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1. 发明申请

US20120058152A1 BONE REGENERATION MATERIALS BASED ON COMBINATIONS OF MONETITE AND OTHER BIOACTIVE CALCIUM AND SILICON COMPOUNDS 有权
标题翻译：基于骨骼和其他生物钙和硅化合物的组合的骨再生材料
公开(公告)号：US20120058152A1
公开(公告)日：2012-03-08
申请号：US13148147
申请日：2010-02-04
申请人： Arcadio Garcia de Castro Andrews , Raul Garcia Carrodeguas , Sussette Padilla Mondéjar , Niuris Acosta Contreras
发明人： Arcadio Garcia de Castro Andrews , Raul Garcia Carrodeguas , Sussette Padilla Mondéjar , Niuris Acosta Contreras
IPC分类号： A61K33/42 , A61K35/12 , A61K9/16
CPC分类号： A61F2/02 , A61L27/425
摘要： The present invention incorporates new materials for bone regeneration, methods for their manufacture, and application in traumatology surgery, maxillo facial surgery, dental surgery, orthognatic surgery, endodontics, ophthalmology, neurosurgery and/or osteoporotic processes, and other indications where bone regeneration is required. In particular, the present invention incorporates synthetic materials with a 20% to a 95%, preferably between 40% and 90% in mass of monetite [Ca1-XMXHPO4, where 0≦x≦0.05, and where M can be a divalent metallic ion], and which in their final composition incorporate between 5% and 80%, preferably between 0% and 60%, in mass of bioactive calcium compounds chosen from calcium phosphates and between 5% and 80% in total mass of bioactive silicon compounds chosen from calcium silicates and/or bioactive silica glasses and gels.
摘要翻译：本发明包括用于骨再生的新材料，其制造方法，以及在创伤手术，上颌面手术，牙科手术，正面手术，牙髓治疗，眼科，神经外科和/或骨质疏松过程中的应用，以及需要骨再生的其他适应症。特别地，本发明包含具有20％至95％，优选40％至90％质量的六钙矿[Ca1-XMXHPO4，其中0和nlE; x和nlE; 0.05，其中M可以是二价金属离子 ]，并且其最终组合物以选自磷酸钙的生物活性钙化合物的质量计含有5％至80％，优选0％至60％，并且选自以下的生物活性硅化合物的总质量为5％至80％硅酸钙和/或生物活性二氧化硅玻璃和凝胶。

2. 发明申请

US20100286598A1 HYPODERMIC NEEDLE WITH WATER-SOLUBLE OBSTRUCTION FOR THE ADMINISTRATION OF DRUGS AND VACCINES 审中-公开
标题翻译：用于治疗药物和疫苗的水溶性针刺的超细针
公开(公告)号：US20100286598A1
公开(公告)日：2010-11-11
申请号：US12682209
申请日：2008-10-08
申请人： Arcadio Garcia De Castro Andrews
发明人： Arcadio Garcia De Castro Andrews
IPC分类号： A61M5/32
CPC分类号： A61M5/32 , A61M5/3286 , A61M5/3294 , A61M2005/311
摘要： The application refers to hypodermic needles (101) for the parenteral administration of liquids. The needles incorporate at their sharp-end an obstruction (102) of rapidly water-soluble material that dissolves within living tissues once the needle is injected. These needles ensure that the end user can only operate the syringe, or injection device, once the needle has been injected. The use of these hypodermic needles avoids the possibility of the user expelling any amount of liquid prior injection, ensuring the administration of the complete dose. These hypodermic needles are of special interest in preloaded injection devices and in the administration of small volumes of liquid were ejection of part of the dose by the user may result in the administration of only a fraction of the intended dose.
摘要翻译：该应用是指用于肠胃外给药液体的皮下注射针（101）。这些针在其尖端处包含快速水溶性材料的阻塞物（102），一旦针头被注射就溶解在活组织内。这些针确保一旦注射针头，最终用户只能操作注射器或注射装置。使用这些皮下注射针避免了用户在注射前排出任何量的液体的可能性，从而确保了完整剂量的给药。这些皮下注射针对预加载的注射装置是特别有用的，并且在施用小体积的液体时，使用者的部分剂量的喷射可能仅导致预期剂量的一部分。

