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1. 发明授权

US07747683B2 Method and system for operating applications for remote terminal devices 有权
标题翻译：用于远程终端设备操作应用的方法和系统
公开(公告)号：US07747683B2
公开(公告)日：2010-06-29
申请号：US12159553
申请日：2006-12-28
申请人： Shai Kurianski , Assaf Friedler
发明人： Shai Kurianski , Assaf Friedler
IPC分类号： G06F15/16
CPC分类号： H04L67/303 , H04L67/02 , H04L67/04 , H04L67/10
摘要： Method for allowing a user of a mobile terminal device having predetermined computational resources to remotely develop and operate upgraded content delivery applications. A client-side application and a corresponding remote application are installed on the terminal device and on a server connected to the terminal device. The remote application dynamically splits the tasks to be performed by the content delivery application between the client-side application and remote application, according to its computational resources and processes, in real-time, the content and its associated logic and input data to be delivered to the terminal device. The processed content is then transmitted to the terminal device over the data network and the content is rendered by the client-side application. The client-side application responds to inputs from the user and/or to messages from the server or further connected devices.
摘要翻译：允许具有预定计算资源的移动终端设备的用户远程开发和操作升级的内容传送应用的方法。客户端应用程序和对应的远程应用程序安装在终端设备和连接到终端设备的服务器上。远程应用程序根据其计算资源和过程实时动态地将内容交付应用执行的任务在客户端应用程序和远程应用程序之间进行动态分割，内容及其相关逻辑和要传递的输入数据到终端设备。然后，经处理的内容通过数据网络发送到终端设备，并且内容由客户端应用呈现。客户端应用程序响应来自用户的输入和/或来自服务器或其他连接设备的消息。

2. 发明专利

IL212152D0 HIV-1 INTEGRASE DERIVED PEPTIDES AND COMPOSITIONS 未知
公开(公告)号：IL212152D0
公开(公告)日：2011-06-30
申请号：IL21215211
申请日：2011-04-05
申请人： ASSAF FRIEDLER , ABRAHAM LOYTER , YISSUM RES DEV CO , LEVIN AVIAD , HAYOUKA ZVI
IPC分类号： A61K20060101

3. 发明申请

US20050008653A1 Stabilizing molecule 审中-公开
标题翻译：稳定分子
公开(公告)号：US20050008653A1
公开(公告)日：2005-01-13
申请号：US10775679
申请日：2004-02-10
申请人： Assaf Friedler , Alan Fersht
发明人： Assaf Friedler , Alan Fersht
IPC分类号： G01N33/50 , A61K38/00 , A61P35/00 , A61P43/00 , C07K1/113 , C07K7/00 , C07K14/47 , G01N33/15 , A61K39/00
CPC分类号： C07K14/4746 , A61K38/00 , C07K1/1136
摘要： Disclosed is a method of stabilising the native state of a polypeptide, the method comprising exposing the polypeptide to a stabilising molecule capable of binding to the polypeptide at a site which at least partially overlaps a functional site in its native state.
摘要翻译：公开了稳定多肽的天然状态的方法，该方法包括将多肽暴露于能够在其天然状态下至少部分重叠功能位点的位点上结合多肽的稳定分子。

4. 发明授权

US09163067B2 HIV-1 integrase derived stimulatory peptides interfering with integrase—Rev protein binding 有权
标题翻译： HIV-1整合酶衍生的刺激肽干扰整合酶-Rev蛋白结合
公开(公告)号：US09163067B2
公开(公告)日：2015-10-20
申请号：US13122548
申请日：2009-10-01
申请人： Aviad Levin , Zvi Hayouka , Assaf Friedler , Abraham Loyter
发明人： Aviad Levin , Zvi Hayouka , Assaf Friedler , Abraham Loyter
IPC分类号： A61K38/00 , A01N37/18 , A61P31/18 , A61K38/10 , A61K38/16 , C07K14/005
CPC分类号： C12N9/1276 , A61K38/162 , A61K38/45 , A61K45/06 , C07K14/005 , C07K2319/10 , C12N7/00 , C12N2740/16222 , C12Y207/07049
摘要： Isolated peptides comprising sequences derived from the protein integrase of HIV-1, as well as their analogs, mixtures, conjugates with permeability enhancing moieties, and pharmaceutical compositions are disclosed. The peptides and compositions are capable of selectively killing HIV-1 infected cells and are used in treatment of HIV infection and AIDS.
摘要翻译：公开了包含衍生自HIV-1的蛋白质整合酶的序列的分离的肽，以及它们的类似物，混合物，与渗透性增强部分的缀合物和药物组合物。肽和组合物能够选择性地杀死HIV-1感染的细胞并用于治疗HIV感染和AIDS。

