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1. 发明申请

US20080253935A1 METHODS OF MANIPULATING SMALL AMOUNTS OF SOLIDS 审中-公开
标题翻译：控制固体微量元素的方法
公开(公告)号：US20080253935A1
公开(公告)日：2008-10-16
申请号：US12143220
申请日：2008-06-20
申请人： Nathan Kane , Michael Cima , Javier Gonzalez-Zugasti , Jeanie Cherng , Anthony Lemmo , J. Richard Gyory , Wendy Pryce-Lewis , Hongming Chen
发明人： Nathan Kane , Michael Cima , Javier Gonzalez-Zugasti , Jeanie Cherng , Anthony Lemmo , J. Richard Gyory , Wendy Pryce-Lewis , Hongming Chen
IPC分类号： B01L3/02 , B01L3/00
CPC分类号： B01F3/18 , B01F7/00258 , B01F7/18 , B01F11/0065 , B01F13/0059 , B01F13/0272 , B01F13/08 , B01L3/0217 , B01L2200/0657 , G01F11/021 , G01F11/10 , G01F11/18 , G01G19/00 , G01N1/286 , G01N1/36 , G01N35/0099 , G01N2001/368 , Y10T436/2575
摘要： The invention relates to methods and apparatuses for manipulating small amounts of solids. Specific embodiments of the invention are particularly suited for the automated transfer of small amounts of solids. In one embodiment, a uniform powder bed is lightly compressed into plugs of powder and dispensed. In another embodiment, the solid is placed in a liquid carrier to form a slurry, dispensed, and the liquid component is subsequently removed. In yet another embodiment, solids are manipulated using adhesive surfaces.
摘要翻译：本发明涉及用于操作少量固体的方法和装置。本发明的具体实施方案特别适用于少量固体的自动转移。在一个实施方案中，将均匀的粉末床轻轻压缩成粉末塞并分配。在另一个实施方案中，将固体置于液体载体中以形成浆液，分配，随后除去液体组分。在另一个实施方案中，使用粘合剂表面操纵固体。

2. 发明申请

US20070105185A1 Raised surface assay plate 失效
标题翻译：升高的表面测定板
公开(公告)号：US20070105185A1
公开(公告)日：2007-05-10
申请号：US10556996
申请日：2004-05-13
申请人： Michael Cima , Wendy Pryce Lewis , Javier Gonzalez-Zugasli , J. Gyory , Anthony Lemmo , Julie Monagle
发明人： Michael Cima , Wendy Pryce Lewis , Javier Gonzalez-Zugasli , J. Gyory , Anthony Lemmo , Julie Monagle
IPC分类号： C12M1/34 , C12Q1/20
CPC分类号： B01L3/5085 , B01L3/5025 , B01L3/5088 , B01L2300/0609 , B01L2300/0819 , B01L2300/0829
摘要： The assay plate includes a substrate having an substrate surface and at least one raised pad extending from the substrate surface. The raised pad includes a substantially planar sample receiving surface configured for holding a sample thereon for in situ experimentation. The sample receiving surface preferably has at least one sharp edge at the junction between a sidewall coupling the sample receiving surface to the substrate surface. The sample receiving surface is preferably a circle, oval, square, rectangle, triangle, pentagon, hexagon, or octagon shape that is sized to hold a predetermined volume of the sample. A method of using the above described assay plate is also provided. Once a raised pad extending from a substrate is formed, a sample is deposited on the raised pad. Experiments are subsequently performed using the sample on the raised pad.
摘要翻译：测定板包括具有基底表面的基底和从基底表面延伸的至少一个凸起垫。凸起垫包括基本平坦的样品接收表面，其构造成用于将样品保持在其上用于原位实验。样品接收表面优选在将样品接收表面耦合到衬底表面的侧壁之间的接合处具有至少一个尖锐边缘。样品接收表面优选为圆形，椭圆形，正方形，矩形，三角形，五边形，六边形或八边形，其尺寸适于保持样品的预定体积。还提供了使用上述测定板的方法。一旦形成了从衬底延伸的凸起垫，则将样品沉积在凸起垫上。随后使用凸起垫上的样品进行实验。

