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1. 发明申请

US20100196918A1 ANALYTE SENSORS, METHODS FOR PREPARING AND USING SUCH SENSORS, AND METHODS OF DETECTING ANALYTE ACTIVITY 有权
标题翻译：分析传感器，用于制备和使用这样的传感器的方法以及检测分析物活性的方法
公开(公告)号：US20100196918A1
公开(公告)日：2010-08-05
申请号：US12448101
申请日：2007-12-14
申请人： April L. Ellis , Yiming Ye , Angela Holder , Yun Huang , Michael Kirberger , Jenny Jie Yang , Jin Zou , Wei Yang
发明人： April L. Ellis , Yiming Ye , Angela Holder , Yun Huang , Michael Kirberger , Jenny Jie Yang , Jin Zou , Wei Yang
IPC分类号： G01N33/53 , C07K14/00 , C07H21/04 , C12N15/63
CPC分类号： G01N21/6486 , G01N33/542 , G01N33/84 , G01N2333/43595
摘要： Embodiments of the present disclosure provide for analyte sensors, methods for producing and using the analyte sensors, methods of detecting and/or measuring analyte activity, methods for characterizing analyte cellular activity, methods of detecting pH change in a system, method of controlling the concentration of an analyte in a system, fusion proteins, polynucleotides, and vectors corresponding to the analyte sensors, kits, and the like.
摘要翻译：本公开的实施方案提供了分析物传感器，用于生产和使用分析物传感器的方法，检测和/或测量分析物活性的方法，用于表征分析物细胞活性的方法，检测系统中pH变化的方法，控制浓度的方法的系统中的分析物，融合蛋白，多核苷酸和对应于分析物传感器，试剂盒等的载体。

2. 发明授权

US07666852B2 Wound and cutaneous injury healing with a nucleic acid encoding a proteoglycan polypeptide 失效
标题翻译：用编码蛋白聚糖多肽的核酸伤口和皮肤损伤愈合
公开(公告)号：US07666852B2
公开(公告)日：2010-02-23
申请号：US11803404
申请日：2007-05-14
申请人： Arthur A. Decarlo , John Whitelock , April L. Ellis
发明人： Arthur A. Decarlo , John Whitelock , April L. Ellis
IPC分类号： A01K63/00 , A61K48/00
CPC分类号： C07K14/4725 , A61K38/00 , A61K38/14 , A61K38/177 , A61K38/179 , A61K48/005
摘要： The present disclosure provides nucleic acid constructs encoding one or more polypeptides containing at least one glycosaminoglycan chain, such as, but not limited to, a proteoglycan polypeptide, and methods for delivering to the site of a wound or cutaneous injury at least one nucleic acid construct encoding one or more such polypeptides, such that the expressed polypeptide is glycated by glycosaminoglycan chains through the normal physiological processes of the subject at the site of administration to produce a functional proteoglycan polypeptide for the healing of the wound or other cutaneous injury. The delivered nucleic acid construct is transcribed, translated and post-translationally modified by the addition of glycosaminoglycan chains (referred herein as “decoration” or “glycation”) to produce a decorated polypeptide. The decorated polypeptide is then secreted from the cell in which it was produced to provide treatment of wounds and/or cutaneous injury in the subject and/or prevention of cutaneous injury in a subject.
摘要翻译：本公开内容提供了编码一种或多种含有至少一种糖胺聚糖链的多肽的核酸构建体，所述多肽包括但不限于蛋白聚糖多肽，以及用于将至少一种核酸构建体递送至伤口或皮肤损伤部位的方法编码一种或多种这样的多肽，使得所表达的多肽在施用部位通过受试者的正常生理过程被糖胺聚糖链糖化，以产生用于伤口愈合或其它皮肤损伤的功能性蛋白多糖多肽。递送的核酸构建体通过加入糖胺聚糖链（本文称为“装饰”或“糖基化”）被转录，翻译和翻译后修饰以产生装饰的多肽。然后将装饰的多肽从其产生的细胞分泌，以在受试者中提供伤口和/或皮肤损伤的治疗和/或预防受试者的皮肤损伤。

