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1. 发明授权

US5714138A Polyaspartamide derivatives as adsorbents for bile acids, polyaspartamide derivatives loaded with bile acids and process for their preparation and their use as pharmaceuticals 失效
标题翻译：聚天冬酰胺衍生物作为胆汁酸的吸附剂，负载胆汁酸的聚天冬酰胺衍生物及其制备方法及其作为药物的用途
公开(公告)号：US5714138A
公开(公告)日：1998-02-03
申请号：US164767
申请日：1993-12-10
申请人： Volker Krone , Axel Walch , Stefan Mullner , Ernold Granzer
发明人： Volker Krone , Axel Walch , Stefan Mullner , Ernold Granzer
IPC分类号： A61K38/00 , A61K9/16 , A61K47/48 , A61P3/06 , C08G69/10 , C08G69/36 , C08G69/48 , C08G73/10 , C08G73/14 , A61K31/765 , A61K31/785
CPC分类号： A61K47/48315 , C08G69/10 , C08G69/36 , C08G73/1092 , C08G73/14
摘要： Polyaspartamide derivatives as adsorbents for bile acids, polyaspartamide derivatives loaded with bile acids and process for their preparation and their use as pharmaceuticals .alpha..sup.- or .beta.-linked polyaspartamide derivatives of the formula I ##STR1## in which R.sup.I R.sup.II, R.sup.III, R.sup.IV, r, s, t, u and v have the stated meanings, are described. They adsorb bile acids and can be used as pharmaceuticals.
摘要翻译：聚天冬酰胺衍生物作为胆汁酸的吸附剂，负载胆汁酸的聚天冬氨酸衍生物及其制备方法及其作为药物的α-或β-连接的聚天冬酰胺衍生物，其中RI RII， RIII，RIV，r，s，t，u和v具有所述的含义。它们吸附胆汁酸，可用作药物。

2. 发明授权

US5505784A Polycondensates which contain tartaric acid derivatives, processes for their preparation and use thereof 失效
标题翻译：含有酒石酸衍生物的缩聚物，其制备方法和用途
公开(公告)号：US5505784A
公开(公告)日：1996-04-09
申请号：US370885
申请日：1995-01-10
申请人： Volker Krone , Michael Magerstadt , Axel Walch , Gunter Ditzinger , Norbert Lill
发明人： Volker Krone , Michael Magerstadt , Axel Walch , Gunter Ditzinger , Norbert Lill
IPC分类号： A61K31/765 , A61K9/16 , A61K9/20 , A61K9/22 , A61K31/785 , A61K31/795 , A61K49/22 , C08G63/16 , C08G63/60 , C08G63/66 , C08G63/68 , C08G69/26 , C08G75/00 , C08G75/26 , A61B8/14
CPC分类号： C08G63/66 , A61K49/225 , A61K9/1641 , A61K9/1647 , A61K9/204 , A61K9/2045 , C08G63/16 , C08G63/60 , C08G63/68 , C08G69/26
摘要： The invention relates to polycondensates which consist of at least 95 mol % of recurring structural units of the formula I ##STR1## where R.sup.1 is a 2,3-O-alkylidenetartaric acid derivative (II) or furo[2,5] (V), alkyl, alkenyl, cycloalkyl, cycloalkenyl, aryl or a heterocycle, X is --O--, --NH-- or --S-- and R.sup.2 is 2,3-O-alkylidene-L-threitol (III) or a compound of the formula VI, alkyl, alkenyl, cycloalkyl, cycloalkenyl, aryl or a heterocycle, with the proviso that more than 5 mol % of the radicals R.sup.1 and/or R.sup.2 are present in the polycondensate of the formula I, where R.sup.1 is compound of the formula II or R.sup.2 is a compound of the formula III or R.sup.1 is a compound of the formula II and R.sup.2 is a compound of the formula III, or in which more than 5 mol % of the radicals R.sup.1 and R.sup.2 are present in the polycondensate of the formula I, wherea) R.sup.1 is a compound of the formula V and R.sup.2 is a compound of the formula VI, orb) R.sup.1 is phenyl[1,2], phenyl[1,3] or phenyl[1,4] and R.sup.2 is a compound of the formula VI,to a process for the preparation of these polycondensates, and to their use for the production of depot preparations with controlled release of active substance or for the production of ultrasonic contrast agents.
摘要翻译：本发明涉及由至少95摩尔％的式I（I）的重复结构单元组成的缩聚物，其中R 1是2,3-O-亚烷基二十二烷酸衍生物（II）或呋喃并[2,5] （V），烷基，烯基，环烷基，环烯基，芳基或杂环，X是-O-，-NH-或-S-，R2是2,3-O-亚烷基-L-苏糖醇（III）式VI的烷基，烯基，环烷基，环烯基，芳基或杂环，条件是在式I的缩聚物中存在大于5摩尔％的基团R 1和/或R 2，其中R 1是式II或R2是式III化合物或R1是式II化合物，R2是式III化合物，或其中基团R1和R2多于5mol％存在于缩聚物中其中a）R 1是式V的化合物，R 2是式VI的化合物，或b）R 1是苯基[1,2]，苯基[1,3]或苯基[1,4 并且R 2是式V的化合物本发明涉及一种制备这些缩聚物的方法，以及它们用于生产具有活性物质的控制释放或用于生产超声造影剂的贮库制剂的用途。

