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1. 发明申请

US20140155443A1 COMPOSITIONS AND METHODS OF TREATMENT FOR PSORIASIS 审中-公开
标题翻译： PSORIASIS的组合物和处理方法
公开(公告)号：US20140155443A1
公开(公告)日：2014-06-05
申请号：US14170718
申请日：2014-02-03
申请人： AVI DASCALU
发明人： AVI DASCALU
IPC分类号： A61K9/00 , A61K31/4196 , A61K31/422 , A61K31/4045
CPC分类号： A61K9/0014 , A61K9/06 , A61K9/08 , A61K9/107 , A61K31/4045 , A61K31/4196 , A61K31/422
摘要： The present invention provides for a composition comprising a tryptamine based drug that acts as a 5-hydroxytryptamine-1 inhibitor in an amount sufficient to reduce the effects of psoriasis and wherein the composition is formulated for topical or oral administration.
摘要翻译：本发明提供了一种组合物，其包含基于色胺的药物，其作为5-羟色胺-1抑制剂的量足以降低牛皮癣的作用，并且其中所述组合物被配制用于局部或口服给药。

2. 发明申请

US20200268791A1 A COMPOSITION AND METHOD FOR THE TREATMENT OF ACNE VULGARIS 审中-公开
公开(公告)号：US20200268791A1
公开(公告)日：2020-08-27
申请号：US16464406
申请日：2017-04-07
申请人： AVI DASCALU
发明人： AVI DASCALU
IPC分类号： A61K33/16 , A61K33/04 , A61P17/10
摘要： The present invention is directed to methods and compositions for treatment and reduction of acne vulgaris and related skin disorders, and more specifically, to a composition comprising a combination of aluminum fluoride and sulfur as the sole active agents for the treatment of the acne vulgaris and related skin disorders.

3. 发明申请

US20170216350A1 COMPOSITIONS OF ALUMINUM FLUORIDE AND METHODS OF USE THEREOF FOR THE TREATMENT AND PREVENTION OF ACTINIC KERATOSIS AND SUN-INDUCED DAMAGES 审中-公开
公开(公告)号：US20170216350A1
公开(公告)日：2017-08-03
申请号：US15488919
申请日：2017-04-17
申请人： AVI DASCALU
发明人： AVI DASCALU
IPC分类号： A61K33/16 , A61K47/12 , A61K47/14 , A61K47/22 , A61K47/02 , A61K47/44 , A61K9/06 , A61K47/26 , A61K9/00 , A61K47/10
CPC分类号： A61K33/16 , A61K8/26 , A61K8/347 , A61K8/361 , A61K8/39 , A61K8/49 , A61K8/86 , A61K9/0014 , A61K9/06 , A61K45/06 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/44 , A61Q17/04 , A61Q19/02 , A61Q19/08
摘要： The present invention is directed to methods and compositions for the treatment or prevention of actinic keratosis and/ or for countering the effects of skin aging and/ or damage to blood vessels and fine wrinkling. The present invention provides for a composition comprising aluminum fluoride or chemical compounds which releases aluminum fluoride to be used to treat or reduce the negative effects of actinic keratosis or sun-induced skin aging and associated conditions, for example, damaged blood vessels and fine wrinkling.

4. 发明申请

US20150313936A1 COMPOSITIONS OF ALUMINUM FLUORIDE AND METHODS OF USE THEREOF FOR THE TREATMENT AND PREVENTION OF ACTINIC KERATOSIS AND SUN-INDUCED DAMAGES 审中-公开
标题翻译：氟化铝的组合物及其用于治疗和预防治疗和诱导性损伤的方法
公开(公告)号：US20150313936A1
公开(公告)日：2015-11-05
申请号：US14651287
申请日：2013-12-16
申请人： Avi DASCALU
发明人： AVI DASCALU
IPC分类号： A61K33/16 , A61K45/06 , A61Q17/04 , A61K8/26
CPC分类号： A61K33/16 , A61K8/26 , A61K8/347 , A61K8/361 , A61K8/39 , A61K8/49 , A61K8/86 , A61K9/0014 , A61K9/06 , A61K45/06 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/44 , A61Q17/04 , A61Q19/02 , A61Q19/08
摘要： The present invention is directed to methods and compositions for the treatment or prevention of actinic keratosis and/or for countering the effects of skin aging and/or damage to blood vessels and fine wrinkling The present invention provides for a composition comprising aluminum fluoride or chemical compounds which releases aluminum fluoride to be used to treat or reduce the negative effects of actinic keratosis or sun-induced skin aging and associated conditions, for example, damaged blood vessels and fine wrinkling
摘要翻译：本发明涉及用于治疗或预防光化性角化病和/或抵抗皮肤老化和/或对血管损伤和细皱纹的作用的方法和组合物本发明提供包含氟化铝或化合物的组合物其释放氟化铝用于治疗或减少光化性角化病或阳光诱导的皮肤老化及相关病症的负面影响，例如损伤的血管和细皱纹

