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1. 发明专利

JP2016511261A 鉄欠乏性貧血の迅速かつ効果的な治療のための鉄系ナノ複合材料の新規な製剤审中-公开
标题翻译：铁基复合材料的新颖制剂缺铁性贫血的快速和有效的治疗
公开(公告)号：JP2016511261A
公开(公告)日：2016-04-14
申请号：JP2015560555
申请日：2013-10-29
申请人：ナノテクフォーフォトエレクトロニクスリサーチNanotech For Photoelectronics Research , ナノテクフォーフォトエレクトロニクスリサーチNanotech For Photoelectronics Research , ヨーロピアンエジプシャンファーマスーティカルインダストリーズ(イーイーピーアイ)European Egyptian Pharmaceutical Industries (Eepi) , ヨーロピアンエジプシャンファーマスーティカルインダストリーズ(イーイーピーアイ)European Egyptian Pharmaceutical Industries (Eepi) , マフムード,モナバクルモハメドMAHMOUD, Mona Bakr Mohamed , マフムード,モナバクルモハメドMAHMOUD, Mona Bakr Mohamed , ヘルミー,シェリーンハッサンアッバースHELMY, Sherine Hassan Abbas , ヘルミー,シェリーンハッサンアッバースHELMY, Sherine Hassan Abbas
发明人：バクルモハメドマフムード，モナ , バクルモハメドマフムード，モナ , ハッサンアッバースヘルミー，シェリーン , ハッサンアッバースヘルミー，シェリーン
IPC分类号： A61K33/26 , A61K9/51 , A61K31/375 , A61K31/455 , A61K31/519 , A61P7/06 , A61P43/00
CPC分类号： A61K33/26 , A23L33/15 , A23L33/16 , A61K9/0053 , A61K9/48 , A61K9/5115 , A61K31/375 , A61K31/455 , A61K31/519 , A61K2300/00
摘要：致死的な鉄欠乏性貧血の迅速かつ効率的な治療のため、葉酸、ニコチン酸(ビタミンB9)及びアスコルビン酸(ビタミンC)等のマルチビタミンの混合物でキャップされた酸化鉄ナノ粒子の新たな製剤を開発した。1投与量当たり25mg鉄元素という低量の酸化鉄−マルチビタミンナノ複合材料の少量単回用量が、投与後わずか4日以内にヘモグロビンレベルを4.4g/dlから14.6g/dlまで増加させるのに十分であった。このナノ複合材料に使用されるマルチビタミンは、鉄吸収を顕著に増強し、ヘモグロビンの濃度を上昇させた。鉄ナノ複合材料の2つの剤形、すなわち経口投与用のゲルカプセル及び水溶液を開発した。動物予備研究によれば、ラット体重1kg当たり2.57mg(ヒトでは25mgに相当)の鉄元素を含有する酸化鉄−ビタミンナノ複合材料の単回用量を投与することは、経口投与を介してヘモグロビンレベルを補正し、貧血を治癒するのに十分であることが明らかである。毒性研究によれば、本発明者らの新たな鉄ナノ複合材料のLD50は、ラット体重1kg当たり1425.3mgであることが明らかであり、このことは、標準的なヒト(体重60kg)においてナノサイズの鉄ナノ複合材料のLD50は13854mgであることを意味する。したがって、鉄欠乏性貧血の迅速な治療に必要な単回用量は、ヒトにおけるLD50の554分の1である。血液学、生化学又は組織病理学的試験において、いかなる毒性も見られなかった。さらに、骨髄の組織病理学的試験によると、使用した酸化鉄−ビタミンナノ複合材料は、より多くのRBCを産生するよう骨髄を刺激するRBC前駆体の数を増加させることを示唆している。
摘要翻译：对于致死缺铁性贫血，叶酸，烟酸（维生素B9）和铁氧化物纳米颗粒的新制剂与复合维生素的混合物，如抗坏血酸（维生素C）封端的快速和有效的治疗它的开发。低量的氧化铁的每剂量为25mg铁元件 - 次要单剂量维生素纳米复合材料，到内只有4天导致血红蛋白水平的给药是由4.4克/分升增加至14.6克/分升后这是足够的。用于该纳米复合铁的吸收复合维生素显着增强，从而增加血红蛋白的浓度。铁纳米复合材料的两种剂型给药，即开发出一种凝胶胶囊和用于口服给药的水溶液。根据动物试验研究，含铁元件大鼠，体重每2.57Mg1公斤（相当于25毫克在人类）的氧化铁 - 施用维生素的单剂量通过口服给药纳米复合材料的血红蛋白水平纠正，很显然，它足以治愈贫血。据毒性研究，本发明人的新的纳米复合材料的铁LD50，很明显，每鼠体1kg的1425.3mg，这意味着纳米尺寸在标准人（体重60公斤级）该LD50铁纳米复合材料意味着要13854Mg。因此，对于缺铁性贫血的快速治疗所需的单次剂量是在人类中554分钟LD50中的一个。血液学，生物化学或组织病理学测试，任何毒性，没有观察到。此外，根据骨髓的组织病理学检查中，使用了氧化铁 - 维生素纳米复合材料表明，增加RBC前体的数量刺激骨髓产生更多的RBC。

