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1. 发明申请

WO2005063795A1 GLUTATHIONE DERIVATIVES AND THEIR USES FOR THE TREATMENT OF VIRAL DISEASES 审中-公开
标题翻译：谷胱甘肽衍生物及其用于治疗病毒的用途
公开(公告)号：WO2005063795A1
公开(公告)日：2005-07-14
申请号：PCT/EP2004/053726
申请日：2004-12-29
申请人： BENATTI, Umberto , BRANDI, Giorgio , GARACI, Enrico , MAGNANI, Mauro , MILLO, Enrico , PALAMARA, Anna Teresa , ROSSI, Luigia
发明人： BENATTI, Umberto , BRANDI, Giorgio , GARACI, Enrico , MAGNANI, Mauro , MILLO, Enrico , PALAMARA, Anna Teresa , ROSSI, Luigia
IPC分类号： C07K5/02
CPC分类号： A61K38/063 , C07K5/0215
摘要： Glutathione derivatives (GSH) of formula (I) are provided, wherein R is a thiol protection group. The derivatives are useful for the treatment of infections from Paramyxovirus, Orthomyxovirus, Herpes Simplex Virus and Acquired Immunodeficiency Syndrome Virus.
摘要翻译：提供式（I）的谷胱甘肽衍生物（GSH），其中R是硫醇保护基。该衍生物可用于治疗副粘病毒，正粘病毒，单纯疱疹病毒和获得性免疫缺陷综合征病毒感染。

2. 发明申请

WO2006117735A1 NOVEL ADENYL DINUCLEOTIDES WITH ANTITUMOUR ACTIVITY AND A METHOD FOR PREPARING THEREOF 审中-公开
标题翻译：具有抗菌活性的新型丙烯酸丁酯及其制备方法
公开(公告)号：WO2006117735A1
公开(公告)日：2006-11-09
申请号：PCT/IB2006/051330
申请日：2006-04-28
申请人： UNIVERSITA' DEGLI STUDI DI GENOVA , CENTRO BIOTECNOLOGIE AVANZATE , BASILE, Giovanna , BENATTI, Umberto , BRUZZONE, Santina , DAMONTE, Gianluca , DE FLORA, Antonio , FATTORUSSO, Ernesto , FRANCO, Luisa , GUIDA, Lucrezia , TAGLIALATELA-SCAFATI, Orazio , ZOCCHI, Elena
发明人： BASILE, Giovanna , BENATTI, Umberto , BRUZZONE, Santina , DAMONTE, Gianluca , DE FLORA, Antonio , FATTORUSSO, Ernesto , FRANCO, Luisa , GUIDA, Lucrezia , TAGLIALATELA-SCAFATI, Orazio , ZOCCHI, Elena
IPC分类号： C07H21/04
CPC分类号： C07H21/04
摘要： The invention relates to novel adenyl dinucleotides which are isomers of the dinucleotide Ap2A, having formulae (I) and (II) . The dinucleotides of the invention have antitumour activity, particularly against tumours of haematological origin, such as for example leukaemias and lymphomas. The invention further relates to the use of such dinucleotides as antitumour medicaments. Finally, the invention relates to an enzymatic method for preparing the dinucleotides of formulae (I) and (II) and to an enzymatic assay method for the dinucleotide of formula (I) which is based on its complete conversion to NAD + .
摘要翻译：本发明涉及具有式（I）和（II）的二核苷酸Ap2A的异构体的新颖腺苷二核苷酸。本发明的二核苷酸具有抗肿瘤活性，特别是抗血液学起源的肿瘤，例如白血病和淋巴瘤。本发明还涉及这种二核苷酸作为抗肿瘤药物的用途。最后，本发明涉及制备式（I）和（II）的二核苷酸的酶法和式（I）的二核苷酸的酶测定方法，其基于其完全转化为NAD + / SUP>。

