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1. 发明授权

US08283625B2 Method of preparing sample for matrix-assisted laser desorption ionization mass spectrometry and matrix-assisted laser desorption ionization mass spectrometry 有权
标题翻译：基质辅助激光解吸电离质谱法和基质辅助激光解吸电离质谱法制备样品的方法
公开(公告)号：US08283625B2
公开(公告)日：2012-10-09
申请号：US12443461
申请日：2007-09-21
申请人： Taka-aki Sato , Yutaka Aoki , Takashi Shimada , Atsuhiko Toyama
发明人： Taka-aki Sato , Yutaka Aoki , Takashi Shimada , Atsuhiko Toyama
IPC分类号： B01D59/44
CPC分类号： H01J49/164 , G01N1/2806 , G01N1/2813 , H01J49/0004 , H01J49/0418
摘要： It is intended to provide a method of preparing sample for matrix-assisted laser desorption/ionization mass spectrometry using a matrix capable of generating preferred crystals that cause effective ionization of a molecule to be measured. A method of preparing a sample for matrix-assisted laser desorption/ionization mass spectrometry comprising the steps of: preparing a solution of 2,5-dihydroxybenzoic acid of 40 mg/mL to saturated concentration as a matrix solution; and dispensing the matrix solution to a sample to be analyzed by using an inkjet mechanism, to crystallize the 2,5-dihydroxybenzoic acid.
摘要翻译：旨在提供一种使用能够产生优选的晶体的基质辅助激光解吸/电离质谱法的样品的制备方法，所述晶体能够产生有效电离被测分子。一种制备用于基体辅助激光解吸/电离质谱的样品的方法，包括以下步骤：以饱和浓度制备40mg / mL的2,5-二羟基苯甲酸溶液作为基质溶液; 并通过使用喷墨机构将基质溶液分配到要分析的样品上，使2,5-二羟基苯甲酸结晶。

2. 发明申请

US20100075354A1 MARKER FOR IDENTIFICATION OF TISSUE TYPE OF EPITHELIAL OVARIAN CANCER, AND METHOD FOR DETERMINATION OF THE OCCURRENCE OF EPITHELIAL OVARIAN CANCER BASED ON TISSUE TYPE BY USING THE MARKER 有权
标题翻译：用于鉴定组织型上皮癌的标记，以及使用标记确定基于组织类型的上皮癌的发生的方法
公开(公告)号：US20100075354A1
公开(公告)日：2010-03-25
申请号：US12527191
申请日：2008-02-15
申请人： Taka-aki Sato , Atsuhiko Toyama , Takashi Shimada , Tetsuyoshi Sugita , Daisuke Aoki , Atsushi Suzuki , Nobuyuki Susumu , Hiroyuki Nomura
发明人： Taka-aki Sato , Atsuhiko Toyama , Takashi Shimada , Tetsuyoshi Sugita , Daisuke Aoki , Atsushi Suzuki , Nobuyuki Susumu , Hiroyuki Nomura
IPC分类号： C12Q1/48 , C12Q1/34 , C12Q1/02 , C12N9/10 , C12N9/14 , C07K14/00
CPC分类号： G01N33/57449 , G01N2800/56
摘要： It is provided a method for identification of the morbidity of epithelial ovarian cancer based on a tissue-type in view of molecular typing which is different from a conventional histopathology, and a marker for identification of a tissue-type of epithelial ovarian cancer. A method for identification of the morbidity of epithelial ovarian cancer based on a tissue-type, comprising: subjecting a sample originated from an individual of interest to a treatment for detecting at least one selected from the group consisting of biological molecules specifically showing an upregulation in expression in a specific tissue-type of epithelial ovarian cancer, and/or at least one selected from the group consisting of biological molecules specifically showing a downregulation in expression in a specific tissue-type of epithelial ovarian cancer, and identifying whether or not the significant detection of the protein is achieved, thereby identifying the tissue-type.
摘要翻译：提供了一种鉴定与常规组织病理学不同的分子分型的基于组织型的上皮性卵巢癌的发病率的方法和用于鉴定组织型上皮性卵巢癌的标志物。一种用于鉴定基于组织型的上皮性卵巢癌的发病率的方法，其包括：对来自感兴趣个体的样品进行处理，以检测选自特异性显示上调的生物分子中的至少一种在特定组织型上皮性卵巢癌中的表达，和/或选自特异性显示特定组织型上皮性卵巢癌中的下调的生物分子中的至少一种，以及鉴定是否显着实现蛋白质的检测，从而鉴定组织型。