2. 发明公开

EP2964205A4 NOVEL FORMULA OF IRON BASED NANOCOMPOSITES FOR RAPID AND EFFICIENT TREATMENT OF IRON DEFICIENCY ANEMIA 审中-公开
标题翻译：新公式纳米复合材料对铁基地，为快速，缺铁性贫血的有效的处理
公开(公告)号：EP2964205A4
公开(公告)日：2016-07-27
申请号：EP13876801
申请日：2013-10-29
申请人： NANOTECH FOR PHOTOELECTRONICS RES , EUROP EGYPTIAN PHARMACEUTICAL IND EEPI , MAHMOUD MONA BAKR MOHAMED , HELMY SHERINE HASSAN ABBAS
发明人： MAHMOUD MONA BAKR MOHAMED , HELMY SHERINE HASSAN ABBAS
IPC分类号： A61K9/51 , A61K31/375 , A61K31/455 , A61K31/465 , A61K31/519 , A61K33/26
CPC分类号： A61K33/26 , A23L33/15 , A23L33/16 , A61K9/0053 , A61K9/48 , A61K9/5115 , A61K31/375 , A61K31/455 , A61K31/519 , A61K2300/00

3. 发明公开

EP2964205A1 NOVEL FORMULA OF IRON BASED NANOCOMPOSITES FOR RAPID AND EFFICIENT TREATMENT OF IRON DEFICIENCY ANEMIA 审中-公开
标题翻译：新公式纳米复合材料对铁基地，为快速，缺铁性贫血的有效的处理
公开(公告)号：EP2964205A1
公开(公告)日：2016-01-13
申请号：EP13876801.5
申请日：2013-10-29
申请人： Nanotech For Photoelectronics Research , European Egyptian Pharmaceutical Industries (EEPI) , Mahmoud, Mona Bakr Mohamed , Helmy, Sherine Hassan Abbas
发明人： MAHMOUD, Mona Bakr Mohamed , HELMY, Sherine Hassan Abbas
IPC分类号： A61K9/51 , A61K33/26 , A61K31/375 , A61K31/465 , A61K31/51
CPC分类号： A61K33/26 , A23L33/15 , A23L33/16 , A61K9/0053 , A61K9/48 , A61K9/5115 , A61K31/375 , A61K31/455 , A61K31/519 , A61K2300/00
摘要： New formulas of Iron oxides nanoparticles capped with a mixture of multivitamins such as folic acid, Nicotinic acid (vitamin B9) and Ascorbic acid (vitamin C) has been developed for the rapid and efficient treatment of life threatening iron-deficiency anemia. Small single dose of iron oxides-multivitamin nano-composite as low as 25 mg elemental iron per does is sufficient to increase the hemoglobin level from 4.4 g/dl up to 14.6 g/dl within only four days after administration. The multivitamin which used in this nano-composite enhances iron absorption significantly and elevated the concentration of hemoglobin. Two dosage forms of Iron nano-composites have been developed, gel capsules and aqueous solution for oral administration. Animal trials studies reveal that introducing single dose of Iron Oxide- vitamin nano-composites containing 2.57 mg elemental iron per kg rat body weight (equal to 25 mg in human) is sufficient to correct the hemoglobin level and cure Anemia via oral administration. The toxicity study reveals that the LD50 of our new iron nano-composite is 1425.3 mg/kg rat body weight, means that the LD50 of nano-sized iron nano-composites in standard human (60 kg weight) is 13,854 mg. Thus, the single dose required for rapid treatment of iron deficiency anemia is 554 times less than the LD50 in human. No apparent of any sight of toxicity on hematological, biochemistry or histopathology studies. Moreover, the histopathology study of the bone-marrow suggests that the used iron oxides -vitamin nano-composites increase the number of the RBCs precursors which stimulate the bone- marrow to produce more RBCS.