5. 发明授权

US11298072B2 Dermoscopy diagnosis of cancerous lesions utilizing dual deep learning algorithms via visual and audio (sonification) outputs 有权
公开(公告)号：US11298072B2
公开(公告)日：2022-04-12
申请号：US16445684
申请日：2019-06-19
申请人： Avi Dascalu
发明人： Avi Dascalu
IPC分类号： A61B5/00 , G06N3/02 , G06T7/00 , G06N20/00 , G06F40/58
摘要： The present invention provides for a system and method for the diagnosis of skin cancer, wherein visual data is acquired from a skin lesion by a passive or active optical, electronical, thermal or mechanical method, processing the acquired visual field image into a classifier, applying a dermoscopic classification analysis to the image and converting, by sonification techniques, the data to raw audio signals, wherein the raw audio signals are analyzed with a second machine learning algorithm to increase interpretability and the precision of diagnosis.

6. 发明授权

US08372383B2 Agent for inducing hair growth containing extracts of saw palmetto and swertia 有权
标题翻译：用于诱导含有棕榈梅和挥发油提取物的毛发生长的试剂
公开(公告)号：US08372383B2
公开(公告)日：2013-02-12
申请号：US11608288
申请日：2006-12-08
申请人： Avi Dascalu
发明人： Avi Dascalu
IPC分类号： A61K8/97
CPC分类号： A61Q5/006 , A61K8/97 , A61Q7/00
摘要： The present invention consists in a composition comprising a mixture of extracts of saw palmetto and swertia, of derivatives thereof and of active components being part of said extracts. The composition may comprise additional agents and/or extracts, for example, irritating agents, extracts for hair invigoration, hair nourishment agents, antidandruff anti-proliferative compounds, extracts with an antimicrobial, extracts with an antifungal, extracts with anti-inflammatory agents, extracts with a steroid, extracts with a nitric oxide donor and extracts with minoxidil. The concentration of saw palmetto extract in the composition is suitably 0.01-100%. The composition may comprise a suitable carrier, solvent and/or emulgent. The composition may be, for example, an internally ingested tablet, a capsule, drops or a suspension. The invention relates also to the use of said composition in the preparation of a mixture for the application to humans and animals against the loss of hair and to method for the treatment with said composition for the treatment of humans and animals against loss of hair.
摘要翻译：本发明包括一种组合物，其包含锯齿棕榈和挥发油的提取物及其衍生物和作为所述提取物的一部分的活性成分的混合物。组合物可以包含额外的试剂和/或提取物，例如刺激剂，用于头发滋养的提取物，发丝营养剂，去头皮屑抗增殖化合物，具有抗微生物剂的提取物，用抗真菌剂提取物，用抗炎剂提取物，提取物用类固醇，用一氧化氮供体提取，并用米诺地尔提取。组合物中锯棕榈提取物的浓度适宜为0.01-100％。组合物可以包含合适的载体，溶剂和/或渗透剂。组合物可以是例如内部摄取的片剂，胶囊，滴剂或悬浮液。本发明还涉及所述组合物在制备用于人和动物免受毛发损失的混合物的使用以及用于治疗人和动物的所述组合物以防止头发损失的方法。