3. 发明授权

US08518651B2 Marker for identification of tissue type of epithelial ovarian cancer, and method for determination of the occurrence of epithelial ovarian cancer based on tissue type by using the marker 有权
标题翻译：用于鉴定上皮性卵巢癌组织类型的标记物，以及通过使用标记物来确定基于组织类型的上皮性卵巢癌发生的方法
公开(公告)号：US08518651B2
公开(公告)日：2013-08-27
申请号：US12527191
申请日：2008-02-15
申请人： Taka-aki Sato , Atsuhiko Toyama , Takashi Shimada , Tetsuyoshi Sugita , Daisuke Aoki , Atsushi Suzuki , Nobuyuki Susumu , Hiroyuki Nomura
发明人： Taka-aki Sato , Atsuhiko Toyama , Takashi Shimada , Tetsuyoshi Sugita , Daisuke Aoki , Atsushi Suzuki , Nobuyuki Susumu , Hiroyuki Nomura
IPC分类号： G01N33/53
CPC分类号： G01N33/57449 , G01N2800/56
摘要： It is provided a method for identification of the morbidity of epithelial ovarian cancer based on a tissue-type in view of molecular typing which is different from a conventional histopathology, and a marker for identification of a tissue-type of epithelial ovarian cancer. A method for identification of the morbidity of epithelial ovarian cancer based on a tissue-type, comprising: subjecting a sample originated from an individual of interest to a treatment for detecting at least one selected from the group consisting of biological molecules specifically showing an upregulation in expression in a specific tissue-type of epithelial ovarian cancer, and/or at least one selected from the group consisting of biological molecules specifically showing a downregulation in expression in a specific tissue-type of epithelial ovarian cancer, and identifying whether or not the significant detection of the protein is achieved, thereby identifying the tissue-type.
摘要翻译：提供了一种鉴定与常规组织病理学不同的分子分型的基于组织型的上皮性卵巢癌的发病率的方法和用于鉴定组织型上皮性卵巢癌的标志物。一种用于鉴定基于组织型的上皮性卵巢癌的发病率的方法，其包括：对来自感兴趣个体的样品进行处理，以检测选自特异性显示上调的生物分子中的至少一种在特定组织型上皮性卵巢癌中的表达，和/或选自特异性显示特定组织型上皮性卵巢癌中的下调的生物分子中的至少一种，以及鉴定是否显着实现蛋白质的检测，从而鉴定组织型。

4. 发明申请

US20100086938A1 MASS SPECTROMETRY OF BIOLOGICAL SAMPLE USING IMMUNOPRECIPITATION 审中-公开
标题翻译：使用免疫反应的生物样品的质谱分析
公开(公告)号：US20100086938A1
公开(公告)日：2010-04-08
申请号：US12516790
申请日：2007-10-02
申请人： Takashi Shimada , Atsuhiko Toyama , Taka-aki Sato
发明人： Takashi Shimada , Atsuhiko Toyama , Taka-aki Sato
IPC分类号： G01N33/53 , G01N33/543 , G01N33/553 , G01N33/552 , G01N33/544
CPC分类号： G01N33/6848
摘要： It is intended to provide an analysis method for a biological sample with clinical significance, which is a system being simple to such an extent that it can be applied to a clinical field, and capable of capping a molecule ionization suppression in mass spectrometry. Mass spectrometry of a biological sample using immunoprecipitation, comprising the steps of: preparing a sample containing an objective biological molecule; concentrating the biological molecule in the sample by immunoprecipitation using an antibody-bound carrier or a carrier to which a molecule capable of specifically binding to an antibody is bound; washing an immunoprecipitate of the biological molecule by using an aqueous solution containing a charge neutralizing agent as a washing liquid; and detecting the biological molecule by subjecting the washed immunoprecipitate to mass spectrometry.
摘要翻译：旨在为具有临床意义的生物样品提供分析方法，该方法简单到能够应用于临床领域并且能够在质谱法中限制分子离子化抑制的系统。使用免疫沉淀的生物样品的质谱法，包括以下步骤：制备含有客观生物分子的样品; 通过使用抗体结合的载体或能够与抗体特异性结合的分子结合的载体通过免疫沉淀将生物分子浓缩在样品中; 通过使用含有电荷中和剂的水溶液作为洗涤液来洗涤生物分子的免疫沉淀物; 并通过对洗涤的免疫沉淀物进行质谱检测来检测生物分子。