4. 发明专利

CA2777065C DYNAMIC REAL-TIME CALIBRATION FOR ANTENNA MATCHING IN A RADIO FREQUENCY TRANSMITTER SYSTEM 未知
公开(公告)号：CA2777065C
公开(公告)日：2014-08-26
申请号：CA2777065
申请日：2010-10-14
申请人： RESEARCH IN MOTION LTD , BAKR MOHAMED
发明人： ALI SHIROOK , WARDEN JAMES PAUL , BAKR MOHAMED
IPC分类号： H01Q1/24 , H03H7/40 , H04B1/18
摘要： Real-time calibration of a tunable matching network that matches the dynamic impedance of an antenna in a radio frequency transmitter system. The radio frequency transmitter system includes two non-linear equations that may be solved to determine the reflection coefficient of the antenna. The tunable matching network is repeatedly perturbed and the power reflected by the antenna is measured after each perturbation at the same node within the tunable matching network. The power values are used by an optimizer in converging to a solution that provides input impedance of the antenna. The elements of the matching circuit are adjusted to match the input impedance of the antenna.

5. 发明专利

BR112015021212A2 fórmula de nanocompósitos com base de ferro para tratamento rápido e eficiente de anemia ferropriva 未知
公开(公告)号：BR112015021212A2
公开(公告)日：2017-07-18
申请号：BR112015021212
申请日：2013-10-29
申请人： EUROPEAN EGYPTIAN PHARMACEUTICAL IND EEPI , MONA BAKR MOHAMED MAHMOUD , NANOTECH FOR PHOTOELECTRONICS RES , SHERINE HASSAN ABBAS HELMY
发明人： MONA BAKR MOHAMED MAHMOUD , SHERINE HASSAN ABBAS HELMY
IPC分类号： A61K9/51 , A61K31/375 , A61K31/465 , A61K31/51 , A61K33/26
摘要： resumo “fórmula de nanocompósitos com base de ferro para tratamento rápido e eficiente de anemia ferropriva”. trata-se de fórmulas de nanopartículas de óxidos de ferro cobertas com uma mistura de multivitaminas tais como ácido fólico, ácido nicotínico (vitamina b9) e ácido ascórbico (vitamina c) foram desenvolvidas para o tratamento rápido e eficiente de anemia ferropriva fatal. uma pequena dose única de nanocompósito multivitamínico de óxidos de ferro de a partir de 25 mg de ferro elemental por dose é suficiente para aumentar o nível de hemoglobina de 4,4 g/dl para até 14,6 g/dl em apenas quatro dias após a administração. a multivitamina que é utilizada neste nanocompósito melhora significativamente a absorção de ferro e eleva a concentração de hemoglobina. duas formas de dosagem de nanocompósitos de ferro foram desenvolvidas, cápsulas de gel e solução aquosa, para administração oral. estudos em animais revelam que introduzir uma única dose de nanocompósitos vitamínicos de óxido de ferro contendo 2,57 mg de ferro elemental por kg de peso corporal de rato (igual a 25 mg em humanos) é suficiente para corrigir o nível de hemoglobina e curar anemia por meio de administração oral. o estudo de toxicidade revela que o ld50 de nosso novo nanocompósito de ferro é de 1425,3 mg/kg de peso corporal de rato, o que significa que o ld50 de nanocompósitos de ferro de tamanho nanométrico em humanos (peso de 60 kg) é de 13.854 mg. assim, a dose única exigida para tratamento rápido de anemia ferropriva é 554 vezes menor que o ld50 em humanos. nenhum sinal de qualquer tipo de toxicidade em estudos hematológicos, bioquímicos ou histopatológicos. além disso, o estudo de histopatologia da medula óssea sugere que os nanocompósitos vitamínicos de óxidos de ferro aumentam o número de precursores de rcb que estimulam a medula óssea a produzir mais hemácias.

