytes.
摘要翻译：本文描述了检测和/或定量分析物的方法，例如短链脂肪酸。可以对来自受试者的生物样品进行小分子的存在和/或数量的分析。在一些实施方案中，将液相色谱/质谱（LC-MS / MS）仪器与固相萃取（SPE）组合。衍生化方法也可以与LC-MS / MS和SPE仪器结合，以检测和定量目标分析物。除了衍生之外，重组衍生化分子的方法也可以与LC-MS / MS和SPE仪器结合，以检测和定量目标分析物。

3. 发明申请

WO2006105219A2 T CELL THERAPY FOR THE TREATMENT OF CACHEXIA AND CHRONIC DISEASES 审中-公开
标题翻译：用于治疗慢性病和慢性疾病的细胞疗法
公开(公告)号：WO2006105219A2
公开(公告)日：2006-10-05
申请号：PCT/US2006/011502
申请日：2006-03-28
申请人： XCYTE THERAPIES, INC. , BONYHADI, Mark , BERENSON, Ronald, J.
发明人： BONYHADI, Mark , BERENSON, Ronald, J.
IPC分类号： A61K35/14 , A61P9/00 , A61P11/00 , A61P13/12 , A61P1/16
CPC分类号： A61K35/17 , A61K38/2013 , A61K2300/00
摘要： The present invention relates to compositions and methods for the use of T cells and more particularly, activated T cells, in the treatment and/or amelioration of diseases associated with a proinflammatory state, such as cachexia, chronic diseases such as chronic renal failure, and hepatitis.
摘要翻译：本发明涉及使用T细胞的组合物和方法，更具体地说，涉及活化的T细胞，用于治疗和/或改善与促炎状态相关的疾病，例如恶病质，慢性疾病如慢性肾衰竭和肝炎。

4. 发明申请

WO2006133398A3 IN VITRO ACTIVATED DONOR T-CELLS TO PROMOTE TRANSPLANT ENGRAFTMENT 审中-公开
标题翻译：在静脉激活的DONOR T细胞促进移植植入
公开(公告)号：WO2006133398A3
公开(公告)日：2007-04-19
申请号：PCT/US2006022426
申请日：2006-06-08
申请人： INVITROGEN CORP , BERENSON RONALD J
发明人： BERENSON RONALD J
IPC分类号： C07K16/28 , A61P35/00 , A61P37/00
CPC分类号： C07K16/2827 , A61K2039/505 , C07K16/2809 , C07K16/2818
摘要： The present invention relates generally to promoting transplant engraftment, immune reconstitution, and reducing conditioning-related toxicity associated with allotransplantation using allogeneic donor lymphocytes, in particular, activated donor T cells. Further, the present invention relates generally to methods for stimulating and activating cells which can then be used in transplant settings.
摘要翻译：本发明一般涉及使用同种异体供体淋巴细胞，特别是活化的供体T细胞促进移植植入，免疫重建和减少与同种异体移植相关的调理相关毒性。此外，本发明一般涉及用于刺激和激活细胞的方法，其然后可以用于移植设置。

5. 发明申请

WO2006086716A3 DONOR LYMPHOCYTE INFUSION OF ACTIVATED T CELLS FOR THE TREATMENT OF CANCER 审中-公开
公开(公告)号：WO2006086716A3
公开(公告)日：2006-08-17
申请号：PCT/US2006/004895
申请日：2006-02-10
申请人： XCYTE THERAPIES, INC. , BERENSON,, Ronald, J.
发明人： BERENSON,, Ronald, J.
IPC分类号： C12N5/06 , C07K16/28 , A61P35/00 , A61K35/14 , A61K35/28
摘要： The present invention relates generally to the treatment of cancer using donor lymphocyte infusions of T cells. Further, the present invention relates generally to methods for stimulating and activating allogeneic and/or xenogeneic cells which can then be used in a DLI setting.

6. 发明申请

WO2006086716A2 DONOR LYMPHOCYTE INFUSION OF T CELLS FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：用于治疗癌症的T细胞的淋巴管淋巴细胞浸润
公开(公告)号：WO2006086716A2
公开(公告)日：2006-08-17
申请号：PCT/US2006004895
申请日：2006-02-10
申请人： XCYTE THERAPIES INC , BERENSON RONALD J
发明人： BERENSON RONALD J
IPC分类号： C12N5/06 , A61K35/14 , A61K35/28 , A61P35/00 , C07K16/28
CPC分类号： A61K35/17 , A61K2035/124 , A61K2039/505 , C07K16/2809 , C07K16/2818
摘要： The present invention relates generally to the treatment of cancer using donor lymphocyte infusions of T cells. Further, the present invention relates generally to methods for stimulating and activating allogeneic and/or xenogeneic cells which can then be used in a DLI setting.
摘要翻译：本发明一般涉及使用T细胞供体淋巴细胞输注治疗癌症。此外，本发明一般涉及用于刺激和激活同种异体和/或异种细胞的方法，其然后可以在DLI设置中使用。