5. 发明申请

US20120040376A1 LUNG CANCER DIAGNOSTIC POLYPEPTIDE, METHOD FOR DETECTING LUNG CANCER, AND METHOD FOR EVALUATING THERAPEUTIC EFFECT 有权
标题翻译：肺癌诊断性多肽，检测肺癌的方法和评估治疗效果的方法
公开(公告)号：US20120040376A1
公开(公告)日：2012-02-16
申请号：US13197849
申请日：2011-08-04
申请人： Koji Ueda , Hidewaki Nakagawa , Atsuhiko Toyama , Taka-Aki Sato
发明人： Koji Ueda , Hidewaki Nakagawa , Atsuhiko Toyama , Taka-Aki Sato
IPC分类号： G01N33/574 , H01J49/26 , C07K7/06 , C07K7/08 , C07K14/47
CPC分类号： C07K14/4748 , G01N33/57423 , G01N33/6848 , G01N2800/52
摘要： A novel biomarker for use in lung cancer diagnosis is provided.
摘要翻译：提供了一种用于肺癌诊断的新型生物标志物。

6. 发明申请

US20090246769A1 MOLECULAR DIAGNOSIS OF OVARIAN CANCERS 审中-公开
标题翻译：卵巢癌的分子诊断
公开(公告)号：US20090246769A1
公开(公告)日：2009-10-01
申请号：US12246242
申请日：2008-10-06
申请人： Takaaki SATO , Tetsuyoshi Sugita , Atsuhiko Toyama , Takashi Shimada , Daisuke Aoki , Atsushi Suzuki , Nobuyuki Susumu , Hiroyuki Nomura
发明人： Takaaki SATO , Tetsuyoshi Sugita , Atsuhiko Toyama , Takashi Shimada , Daisuke Aoki , Atsushi Suzuki , Nobuyuki Susumu , Hiroyuki Nomura
IPC分类号： C12Q1/68 , C12M1/34 , G01N33/574
CPC分类号： G01N33/57449 , C12Q1/6886 , C12Q2600/158
摘要： A molecular diagnosis system of ovarian cancers encompasses a detection device configured to obtain a detected value of an expression amount of an apolipoprotein A1 gene in ovarian tissue as a diagnosis subject, a storage device configured to store a normal value of the expression amount of the apolipoprotein A1 gene in normal ovarian tissue, and a determination mechanism configured to determine that the ovarian tissue as the diagnosis subject is clear cell adenocarcinoma when the detected value is lower than the normal value.
摘要翻译：卵巢癌的分子诊断系统包括：检测装置，其被配置为获得作为诊断对象的卵巢组织中载脂蛋白A1基因的表达量的检测值，存储装置，其被配置为存储载脂蛋白的表达量的正常值 A1基因在正常卵巢组织中的表达，以及确定机制，用于确定当检测值低于正常值时，作为诊断对象的卵巢组织为透明细胞腺癌。

7. 发明授权

US08518654B2 Lung cancer diagnostic polypeptide, method for detecting lung cancer, and method for evaluating therapeutic effect 有权
标题翻译：肺癌诊断多肽，肺癌检测方法，治疗效果评价方法
公开(公告)号：US08518654B2
公开(公告)日：2013-08-27
申请号：US13197849
申请日：2011-08-04
申请人： Koji Ueda , Hidewaki Nakagawa , Atsuhiko Toyama , Taka-Aki Sato
发明人： Koji Ueda , Hidewaki Nakagawa , Atsuhiko Toyama , Taka-Aki Sato
IPC分类号： G01N33/53 , C12N5/00
CPC分类号： C07K14/4748 , G01N33/57423 , G01N33/6848 , G01N2800/52
摘要： A novel biomarker for use in lung cancer diagnosis is provided.
摘要翻译：提供了一种用于肺癌诊断的新型生物标志物。

8. 发明申请

US20140242726A1 LUNG CANCER MARKER COMPLEMENT C3dg MOLECULE, AND METHOD FOR ANALYZING LUNG CANCER MARKER 审中-公开
标题翻译：肺癌标记补体C3dg分子及分析肺癌标记物的方法
公开(公告)号：US20140242726A1
公开(公告)日：2014-08-28
申请号：US14343895
申请日：2012-03-19
申请人： Atsuhiko Toyama , Taka-Aki Sato , Koji Ueda
发明人： Atsuhiko Toyama , Taka-Aki Sato , Koji Ueda
IPC分类号： G01N33/574
CPC分类号： G01N33/57423 , G01N2333/4716
摘要： [Problem]To provide a method for detecting early-stage lung cancer, which reduce a burden on a subject and are excellent in specificity and sensitivity. [Solution]A lung cancer marker comprising a complement C3dg molecule. A method for analyzing a lung cancer marker comprising the steps of: measuring a level of a complement C3dg molecule as a lung cancer marker in a biological sample to acquire a measured level of the complement C3dg molecule; and making an evaluation as to whether the measured level is high or low based on a reference level of the complement C3dg molecule. Preferably, the measured level of the complement C3dg molecule is a value relative to a measured level of a complement C3 full-length molecule in the biological sample, and herein the reference level of the complement C3dg molecule is a value relative to a reference level of the complement C3 full-length molecule.
摘要翻译： [问题]提供一种检测早期肺癌的方法，其减少受试者的负担并且特异性和灵敏度优异。 [解决方案]包含补体C3dg分子的肺癌标记物。一种用于分析肺癌标志物的方法，包括以下步骤：测量生物样品中作为肺癌标志物的补体C3dg分子的水平，以获得测量的补体C3dg分子水平; 并基于补体C3dg分子的参考水平评估所测量的水平是高还是低。优选地，补体C3dg分子的测量水平是相对于生物样品中补体C3全长分子的测量水平的值，并且在此，补体C3dg分子的参考水平是相对于参考水平补体C3全长分子。

