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1. 发明授权

US06251881B1 Method of treating diabetic angiopathy 失效
标题翻译：治疗糖尿病性血管病的方法
公开(公告)号：US06251881B1
公开(公告)日：2001-06-26
申请号：US09422478
申请日：1999-10-21
申请人： Frederick H. Hausheer , Aulma Parker , Seetharamulu Peddaiaghari
发明人： Frederick H. Hausheer , Aulma Parker , Seetharamulu Peddaiaghari
IPC分类号： A61K3166
CPC分类号： A61K31/185 , A61K31/66
摘要： This invention relates to a method of treating patients afflicted with diabetic angiopathy. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set forth in the specification.
摘要翻译：本发明涉及治疗患有糖尿病血管病的患者的方法。该方法包括向需要治疗的患者施用有效量的根据说明书中阐述的式的硫醇或可还原的二硫化物化合物。

2. 发明授权

US6031006A Method of treating diabetic nephropathy 有权
标题翻译：治疗糖尿病肾病的方法
公开(公告)号：US6031006A
公开(公告)日：2000-02-29
申请号：US422486
申请日：1999-10-21
申请人： Frederick H. Hausheer , Aulma Parker , Seetharamulu Peddaiaghari
发明人： Frederick H. Hausheer , Aulma Parker , Seetharamulu Peddaiaghari
IPC分类号： A61K31/00 , A61K31/10
CPC分类号： A61K31/00
摘要： This invention relates to a method of treating patients afflicted with diabetic nephropathy. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set forth in the specification.
摘要翻译：本发明涉及治疗患有糖尿病肾病的患者的方法。该方法包括向需要治疗的患者施用有效量的根据说明书中阐述的式的硫醇或可还原的二硫化物化合物。

3. 发明授权

US6043274A Method of treating diabetic cardiomyopathy 失效
标题翻译：治疗糖尿病性心肌病的方法
公开(公告)号：US6043274A
公开(公告)日：2000-03-28
申请号：US422479
申请日：1999-10-21
申请人： Frederick H. Hausheer , Aulma Parker , Seetharamulu Peddaiahgari
发明人： Frederick H. Hausheer , Aulma Parker , Seetharamulu Peddaiahgari
IPC分类号： A61K31/185 , A61K31/662 , A61K31/255 , A61K31/663
CPC分类号： A61K31/185
摘要： This invention relates to a method of treating patients afflicted with diabetic cardiomyopathy. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set forth in the specification.
摘要翻译：本发明涉及治疗患有糖尿病性心肌病的患者的方法。该方法包括向需要治疗的患者施用有效量的根据说明书中阐述的式的硫醇或可还原的二硫化物化合物。

4. 发明申请

US20140073793A1 Germanium-containing camptothecin analogues 审中-公开
标题翻译：含锗喜树碱类似物
公开(公告)号：US20140073793A1
公开(公告)日：2014-03-13
申请号：US13573294
申请日：2012-09-07
申请人： Xinghai Chen , Harry Kochat , Pavankumar N.V. Petluru , Aulma Parker , Frederick H. Hausheer
发明人： Xinghai Chen , Harry Kochat , Pavankumar N.V. Petluru , Aulma Parker , Frederick H. Hausheer
IPC分类号： C07F7/30
CPC分类号： C07F7/30
摘要： The present invention discloses: (i) the novel germanium-containing camptothecin compound, 7[2′-trimethylgermanyl]ethyl-20(S) camptothecin, and pharmaceutically-acceptable salts thereof; (ii) methods of synthesis of said novel germanium-containing camptothecin compound, 7[2′-trimethylgermanyl]ethyl-20(S) camptothecin, and pharmaceutically-acceptable salts; (iii) pharmaceutically-acceptable formulations comprising said novel germanium-containing camptothecin compound, 7[2′-trimethylgermanyl]ethyl-20(S) camptothecin, and pharmaceutically-acceptable salts thereof; and (iv) methods of administration of said novel germanium-containing camptothecin compound, 7[2′-trimethylgermanyl]ethyl-20(S) camptothecin, and pharmaceutically-acceptable salts thereof to subjects in need thereof, including subjects with cancer.
摘要翻译：本发明公开：（i）新颖的含锗喜树碱化合物，7 [2'-三甲基甲酰基]乙基-20（S）喜树碱及其药学上可接受的盐; （ii）合成所述新颖的含锗喜树碱化合物的方法，7 [2'-三甲基麦角糖基]乙基-20（S）喜树碱及其药学上可接受的盐; （iii）包含所述新颖的含锗喜树碱化合物，7 [2'-三甲基麦角糖基]乙基-20（S）喜树碱的药学上可接受的制剂及其药学上可接受的盐; 和（iv）将所述新颖的含锗喜树碱化合物，7 [2'-三甲基甲酰基]乙基-20（S）喜树碱及其药学上可接受的盐给予需要的受试者，包括患有癌症的受试者的方法。