7. 发明申请

WO2003067221A3 COMPOSITIONS AND METHODS FOR RESTORING IMMUNE RESPONSIVENESS IN PATIENTS WITH IMMUNOLOGICAL DEFECTS 审中-公开
公开(公告)号：WO2003067221A3
公开(公告)日：2003-08-14
申请号：PCT/US2003/005850
申请日：2003-02-07
申请人： XCYTE THERAPIES, INC. , BONYHADI, Mark , BERENSON, Ronald, J.
发明人： BONYHADI, Mark , BERENSON, Ronald, J.
IPC分类号： C12N5/00
摘要： The present invention relates generally to methods for stimulating, activating, and maintaining or increasing the polyclonality of expressed TCRs in a population of T cells. In the various embodiments, cells are stimulated with a surface, wherein the surface has attached thereto one or more agents that ligate a cell surface moiety of at least a portion of the T cells and stimulates at least a portion of the T cells, yielding enhanced proliferation, cell signal transduction, and/or cell surface moiety aggregation. In certain aspects methods for stimulating a population of cells such as T-cells, by cell surface moiety ligation are provided by contacting the population of cells with a surface, that has attached thereto one or more agents that ligate a cell surface moiety thereby inducing cell stimulation, cell surface moiety aggregation, and/or receptor signaling enhancement. Also provided are methods for producing T-cells for the use in diagnostics and the treatment of a variety of indications, including cancer, viral infection, and immune related disorders. Compositions of cells having increased polyclonality produced by these processes are further provided.

8. 发明申请

WO1987004628A1 IMMUNOSELECTION METHOD 审中-公开
标题翻译：免疫选择方法
公开(公告)号：WO1987004628A1
公开(公告)日：1987-08-13
申请号：PCT/US1987000101
申请日：1987-01-27
申请人： FRED HUTCHINSON CANCER RESEARCH CENTER , BERENSON, Ronald, J. , BENSINGER, William, I.
发明人： FRED HUTCHINSON CANCER RESEARCH CENTER
IPC分类号： A61M01/36
CPC分类号： A61M1/3687 , A61M1/3693 , A61M1/3696 , A61M2202/0439 , A61M2202/10
摘要： The selectivity of immunoselection systems employing insolubilized avidin and biotinylated specific antibody is amplified, and nonspecific recovery is improved, by employing an indirect sandwich technique using a biotin-conjugated antispecies immunoglobulin that is directed to one or more nonbiotinylated specific antibodies in conjuction with insolubilized avidin. Specific cell populations can be removed and recovered from bone marrow, providing excellent recovery of bone marrow and preservation of hematopoietic stem cells for transplantation. Mixed populations of T cells or of tumor cells can be conveniently and simultaneously removed with minimal manipulation of the marrow cells. An improved positive immunoselection method provides viable and functional recovered cells, e.g., hematopoietic stem cells or activated killer cells, that can be clinically employed.
摘要翻译：通过使用与不结合的抗生物素蛋白结合的一种或多种非生物素化特异性抗体的生物素缀合的抗病毒免疫球蛋白的间接夹心技术，扩增使用不溶性抗生物素蛋白和生物素化特异性抗体的免疫选择系统的选择性，并且非特异性恢复得到改善。可以从骨髓中去除和回收特异性细胞群，提供良好的骨髓恢复和用于移植的造血干细胞的保存。 T细胞或肿瘤细胞的混合群体可以方便地同时去除，同时对骨髓细胞进行最少的操作。改进的阳性免疫选择方法提供可临床使用的可行和功能性的回收细胞，例如造血干细胞或活化的杀伤细胞。

9. 发明申请

WO2021168479A1 WOUND CLOSURE DEVICE FOR WIDE TREATMENT AREAS 审中-公开
公开(公告)号：WO2021168479A1
公开(公告)日：2021-08-26
申请号：PCT/US2021/070164
申请日：2021-02-19
申请人： KITOTECH MEDICAL, INC. , LEUNG, Cheuk Yin Paul , BERENSON, Ronald J.
发明人： LEUNG, Cheuk Yin Paul , BERENSON, Ronald J.
IPC分类号： A61B17/00 , A61B17/03 , A61B17/06 , A61B17/08 , A61B5/15 , A61F13/02 , A61M37/00
摘要： A wound closure device includes an elastic substrate and one or more microstructure arrays coupled to the elastic substrate via an adhesive layer. The device is long enough or wide enough to treat large wounds.

10. 发明申请

WO2011113013A2 METHODS AND COMPOSITIONS FOR TREATING VIRAL OR VIRALLY-INDUCED CONDITIONS 审中-公开
标题翻译：用于治疗病毒或毒素诱导条件的方法和组合物
公开(公告)号：WO2011113013A2
公开(公告)日：2011-09-15
申请号：PCT/US2011/028214
申请日：2011-03-11
申请人： HEMAQUEST PHARMACEUTICALS, INC. , TRUSTEES OF BOSTON UNIVERSITY , BERENSON, Ronald, J. , FALLER, Douglas, V
发明人： BERENSON, Ronald, J. , FALLER, Douglas, V
IPC分类号： A61K38/12 , A61K31/167 , A61K31/513 , A61K31/4045 , A61K31/27 , A61K31/19 , A61P31/12 , A61P29/00 , A61P31/22 , A61P31/20
CPC分类号： A61K31/506 , A61K9/0053 , A61K31/165 , A61K31/167 , A61K31/18 , A61K31/19 , A61K31/27 , A61K31/4045 , A61K31/4402 , A61K31/473 , A61K31/513 , A61K31/522 , A61K38/12 , A61K38/15 , A61K45/06 , Y02A50/467 , A61K2300/00
摘要： Provided are methods and compositions for the prevention and/or treatment of viral conditions, virally-induced conditions and inflammatory conditions. The methods can comprise administering to a subject a viral inducing agent with an antiviral agent, and optionally an additional agent. The viral inducing agent can be a HDAC inhibitor administered orally.
摘要翻译：提供用于预防和/或治疗病毒状况，病毒诱导的病症和炎性病症的方法和组合物。所述方法可以包括用抗病毒剂和任选的另外的药剂向受试者施用病毒诱导剂。病毒诱导剂可以是口服施用的HDAC抑制剂。

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