3. 发明授权

US08420327B2 Analyte sensors, methods for preparing and using such sensors, and methods of detecting analyte activity 有权
标题翻译：分析物传感器，制备和使用这些传感器的方法以及检测分析物活性的方法
公开(公告)号：US08420327B2
公开(公告)日：2013-04-16
申请号：US12448101
申请日：2007-12-14
申请人： April L. Ellis , Yiming Ye , Angela Holder , Yun Huang , Michael Kirberger , Jenny Jie Yang , Jin Zou , Wei Yang
发明人： April L. Ellis , Yiming Ye , Angela Holder , Yun Huang , Michael Kirberger , Jenny Jie Yang , Jin Zou , Wei Yang
IPC分类号： G01N33/53
CPC分类号： G01N21/6486 , G01N33/542 , G01N33/84 , G01N2333/43595
摘要： Embodiments of the present disclosure provide for analyte sensors, methods for producing and using the analyte sensors, methods of detecting and/or measuring analyte activity, methods for characterizing analyte cellular activity, methods of detecting pH change in a system, method of controlling the concentration of an analyte in a system, fusion proteins, polynucleotides, and vectors corresponding to the analyte sensors, kits, and the like.
摘要翻译：本公开的实施方案提供了分析物传感器，用于生产和使用分析物传感器的方法，检测和/或测量分析物活性的方法，用于表征分析物细胞活性的方法，检测系统中pH变化的方法，控制浓度的方法的系统中的分析物，融合蛋白，多核苷酸和对应于分析物传感器，试剂盒等的载体。

4. 发明申请

US20080247995A1 Wound and cutaneous injury healing with a nucleic acid encoding a proteoglycan polypeptide 失效
标题翻译：用编码蛋白聚糖多肽的核酸伤口和皮肤损伤愈合
公开(公告)号：US20080247995A1
公开(公告)日：2008-10-09
申请号：US11803404
申请日：2007-05-14
申请人： Arthur A. Decarlo , John Whitelock , April L. Ellis
发明人： Arthur A. Decarlo , John Whitelock , April L. Ellis
IPC分类号： A61K48/00 , A61K31/7088 , A61P17/02
CPC分类号： C07K14/4725 , A61K38/00 , A61K38/14 , A61K38/177 , A61K38/179 , A61K48/005
摘要： The present disclosure provides nucleic acid constructs encoding one or more polypeptides containing at least one glycosaminoglycan chain, such as, but not limited to, a proteoglycan polypeptide, and methods for delivering to the site of a wound or cutaneous injury at least one nucleic acid construct encoding one or more such polypeptides, such that the expressed polypeptide is glycated by glycosaminoglycan chains through the normal physiological processes of the subject at the site of administration to produce a functional proteoglycan polypeptide for the healing of the wound or other cutaneous injury. The delivered nucleic acid construct is transcribed, translated and post-translationally modified by the addition of glycosaminoglycan chains (referred herein as “decoration” or “glycation”) to produce a decorated polypeptide. The decorated polypeptide is then secreted from the cell in which it was produced to provide treatment of wounds and/or cutaneous injury in the subject and/or prevention of cutaneous injury in a subject.
摘要翻译：本公开内容提供了编码一种或多种含有至少一种糖胺聚糖链的多肽的核酸构建体，所述多肽包括但不限于蛋白聚糖多肽，以及用于将至少一种核酸构建体递送至伤口或皮肤损伤部位的方法编码一种或多种这样的多肽，使得所表达的多肽在施用部位通过受试者的正常生理过程被糖胺聚糖链糖化，以产生用于伤口愈合或其它皮肤损伤的功能性蛋白多糖多肽。递送的核酸构建体通过加入糖胺聚糖链（本文称为“装饰”或“糖基化”）被转录，翻译和翻译后修饰以产生装饰的多肽。然后将装饰的多肽从其产生的细胞分泌，以在受试者中提供伤口和/或皮肤损伤的治疗和/或预防受试者的皮肤损伤。

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