专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP0086095A3 Assay 有权转让
标题翻译：化验
公开(公告)号：EP0086095A3
公开(公告)日：1984-03-21
申请号：EP83300569
申请日：1983-02-04
申请人： Baker, Terence Seward , Coulson, William Frederick
发明人： Baker, Terence Seward
IPC分类号： G01N33/54 , G01N33/74
CPC分类号： G01N33/54306 , G01N33/531 , G01N33/743 , Y10S435/961 , Y10S435/973 , Y10S435/975 , Y10S436/808 , Y10S436/809 , Y10S436/814 , Y10S436/817
摘要： There is described an assay for determining the relative concentrations of two antigenic solutes in a sample. The assay involves a first antibody to the first antigenic solute, a second antibody to the second antigenic solute and a ligand molecule having substituents to which the first and second antibodies may bind. The second antibody is immobilized upon a solid phase support and the other components are in solution. The components are mixed with a sample containing the antigenic solutes causing competition between the ligand molecule and each of the antigenic solutes for binding to the first and second antibodies. In the situation where there is a relatively higher concentration of the first antigenic solute to the second antigenic solute in the sample, a significant number of the ligand molecules become attached to the solid phase via the second antibody yet are capable of binding to a labelled antibody having the same specificity as the first antibody. The presence of labelled antibody bound to the solid phase support is indicative of the above mentioned situation. A method is described using the assay for determining the fertile period of the menstrual cycle by monitoring the relative concentration of oestrone-3- glucuronide and preganediol-3-glucuronide in urine. A reagent kit for use in performing the assay and method is described. A ligand molecule is described which comprises two, different antigenic radicals bound together through a bridging support molecule in which the bridging support molecule is a divalent radical derived from an organic compound having two reactive functional groups.
摘要翻译：描述了用于确定样品中两种抗原性溶质的相对浓度的测定。该测定包括针对第一抗原溶质的第一抗体，针对第二抗原溶质的第二抗体和具有第一和第二抗体可以结合的取代基的配体分子。第二抗体固定在固相载体上，其他组分在溶液中。将组分与含有引起配体分子与每种抗原溶质之间竞争结合第一和第二抗体的抗原溶质的样品混合。在样品中第一抗原溶质对第二抗原溶质的浓度相对较高的情况下，大量配体分子通过第二抗体附着于固相，但能够结合标记抗体具有与第一抗体相同的特异性。与固相载体结合的标记抗体的存在表明上述情况。使用用于通过监测尿中雌酮-3-葡糖苷酸和孕二醇-3-葡糖苷酸的相对浓度来确定月经周期的肥沃期的测定来描述方法。描述了用于进行测定和方法的试剂盒。描述了配体分子，其包含通过桥连支持分子结合在一起的两个不同的抗原性基团，其中桥连支持分子是衍生自具有两个反应性官能团的有机化合物的二价基团。

2. 发明申请

WO2012095662A1 ANTIBODY MOLECULES WHICH BIND IL-17A AND IL-17F 审中-公开
标题翻译：抗体IL-17A和IL-17F的抗体分子
公开(公告)号：WO2012095662A1
公开(公告)日：2012-07-19
申请号：PCT/GB2012/050050
申请日：2012-01-11
申请人： UCB PHARMA S.A. , ADAMS, Ralph , BAKER, Terence Seward , LAWSON, Alastair David Griffiths
发明人： ADAMS, Ralph , BAKER, Terence Seward , LAWSON, Alastair David Griffiths
IPC分类号： C07K16/24
CPC分类号： C07K16/244 , C07K2317/33 , C07K2317/92
摘要： The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
摘要翻译：本发明涉及对IL-17A和IL-17F的抗原决定簇具有特异性的抗体分子，抗体分子的治疗用途和产生所述抗体分子的方法。

3. 发明申请

WO1987002774A1 BINDING ASSAY DEVICE 审中-公开
标题翻译：绑定测试设备
公开(公告)号：WO1987002774A1
公开(公告)日：1987-05-07
申请号：PCT/GB1986000670
申请日：1986-10-30
申请人： BOOTS-CELLTECH DIAGNOSTICS LIMITED , BAKER, Terence, Seward , PERRY, Martin, John , FLEMING, Ian, Michael
发明人： BOOTS-CELLTECH DIAGNOSTICS LIMITED
IPC分类号： G01N33/52
CPC分类号： G01N33/54386 , G01N33/558
摘要： A device for performing an enzyme-labelled binding assay comprises an absorbent material and a developing solution, wherein the absorbent material is provided with a plurality of reagent zones including an indicator reagent zone, and is capable of transporting the developing solution by capillary action sequentially through each reagent zone, and wherein the indicator reagent zone includes a reagent capable, directly or indirectly, of immobilising an enzyme-labelled reagent in an amount dependent upon the assay result, characterised in that the developing solution includes a signal producing-substrate for the enzyme. The substrate moves slower through the absorbent material than the enzyme-labelled reagent or any compound of the enzyme-labelled reagent formed in the assay. The absorbent material is suitably in the form of an elongate strip provided with transverse reagent zones. The device is useful for performing immunoassays including immunometric assays and dual analyte assays.

