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1. 发明授权

US08685961B2 Diazepan orexin receptor antagonists 有权
标题翻译：二氮杂食欲素受体拮抗剂
公开(公告)号：US08685961B2
公开(公告)日：2014-04-01
申请号：US12225506
申请日：2007-03-27
申请人： Karen M. Brashear , Paul J. Coleman , Christopher D. Cox , Anthony M. Smith , David B. Whitman
发明人： Karen M. Brashear , Paul J. Coleman , Christopher D. Cox , Anthony M. Smith , David B. Whitman
IPC分类号： A61P3/04 , A61K31/55 , C07D243/08
CPC分类号： C07D417/04 , C07D401/04 , C07D403/04 , C07D413/04 , C07D413/14
摘要： The present invention is directed to diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译：本发明涉及作为食欲肽受体的拮抗剂的二氮杂环庚烷化合物，其可用于治疗或预防涉及食欲肽受体的神经和精神病症和疾病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。

2. 发明授权

US07043715B1 Method and apparatus for customizing software 有权
标题翻译：用于定制软件的方法和装置
公开(公告)号：US07043715B1
公开(公告)日：2006-05-09
申请号：US09587783
申请日：2000-06-06
申请人： Andreas L. Bauer , Thomas M. Price , Munish T. Desai , Anthony M. Smith
发明人： Andreas L. Bauer , Thomas M. Price , Munish T. Desai , Anthony M. Smith
IPC分类号： G06F9/44
CPC分类号： G06F9/44505 , G06F8/38
摘要： There is disclosed improved apparatus and methodology for customizing software. With respect to GUI resources such as splash-screens, a dynamic link library containing a customer's customized resources and a default link library containing the manufacturer's default resources are prepared at design time. Source code is normally not included in the customized dynamic link library. At run time, the customer resources are automatically included by operation of a resource manager algorithm and appear on the computer terminal screen unless they were not made available initially in which case the equivalent default resource is shown on the screen. If there are any bugs which are induced by the customer's specifications to be corrected, or if the customized dynamic link library is changed for some other reason, the source code does not have to be rewritten as it is not included in the dynamic link library.
摘要翻译：公开了用于定制软件的改进的装置和方法。关于GUI资源（如闪屏），在设计时准备包含客户定制资源的动态链接库和包含制造商默认资源的默认链接库。源代码通常不包括在定制的动态链接库中。在运行时，通过资源管理器算法的操作自动包含客户资源，并且出现在计算机终端屏幕上，除非最初没有提供这些资源，否则在屏幕上显示相同的默认资源。如果由于客户的规范引起的任何错误被纠正，或者由于某种其他原因而改变了自定义的动态链接库，则源代码不需要重写，因为它不包括在动态链接库中。

3. 发明授权

US06358956B1 Inhibitors of prenyl-protein transferase 失效
标题翻译：异戊烯基蛋白转移酶的抑制剂
公开(公告)号：US06358956B1
公开(公告)日：2002-03-19
申请号：US09516750
申请日：2000-03-01
申请人： George D. Hartman , William C. Lumma, Jr. , John T. Sisko , Anthony M. Smith , Thomas J. Tucker , Gerald E. Stokker
发明人： George D. Hartman , William C. Lumma, Jr. , John T. Sisko , Anthony M. Smith , Thomas J. Tucker , Gerald E. Stokker
IPC分类号： A06L31295
CPC分类号： C07D233/64 , C07D401/12 , C07D405/12
摘要： The present invention comprises piperazine-containing compounds which inhibit prenyl-protein transferases, including-farnesyl-protein transferase and geranylgeranyl-protein transferase type I. Such therapeutic compounds are useful in the treatment of cancer.
摘要翻译：本发明包括抑制异戊烯基 - 蛋白质转移酶的含哌嗪化合物，包括法呢基蛋白转移酶和er牛鞭毛蛋白转移酶I型。这种治疗化合物可用于治疗癌症。