3. 发明授权

US06190701B1 Composition and method for stable injectable liquids 有权
标题翻译：稳定注射液体的组成和方法
公开(公告)号：US06190701B1
公开(公告)日：2001-02-20
申请号：US09271204
申请日：1999-03-17
申请人： Bruce Joseph Roser , Arcadio Garcia De Castro , James Maki
发明人： Bruce Joseph Roser , Arcadio Garcia De Castro , James Maki
IPC分类号： A61K950
CPC分类号： A61K47/26 , A61K9/0019 , A61K9/10 , A61K9/143 , A61K9/145 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K47/02 , A61K47/12 , Y10T428/2985
摘要： A composition for delivering a stable, bioactive compound to a subject comprising a first component and a second component, the first component comprises microparticles of sugar glass or a phosphate glass containing the bioactive agent. The sugar glass or phosphate glass optionally includes a glass formation facilitator compound, and the second component comprises at least one biocompatible liquid perfluorocarbon in which the first component is insoluble and dispersed. The liquid perfluorocarbon optionally includes a surfactant.
摘要翻译：用于将稳定的生物活性化合物递送至包含第一组分和第二组分的对象的组合物，所述第一组分包含含有所述生物活性剂的糖玻璃微粒或磷酸盐玻璃。糖玻璃或磷酸盐玻璃任选地包括玻璃形成促进剂化合物，第二组分包含至少一种生物相容性液体全氟化碳，其中第一组分不溶和分散。液体全氟化碳任选地包括表面活性剂。

4. 发明授权

US06623762B2 Composition and method for controlled release injections 失效
标题翻译：控释注射用组合物和方法
公开(公告)号：US06623762B2
公开(公告)日：2003-09-23
申请号：US09784153
申请日：2001-02-16
申请人： Bruce Joseph Roser , Arcadio Garcia De Castro
发明人： Bruce Joseph Roser , Arcadio Garcia De Castro
IPC分类号： A61K934
CPC分类号： A61K9/1623 , Y10T428/2985
摘要： The present invention is a pharmaceutical composition and method for controlling the release of a drug or vaccine to a patient where a slow, controlled release of drug or antigen occurs over a considerable period of time after injection. The drug or vaccine is contained in sugar glass microspheres and then placed in an anhydrous liquid, preferably perfluorocarbon, so that the vaccine is protected against dissolution while remaining surrounded by anhydrous liquid. This simple non-toxic system, deliverable by current syringe or present or future needle-free systems, is inexpensive and reliable and aids in parenteral drug delivery or mass immunization campaigns by reducing the need for repeated injections.
摘要翻译：本发明是用于控制药物或疫苗释放到患者的药物组合物和方法，其中在注射后相当长的一段时间内发生药物或抗原的缓慢的受控释放。药物或疫苗包含在糖玻璃微球中，然后置于无水液体中，优选全氟化碳，以使疫苗得到保护以防止溶解，同时保持被无水液体包围。这种简单的无毒系统，可由当前的注射器或现在或将来的无针系统交付，价格便宜且可靠，通过减少重复注射的需要，有助于肠胃外药物输送或大规模免疫运动。

