专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1997028262A1 LYST1 AND LYST2 GENE COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： LYST1和LYST2基因组成及使用方法
公开(公告)号：WO1997028262A1
公开(公告)日：1997-08-07
申请号：PCT/US1997001748
申请日：1997-01-31
申请人： UNIVERSITY OF FLORIDA , KINGSMORE, Stephen, F. , BARBOSA-ALLEYNE, Maria, D., F., S.
发明人： UNIVERSITY OF FLORIDA
IPC分类号： C12N15/12
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00
摘要： Disclosed are compositions comprising murine Lyst1 and Lyst2 genes and human LYST1 and LYST2 genes. Also disclosed are the Lyst1, Lyst2, LYST1, and LYST2 proteins encoded by these genes, respectively. Also disclosed are methods of using these genes in identifying patients with Chediak-Higashi Syndrome and detecting CHS-related nucleic acid and/or protein sequences. Also disclosed are methods for the recombinant expression of LYST1, Lyst1, LYST2, and Lyst2 polypeptides, antibodies raised against these polypeptides, and therapeutic approaches to treatment of autoimmune diseases and certain types of tumors. Assays for detection of the gene mutations resulting in CH Syndrome, as well as diagnostic probes for the detection of Lyst1, Lyst2, LYST1, and LYST2 genes are also provided.
摘要翻译：公开了包含鼠Lyst1和Lyst2基因和人LYST1和LYST2基因的组合物。还公开了分别由这些基因编码的Lyst1，Lyst2，LYST1和LYST2蛋白。还公开了使用这些基因鉴定Chediak-Higashi综合征患者并检测CHS相关核酸和/或蛋白质序列的方法。还公开了用于重组表达LYST1，Lyst1，LYST2和Lyst2多肽的方法，针对这些多肽产生的抗体，以及用于治疗自身免疫性疾病和某些类型的肿瘤的治疗方法。还提供了用于检测导致CH综合征的基因突变的检测以及用于检测Lyst1，Lyst2，LYST1和LYST2基因的诊断探针。

IPRDB

热门服务

关于我们

友情链接

联系方式