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1. 发明授权

US09422342B2 Recoding method that removes inhibitory sequences and improves HIV gene expression 有权
标题翻译：去除抑制性序列并改善HIV基因表达的重新编码方法
公开(公告)号：US09422342B2
公开(公告)日：2016-08-23
申请号：US12373605
申请日：2007-07-12
申请人： Raul Rabadan , Michael Krasnitz , Harlan Robins , Daniela Witten , Arnold Levine
发明人： Raul Rabadan , Michael Krasnitz , Harlan Robins , Daniela Witten , Arnold Levine
IPC分类号： C12N7/00 , C07K14/005 , A61K39/21 , A61K39/12 , A61K39/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/525 , A61K2039/5252 , A61K2039/5254 , A61K2039/53 , C12N7/00 , C12N2740/16021 , C12N2740/16043 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234
摘要： The invention relates to inhibitory nucleotide signal sequences or “INS” sequences in the genomes of lentiviruses. In particular the invention relates to the AGG motif present in all viral genomes. The AGG motif may have an inhibitory effect on a virus, for example by reducing the levels of, or maintaining low steady-state levels of, viral RNAs in host cells, and inducing and/or maintaining in viral latency. In one aspect, the invention provides vaccines that contain, or are produced from, viral nucleic acids in which the AGG sequences have been mutated. In another aspect, the invention provides methods and compositions for affecting the function of the AGG motif, and methods for identifying other INS sequences in viral genomes.
摘要翻译：本发明涉及慢病毒基因组中的抑制性核苷酸信号序列或“INS”序列。特别地，本发明涉及存在于所有病毒基因组中的AGG基序。 AGG基序可以对病毒具有抑制作用，例如通过降低宿主细胞中的病毒RNA的水平或保持低稳态水平，以及诱导和/或维持病毒潜伏期。一方面，本发明提供了含有AGG序列突变的病毒核酸或由其产生的疫苗。另一方面，本发明提供了影响AGG基序功能的方法和组合物，以及用于鉴定病毒基因组中其他INS序列的方法。

2. 发明申请

US20130345164A1 TREATMENTS FOR CELLULAR PROLIFERATIVE DISORDERS AND IDENTIFICATION THEREOF 审中-公开
标题翻译：细胞增生性疾病的治疗及其鉴定
公开(公告)号：US20130345164A1
公开(公告)日：2013-12-26
申请号：US13642613
申请日：2011-04-21
申请人： Alexei Vazquez , Darren Carpizo , Arnold Levine
发明人： Alexei Vazquez , Darren Carpizo , Arnold Levine
IPC分类号： G06F19/00 , A61K31/7068 , A61K31/58 , A61K31/4427 , A61K31/519 , A61K31/496 , A61K31/4741 , A61K31/4745 , A61K31/4709 , A61K31/437 , A61K31/4545 , A61K31/4402 , A61K31/4184 , A61K31/407 , A61K31/381 , A61K31/365 , A61K31/282 , A61K31/17 , A61K31/136 , A61K31/473 , A61K31/706
CPC分类号： G06F19/34 , A61K31/136 , A61K31/17 , A61K31/282 , A61K31/365 , A61K31/381 , A61K31/407 , A61K31/4184 , A61K31/437 , A61K31/44 , A61K31/4402 , A61K31/4427 , A61K31/4545 , A61K31/4709 , A61K31/473 , A61K31/4741 , A61K31/4745 , A61K31/475 , A61K31/496 , A61K31/499 , A61K31/519 , A61K31/58 , A61K31/706 , A61K31/7068
摘要： This invention concerns methods of identifying treatments for treating various disorders and related computer products and systems. Also disclosed are methods for treating cellular proliferative disorders and use of compounds identified for such treatment.
摘要翻译：本发明涉及鉴定用于治疗各种疾病和相关计算机产品和系统的治疗方法。还公开了治疗细胞增殖性疾病的方法和用于这种治疗的化合物的使用。