5. 发明授权

US08784827B2 Chimeric fusion proteins and virus like particles from Birnavirus VP2 有权
标题翻译：来自Birnavirus VP2的嵌合融合蛋白和病毒样颗粒
公开(公告)号：US08784827B2
公开(公告)日：2014-07-22
申请号：US12991689
申请日：2008-05-09
申请人： Thomas Zürcher , Juan José Bernal , Cayetano von Kobbe , Ignacio Jiménez Torres , Ana Diaz Blázquez , Diana Martin Lorenzo , Gloria Calderita Lucas , Arcadio Garcia de Castro
发明人： Thomas Zürcher , Juan José Bernal , Cayetano von Kobbe , Ignacio Jiménez Torres , Ana Diaz Blázquez , Diana Martin Lorenzo , Gloria Calderita Lucas , Arcadio Garcia de Castro
IPC分类号： A61K39/00 , A61K39/12 , C07K14/005
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5256 , A61K2039/5258 , C07K2319/40 , C12N2720/10022 , C12N2720/10023
摘要： The field of the invention refers to chimeric Virus Like Particles (VLP) derived from Birnavirus chimeric VP2 protein. In particular, the invention refers to chimeric VP2 fusion proteins which incorporate insertions and/or substitutions with one or more amino acids or particular peptide of interest while maintaining the capacity to assemble in the form of VLP. The invention identifies particular insertion and/or substitutions sites within VP2 P loop regions and outside said P loop regions. The invention also incorporates methods for the identification of preferred insertion and substitution sites within VP2 for the incorporation of particular amino acids and peptides of interest. The resulting chimeric VLP are of interest in the design of therapeutic and prophylactic vaccines as well as in the design of drug delivery systems, carriers for DNA and RNA in gene therapy, as targeted agents, in the development of antitoxins, and as diagnostic reagents.
摘要翻译：本发明的领域是指衍生自Birnavirus嵌合VP2蛋白的嵌合病毒样颗粒（VLP）。特别地，本发明涉及嵌合VP2融合蛋白，其掺入一个或多个氨基酸或特定感兴趣肽的插入和/或取代，同时保持以VLP形式组装的能力。本发明鉴定VP2P环区域内的所述P环区域内的特定插入和/或取代位点。本发明还包括用于鉴定VP2内优选的插入和取代位点以便并入特定的目的氨基酸和肽的方法。所产生的嵌合VLP在治疗和预防性疫苗的设计以及药物递送系统的设计，基因治疗中的DNA和RNA的载体，靶向剂，抗毒素的开发和诊断试剂方面都是感兴趣的。

6. 发明授权

US08506985B2 Bone regeneration materials based on combinations of monetite and other bioactive calcium and silicon compounds 有权
标题翻译：骨再生材料基于三钙和其他生物活性钙和硅化合物的组合
公开(公告)号：US08506985B2
公开(公告)日：2013-08-13
申请号：US13148147
申请日：2010-02-04
申请人： Arcadio Garcia De Castro Andrews , Raul Garcia Carrodeguas , Sussette Padilla Mondéjar , Niuris Acosta Contreras
发明人： Arcadio Garcia De Castro Andrews , Raul Garcia Carrodeguas , Sussette Padilla Mondéjar , Niuris Acosta Contreras
IPC分类号： A61F2/02
CPC分类号： A61F2/02 , A61L27/425
摘要： The present invention incorporates new materials for bone regeneration, methods for their manufacture, and application in traumatology surgery, maxillofacial surgery, dental surgery, orthognatic surgery, endodontics, ophthalmology, neurosurgery and/or osteoporotic processes, and other indications where bone regeneration is required. In particular, the present invention incorporates synthetic materials with a 20% to a 95%, preferably between 40% and 90% in mass of monetite [Ca1-XMXHPO4, where 0≦x≦0.05, and where M can be a divalent metallic ion], and which in their final composition incorporate between 5% and 80%, preferably between 0% and 60%, in mass of bioactive calcium compounds chosen from calcium phosphates and between 5% and 80% in total mass of bioactive silicon compounds chosen from calcium silicates and/or bioactive silica glasses and gels.
摘要翻译：本发明包括用于骨再生的新材料，其制造方法，以及在创伤手术，颌面外科，牙科手术，正面手术，牙髓学，眼科，神经外科和/或骨质疏松过程中的应用，以及需要骨再生的其它适应症。特别地，本发明结合了合成材料，它具有质量分数为20％至95％，优选为40％至90％的六钙石[Ca1-XMXHPO4，其中0≤x≤0.05，其中M可为二价金属离子 ]，并且其最终组合物以选自磷酸钙的生物活性钙化合物的质量计含有5％至80％，优选0％至60％，并且选自以下的生物活性硅化合物的总质量为5％至80％硅酸钙和/或生物活性二氧化硅玻璃和凝胶。