5. 发明申请

US20080307048A1 Method and System for Operating Applications for Remote Terminal Devices 有权
标题翻译：远程终端设备操作应用的方法和系统
公开(公告)号：US20080307048A1
公开(公告)日：2008-12-11
申请号：US12159553
申请日：2006-12-28
申请人： Assaf Friedler , Shai Kurianski
发明人： Assaf Friedler , Shai Kurianski
IPC分类号： H04L29/08 , G06F15/16
CPC分类号： H04L67/303 , H04L67/02 , H04L67/04 , H04L67/10
摘要： Method for allowing a user of a mobile terminal device having predetermined computational resources to remotely develop and operate upgraded content delivery applications. A client-side application and a corresponding remote application are installed on the terminal device and on a server connected to the terminal device. The remote application dynamically splits the tasks to be performed by the content delivery application between the client-side application and remote application, according to its computational resources and processes, in real-time, the content and its associated logic and input data to be delivered to the terminal device. The processed content is then transmitted to the terminal device over the data network and the content is rendered by the client-side application. The client-side application responds to inputs from the user and/or to messages from the server or further connected devices.
摘要翻译：允许具有预定计算资源的移动终端设备的用户远程开发和操作升级的内容传送应用的方法。客户端应用程序和对应的远程应用程序安装在终端设备和连接到终端设备的服务器上。远程应用程序根据其计算资源和过程实时动态地将内容交付应用执行的任务在客户端应用程序和远程应用程序之间进行动态分割，内容及其相关逻辑和要传递的输入数据到终端设备。然后，经处理的内容通过数据网络发送到终端设备，并且内容由客户端应用呈现。客户端应用程序响应来自用户的输入和/或来自服务器或其他连接设备的消息。

6. 发明专利

IL212152A Hiv-1 integrase derived peptides and compositions comprising them 未知
公开(公告)号：IL212152A
公开(公告)日：2018-03-29
申请号：IL21215211
申请日：2011-04-05
申请人： ASSAF FRIEDLER , ABRAHAM LOYTER , YISSUM RES DEV CO OF HEBREW UNIV JERUSALEM LTD , AVIAD LEVIN , ZVI HAYOUKA
发明人： ASSAF FRIEDLER , ABRAHAM LOYTER , AVIAD LEVIN , ZVI HAYOUKA

7. 发明申请

US20110257082A1 HIV-1 INTEGRASE DERIVED STIMULATORY PEPTIDES INTERFERING WITH INTEGRASE -- REV PROTEIN BINDING 有权
标题翻译： HIV-1 INTEGRASE衍生刺激性干扰素与INTEGRASE - REV蛋白结合
公开(公告)号：US20110257082A1
公开(公告)日：2011-10-20
申请号：US13122548
申请日：2009-10-01
申请人： Aviad Levin , Zvi Hayouka , Assaf Friedler , Abraham Loyter
发明人： Aviad Levin , Zvi Hayouka , Assaf Friedler , Abraham Loyter
IPC分类号： A61K38/10 , C12N5/07 , C07K7/08 , A61K38/08 , A61P31/18 , C07K7/06
CPC分类号： C12N9/1276 , A61K38/162 , A61K38/45 , A61K45/06 , C07K14/005 , C07K2319/10 , C12N7/00 , C12N2740/16222 , C12Y207/07049
摘要： Isolated peptides comprising sequences derived from the protein integrase of HIV-1, as well as their analogs, mixtures, conjugates with permeability enhancing moieties, and pharmaceutical compositions are disclosed. The peptides and compositions are capable of selectively killing HIV-1 infected cells and are used in treatment of HIV infection and AIDS.
摘要翻译：公开了包含衍生自HIV-1的蛋白质整合酶的序列的分离的肽，以及它们的类似物，混合物，与渗透性增强部分的缀合物和药物组合物。肽和组合物能够选择性地杀死HIV-1感染的细胞并用于治疗HIV感染和AIDS。

8. 发明授权

US06664368B1 Inhibition of nuclear import by backbone cyclic peptide analogs 失效
标题翻译：通过骨架环肽类似物抑制核进口
公开(公告)号：US06664368B1
公开(公告)日：2003-12-16
申请号：US09564677
申请日：2000-05-04
申请人： Assaf Friedler , Abraham Loyter , Chaim Gilon , Amnon Wolf
发明人： Assaf Friedler , Abraham Loyter , Chaim Gilon , Amnon Wolf
IPC分类号： C07K750
CPC分类号： C07K14/005 , C12N2740/16322
摘要： The design and the synthesis of backbone cyclic peptide analogs which functionally mimic the nuclear localization signal (NLS) region of macromolecules is disclosed. The principles of the invention are exemplified for the NLS sequences of the human immunodeficiency virus type 1 proteins MA, Vpr, Tat and NLS-like sequences of HIV-1 protein Vif. We disclose the discovery of a novel, highly potent backbone cyclic peptide, designated BCvir, which inhibits nuclear import with an IC50 value of 35 nM. This inhibitory potency is to be compared to 12 &mgr;M exhibited by the linear parent HIV-1 MA NLS peptide. BCvir also reduced HIV-1 production by 75% in infected non-dividing cultured human T-cells and was relatively resistant to tryptic digestion. These properties render backbone cyclic peptide analogs of NLS or NLS-like sequences as candidates for novel drugs based on blocking nuclear import of viral genomes.
摘要翻译：公开了功能上模拟大分子的核定位信号（NLS）区域的骨架环肽类似物的设计和合成。对于HIV-1蛋白Vif的人免疫缺陷病毒1型蛋白MA，Vpr，Tat和NLS样序列的NLS序列，举例说明了本发明的原理。我们公开了一种称为BCvir的新型高效骨架环肽的发现，其抑制核导入，IC50值为35nM。将该抑制效力与线性亲本HIV-1 MA NLS肽显示的12μM进行比较。在感染的非分裂培养的人类T细胞中，BCvir还将艾滋病毒1的产量降低了75％，并且相对抗胰蛋白酶消化。这些性质使NLS或NLS样序列的骨架环肽类似物作为基于阻断核进入病毒基因组的新型药物的候选物。

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