7. 发明专利

CA2777065A1 DYNAMIC REAL-TIME CALIBRATION FOR ANTENNA MATCHING IN A RADIO FREQUENCY TRANSMITTER SYSTEM 未知
公开(公告)号：CA2777065A1
公开(公告)日：2011-04-21
申请号：CA2777065
申请日：2010-10-14
申请人： RESEARCH IN MOTION LTD , BAKR MOHAMED
发明人： ALI SHIROOK , WARDEN JAMES PAUL , BAKR MOHAMED
IPC分类号： H01Q1/24 , H03H7/40 , H04B1/18
摘要： Real-time calibration of a tunable matching network that matches the dynamic impedance of an antenna in a radio frequency transmitter system. The radio frequency transmitter system includes two non-linear equations that may be solved to determine the reflection coefficient of the antenna. The tunable matching network is repeatedly perturbed and the power reflected by the antenna is measured after each perturbation at the same node within the tunable matching network. The power values are used by an optimizer in converging to a solution that provides input impedance of the antenna. The elements of the matching circuit are adjusted to match the input impedance of the antenna.

8. 发明申请

WO2014135170A1 NOVEL FORMULA OF IRON BASED NANOCOMPOSITES FOR RAPID AND EFFICIENT TREATMENT OF IRON DEFICIENCY ANEMIA 审中-公开
标题翻译：基于铁的纳米复合材料的新型配方，用于快速和有效治疗铁缺乏症
公开(公告)号：WO2014135170A1
公开(公告)日：2014-09-12
申请号：PCT/EG2013/000027
申请日：2013-10-29
申请人： NANOTECH FOR PHOTOELECTRONICS RESEARCH , EUROPEAN EGYPTIAN PHARMACEUTICAL INDUSTRIES (EEPI) , MAHMOUD, Mona Bakr Mohamed , HELMY, Sherine Hassan Abbas
发明人： MAHMOUD, Mona Bakr Mohamed , HELMY, Sherine Hassan Abbas
IPC分类号： A61K9/51 , A61K33/26 , A61K31/375 , A61K31/465 , A61K31/51
CPC分类号： A61K33/26 , A23L33/15 , A23L33/16 , A61K9/0053 , A61K9/48 , A61K9/5115 , A61K31/375 , A61K31/455 , A61K31/519 , A61K2300/00
摘要： New formulas of Iron oxides nanoparticles capped with a mixture of multivitamins such as folic acid, Nicotinic acid (vitamin B9) and Ascorbic acid (vitamin C) has been developed for the rapid and efficient treatment of life threatening iron-deficiency anemia. Small single dose of iron oxides-multivitamin nano-composite as low as 25 mg elemental iron per does is sufficient to increase the hemoglobin level from 4.4 g/dl up to 14.6 g/dl within only four days after administration. The multivitamin which used in this nano-composite enhances iron absorption significantly and elevated the concentration of hemoglobin. Two dosage forms of Iron nano-composites have been developed, gel capsules and aqueous solution for oral administration. Animal trials studies reveal that introducing single dose of Iron Oxide- vitamin nano-composites containing 2.57 mg elemental iron per kg rat body weight (equal to 25 mg in human) is sufficient to correct the hemoglobin level and cure Anemia via oral administration. The toxicity study reveals that the LD50 of our new iron nano-composite is 1425.3 mg/kg rat body