7. 发明授权

US08465448B2 Devices for the administration of drugs and vaccines in the form of injectable needles 失效
标题翻译：以注射针的形式管理药物和疫苗的装置
公开(公告)号：US08465448B2
公开(公告)日：2013-06-18
申请号：US12867957
申请日：2009-02-18
申请人： Arcadio Garcia De Castro Andrews
发明人： Arcadio Garcia De Castro Andrews
IPC分类号： A61M31/00 , A61M5/00 , A61M5/32
CPC分类号： A61M37/0069
摘要： The present disclosure refers to hand operated disposable devices for the administration of drugs, vaccines and other medicaments in the form of solid injectable needles. The devices incorporate mechanisms for the automatic retraction of the injection rod even when the user continues to exert pressure on the device. The devices can incorporate an injectable needle in a sheath or cartridge that facilitates its manufacture and manipulation. These injection devices can only be used once and their use results in a change of configuration that renders them non operational and prevents contact with parts that have been exposed to the patient's tissues.
摘要翻译：本公开涉及用于施用药物，疫苗和固体注射针形式的其它药物的手动一次性装置。即使用户继续对设备施加压力，这些装置也包括用于注射杆自动缩回的机构。这些装置可以将可注射针装入护套或药筒中，从而有助于其制造和操作。这些注射装置只能使用一次，它们的使用导致配置的改变，使得它们不可操作并且防止与暴露于患者组织的部件接触。

8. 发明申请

US20120269844A1 VACCINES FOR THE TREATMENT OF NEOPLASIAS FROM VIRAL CAPSIDS OF BIRNAVIRUS CONTAINING ANTIGENS OF THE HUMAN PAPILLOMAVIRUS 有权
标题翻译：用于治疗包含人类羊毛病的抗生素的病原体的神经细胞的疫苗
公开(公告)号：US20120269844A1
公开(公告)日：2012-10-25
申请号：US13504875
申请日：2010-11-05
申请人： Thomas Zurcher , Cayetano Von Kobbe , Juan J. Bernal , Ignacio Jiménez Torres , Gloria Calderita Lucas , Margarita Rodriguez Garcia , Ana Garzon Gutierrez , Virginia Gondar Sousa E Silva , Arcadio Garcia De Castro , Irene Pino De La Huerga
发明人： Thomas Zurcher , Cayetano Von Kobbe , Juan J. Bernal , Ignacio Jiménez Torres , Gloria Calderita Lucas , Margarita Rodriguez Garcia , Ana Garzon Gutierrez , Virginia Gondar Sousa E Silva , Arcadio Garcia De Castro , Irene Pino De La Huerga
IPC分类号： A61K39/12 , A61P31/20 , A61P35/00 , A61P37/04 , C07K19/00 , C12P21/02
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5258 , A61K2039/585 , C07K14/005 , C07K2319/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034 , C12N2720/10022 , C12N2720/10023
摘要： The invention relates to therapeutic vaccines for the treatment of neoplasias caused by the human papillomavirus (HPV). In particular, the vaccines of the present invention are formed by chimeric virus-like capsids of birnavirus containing papillomavirus antigens.
摘要翻译：本发明涉及用于治疗由人乳头瘤病毒（HPV）引起的肿瘤的治疗性疫苗。特别地，本发明的疫苗由含有乳头瘤病毒抗原的双鞭毛病病毒的嵌合病毒样衣壳形成。