4. 发明授权

US5574044A Muscarine antagonists 失效
标题翻译：毒蕈碱拮抗剂
公开(公告)号：US5574044A
公开(公告)日：1996-11-12
申请号：US329757
申请日：1994-10-27
申请人： Wayne J. Thompson , Michael F. Sugrue , Richard W. Ransom , Pierre J. Mallorga , Ian M. Bell , Anthony M. Smith
发明人： Wayne J. Thompson , Michael F. Sugrue , Richard W. Ransom , Pierre J. Mallorga , Ian M. Bell , Anthony M. Smith
IPC分类号： C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , A61K31/445
CPC分类号： C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12
摘要： Compounds, 1,3-dihydro-1-{1-[piperidin-4-yl]piperidin-4-yl}-2H-benzimidazol-2-ones and 1,3-dihydro-1-{4-amino-1-cyclohexyl}-2H-benzimidazol-2-ones and derivatives thereof, their preparation, method of use and pharmaceutical compositions are described. These compounds are endowed with antimuscarinic activity and are useful in the treatment and/or prevention of myopia (commonly known as nearsightedness).
摘要翻译：化合物，1,3-二氢-1- {1- [哌啶-4-基]哌啶-4-基} -2H-苯并咪唑-2-酮和1,3-二氢-1- {4-氨基-1- 环己基} -2H-苯并咪唑-2-酮及其衍生物，其制备方法，使用方法和药物组合物。这些化合物具有抗毒蕈碱活性，可用于治疗和/或预防近视（俗称近视）。

5. 发明授权

US5276025A Heterobicyclic sulfonamides 失效
标题翻译：异双环磺酰胺
公开(公告)号：US5276025A
公开(公告)日：1994-01-04
申请号：US942652
申请日：1992-09-09
申请人： John J. Baldwin , Jacob M. Hoffman, Jr. , James H. Jones , Clarence S. Rooney , Anthony M. Smith
发明人： John J. Baldwin , Jacob M. Hoffman, Jr. , James H. Jones , Clarence S. Rooney , Anthony M. Smith
IPC分类号： C07D495/04 , C07D513/04 , A61K31/55
CPC分类号： C07D495/04 , C07D513/04
摘要： Compounds of general formula: ##STR1## are topically effective carbonic anhydrase inhibitors useful in the treatment of ocular hypertension and related disorders such as glaucoma.
摘要翻译：通用化合物：是局部有效的碳酸酐酶抑制剂，可用于治疗高眼压症和相关疾病如青光眼。

6. 发明授权

US4190546A Traction fluid 失效
标题翻译：牵引液
公开(公告)号：US4190546A
公开(公告)日：1980-02-26
申请号：US926233
申请日：1978-07-20
申请人： Stanley Kulik , Anthony M. Smith
发明人： Stanley Kulik , Anthony M. Smith
IPC分类号： C10M171/00 , C10M1/50 , C10M1/16 , C10M1/20
CPC分类号： C10M171/002 , C10M2203/02 , C10M2203/022 , C10M2203/024 , C10M2203/04 , C10M2203/06 , C10M2207/021 , C10M2207/04 , C10M2229/02 , C10M2229/042 , C10M2229/05 , C10N2220/02 , C10N2240/08
摘要： A traction fluid comprises from 50 to 90% wt of a naphthenic hydrocarbon or mixture of naphthenic hydrocarbons, from 8 to 40% wt of a silicone fluid and from 2 to 10% wt of a co-solvent which ensures complete miscibility between the naphthenic hydrocarbon and silicone fluid, the percentages being by weight of the three components. The silicone fluid improves the low temperature properties of the fluid without substantial damage to the good traction properties of the naphthenic hydrocarbons.Preferred co-solvents are aromatic hydrocarbons or aromatic esters.
摘要翻译：牵引流体包含50至90重量％的环烷烃或环烷烃的混合物，8至40重量％的硅氧烷流体和2至10重量％的助溶剂，其确保环烷烃之间的完全混溶性和硅氧烷流体，其百分比是三种组分的重量。硅氧烷流体改善流体的低温性能，而不会显着损害环烷烃的良好牵引性能。优选的共溶剂是芳烃或芳族酯。

