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1. 发明专利

AU2015333738B2 Ataxia telengiectasia and Rad3-related (ATR) protein kinase inhibitors 未知
公开(公告)号：AU2015333738B2
公开(公告)日：2020-03-26
申请号：AU2015333738
申请日：2015-10-13
申请人： ATRIN PHARMACEUTICALS LLC
发明人： BRESLIN HENRY JOSEPH , GILAD OREN
IPC分类号： C07D241/04
摘要： A macrocyclic compound having the structure of Formula (A), wherein each of R1 and R2 is independently (i) a 5-6 membered monocyclic aromatic ring containing 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or (ii) an 8-10 membered bicyclic aromatic ring containing 0-6 heteroatoms independently selected from nitrogen, oxygen, or sulfur. Each R1 and R2 may independently be substituted by 0, 1, 2, 3, or 4 substituents. Z1

2. 发明专利

AU2015333738A1 Ataxia telengiectasia and Rad3-related (ATR) protein kinase inhibitors 未知
公开(公告)号：AU2015333738A1
公开(公告)日：2017-05-04
申请号：AU2015333738
申请日：2015-10-13
申请人： ATRIN PHARMACEUTICALS LLC
发明人： BRESLIN HENRY JOSEPH , GILAD OREN
IPC分类号： C07D241/04
摘要： A macrocyclic compound having the structure of Formula (A), wherein each of R1 and R2 is independently (i) a 5-6 membered monocyclic aromatic ring containing 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or (ii) an 8-10 membered bicyclic aromatic ring containing 0-6 heteroatoms independently selected from nitrogen, oxygen, or sulfur. Each R1 and R2 may independently be substituted by 0, 1, 2, 3, or 4 substituents. Z1

3. 发明专利

CA2963973A1 ATAXIA TELENGIECTASIA AND RAD3-RELATED (ATR) PROTEIN KINASE INHIBITORS 未知
公开(公告)号：CA2963973A1
公开(公告)日：2016-04-21
申请号：CA2963973
申请日：2015-10-13
申请人： ATRIN PHARMACEUTICALS LLC
发明人： BRESLIN HENRY JOSEPH , GILAD OREN
IPC分类号： C07D241/04
摘要： A macrocyclic compound having the structure of Formula (A), wherein each of R1 and R2 is independently (i) a 5-6 membered monocyclic aromatic ring containing 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or (ii) an 8-10 membered bicyclic aromatic ring containing 0-6 heteroatoms independently selected from nitrogen, oxygen, or sulfur. Each R1 and R2 may independently be substituted by 0, 1, 2, 3, or 4 substituents. Z1 represents a covalent bond, an atom, or a functional group comprising a grouping of atoms, wherein the grouping of atoms includes at least one heteroatom selected from the group consisting of N, O, P, and S.

4. 发明授权

US10301324B2 Ataxia telengiectasia and rad3-related (ATR) inhibitors and methods of their use 有权
公开(公告)号：US10301324B2
公开(公告)日：2019-05-28
申请号：US15486017
申请日：2017-04-12
申请人： Atrin Pharmaceuticals LLC
发明人： Henry Joseph Breslin , Oren Gilad , Gerhard Sperl , Eric J. Brown , Laura Butler
IPC分类号： C07D515/04 , A61K31/4985 , A61K45/06
摘要： The disclosure is directed to compounds and compositions that inhibit Ataxia Telengiectasia And Rad3-Related (ATR) Protein Kinase and methods of their use.

5. 发明申请

US20160102104A1 Ataxia Telengiectasia And Rad3-Related (ATR) Protein Kinase Inhibitors 有权
公开(公告)号：US20160102104A1
公开(公告)日：2016-04-14
申请号：US14881680
申请日：2015-10-13
申请人： Atrin Pharmaceuticals LLC
发明人： Henry Joseph Breslin , Oren Gilad
IPC分类号： C07D498/08 , A61K31/4985 , A61N5/10 , C07D498/18 , A61K31/5377 , C07D515/08 , A61K45/06
CPC分类号： C07D519/00 , A61K31/4985 , A61K31/5377 , A61K45/06 , C07D498/08 , C07D498/18 , C07D515/08 , C07D515/18
摘要： A macrocyclic compound having the structure of Formula (A), wherein each of R1 and R2 is independently (i) a 5-6 membered monocyclic aromatic ring containing 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or (ii) an 8-10 membered bicyclic aromatic ring containing 0-6 heteroatoms independently selected from nitrogen, oxygen, or sulfur. Each R1 and R2 may independently be substituted by 0, 1, 2, 3, or 4 substituents. Z1 represents a covalent bond, an atom, or a functional group comprising a grouping of atoms, wherein the grouping of atoms includes at least one heteroatom selected from the group consisting of N, O, P, and S. Also, Z1 may represent (i) a 5-6 membered monocyclic aromatic ring containing 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or (ii) an 8-10 membered bicyclic aromatic ring containing 0-6 heteroatoms independently selected from nitrogen, oxygen, or sulfur. Z2 represents a covalent bond, an atom, or a functional group comprising a grouping of atoms, wherein the grouping of atoms includes at least one heteroatom selected from the group consisting of N, O, P, and S. Variable v is an integer having a value of 1 or 0. T is a carbon atom, a nitrogen atom, a sulfur atom, or an oxygen atom. L is a linking group covalently bonded to T when v has a value of 1 or L is covalently bonded to R1 when v has a value of 0. L is covalently bonded to Z2 when Z2 is an atom or a functional group comprising grouping of atoms and/or L is covalently bonded to R2 when Z2 is a covalent bond. Each of R3, R4 and R5 may be the same as or different from each other and each is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, and heteraralkyl, wherein each alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, and heteraralkyl is optionally substituted by one or more suitable substituents.