9. 发明申请

US20110190164A1 CHIMERIC FUSION PROTEINS AND VIRUS LIKE PARTICLES FROM BIRNAVIRUS VP2 有权
标题翻译：来自BIRNAVIRUS VP2的CHIMERIC融合蛋白和病毒颗粒
公开(公告)号：US20110190164A1
公开(公告)日：2011-08-04
申请号：US12991689
申请日：2008-05-09
申请人： Thomas Zurcher , Juan Jose Bernal , Cayetano von Kobbe , Ignacio JimenezTorres , Ana Diaz Blázquez , Diana Martin Lorenzo , Gloria Calderita Lucas , Arcadio Garcia de Castro
发明人： Thomas Zurcher , Juan Jose Bernal , Cayetano von Kobbe , Ignacio JimenezTorres , Ana Diaz Blázquez , Diana Martin Lorenzo , Gloria Calderita Lucas , Arcadio Garcia de Castro
IPC分类号： C40B30/06 , C07K19/00 , C07H21/00 , C12N15/63 , C40B40/02 , C12P21/00 , C12N1/00 , C12N5/10
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5256 , A61K2039/5258 , C07K2319/40 , C12N2720/10022 , C12N2720/10023
摘要： The field of the invention refers to chimeric Virus Like Particles (VLP) derived from Birnavirus chimeric VP2 protein. In particular, the invention refers to chimeric VP2 fusion proteins which incorporate insertions and/or substitutions with one or more amino acids or particular peptide of interest while maintaining the capacity to assemble in the form of VLP. The invention identifies particular insertion and/or substitutions sites within VP2 P loop regions and outside said P loop regions. The invention also incorporates methods for the identification of preferred insertion and substitution sites within VP2 for the incorporation of particular amino acids and peptides of interest. The resulting chimeric VLP are of interest in the design of therapeutic and prophylactic vaccines as well as in the design of drug delivery systems, carriers for DNA and RNA in gene therapy, as targeted agents, in the development of antitoxins, and as diagnostic reagents.
摘要翻译：本发明的领域是指衍生自Birnavirus嵌合VP2蛋白的嵌合病毒样颗粒（VLP）。特别地，本发明涉及嵌合VP2融合蛋白，其掺入一个或多个氨基酸或特定感兴趣肽的插入和/或取代，同时保持以VLP形式组装的能力。本发明鉴定VP2P环区域内的所述P环区域内的特定插入和/或取代位点。本发明还包括用于鉴定VP2内优选的插入和取代位点以便并入特定的目的氨基酸和肽的方法。所产生的嵌合VLP在治疗和预防性疫苗的设计以及药物递送系统的设计，基因治疗中的DNA和RNA的载体，靶向剂，抗毒素的开发和诊断试剂方面都是感兴趣的。

10. 发明申请

US20110040245A1 DEVICES FOR THE ADMINISTRATION OF DRUGS AND VACCINES IN THE FORM OF INJECTABLE NEEDLES 失效
标题翻译：药剂和疫苗在注射针管形式中的管理设备
公开(公告)号：US20110040245A1
公开(公告)日：2011-02-17
申请号：US12867957
申请日：2009-02-18
申请人： Arcadio Garcia De Castro Andrews
发明人： Arcadio Garcia De Castro Andrews
IPC分类号： A61M5/50
CPC分类号： A61M37/0069
摘要： The present disclosure refers to hand operated disposable devices for the administration of drugs, vaccines and other medicaments in the form of solid injectable needles. The devices incorporate mechanisms for the automatic retraction of the injection rod even when the user continues to exert pressure on the device. The devices can incorporate an injectable needle in a sheath or cartridge that facilitates its manufacture and manipulation. These injection devices can only be used once and their use results in a change of configuration that renders them non operational and prevents contact with parts that have been exposed to the patient's tissues.
摘要翻译：本公开涉及用于施用药物，疫苗和固体注射针形式的其它药物的手动一次性装置。即使用户继续对设备施加压力，这些装置也包括用于注射杆自动缩回的机构。这些装置可以将可注射针装入护套或药筒中，从而有助于其制造和操作。这些注射装置只能使用一次，它们的使用导致配置的改变，使得它们不可操作并且防止与暴露于患者组织的部件接触。

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