7. 发明授权

US07452556B2 Compositions for the treatment of pilosebaceous gland inflammations comprising aluminum fluoride 有权
标题翻译：用于治疗包括氟化铝的毛囊炎炎症的组合物
公开(公告)号：US07452556B2
公开(公告)日：2008-11-18
申请号：US10490600
申请日：2002-10-02
申请人： Avi Dascalu
发明人： Avi Dascalu
IPC分类号： A61K33/14 , A61K33/06 , A61K31/203 , A61K31/343 , A61P17/00 , A61P17/10 , A61P29/00
CPC分类号： A61Q19/00 , A61K8/26 , A61K33/06 , A61K33/16 , A61K45/06 , Y10S514/859 , Y10S514/887 , A61K2300/00
摘要： The present invention relates to compositions for the treatment of pilosebaceous gland inflammations, especially of the hair follicle and its appendages, in particular of Acne Vulgaris and Folliculitis, comprising as active ingredient AIF or chemical compounds which finally release AIF, or combinations of aluminum and fluoride salts which finally release AIF. AIF in accordance with the present invention relates to Aluminum fluoride (Aluminum Trifluoride; Aluminum Fluoride), CAS No 7784-18-1, EINECS No. 232-051-1, having an empirical formula of AIF3. Said compositions have, inter alia, pharmaceutical, cosmetic or quasi-cosmetic properties. The present invention also relates to the use of said compositions in said treatment, and to methods for the treatment of pilosebaceous gland inflammations with said compositions.
摘要翻译：本发明涉及用于治疗皮脂腺炎的组合物，特别是毛囊及其附属物，特别是痤疮和毛囊炎的组合物，其包含作为活性成分的AIF或最终释放AIF的化合物或铝和氟化物的组合最终释放AIF的盐。根据本发明的AIF涉及氟化铝（氟化三氟化铝;氟化铝），CAS号7784-18-1，EINECS号232-051-1，其具有经验式为AIF 3 。所述组合物尤其具有药物，化妆品或准化妆品的特性。本发明还涉及所述组合物在所述治疗中的用途以及用所述组合物治疗皮脂腺炎炎症的方法。

8. 发明申请

US20080260864A1 Topical Compositions for the Treatment of Depilation-Induced Irritation or Prevention Thereof 审中-公开
标题翻译：用于治疗脱发诱发刺激或预防的专题组成
公开(公告)号：US20080260864A1
公开(公告)日：2008-10-23
申请号：US12067219
申请日：2006-10-18
申请人： Avi Dascalu
发明人： Avi Dascalu
IPC分类号： A61K33/06 , A61P17/00
CPC分类号： A61Q19/00 , A61K8/23 , A61K8/26 , A61K2800/75 , A61Q9/04
摘要： The present invention relates to topical compositions comprising as active ingredients Aluminium Chloride and Sulfur for treatment of skin irritation induced by depilation. Said compositions have pharmaceutical and/or cosmetic and/or quasi cosmetic properties. The present invention also involves methods of making and methods of using such compositions. Furthermore, the present invention consists of a method for prevention and/or treatment of skin irritation induced by depilation.
摘要翻译：本发明涉及包含作为活性成分的氯化铝和硫磺用于治疗由脱毛引起的皮肤刺激的局部组合物。所述组合物具有药物和/或化妆品和/或准化妆品性质。本发明还涉及制备方法和使用这些组合物的方法。此外，本发明包括预防和/或治疗由脱毛引起的皮肤刺激的方法。

9. 发明申请

US20190336063A1 DERMOSCOPY DIAGNOSIS OF CANCEROUS LESIONS UTILIZING DUAL DEEP LEARNING ALGORITHMS VIA VISUAL AND AUDIO (SONIFICATION) OUTPUTS 审中-公开
公开(公告)号：US20190336063A1
公开(公告)日：2019-11-07
申请号：US16445684
申请日：2019-06-19
申请人： AVI DASCALU
发明人： AVI DASCALU
IPC分类号： A61B5/00 , G06N3/02
摘要： The present invention provides for a system and method for the diagnosis of skin cancer, wherein visual data is acquired from a skin lesion by a passive or active optical, electronical, thermal or mechanical method, processing the acquired visual field image into a classifier, applying a dermoscopic classification analysis to the image and converting, by sonification techniques, the data to raw audio signals, wherein the raw audio signals are analyzed with a second machine learning algorithm to increase interpretability and the precision of diagnosis.

10. 发明申请

US20120252863A1 TRIPTANS FOR THE TREATMENT OF PSORIASIS 有权
标题翻译：用于治疗PSORIASIS的TRIPTAN
公开(公告)号：US20120252863A1
公开(公告)日：2012-10-04
申请号：US13503418
申请日：2010-10-22
申请人： Avi Dascalu
发明人： Avi Dascalu
IPC分类号： A61K31/405 , C07D209/16 , A61P17/06
CPC分类号： A61K9/0014 , A61K9/06 , A61K9/08 , A61K9/107 , A61K31/4045 , A61K31/4196 , A61K31/422
摘要： The present invention provides for a composition comprising a tryptamine based drug that acts as a 5-hydroxytryptamine-1 inhibitor in an amount sufficient to reduce the effects of psoriasis and wherein the composition is formulated for topical or oral administration.
摘要翻译：本发明提供了一种组合物，其包含基于色胺的药物，其作为5-羟色胺-1抑制剂的量足以降低牛皮癣的作用，并且其中所述组合物被配制用于局部或口服给药。

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