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1. 发明申请

US20070179535A1 Apparatus for use in the prophylaxis or treatment of tissue 有权
标题翻译：用于预防或治疗组织的装置
公开(公告)号：US20070179535A1
公开(公告)日：2007-08-02
申请号：US11525204
申请日：2006-09-22
申请人： Anthony Morrissey , Declan Soden , Gerald O'Sullivan , Christopher Collins , Colum Dunne , John Piggott , Denton Prior , Andrew Watson , Peter McGeehin
发明人： Anthony Morrissey , Declan Soden , Gerald O'Sullivan , Christopher Collins , Colum Dunne , John Piggott , Denton Prior , Andrew Watson , Peter McGeehin
IPC分类号： A61N1/00 , A61B18/18 , A61N1/30 , A61B18/04 , A61N5/06
CPC分类号： C12M35/02 , A61B18/1477 , A61B18/1492 , A61B2018/0016 , A61B2018/00291 , A61B2018/00482 , A61B2018/00494 , A61B2018/1425 , A61B2018/143 , A61B2218/002 , A61N1/0424 , A61N1/0476 , A61N1/327 , A61N5/0601 , A61N5/062
摘要： Apparatus (20) for carrying out a prophylactic or treatment procedure on tissue comprises a device (21) having a chamber (22) and at least one active element such as an electrode (23) within the chamber (22). The chamber (22) has an opening (26) through which tissue is drawn into the chamber (22). Means for drawing the tissue into the chamber may comprise a vacuum lumen with vacuum orifices (25) in the chamber (22). Treatment such as electroporation may be applied to tissue in the chamber (22).
摘要翻译：用于在组织上执行预防或治疗过程的装置（20）包括在腔室（22）内具有腔室（22）和至少一个有源元件（例如电极（23））的装置（21）。腔室（22）具有一个开口（26），组织被吸入腔室（22）中。用于将组织拉入腔室的装置可以包括在腔室（22）中具有真空孔（25）的真空腔。诸如电穿孔的治疗可以施加到腔室（22）中的组织。

2. 发明授权

US07651946B2 Wet etch processing 失效
标题翻译：湿式蚀刻处理
公开(公告)号：US07651946B2
公开(公告)日：2010-01-26
申请号：US11637020
申请日：2006-12-12
申请人： Nicolle Wilke , Anthony Morrissey
发明人： Nicolle Wilke , Anthony Morrissey
IPC分类号： H01L21/311
CPC分类号： A61M37/0015 , A61M2037/003 , A61M2037/0046 , A61M2037/0053 , B81B2201/055 , B81C1/00626 , B81C99/0065 , B81C2201/0133 , B81C2201/0138
摘要： A method of wet etching produces high-precision microneedle arrays for use in medical applications. The method achieves precise process control over microneedle fabrication, at single wafer or batch-level, using wet etching of silicon with potassium hydroxide (KOH) solution by accurately identifying the etch time endpoint. Hence, microneedles of an exactly required height, shape, sharpness and surface quality are achieved. The outcome is a reliable, reproducible, robust and relatively inexpensive microneedle fabrication process. Microneedles formed by KOH wet etching have extremely smooth surfaces and exhibit superior mechanical and structural robustness to their dry etched counterparts. These properties afford extra reliability to such silicon microneedles, making them ideal for medical applications. The needles can also be hollowed. Wet etched silicon microneedles can then be employed as masters to replicate the improved surface and structural properties in other materials (such as polymers) by moulding.
摘要翻译：湿蚀刻的方法产生用于医疗应用的高精度微针阵列。该方法通过精确地识别蚀刻时间终点，通过使用氢氧化钾（KOH）溶液对硅进行湿蚀刻，在单晶片或批次水平上实现了微针制造的精确过程控制。因此，实现了精确要求的高度，形状，锐度和表面质量的微针。结果是可靠，可重现，稳健且相对便宜的微针制作工艺。通过KOH湿蚀刻形成的微针具有非常光滑的表面，并且对其干蚀刻的对应物表现出优异的机械和结构坚固性。这些性能为这种硅微针提供了额外的可靠性，使其成为医疗应用的理想选择。针也可以是中空的。湿法蚀刻的硅微针可用作主机，通过模制复制其他材料（如聚合物）中改进的表面和结构性能。

3. 发明授权

US09549746B2 Delivery device and method 有权
标题翻译：送货装置和方法
公开(公告)号：US09549746B2
公开(公告)日：2017-01-24
申请号：US12680118
申请日：2008-09-29
申请人： A. David Woolfson , Desmond Ian John Morrow , Anthony Morrissey , Ryan F. Donnelly , Paul A. McCarron
发明人： A. David Woolfson , Desmond Ian John Morrow , Anthony Morrissey , Ryan F. Donnelly , Paul A. McCarron
IPC分类号： A61K9/70 , A61M5/32 , A61M31/00 , A61B17/20 , A61M37/00 , A61F2/848 , A61K9/00
CPC分类号： A61B17/205 , A61F2/848 , A61K9/0021 , A61M37/0015 , A61M2037/0046
摘要： A microprotrusion array for use in transport of a material across a biological barrier, wherein said array comprises a plurality of microprotusions composed of a swellable polymer composition.
摘要翻译：一种用于在生物屏障上传送材料的微量挤压阵列，其中所述阵列包括由可溶胀聚合物组合物组成的多个微型悬浮液。