6. 发明授权

US10196405B2 Ataxia telengiectasia and Rad3-related (ATR) protein kinase inhibitors 有权
公开(公告)号：US10196405B2
公开(公告)日：2019-02-05
申请号：US15951302
申请日：2018-04-12
申请人： Atrin Pharmaceuticals LLC
发明人： Henry Joseph Breslin , Oren Gilad
IPC分类号： C07D519/00 , C07D498/08 , C07D515/08 , C07D498/18 , C07D515/18 , A61K31/4985 , A61K31/5377 , A61K45/06
摘要： Macrocyclic compounds having the structure of Formula (A), or pharmaceutically acceptable salts thereof, are provided: wherein R1, R2, R3, R4 and R5 are defined herein. Also provided are pharmaceutical compositions comprising the macrocyclic compound and methods for treating cancer in a patient comprising administering to the patient the macrocyclic compound.

7. 发明申请

US20180230168A1 Ataxia Telengiectasia And Rad3-Related (ATR) Protein Kinase Inhibitors 审中-公开
公开(公告)号：US20180230168A1
公开(公告)日：2018-08-16
申请号：US15951302
申请日：2018-04-12
申请人： Atrin Pharmaceuticals LLC
发明人： Henry Joseph Breslin , Oren Gilad
IPC分类号： C07D519/00 , C07D515/18 , C07D498/18 , C07D498/08 , C07D515/08
CPC分类号： C07D519/00 , A61K31/4985 , A61K31/5377 , A61K45/06 , C07D498/08 , C07D498/18 , C07D515/08 , C07D515/18
摘要： Macrocyclic compounds having the structure of Formula (A), or pharmaceutically acceptable salts thereof, are provided: wherein R1, R2, R3, R4 and R5 are defined herein. Also provided are pharmaceutical compositions comprising the macrocyclic compound and methods for treating cancer in a patient comprising administering to the patient the macrocyclic compound.

8. 发明授权

US09981989B2 Ataxia telengiectasia and Rad3-related (ATR) protein kinase inhibitors 有权
公开(公告)号：US09981989B2
公开(公告)日：2018-05-29
申请号：US15498631
申请日：2017-04-27
申请人： Atrin Pharmaceuticals LLC
发明人： Henry Joseph Breslin , Oren Gilad
IPC分类号： C07D519/00 , C07D515/08 , C07D498/08 , C07D498/18 , C07D515/18 , A61K31/4985 , A61K31/06 , A61K31/5377
CPC分类号： C07D519/00 , A61K31/4985 , A61K31/5377 , A61K45/06 , C07D498/08 , C07D498/18 , C07D515/08 , C07D515/18
摘要： Macrocyclic compounds having the structure of Formula (A), or pharmaceutically acceptable salts thereof, are provided, wherein R1, R2, R3, R4 and R5 are defined herein. Also provided are pharmaceutical compositions comprising the macrocyclic compound and methods for treating cancer in a patient comprising administering to the patient the macrocyclic compound.

9. 发明申请

US20170226130A1 Ataxia Telengiectasia And Rad3-Related (ATR) Protein Kinase Inhibitors 审中-公开
公开(公告)号：US20170226130A1
公开(公告)日：2017-08-10
申请号：US15498631
申请日：2017-04-27
申请人： Atrin Pharmaceuticals LLC
发明人： Henry Joseph Breslin , Oren Gilad
IPC分类号： C07D519/00 , C07D515/18 , C07D498/18 , C07D515/08 , C07D498/08
CPC分类号： C07D519/00 , A61K31/4985 , A61K31/5377 , A61K45/06 , C07D498/08 , C07D498/18 , C07D515/08 , C07D515/18
摘要： Macrocyclic compounds having the structure of Formula (A), or pharmaceutically acceptable salts thereof, are provided, wherein R1, R2, R3, R4 and R5 are defined herein. Also provided are pharmaceutical compositions comprising the macrocyclic compound and methods for treating cancer in a patient comprising administering to the patient the macrocyclic compound.

10. 发明申请

US20170291911A1 Ataxia Telengiectasia And RAD3-Related (ATR) Inhibitors And Methods Of Their Use 审中-公开
公开(公告)号：US20170291911A1
公开(公告)日：2017-10-12
申请号：US15486017
申请日：2017-04-12
申请人： Atrin Pharmaceuticals LLC
发明人： Henry Joseph Breslin , Oren Gilad , Gerhard Sperl , Eric J. Brown , Laura Butler
IPC分类号： C07D515/04 , A61K31/4985 , A61K45/06
CPC分类号： C07D515/04 , A61K31/4985 , A61K45/06
摘要： The disclosure is directed to compounds and compositions that inhibit Ataxia Telengiectasia And Rad3-Related (ATR) Protein Kinase and methods of their use.

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