7. 发明申请

US20090030043A1 Potassium Channel Inhibitors 审中-公开
标题翻译：钾通道抑制剂
公开(公告)号：US20090030043A1
公开(公告)日：2009-01-29
申请号：US12223356
申请日：2007-01-29
申请人： Jacob M. Hoffman , Anthony M. Smith , John Hartnett , Zhicai Wu , Mark T. Bilodeau
发明人： Jacob M. Hoffman , Anthony M. Smith , John Hartnett , Zhicai Wu , Mark T. Bilodeau
IPC分类号： A61K31/444 , C07D401/14
CPC分类号： C07D213/74
摘要： The present invention relates to tetraaryl methyl amine compounds and derivatives thereof having the structure (I) useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
摘要翻译：本发明涉及具有用作治疗心律失常的钾通道抑制剂的结构（I）的四芳基甲胺化合物及其衍生物等。

8. 发明授权

US06335343B1 Inhibitors of prenyl-protein transferase 失效
标题翻译：异戊烯基蛋白转移酶的抑制剂
公开(公告)号：US06335343B1
公开(公告)日：2002-01-01
申请号：US09516945
申请日：2000-03-01
申请人： William C. Lumma, Jr. , Anthony M. Smith , John T. Sisko
发明人： William C. Lumma, Jr. , Anthony M. Smith , John T. Sisko
IPC分类号： A61K31496
CPC分类号： C07D233/64 , C07D403/06
摘要： The present invention comprises piperazine/piperazinone-containing compounds having multicyclic ring system substituents on one of the piperazine/piperazinone nitrogens, which inhibit prenyl-protein transferases, including farnesyl-protein transferase and geranylgeranyl-protein transferase type I. Such therapeutic compounds are useful in the treatment of cancer.
摘要翻译：本发明包括在哌嗪/哌嗪酮氮之一上具有多环系统取代基的哌嗪/哌嗪酮化合物，其抑制异戊烯基 - 蛋白转移酶，包括法尼基蛋白转移酶和er牛儿基ger牛儿基因型I型转运酶。这种治疗化合物可用于治疗癌症。

9. 发明授权

US4947424A Shutter mechanism for telephone directory 失效
标题翻译：电话簿快门机制
公开(公告)号：US4947424A
公开(公告)日：1990-08-07
申请号：US424032
申请日：1989-10-19
申请人： Gad J. Shaanan , George V. Lenaerts , Ian D. Buchanan , Anthony M. Smith
发明人： Gad J. Shaanan , George V. Lenaerts , Ian D. Buchanan , Anthony M. Smith
IPC分类号： H04M1/2745
CPC分类号： H04M1/2745
摘要： A shutter mechanism for a telephone directory that stores telephone numbers to be dialed. The directory has physical spaces for the entry of descriptive labels (e.g. names). The shutter mechanism has a first planar surface for providing these physical spaces. It has a second planar surface overlying the first surface. The second surface is divided into alternating opaque and transparent sections such that the surface having the names can be moved underneath the second surface such that the names can be hidden by the opaque sections or revealed by the transparent sections.
摘要翻译：一种用于存储要拨打的电话号码的电话簿的快门机构。该目录具有用于描述性标签（例如名称）的输入的物理空间。快门机构具有用于提供这些物理空间的第一平面。它具有覆盖第一表面的第二平面。第二表面被分成交替的不透明部分和透明部分，使得具有名称的表面可以在第二表面下方移动，使得名称可以被不透明部分隐藏或被透明部分透露。

10. 发明授权

US07265134B2 Tyrosine kinase inhibitors 失效
公开(公告)号：US07265134B2
公开(公告)日：2007-09-04
申请号：US10486574
申请日：2002-08-13
申请人： George D. Hartman , Thomas J. Tucker , John T. Sisko , Anthony M. Smith , William C. Lumma, Jr.
发明人： George D. Hartman , Thomas J. Tucker , John T. Sisko , Anthony M. Smith , William C. Lumma, Jr.
IPC分类号： A61K31/426 , A61K31/4535 , C07D417/12 , C07D401/12 , C07D277/38
CPC分类号： C07D417/12 , A61K31/427 , A61K31/4439 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D277/48 , C07D417/14 , A61K2300/00
摘要： The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.

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