4. 发明申请

WO2011051349A1 ANTIBODIES TO ION CHANNELS 审中-公开
标题翻译：抗体通道
公开(公告)号：WO2011051349A1
公开(公告)日：2011-05-05
申请号：PCT/EP2010/066274
申请日：2010-10-27
申请人： UCB PHARMA S.A. , MILLER, Karen Margrete , DE RYCK, Marc Roger , WOLFF, Christian Gilbert J. , LAWSON, Alastair David Griffiths , FINNEY, Helene Margaret , BAKER, Terence Seward
发明人： MILLER, Karen Margrete , DE RYCK, Marc Roger , WOLFF, Christian Gilbert J. , LAWSON, Alastair David Griffiths , FINNEY, Helene Margaret , BAKER, Terence Seward
IPC分类号： C07K16/28
CPC分类号： C07K16/18 , C07K16/28 , C07K2317/34
摘要： An anti- E1 ion channel antibody or binding fragment thereof, pharmaceutical compositions comprising said antibodies, use of the antibodies and compositions comprising the same, in treatment, for example in the treatment/modulation of pain and processes for generating and preparing said antibodies.
摘要翻译：抗E1离子通道抗体或其结合片段，包含所述抗体的药物组合物，抗体及其组合物的使用，例如用于治疗/调节疼痛以及产生和制备所述抗体的方法。

5. 发明申请

WO2005113605A1 CROSS-LINKED ANTIBODIES 审中-公开
标题翻译：交联抗体
公开(公告)号：WO2005113605A1
公开(公告)日：2005-12-01
申请号：PCT/GB2005/001950
申请日：2005-05-17
申请人： CELLTECH R & D LIMITED , BAKER, Terence, Seward , McKAY, Catherine , NORMAN, Timothy, John , PORTER, John, Robert
发明人： BAKER, Terence, Seward , McKAY, Catherine , NORMAN, Timothy, John , PORTER, John, Robert
IPC分类号： C07K16/46
CPC分类号： C07D403/14 , A61K47/6875 , C07D403/12
摘要： The present invention provides a compound consisting essentially of the following elements : one or more reactive groups ; and two or more cross-linked antibodies or fragments thereof ; characterised in that the or each reactive group is suitable for attaching an effector molecule but does not react with any of the antibodies or fragments thereof.
摘要翻译：本发明提供基本上由以下元素组成的化合物：一个或多个反应性基团; 和两种或多种交联抗体或其片段; 其特征在于所述或每个反应性基团适于附着效应分子，但不与任何抗体或其片段反应。

6. 发明申请

WO1995002045A2 GELATINASE ANTAGONISTS USED FOR TREATING CANCER 审中-公开
标题翻译：用于治疗癌症的GELATINASE ANTAGONISTS
公开(公告)号：WO1995002045A2
公开(公告)日：1995-01-19
申请号：PCT/GB1994001485
申请日：1994-07-08
申请人： CELLTECH LIMITED , CRABBE, Thomas , DOCHERTY, Andrew, James, Penrose , BAKER, Terence, Seward
发明人： CELLTECH LIMITED
IPC分类号： C12N09/64
CPC分类号： C12N9/6491 , A61K38/00
摘要： This invention describes a method of treating diseases in which gelatinase mediated cell migration and invasion is an essential feature of the pathology of the disease. The method comprises administering an effective amount of an antagonist which inhibits gelatinase mediated cell migration and invasion.
摘要翻译：本发明描述了一种治疗疾病的方法，其中明胶酶介导的细胞迁移和侵袭是疾病病理学的基本特征。该方法包括施用有效量的抑制明胶酶介导的细胞迁移和侵袭的拮抗剂。

7. 发明申请

WO2011051350A1 FUNCTION MODIFYING NAV 1.7 ANTIBODIES 审中-公开
标题翻译：功能修改资产净值1.7抗体
公开(公告)号：WO2011051350A1
公开(公告)日：2011-05-05
申请号：PCT/EP2010/066276
申请日：2010-10-27
申请人： UCB PHARMA S.A. , MILLER, Karen Margrete , DE RYCK, Marc Roger , WOLFF, Christian Gilbert J. , LAWSON, Alastair David Griffiths , FINNEY, Helene Margaret , BAKER, Terence Seward
发明人： MILLER, Karen Margrete , DE RYCK, Marc Roger , WOLFF, Christian Gilbert J. , LAWSON, Alastair David Griffiths , FINNEY, Helene Margaret , BAKER, Terence Seward
IPC分类号： C07K16/28
CPC分类号： C07K16/28 , A61K39/3955 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76
摘要： A Na v 1.7 binding entity that after binding functionally modifies the activity of the ion channel, in particular an anti- Na v 1.7 antibody or binding fragment thereof, pharmaceutical compositions comprising said antibodies, use of the antibodies and compositions comprising the same, in treatment, for example in the treatment/modulation of pain and processes for generating and preparing said antibodies.
摘要翻译：结合后的Nav1.7结合实体功能性地修饰离子通道的活性，特别是抗Nav1.7抗体或其结合片段，包含所述抗体的药物组合物，使用抗体及其组合物在治疗中，例如在疼痛的治疗/调节中以及产生和制备所述抗体的方法。

8. 发明申请

WO2011051351A1 METHOD TO GENERATE ANTIBODIES TO ION CHANNELS 审中-公开
标题翻译：将抗体生成离子通道的方法
公开(公告)号：WO2011051351A1
公开(公告)日：2011-05-05
申请号：PCT/EP2010/066279
申请日：2010-10-27
申请人： UCB PHARMA S.A. , BAKER, Terence Seward
发明人： BAKER, Terence Seward
IPC分类号： C07K16/28
CPC分类号： C07K16/28 , C07K2317/34
摘要： The present invention provides a method for generating a functionally modifying antibody to an ion channel comprising immunizing a host with a cyclic peptide comprising at least part of an extracellular sequence of said ion channel.
摘要翻译：本发明提供了一种产生功能性改变的离子通道抗体的方法，包括用包含至少部分所述离子通道的细胞外序列的环肽免疫宿主。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式