3. 发明申请

WO1996002554A1 DINUCLEOSIDE-5',5'-PYROPHOSPHATES 审中-公开
标题翻译：二核苷-5' ，5'-焦磷酸盐
公开(公告)号：WO1996002554A1
公开(公告)日：1996-02-01
申请号：PCT/EP1995002676
申请日：1995-07-10
申请人： GRUPPO LEPETIT S.P.A. , UNIVERSITA' DEGLI STUDI DI GENOVA , DE FLORA, Antonio , BENATTI, Umberto , GIOVINE, Marco
发明人： GRUPPO LEPETIT S.P.A. , UNIVERSITA' DEGLI STUDI DI GENOVA
IPC分类号： C07H21/00
CPC分类号： C07H21/00
摘要： 5',5'-Pyrophosphates of non-naturally occurring nucleosides selected from thymine-3'-azido-2',3'-dideoxy-D-riboside, 5-fluorouracil-2'-deoxy-D-riboside, uracil-3'-azido-2',3'-dideoxy-D-riboside, guanine-2',3'-dideoxy-D-riboside, hypoxanthine-2',3'-dideoxy-D-riboside, cytosine-2',3'-dideoxy-D-riboside, and adenine-2',3'-dideoxy-D-riboside, are described as well as their manufacture and use as therapeutical agents against tumors and retroviral infections including HIV infections. The compounds may be administered as the active ingredients of pharmaceutical compositions or as pro-drugs encapsulated into biological carriers, e.g., transformed erythrocytes, for targeting to specific cell population responsible of the development of the pathological disorders.
摘要翻译：选自胸腺嘧啶-3'-叠氮基-2'，3'-二脱氧-D-核糖苷，5-氟尿嘧啶-2'-脱氧-D-核糖核苷，尿嘧啶-3的非天然存在的核苷的5'，5'-焦磷酸 '叠氮基-2'，3'-二脱氧-D-核糖苷，鸟嘌呤-2'，3'-二脱氧-D-核糖，次黄嘌呤-2'，3'-二脱氧-D-核糖，胞嘧啶-2'，3 描述了'二脱氧-D-核糖苷和腺嘌呤-2'，3'-二脱氧-D-核糖核苷，以及它们作为抗肿瘤和逆转录病毒感染（包括HIV感染）的治疗剂的制备和用途。化合物可以作为药物组合物的活性成分或作为包封在生物载体例如转化的红细胞中的前体药物施用，用于靶向负责病理性疾病发展的特定细胞群。

4. 发明申请

WO2007042983A3 FLURIDONE AS AN ANTI-INFLAMMATORY AGENT 审中-公开
标题翻译：氟替卡松作为抗炎剂
公开(公告)号：WO2007042983A3
公开(公告)日：2007-07-26
申请号：PCT/IB2006053669
申请日：2006-10-06
申请人： UNIV DEGLI STUDI GENOVA , ZOCCHI ELENA , GUIDA LUCREZIA , BRUZZONE SANTINA , SCARFI SONIA , MAGNONE MIRKO , BASILE GIOVANNA , BENATTI UMBERTO , DE FLORA ANTONIO , MORESCHI ILIANA , FRANCO LUISA , SALIS ANNALISA
发明人： ZOCCHI ELENA , GUIDA LUCREZIA , BRUZZONE SANTINA , SCARFI SONIA , MAGNONE MIRKO , BASILE GIOVANNA , BENATTI UMBERTO , DE FLORA ANTONIO , MORESCHI ILIANA , FRANCO LUISA , SALIS ANNALISA
IPC分类号： A61K31/4412 , A61K31/19 , A61P29/00
CPC分类号： A61K31/19 , A61K31/4412 , C07D213/68 , Y10S514/886
摘要： The invention relates to a novel use of fluridone - compound known per se and used as an aquatic erbicide - in the medical field, in particular as an active compound for preparing a medicament having anti-inflammatory activity. Pharmaceutical compositions comprising fluridone as an active compound and pharmaceutically acceptable carriers and/or diluents are also disclosed. Finally, there is disclosed the pro-inflammatory activity of abscisic acid (ABA), a plant hormone which is also found in mammal serum and against which fluridone acts an an inhibitor.
摘要翻译：本发明涉及在医学领域本身已知的并用作水除外剂的氟利酮化合物的新用途，特别是作为制备具有抗炎活性的药物的活性化合物。还公开了包含氟利酮作为活性化合物的药物组合物和药学上可接受的载体和/或稀释剂。最后，公开了脱落酸（ABA）的促炎活性，其是在哺乳动物血清中也发现的植物激素，其中氟利酮作为抑制剂。