3. 发明申请

US20090208955A1 METHODS FOR IDENTIFYING SEQUENCE MOTIFS, AND APPLICATIONS THEREOF 审中-公开
标题翻译：识别序列运动的方法及其应用
公开(公告)号：US20090208955A1
公开(公告)日：2009-08-20
申请号：US12302199
申请日：2006-11-30
申请人： Harlan Robins , Michael Krasnitz , Arnold Levine
发明人： Harlan Robins , Michael Krasnitz , Arnold Levine
IPC分类号： C12Q1/68
CPC分类号： G16B30/00 , C12P21/00 , G16B10/00
摘要： The present invention relates to methods and algorithms that can be used to identify sequence motifs that are either under- or over-represented in a given nucleotide sequence as compared to the frequency of those sequences that would be expected to occur by chance, or that are either under- or over-represented as compared to the frequency of those sequences that occur in other nucleotide sequences, and to methods of scoring sequences based on the occurrence of these sequence motifs. Such sequence motifs may be biologically significant, for example they may constitute transcription factor binding sites, mRNA stability/instability signals, epigenetic signals, and the like. The methods of the invention can also be used, inter alia, to classify sequences or organisms in terms of their phylogenetic relationships, or to identify the likely host of a pathogenic organism. The methods of the present invention can also be used to optimize expression of proteins.
摘要翻译：本发明涉及可用于鉴定在给定核苷酸序列中低于或过表达的序列基序的方法和算法，与预期偶然发生的那些序列的频率相比，或者与在其他核苷酸序列中发生的那些序列的频率相比或低于或过度表达，以及基于这些序列基序的出现对序列进行评分的方法。这样的序列基序可能是生物学上重要的，例如它们可能构成转录因子结合位点，mRNA稳定性/不稳定性信号，表观遗传信号等。本发明的方法还可以用于根据其系统发育关系对序列或生物体进行分类，或鉴定病原体的可能宿主。本发明的方法也可用于优化蛋白质的表达。

4. 发明申请

US20070041964A1 WISP polypeptides and nucleic acids encoding same 审中-公开
标题翻译： WISP多肽和编码相同的核酸
公开(公告)号：US20070041964A1
公开(公告)日：2007-02-22
申请号：US11488375
申请日：2006-07-17
申请人： David Botstein , Robert Cohen , Audrey Goddard , Austin Gurney , Kenneth Hillan , David Lawrence , Arnold Levine , Diane Pennica , Margaret Roy , William Wood
发明人： David Botstein , Robert Cohen , Audrey Goddard , Austin Gurney , Kenneth Hillan , David Lawrence , Arnold Levine , Diane Pennica , Margaret Roy , William Wood
IPC分类号： A61K39/395 , C07K16/40 , C07K16/42
CPC分类号： C07K14/47 , C07K14/475 , C07K16/18 , C07K16/22 , C07K16/30 , C07K16/32 , C07K2317/73 , C07K2317/74 , C12Q1/6886 , C12Q2600/136
摘要： Wnt-1-Induced Secreted Proteins (WISPs) are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides, and methods for producing the polypeptides.
摘要翻译：提供了Wnt-1诱导的分泌蛋白（WISP），其基因至少被Wnt-1诱导。还提供了编码那些多肽的核酸分子，以及包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的多肽的嵌合多肽分子，与多肽结合的抗体，以及用于产生多肽的方法。

5. 发明申请

US20100203081A1 VIRAL INHIBITORY NUCLEOTIDE SEQUENCES AND VACCINES 有权
标题翻译：病毒核苷酸序列和疫苗
公开(公告)号：US20100203081A1
公开(公告)日：2010-08-12
申请号：US12373605
申请日：2007-07-12
申请人： Raul Rabadan , Michael Krasnitz , Harlan Robins , Daniela Witten , Arnold Levine
发明人： Raul Rabadan , Michael Krasnitz , Harlan Robins , Daniela Witten , Arnold Levine
IPC分类号： A61K39/12 , C07H21/00 , C07K14/00 , C12N7/01 , C12N5/10 , A61P31/12 , A61P37/04
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/525 , A61K2039/5252 , A61K2039/5254 , A61K2039/53 , C12N7/00 , C12N2740/16021 , C12N2740/16043 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234
摘要： The invention relates to inhibitory nucleotide signal sequences or “INS” sequences in the genomes of lentiviruses. In particular the invention relates to the AGG motif present in all viral genomes. The AGG motif may have an inhibitory effect on a virus, for example by reducing the levels of, or maintaining low steady-state levels of, viral RNAs in host cells, and inducing and/or maintaining in viral latency. In one aspect, the invention provides vaccines that contain, or are produced from, viral nucleic acids in which the AGG sequences have been mutated. In another aspect, the invention provides methods and compositions for affecting the function of the AGG motif, and methods for identifying other INS sequences in viral genomes.
摘要翻译：本发明涉及慢病毒基因组中的抑制性核苷酸信号序列或“INS”序列。特别地，本发明涉及存在于所有病毒基因组中的AGG基序。 AGG基序可以对病毒具有抑制作用，例如通过降低宿主细胞中的病毒RNA的水平或保持低稳态水平，以及诱导和/或维持病毒潜伏期。一方面，本发明提供了含有AGG序列突变的病毒核酸或由其产生的疫苗。另一方面，本发明提供了影响AGG基序功能的方法和组合物，以及用于鉴定病毒基因组中其他INS序列的方法。

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