weight, means that the LD50 of nano-sized iron nano-composites in standard human (60 kg weight) is 13,854 mg. Thus, the single dose required for rapid treatment of iron deficiency anemia is 554 times less than the LD50 in human. No apparent of any sight of toxicity on hematological, biochemistry or histopathology studies. Moreover, the histopathology study of the bone-marrow suggests that the used iron oxides -vitamin nano-composites increase the number of the RBCs precursors which stimulate the bone- marrow to produce more RBCS.
摘要翻译：已经开发了用多种维生素如叶酸，烟酸（维生素B9）和抗坏血酸（维生素C）混合物覆盖的铁氧化物纳米颗粒的新配方，用于快速有效地治疗危及生命的缺铁性贫血。小单次剂量的铁氧化物 - 多种维生素纳米复合材料低至25mg元素铁足以在给药后仅4天内将血红蛋白水平从4.4g / dl升至14.6g / dl。在纳米复合材料中使用的多种维生素显着增强了铁的吸收，提高了血红蛋白的浓度。已经开发了两种剂型的铁纳米复合材料，胶囊和口服水溶液。动物试验研究显示，每kg体重（相当于人体25mg）含有2.57mg元素铁的单剂量氧化铁 - 维生素纳米复合物足以校正血红蛋白水平，并通过口服治疗治愈贫血。毒性研究表明，我们的新型铁纳米复合材料的LD50值为1425.3 mg / kg，体重大小，意味着纳米级铁纳米复合材料在标准人体（60kg重量）中的LD50为13,854mg。因此，快速治疗缺铁性贫血所需的单剂量比人类LD50低554倍。对血液学，生物化学或组织病理学研究没有明显的毒性。此外，骨髓的组织病理学研究表明，使用的氧化铁 - 维生素纳米复合材料增加了刺激骨髓以产生更多RBCS的RBC前体的数量。

9. 发明申请

WO2011047139A1 DYNAMIC REAL-TIME CALIBRATION FOR ANTENNA MATCHING IN A RADIO FREQUENCY RECEIVER SYSTEM 审中-公开
标题翻译：无线电频率接收系统中天线匹配的动态实时校准
公开(公告)号：WO2011047139A1
公开(公告)日：2011-04-21
申请号：PCT/US2010/052648
申请日：2010-10-14
申请人： RESEARCH IN MOTION LIMITED , ALI, Shirook , WARDEN, James, Paul , BAKR, Mohamed
发明人： ALI, Shirook , WARDEN, James, Paul , BAKR, Mohamed
IPC分类号： H03H7/40 , H04B1/18 , H01Q1/24
CPC分类号： H01Q1/50 , H01Q3/267 , H03H7/40
摘要： Real-time calibration of a tunable matching network (242) that matches the dynamic impedance of an antenna (202) in a radio frequency receiver system (240) is disclosed. The tuning algorithm in the radio frequenzy system (240) includes two non-linear equations that may be solved to determine the reflection coefficient of the antenna. The tunable matching network (242) is repeatedly pertubed and the power received by the antenna (202) is measured after each pertubation at the same node (power detector 246) in the matching network (242). The measured power values (222) are used by an optimizer (216) in converging to a solution that provides the reflection coefficient of the antenna. The reflection of the antenna may be used to determine the input impedance of the antenna. The elements of the matching circuit (242) are then adjusted to match the input impedance of the antenna (202). Thus, effects of changes in the environment of the antenna (202) affecting the impedance may be compensated in realtime.
摘要翻译：公开了与射频接收机系统（240）中的天线（202）的动态阻抗匹配的可调匹配网络（242）的实时校准。无线电频率系统（240）中的调谐算法包括可以求解以确定天线反射系数的两个非线性方程。可调谐匹配网络（242）被重复地支配，并且在匹配网络（242）中的相同节点（功率检测器246）的每个经过之后测量由天线（202）接收的功率。测量的功率值（222）由优化器（216）用于会聚到提供天线的反射系数的解。天线的反射可以用于确定天线的输入阻抗。然后调整匹配电路（242）的元件以匹配天线（202）的输入阻抗。因此，可以实时地补偿影响阻抗的天线（202）的环境变化的影响。