5. 发明申请

WO2007042983A2 FLURIDONE AS AN ANTI-INFLAMMATORY AGENT 审中-公开
标题翻译： FLURIDONE作为抗炎剂
公开(公告)号：WO2007042983A2
公开(公告)日：2007-04-19
申请号：PCT/IB2006/053669
申请日：2006-10-06
申请人： UNIVERSITA' DEGLI STUDI DI GENOVA , ZOCCHI, Elena , GUIDA, Lucrezia , BRUZZONE, Santina , SCARFI', Sonia , MAGNONE, Mirko , BASILE, Giovanna , BENATTI, Umberto , DE FLORA, Antonio , MORESCHI, Iliana , FRANCO, Luisa , SALIS, Annalisa
发明人： ZOCCHI, Elena , GUIDA, Lucrezia , BRUZZONE, Santina , SCARFI', Sonia , MAGNONE, Mirko , BASILE, Giovanna , BENATTI, Umberto , DE FLORA, Antonio , MORESCHI, Iliana , FRANCO, Luisa , SALIS, Annalisa
IPC分类号： A61K31/4412 , A61P29/00 , A61K31/19
CPC分类号： A61K31/19 , A61K31/4412 , C07D213/68 , Y10S514/886
摘要： The invention relates to a novel use of fluridone - compound known per se and used as an aquatic erbicide - in the medical field, in particular as an active compound for preparing a medicament having anti-inflammatory activity. Pharmaceutical compositions comprising fluridone as an active compound and pharmaceutically acceptable carriers and/or diluents are also disclosed. Finally, there is disclosed the pro-inflammatory activity of abscisic acid (ABA), a plant hormone which is also found in mammal serum and against which fluridone acts an an inhibitor.
摘要翻译：本发明涉及在医学领域中本身已知的并且用作水性除草剂的氟草酮化合物的新用途，特别是作为用于制备具有抗炎活性的药物。还公开了包含作为活性化合物的氟啶酮和药学上可接受的载体和/或稀释剂的药物组合物。最后，公开了脱落酸（ABA）的促炎症活性，ABA是在哺乳动物血清中也发现的植物激素，并且fluridone可以作为抑制剂发挥作用。

6. 发明申请

WO1992021378A1 VACCINES WITH ERYTHROCYTES AS ANTIGEN CARRIERS 审中-公开
标题翻译：抗生素作为抗原载体的疫苗
公开(公告)号：WO1992021378A1
公开(公告)日：1992-12-10
申请号：PCT/IT1992000061
申请日：1992-06-02
申请人： CONSIGLIO NAZIONALE DELLE RICERCHE , BIOCINE SCLAVO S.P.A. , BENATTI, Umberto , DE FLORA, Antonio , NENCIONI, Luciano , POLVANI, Carolina , SILVESTRI, Sergio
发明人： CONSIGLIO NAZIONALE DELLE RICERCHE , BIOCINE SCLAVO S.P.A.
IPC分类号： A61K39/385
CPC分类号： A61K39/385 , A61K9/5068 , A61K2039/515 , A61K2039/6006
摘要： This invention discloses vaccines obtained employing as the antigen carriers as well as the adjuvants cells of the erythrocyte lineage, in particular erythrocytes which induce, if injected into the organism to immunize through intravenous route, the production of specific and neutralizing antibodies. More particularly, vaccines against whooping-cough, diphtheria and tetanic infection are disclosed.
摘要翻译：本发明公开了使用作为抗原载体的疫苗以及红细胞谱系的辅助细胞，特别是红细胞，如果通过静脉内途径注射到生物体中以诱导特异性和中和抗体的产生，则其可诱导。更具体地，公开了针对百日咳，白喉和破伤风感染的疫苗。

7. 发明公开

EP1701973A1 GLUTATHIONE DERIVATIVES AND THEIR USES FOR THE TREATMENT OF VIRAL DISEASES 有权转让
标题翻译：谷胱甘肽衍生物及其在治疗病毒性疾病使用
公开(公告)号：EP1701973A1
公开(公告)日：2006-09-20
申请号：EP04805051.2
申请日：2004-12-29
申请人： Benatti, Umberto , Brandi, Giorgio , Garaci, Enrico , Magnani, Mauro , Millo, Enrico , Palamara, Anna Teresa , Rossi, Luigia
发明人： Benatti, Umberto , Brandi, Giorgio , Garaci, Enrico , Magnani, Mauro , Millo, Enrico , Palamara, Anna Teresa , Rossi, Luigia
IPC分类号： C07K5/02 , A61K38/06
CPC分类号： A61K38/063 , C07K5/0215
摘要： Glutathione derivatives (GSH) of formula (I) are provided, wherein R is a thiol protection group. The derivatives are useful for the treatment of infections from Paramyxovirus, Orthomyxovirus, Herpes Simplex Virus and Acquired Immunodeficiency Syndrome Virus.

8. 发明专利

ITTO20031048A1 DERIVATI DEL GLUTATIONE E LORO UTILIZZI PER IL TRATTAMENTO DI MALATTIE VIRALI. 未知
公开(公告)号：ITTO20031048A1
公开(公告)日：2005-06-30
申请号：ITTO20031048
申请日：2003-12-30
申请人： BENATTI UMBERTO , BRANDI GIORGIO , GARACI ENRICO , MAGNANI MAURO , MILLO ENRICO , PALAMARA ANNA TERESA , ROSSI LUIGIA
发明人： BENATTI UMBERTO , BRANDI GIORGIO , GARACI ENRICO , MAGNANI MAURO , MILLO ENRICO , PALAMARA ANNA TERESA , ROSSI LUIGIA
IPC分类号： A61K38/00 , A61K38/06 , C07K5/02

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