5. 发明授权

US06274622B1 Method of treating diabetic ophthalmopathy 失效
标题翻译：治疗糖尿病眼病的方法
公开(公告)号：US06274622B1
公开(公告)日：2001-08-14
申请号：US09427812
申请日：1999-10-27
申请人： Frederick H. Hausheer , Aulma Parker , Seetharamulu Peddaiaghari
发明人： Frederick H. Hausheer , Aulma Parker , Seetharamulu Peddaiaghari
IPC分类号： A61K31255
CPC分类号： A61K31/255 , Y10S514/912
摘要： This invention relates to a method of treating patients afflicted with diabetic ophthalmopathy. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set forth in the specification.
摘要翻译：本发明涉及治疗患有糖尿病性眼病的患者的方法。该方法包括向需要治疗的患者施用有效量的根据说明书中阐述的式的硫醇或可还原的二硫化物化合物。

6. 发明授权

US06468963B1 Methods and formulations for reducing toxicity associated with diabetes treatments 有权
标题翻译：减少与糖尿病治疗有关的毒性的方法和制剂
公开(公告)号：US06468963B1
公开(公告)日：2002-10-22
申请号：US09562160
申请日：2000-05-01
申请人： Frederick H. Hausheer , Aulma Parker , Susan E. Hamilton
发明人： Frederick H. Hausheer , Aulma Parker , Susan E. Hamilton
IPC分类号： A61K31155
CPC分类号： A61K31/662 , A61K31/155 , A61K31/185 , A61K38/26 , A61K38/28 , A61K2300/00
摘要： Formulations and methods for reducing the unwanted toxicity and complications associated with treatments for diabetes mellitus. The formulations include co-formulations of an anti-diabetic agent and a toxicity reducing agent of the formula described in the specification. The methods include administration of effective amounts of the anti-diabetic agent and the toxicity reducing agent to safely treat the diabetic patient.
摘要翻译：用于减少与糖尿病治疗相关的不想要的毒性和并发症的制剂和方法。该制剂包括说明书中描述的抗糖尿病药物和毒性降低剂的配制剂。所述方法包括施用有效量的抗糖尿病药和毒性降低剂以安全治疗糖尿病患者。

7. 发明授权

US06100247A Method of treating diabetic neuropathy 有权
标题翻译：治疗糖尿病性神经病变的方法
公开(公告)号：US06100247A
公开(公告)日：2000-08-08
申请号：US422485
申请日：1999-10-21
申请人： Frederick H. Hausheer , Aulma Parker , Seetharamulu Peddaiaghari
发明人： Frederick H. Hausheer , Aulma Parker , Seetharamulu Peddaiaghari
IPC分类号： A61K31/185 , A61K31/10
CPC分类号： A61K31/185
摘要： This invention relates to a method of treating patients afflicted with diabetic neuropathy. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set forth in the specification.
摘要翻译：本发明涉及治疗患有糖尿病性神经病变的患者的方法。该方法包括向需要治疗的患者施用有效量的根据说明书中阐述的式的硫醇或可还原的二硫化物化合物。

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