9. 发明申请

US20100075372A1 METHOD FOR DEPARAFFINIZATION OF PARAFFIN-EMBEDDED SPECIMEN AND METHOD FOR ANALYSIS OF PARAFFIN-EMBEDDED SPECIMEN 审中-公开
标题翻译： PARAFFIN嵌入样本的分离方法和PARAFFIN嵌入样本分析方法
公开(公告)号：US20100075372A1
公开(公告)日：2010-03-25
申请号：US12443437
申请日：2007-09-21
申请人： Taka-aki Sato , Yutaka Aoki , Takashi Shimada , Atsuhiko Toyama
发明人： Taka-aki Sato , Yutaka Aoki , Takashi Shimada , Atsuhiko Toyama
IPC分类号： G01N1/28
CPC分类号： G01N1/30 , G01N1/36 , H01J49/0004
摘要： The present invention provides a method for deparaffinization useful for mass spectrometric imaging from a paraffin-embedded specimen. A method for deparaffinization of paraffin-embedded specimen comprising the steps of: exposing a biological sample by subjecting a specimen in which the biological sample is embedded in paraffin, to an organic solvent that is compatible with the paraffin under heating condition, to make the paraffin be melted and dissolved in the organic solvent; and removing the paraffin from the specimen by separating the organic solvent dissolving the paraffin, from the exposed biological sample.
摘要翻译：本发明提供了可用于石蜡包埋样品的质谱成像的脱蜡方法。一种石蜡包埋试样的脱蜡方法，其特征在于，包括以下步骤：使生物样品在石蜡中包埋的样品在加热条件下与石蜡相容的有机溶剂进行曝光，使石蜡熔化并溶解在有机溶剂中; 通过从暴露的生物样品中分离溶解石蜡的有机溶剂，从样品中除去石蜡。

10. 发明申请

US20100038529A1 METHOD OF PREPARING SAMPLE FOR MATRIX-ASSISTED LASER DESORPTION IONIZATION MASS SPECTROMETRY AND MATRIX-ASSISTED LASER DESORPTION IONIZATION MASS SPECTROMETRY 有权
标题翻译：制备基质辅助激光解吸浓度大分子光谱和基质辅助激光解吸浓度质谱的方法
公开(公告)号：US20100038529A1
公开(公告)日：2010-02-18
申请号：US12443461
申请日：2007-09-21
申请人： Taka-aki Sato , Yutaka Aoki , Takashi Shimada , Atsuhiko Toyama
发明人： Taka-aki Sato , Yutaka Aoki , Takashi Shimada , Atsuhiko Toyama
IPC分类号： H01J49/02 , B01D59/44
CPC分类号： H01J49/164 , G01N1/2806 , G01N1/2813 , H01J49/0004 , H01J49/0418
摘要： It is intended to provide a method of preparing sample for matrix-assisted laser desorption/ionization mass spectrometry using a matrix capable of generating preferred crystals that cause effective ionization of a molecule to be measured. A method of preparing a sample for matrix-assisted laser desorption/ionization mass spectrometry comprising the steps of: preparing a solution of 2,5-dihydroxybenzoic acid of 40 mg/mL to saturated concentration as a matrix solution; and dispensing the matrix solution to a sample to be analyzed by using an inkjet mechanism, to crystallize the 2,5-dihydroxybenzoic acid.
摘要翻译：旨在提供一种使用能够产生优选的晶体的基质辅助激光解吸/电离质谱法的样品的制备方法，所述晶体能够引起待测分子的有效电离。一种制备用于基体辅助激光解吸/电离质谱的样品的方法，包括以下步骤：以饱和浓度制备40mg / mL的2,5-二羟基苯甲酸溶液作为基质溶液; 并通过使用喷墨机构将基质溶液分配到要分析的样品上，使2,5-二羟基苯甲酸结晶。

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