3. 发明授权

US5470843A Carbohydrate-containing polymers, their preparation and use 失效
标题翻译：含碳水化合物的聚合物，其制备和用途
公开(公告)号：US5470843A
公开(公告)日：1995-11-28
申请号：US165805
申请日：1993-12-13
申请人： Wilhelm Stahl , Michael Ahlers , Axel Walch , Eckhart Bartnik , Gerhard Kretzschmar , Susanne Grabley , Rudolf Schleyerbach
发明人： Wilhelm Stahl , Michael Ahlers , Axel Walch , Eckhart Bartnik , Gerhard Kretzschmar , Susanne Grabley , Rudolf Schleyerbach
IPC分类号： A61K31/715 , A61K31/765 , A61K31/785 , A61K31/80 , A61K47/48 , A61K49/00 , A61P29/00 , A61P31/04 , A61P31/12 , A61P35/00 , A61P43/00 , C07H15/04 , C07H15/203 , C08B37/00 , C08G63/00 , C08G63/06 , C08G64/00 , C08G64/42 , C08G65/16 , C08G67/04 , C08G69/00 , C08G69/10 , C08G73/16 , A61K31/735
CPC分类号： C07H15/203 , A61K47/48207 , A61K47/48315 , C07H15/04
摘要： Carbohydrate-containing polymers which can have an HLB* of from about 10 to about 20 are disclosed. The compounds comprise a hydrophilic polymer portion, a carbohydrate portion comprising from 1 to about 20 naturally occurring, identical or different, monosaccharide units, at least one bifunctional spacer coupling the carbohydrate portion to the hydrophilic polymer portion, and a potentiator moiety. The potentiator moiety can be is a crosslinking moiety located within the hydrophilic polymer or a hydrophobic, hydrophilic or ionic moiety. Processes for the preparation and use of such polymers are also disclosed.
摘要翻译：公开了可以具有约10至约20的HLB *的含碳水化合物的聚合物。所述化合物包括亲水性聚合物部分，包含1至约20个天然存在的，相同或不同的单糖单元的碳水化合物部分，将碳水化合物部分与亲水性聚合物部分偶联的至少一个双功能间隔基和增强剂部分。增效剂部分可以是位于亲水性聚合物内的交联部分或疏水的，亲水的或离子的部分。还公开了制备和使用这些聚合物的方法。

4. 发明授权

US5041291A Biodegradable poly(hydroxyalkyl)amino dicarboxylic acid) derivatives, a process for their preparation, and the use thereof for depot formulations with controlled deivery of active ingredient 失效
标题翻译：可生物降解的聚（羟烷基）氨基二羧酸）衍生物，其制备方法及其用于具有受控输送活性成分的贮库制剂
公开(公告)号：US5041291A
公开(公告)日：1991-08-20
申请号：US402609
申请日：1989-09-05
申请人： Hubert Bader , Diether Ruppel , Axel Walch
发明人： Hubert Bader , Diether Ruppel , Axel Walch
IPC分类号： A61K38/04 , A61K9/16 , A61K9/20 , A61K9/22 , A61K9/50 , A61K47/00 , A61K47/42 , C07C237/12 , C08G69/00 , C08G69/10 , C08G69/48
CPC分类号： C08G69/10 , A61K9/1641 , A61K9/2045 , A61K9/5031
摘要： The invention relates to biodegradable poly((hydroxyalkyl)amino dicarboxylic acid) derivatives of the formula I ##STR1## in which n, m, x, y, z, R and R' have the indicated meanings, and to a process for their preparation and to the use thereof for depot formulations with controlled delivery of active ingredient.

