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1. 发明专利

DE19960660A1 Generation of reactive groups on poly(tetrafluoroethylene) by treatment with hydrogen peroxide and sulfuric acid, are useful for subsequent attachment of cells to vascular prostheses 未知
公开(公告)号：DE19960660A1
公开(公告)日：2001-06-28
申请号：DE19960660
申请日：1999-12-15
申请人： BAKOWSKY UDO , KNEUER CARSTEN , LEHR CLAUS MICHAEL , LOEHBACH CHRISTOPH
发明人： BAKOWSKIY UDO , KNEUER CARSTEN , GRAETER THOMAS , LEHR CLAUS-MICHAEL , JAHN DIETER , LOEHBACH CHRISTOPH , SCHAEFERS HANS-JOACHIM
IPC分类号： A61L27/16 , A61L27/38 , A61L27/50 , C07K16/28 , C07K17/08 , C08J7/12 , C07B61/00 , B01J20/32 , C07K17/00 , A61K39/44 , A61K9/52 , A61L27/00 , C12N5/00
摘要： Generation of reactive surface groups (A) on poly(tetrafluoroethylene) (PTFE) by wet chemical methods, comprises reaction with a mixture of hydrogen peroxide and sulfuric acid. Independent claims are also included for: (a) coupling of cyanuric chloride to (A) to allow covalent binding of additional functional molecules; (b) covalent binding of protein, peptide or derived mimetics to the surface of (a); (c) other chemical and physical methods for introducing reactive surface groups on to PTFE that can be combined with methods (a) and (b); (d) coupling a crosslinker, reactive with hydroxy, amino or thiol groups, to the modified PTFE surface, provided this reaction can be combined with method (b); (e) loading implants made in (b) with autologous cells; (f) conditioning materials of (e) by culturing under flow conditions with shearing forces comparable with those encountered in vivo; (g) introduction of an intermediate layer (IL) during modification or loading of the implant material; and (h) IL that provides controlled release of a growth factor or pharmaceutical or provides for proteolytic cleavage by cell-specific enzymes.

2. 发明申请

WO2006002616A1 KOMPOSITMATERIALIEN MIT TETRAETHERLIPIDEN UND DEREN HERSTELLUNG 审中-公开
标题翻译：与四醚及其复合材料生产
公开(公告)号：WO2006002616A1
公开(公告)日：2006-01-12
申请号：PCT/DE2005/001162
申请日：2005-06-29
申请人： SURFACE AND INTERFACE TECHNOLOGIES ROSENHOF GMBH , INSTITUT FÜR BIOPROZESS-UND ANALYSENMESSTECNIK E.V. , BAKOWSKY, Udo , KNEUER, Carsten , ROTHE, Ulrich , LIEFEITH, Klaus , FRANT, Marion , DÖLLING, Karin , SCHMID, Ruth , JOHNSEN, Heidi , STENSTAD, Per, Martin
发明人： BAKOWSKY, Udo , KNEUER, Carsten , ROTHE, Ulrich , LIEFEITH, Klaus , FRANT, Marion , DÖLLING, Karin , SCHMID, Ruth , JOHNSEN, Heidi , STENSTAD, Per, Martin
IPC分类号： C09D5/16
CPC分类号： B05D1/185 , B82Y30/00 , B82Y40/00 , C07D323/00 , C09D5/1625
摘要： Die vorliegende Erfindung betrifft Kompositmaterialien mit Tetraetherlipiden, gekennzeichnet durch kovalent angekoppelte monomolekulare Schichten von Tetraetherlipiden mit kleinen Kopfgruppen an planare oder gekrümmte Oberflächen von benannten Basismaterialien. Zur Anbindung der Tetraetherlipide werden die Oberflächen der Basismaterialien voraktiviert oder es wird eine Zwischenschicht erzeugt. Die erfindungsgemäss hergestellten Kompositmaterialien sind unter anderem geeignet als Antihaftbeschichtungen, Bewuchsschutzoberflächen sowie biokompatible Oberflächen beziehungsweise spezifische Sensorbeschichtungen.
摘要翻译：本发明涉及具有四醚脂质复合材料，其特征在于通过与平面或命名基体材料的弯曲表面小头基四醚脂质的共价连接的单分子层。为了连接四醚基体材料的表面是预活化或创建一个中间层。根据制造本发明的复合材料是适合的，尤其是作为非粘涂层，防污表面和生物相容的表面或特定的传感器涂层。

3. 发明申请

WO1997031927A1 TETRAETHER LIPIDS AND LIPOSOMES CONTAINING SAID LIPIDS, AND USE OF THE SAME 审中-公开
标题翻译：四醚和含脂质体及其用途
公开(公告)号：WO1997031927A1
公开(公告)日：1997-09-04
申请号：PCT/EP1997001011
申请日：1997-02-28
申请人： FREISLEBEN, H.-J. , ANTONOPOULOS, Emmanouil , BAKOWSKY, Udo , ROTHE, Ulrich
IPC分类号： C07H15/04
CPC分类号： C07H15/04 , A61K9/1272 , A61K48/00
摘要： The invention relates to a tetraether lipid with the general formula (I) in which R1 is a modified or unmodified gulose radical or an oxidation product of said gulose, and R2 is hydrogen, modified or unmodified phosphoglycerine or an oxidation product thereof. It also relates to the use of a tetraether lipid according to the invention and liposomes which contain 0.1 to 100 % by weight, in relation to the whole lipid, of the tetraether lipid according to the invention. Conventional liposomes have a low level of stability in storage and are acid-labile. The use thereof for oral administration of pharmaceuticals which should not be released until they are in the duodenum is therefore not possible. In contrast, liposomes containing the tetraether lipid according to the invention are acid-stable and can therefore move easily through the stomach into the small intestine, and cause resorption therein of active ingredients which are contained in said liposomes and cannot usually be absorbed into the blood stream after oral administration.
摘要翻译：本发明涉及具有通式（I）的四醚，其中R 1是指经修饰的或未经修饰的Guloserest或这样古洛糖和R的氧化产物2为氢，改性或未改性的磷酸甘油或其氧化产物可以是，使用根据本发明的Tetraetherlipides的以及脂质体本发明Tetraetherlipides的含有0.1〜100重量％，基于总脂质，包括在内。常规脂质体具有低的贮存稳定性和是酸不稳定的。因此它们对于那些酸敏感药物的口服给药使用仅在十二指肠被释放是不可能的。与此相反，根据包含四醚的本发明的脂质体是酸稳定的，因此可以通过胃通无阻地进入小肠并获得困在其中的物质，其通常不能进入血流口服给药后，在那里吸收。

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