10. 发明申请

US20160022733A1 NOVEL FORMULA OF IRON BASED NANOCOMPOSITES FOR RAPID AND EFFICIENT TREATMENT OF IRON DEFICIENCY ANEMIA 审中-公开
标题翻译：基于铁的纳米复合材料的新型配方，用于快速和有效治疗铁缺乏症
公开(公告)号：US20160022733A1
公开(公告)日：2016-01-28
申请号：US14772648
申请日：2013-10-29
申请人： Mona Bakr Mohamed MAHMOUD , Sherine Hassan Abbas HELMY , NANOTECH FOR PHOTOELECTRONICS RESEARCH , EUROPEAN EGYPTIAN PHARMACEUTICAL INDUSTRIES (EEPI)
发明人： Mona Bakr Mohamed MAHMOUD , Sherine Hassan Abbas HELMY
IPC分类号： A61K33/26 , A61K9/48 , A61K31/375 , A61K9/00 , A61K31/519 , A61K31/455
CPC分类号： A61K33/26 , A23L33/15 , A23L33/16 , A61K9/0053 , A61K9/48 , A61K9/5115 , A61K31/375 , A61K31/455 , A61K31/519 , A61K2300/00
摘要： New formulas of Iron oxides nanoparticles capped with a mixture of multivitamins such as folic acid, Nicotinic acid (vitamin B9) and Ascorbic acid (vitamin C) has been developed for the rapid and efficient treatment of life threatening iron-deficiency anemia. Small single dose of iron oxides-multivitamin nano-composite as low as 8.3 mg elemental iron per does is sufficient to increase the hemoglobin level from 4.4 g/dl up to 14.6 g/dl within only four days after administration. The multivitamin which used in this nano-composite enhances iron absorption significantly and elevated the concentration of hemoglobin. Two dosage forms of Iron nano-composites have been developed, gel capsules and aqueous solution for oral administration. Animal trials studies reveal that introducing single dose of Iron Oxide-vitamin nano-composites containing 8.6 mg elemental iron per kg rat body weight is sufficient to correct the hemoglobin level and cure Anemia via oral administration.
摘要翻译：已经开发了用多种维生素如叶酸，烟酸（维生素B9）和抗坏血酸（维生素C）混合物覆盖的铁氧化物纳米颗粒的新配方，用于快速有效地治疗危及生命的缺铁性贫血。少量单次剂量的铁氧化物 - 多种维生素纳米复合材料每次低至8.3mg元素铁足以在给药后四天内将血红蛋白水平从4.4g / dl升至14.6g / dl。在纳米复合材料中使用的多种维生素显着增强了铁的吸收，提高了血红蛋白的浓度。已经开发了两种剂型的铁纳米复合材料，胶囊和口服水溶液。动物试验研究表明，每千克大鼠体重引入含有8.6毫克元素铁的单剂量氧化铁 - 维生素纳米复合材料足以纠正血红蛋白水平，并通过口服治疗治愈贫血。

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