5. 发明授权

US4229291A Permselective membrane and use 失效
标题翻译：选择膜和使用
公开(公告)号：US4229291A
公开(公告)日：1980-10-21
申请号：US962269
申请日：1978-11-20
申请人： Axel Walch , Jurgen Wildhardt , Dieter Beissel
发明人： Axel Walch , Jurgen Wildhardt , Dieter Beissel
IPC分类号： A61M1/16 , B01D69/06 , B01D71/56 , C08G69/26 , B01D13/00
CPC分类号： C08G69/26 , B01D69/06 , B01D71/56
摘要： Disclosed is a specific polyamide membrane suitable for hemofiltration, comprising a permselective asymmetric membrane of heteroporous structure comprising a polyamide which comprises a plurality of recurring terephthaloyldiamine units. The membrane has an ultrafiltration capacity of from about 1.5.SM.10.sup.-3 to about 15.multidot.10.sup.-3 cm/s.multidot.bar, determined for water at 0.1 bar and 20.degree. C., a thickness of not more than about 100 microns, and a molecular weight exclusion limit of from about 20,000 to about 70,000 Dalton. The membrane is produced in a process which comprises introducing a solution of the polyamide in a water-miscible organic solvent into an aqueous precipitating liquid to obtain a coagulated membrane sheet, which is subsequently washed and dried.
摘要翻译：公开了适用于血液滤过的特定聚酰胺膜，其包含异源结构的选择性不对称膜，其包含聚酰胺，该聚酰胺包含多个重复的对苯二甲酰二胺单元。该膜的超滤能力为约1.5SM×10-3至约15×10-3cm / sxbar，测定为0.1bar和20℃下的水，厚度不大于约100微米，分子量排除限制在约20,000至约70,000道尔顿。膜的制造方法包括将聚酰胺在水混溶性有机溶剂中的溶液引入含水沉淀液中，得到凝结膜片，随后进行洗涤和干燥。

6. 发明授权

US09164098B2 Determining an expression status of human epidermal growth factor receptor 2 (HER2) in a biological sample 有权
标题翻译：确定生物样品中人表皮生长因子受体2（HER2）的表达状态
公开(公告)号：US09164098B2
公开(公告)日：2015-10-20
申请号：US12879619
申请日：2010-09-10
申请人： Christian Albers , Eckhard Belau , Sören-Oliver Deininger , Sandra Rauser , Detlev Suckau , Axel Walch
发明人： Christian Albers , Eckhard Belau , Sören-Oliver Deininger , Sandra Rauser , Detlev Suckau , Axel Walch
IPC分类号： G01N33/483 , G01N33/50 , G01N33/574 , G01N30/72 , G01N33/68
CPC分类号： G01N33/57484 , G01N33/6848 , G01N33/6851 , G01N2333/71 , G01N2800/52
摘要： A method for determining an expression of human epidermal growth factor receptor 2 (HER2) of a subject. The method includes providing a sample from the subject; measuring one of (i) amounts of two or more proteins in the sample, each protein having a molecular weight substantially equal to 4740, 8404, 8419, 8435, 8450, 8455, 8465, 8570, 8607 or 8626 atomic mass units, and (ii) amounts of at least one of human cystein-rich intestinal protein 1 (CRIP1), one or more variants of the human cystein-rich intestinal protein 1 (CRIP1 variants), and proteolytic digestion products thereof in the sample; and comparing the amounts of the proteins to control amounts, which control amounts are determinative of the expression of the human epidermal growth factor receptor 2.
摘要翻译：用于确定受试者的人表皮生长因子受体2（HER2）的表达的方法。该方法包括从受试者提供样品; 测量样品中两种或更多种蛋白质的量之一，每种蛋白质的分子量基本上等于4740,8404,8419,8435,8450,8455,88465,8570,8607或8626原子质量单位，和（ ii）富含人半胱氨酸的肠蛋白1（CRIP1），人半胱氨酸富含肠蛋白1（CRIP1变体）的一个或多个变体）和样品中的蛋白水解消化产物中的至少一种的量; 并将蛋白质的量与对照量进行比较，该控制量决定了人表皮生长因子受体2的表达。