4. 发明申请

US20100256064A1 DELIVERY DEVICE AND METHOD 有权
标题翻译：交付设备和方法
公开(公告)号：US20100256064A1
公开(公告)日：2010-10-07
申请号：US12680118
申请日：2008-09-29
申请人： David A. Woolfson , Desmond Ian John Morrow , Anthony Morrissey , Ryan F. Donnelly , Paul A. McCarron
发明人： David A. Woolfson , Desmond Ian John Morrow , Anthony Morrissey , Ryan F. Donnelly , Paul A. McCarron
IPC分类号： A61M37/00 , A61K31/409 , A61K31/195 , A61K38/38 , A61B5/145 , A61M25/00
CPC分类号： A61B17/205 , A61F2/848 , A61K9/0021 , A61M37/0015 , A61M2037/0046
摘要： A microprotrusion array for use in transport of a material across a biological barrier, wherein said array comprises a plurality of microprotusions composed of a swellable polymer composition.
摘要翻译：一种用于在生物屏障上传送材料的微量挤压阵列，其中所述阵列包括由可溶胀聚合物组合物组成的多个微型悬浮液。

5. 发明申请

US20070134829A1 Wet etch processing 失效
标题翻译：湿式蚀刻处理
公开(公告)号：US20070134829A1
公开(公告)日：2007-06-14
申请号：US11637020
申请日：2006-12-12
申请人： Nicolle Wilke , Anthony Morrissey
发明人： Nicolle Wilke , Anthony Morrissey
IPC分类号： H01L21/00
CPC分类号： A61M37/0015 , A61M2037/003 , A61M2037/0046 , A61M2037/0053 , B81B2201/055 , B81C1/00626 , B81C99/0065 , B81C2201/0133 , B81C2201/0138
摘要： A method of wet etching produces high-precision microneedle arrays for use in medical applications. The method achieves precise process control over microneedle fabrication, at single wafer or batch-level, using wet etching of silicon with potassium hydroxide (KOH) solution by accurately identifying the etch time endpoint. Hence, microneedles of an exactly required height, shape, sharpness and surface quality are achieved. The outcome is a reliable, reproducible, robust and relatively inexpensive microneedle fabrication process. Microneedles formed by KOH wet etching have extremely smooth surfaces and exhibit superior mechanical and structural robustness to their dry etched counterparts. These properties afford extra reliability to such silicon microneedles, making them ideal for medical applications. The needles can also be hollowed. Wet etched silicon microneedles can then be employed as masters to replicate the improved surface and structural properties in other materials (such as polymers) by moulding.
摘要翻译：湿蚀刻的方法产生用于医疗应用的高精度微针阵列。该方法通过精确地识别蚀刻时间终点，通过使用氢氧化钾（KOH）溶液对硅进行湿蚀刻，在单晶片或批次水平上实现了微针制造的精确过程控制。因此，实现了精确要求的高度，形状，锐度和表面质量的微针。结果是可靠，可重现，稳健且相对便宜的微针制作工艺。通过KOH湿蚀刻形成的微针具有非常光滑的表面，并且对其干蚀刻的对应物表现出优异的机械和结构坚固性。这些性能为这种硅微针提供了额外的可靠性，使其成为医疗应用的理想选择。针也可以是中空的。湿法蚀刻的硅微针可用作主机，通过模制复制其他材料（如聚合物）中改进的表面和结构性能。

6. 发明授权

US08545497B2 Apparatus for use in the prophylaxis or treatment of tissue 有权
标题翻译：用于预防或治疗组织的装置
公开(公告)号：US08545497B2
公开(公告)日：2013-10-01
申请号：US11525204
申请日：2006-09-22
申请人： Anthony Morrissey , Declan Soden , Gerald O'Sullivan , Christopher Collins , Colum Dunne , John Piggott , Denton A. M Prior , Andrew Watson , Peter McGeehin
发明人： Anthony Morrissey , Declan Soden , Gerald O'Sullivan , Christopher Collins , Colum Dunne , John Piggott , Denton A. M Prior , Andrew Watson , Peter McGeehin
IPC分类号： A61B18/18
CPC分类号： C12M35/02 , A61B18/1477 , A61B18/1492 , A61B2018/0016 , A61B2018/00291 , A61B2018/00482 , A61B2018/00494 , A61B2018/1425 , A61B2018/143 , A61B2218/002 , A61N1/0424 , A61N1/0476 , A61N1/327 , A61N5/0601 , A61N5/062
摘要： Apparatus (20) for carrying out a prophylactic or treatment procedure on tissue comprises a device (21) having a chamber (22) and at least one active element such as an electrode (23) within the chamber (22). The chamber (22) has an opening (26) through which tissue is drawn into the chamber (22). Means for drawing the tissue into the chamber may comprise a vacuum lumen with vacuum orifices (25) in the chamber (22). Treatment such as electroporation may be applied to tissue in the chamber (22).
摘要翻译：用于在组织上执行预防或治疗过程的装置（20）包括在腔室（22）内具有腔室（22）和至少一个有源元件（例如电极（23））的装置（21）。腔室（22）具有一个开口（26），组织被吸入腔室（22）中。用于将组织拉入腔室的装置可以包括在腔室（22）中具有真空孔（25）的真空腔。诸如电穿孔的治疗可以施加到腔室（22）中的组织。

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