7. 发明授权

US5430110A Polyvinylamine derivatives having hydrophilic centers, processes for their preparation and the use of the compounds as a medicament, active compound carrier and foodstuff auxiliary 失效
标题翻译：具有亲水中心的聚乙烯胺衍生物，其制备方法和化合物作为药物的用途，活性化合物载体和食品助剂
公开(公告)号：US5430110A
公开(公告)日：1995-07-04
申请号：US95623
申请日：1993-07-21
申请人： Michael Ahlers , Heiner Glombik , Susanne Grabley , Ernold Granzer , Stefan Mullner , Axel Walch , Guan-Yu Xu
发明人： Michael Ahlers , Heiner Glombik , Susanne Grabley , Ernold Granzer , Stefan Mullner , Axel Walch , Guan-Yu Xu
IPC分类号： A23L33/00 , A61K31/785 , A61K47/30 , A61P3/06 , A61P3/12 , C08F8/12 , C08F26/00 , C08F226/02 , C08F8/30
CPC分类号： C08F8/12
摘要： Polyvinylamine derivatives having hydrophilic centers, processes for their preparation and the use of the compounds as a medicament, active compound carrier and foodstuff auxiliary.Polyvinylamine derivatives containing hydrophilic centers, of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, X, w, x, y and z have the meanings given, and a process for their preparation, and the use of these compounds as medicaments, active compound carriers and foodstuff auxiliaries are described. Highly pure polyvinylamines having the recurring unit of the formula Ia ##STR2## the preparation of which is likewise described, are used in particular as starting substances for the preparation.
摘要翻译：具有亲水中心的聚乙烯胺衍生物，其制备方法和化合物作为药物的用途，活性化合物载体和食品助剂。含有亲水中心的聚乙烯胺衍生物，其中R 1，R 2，R 3，X，W，x，y和z具有给定的含义的式I（I）及其制备方法，以及这些描述了作为药物的化合物，活性化合物载体和食品助剂。具有式Ia（Ia）的重复单元的高纯度聚乙烯胺其制备同样被描述，特别是用作制备的起始物质。

8. 发明授权

US5229469A Biologically degradable polyamino dicarboxylic acid--CO--anhydro amino dicarboxylic acid derivative 失效
标题翻译：生物降解性聚氨基甲酸二羧酸 - 丙氨酸氨基二羧酸衍生物
公开(公告)号：US5229469A
公开(公告)日：1993-07-20
申请号：US651295
申请日：1991-01-29
申请人： Volker Krone , Axel Walch
发明人： Volker Krone , Axel Walch
IPC分类号： A61K9/00 , A61K9/16 , A61K9/20 , A61K9/52 , A61K9/58 , A61K47/34 , C07D207/416 , C07D211/76 , C08G73/10 , C08G73/14
CPC分类号： A61K9/1641 , A61K9/2045 , C08G73/14
摘要： The invention relates to biologically degradable polymers, in particular polyaminodicarboxylic acid-co-anhydroaminodicarboxylic acid derivatives, to a process for their preparation and to the use thereof for depot preparations having controlled delivery of active compound.
摘要翻译：本发明涉及生物可降解聚合物，特别是聚氨基二羧酸 - 共 - 脱水氨基二羧酸衍生物，涉及其制备方法及其用途，其用于具有受控递送活性化合物的贮库制剂。

9. 发明授权

US5205287A Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents 失效
标题翻译：超声造影剂，其制备方法及其用作诊断和治疗剂
公开(公告)号：US5205287A
公开(公告)日：1993-04-27
申请号：US955146
申请日：1992-10-01
申请人： Raimund Erbel , Rainer Zotz , Volker Krone , Michael Magerstadt , Axel Walch
发明人： Raimund Erbel , Rainer Zotz , Volker Krone , Michael Magerstadt , Axel Walch
IPC分类号： A61K49/22
CPC分类号： A61K49/223
摘要： The invention relates to ultrasonic contrast agents composed of microparticles which contain a gas and polyamino-dicarboxylic acid-co-imide derivatives, to processes for their preparation and to their use as diagnostic and therapeutic agents.
摘要翻译：本发明涉及由含有气体和聚氨基二羧酸 - 共 - 酰亚胺衍生物的微粒组成的超声造影剂，其制备方法及其作为诊断和治疗剂的用途。

10. 发明授权

US5137928A Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents 失效
标题翻译：超声对比剂，其制备方法及其作为诊断和治疗剂的用途
公开(公告)号：US5137928A
公开(公告)日：1992-08-11
申请号：US690761
申请日：1991-04-24
申请人： Raimund Erbel , Rainer Zotz , Volker Krone , Michael Magerstadt , Axel Walch
发明人： Raimund Erbel , Rainer Zotz , Volker Krone , Michael Magerstadt , Axel Walch
IPC分类号： A61K31/785 , A61K49/00 , A61K49/22 , A61P43/00 , C08G69/10
CPC分类号： A61K49/223
摘要： The invention relates to ultrasonic contrast agents composed of microparticles which contain a gas and polyamino-dicarboxylic acid-co-imide derivatives, to processes for their preparation and to their use as diagnostic and therapeutic agents.
摘要翻译：本发明涉及由含有气体和聚氨基 - 二羧酸 - 共 - 酰亚胺衍生物的微粒组成的超声造影剂，其制备方法及其作为诊断和治疗剂的用途。

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