3. 发明申请

US20060141443A1 Apparatus and method for transcellular testing 审中-公开
标题翻译：用于跨细胞测试的装置和方法
公开(公告)号：US20060141443A1
公开(公告)日：2006-06-29
申请号：US10542477
申请日：2004-01-20
申请人： J. Gyory , Michael Cima , Javier Gonzalez-Zugasti , Anthony Lemmo
发明人： J. Gyory , Michael Cima , Javier Gonzalez-Zugasti , Anthony Lemmo
IPC分类号： C12Q1/00 , C12M1/34
CPC分类号： G01N33/5008 , G01N33/502
摘要： The present invention relates to a device and method for facilitating high throughput transcellular flux testing of compounds, such as pharmaceuticals or drugs, other compounds, or compound combinations. In one embodiment, the system and methods of the present invention may be used to identify the optimal components (e.g., solvents, carriers, transport enhancers, adhesives, additives, inhibitors, or other excipients) for pharmaceutical compositions or formulations that are delivered to a patient via tissue transport, including without limitation, pharmaceutical compositions or formulations administered or delivered transcellularly, topically, and ocularly.
摘要翻译：本发明涉及促进化合物如药物或药物，其它化合物或化合物组合的高通量跨细胞通量测试的装置和方法。在一个实施方案中，本发明的系统和方法可用于鉴定用于药物组合物或制剂的最佳组分（例如，溶剂，载体，运输增强剂，粘合剂，添加剂，抑制剂或其它赋形剂）患者通过组织运输，包括但不限于药物组合物或通过跨细胞，局部和眼睛施用或递送的制剂。

4. 发明申请

US20050130220A1 Apparatus and method for high-throughput preparation and spectroscopic classification and characterization of compositions 失效
标题翻译：用于高通量制备和光谱分类和组合物表征的装置和方法
公开(公告)号：US20050130220A1
公开(公告)日：2005-06-16
申请号：US11051517
申请日：2005-01-31
申请人： Anthony Lemmo , Javier Gonzalez-Zugasti , Michael Cima , Douglas Levinson , Alasdair Johnson , Orn Almarsson , Christopher McNulty
发明人： Anthony Lemmo , Javier Gonzalez-Zugasti , Michael Cima , Douglas Levinson , Alasdair Johnson , Orn Almarsson , Christopher McNulty
IPC分类号： B01J19/00 , B01L3/14 , B01L7/00 , C12M1/34 , C12Q1/68 , C30B7/00 , C40B60/14 , C40B70/00 , G01J3/28 , G01J3/44 , G01N21/25 , G01N21/35 , G01N21/65 , G01N33/48 , G01N33/50 , G01N35/00 , G01N35/02 , G01N35/04 , G06F19/00
CPC分类号： G01N35/028 , B01J19/0046 , B01J2219/00274 , B01J2219/00283 , B01J2219/0031 , B01J2219/00335 , B01J2219/00344 , B01J2219/00495 , B01J2219/00547 , B01J2219/00587 , B01J2219/00659 , B01J2219/00689 , B01J2219/00691 , B01J2219/00756 , B01L3/5082 , B01L7/52 , B01L2300/0829 , B01L2300/0851 , B01L2300/1805 , C30B7/00 , C30B29/58 , C40B60/14 , C40B70/00 , G01J3/28 , G01N21/253 , G01N21/35 , G01N21/3563 , G01N21/65 , G01N35/0099 , G01N2021/651 , G01N2035/041 , G01N2035/042 , G01N2035/0425
摘要： Systems and methods are described that allow the high-throughput preparation, processing, and study of arrays of samples, each of which comprises at least one compound. Particular embodiments of the invention allow a large number of experiments to be performed in parallel on samples that comprised of one or more compounds on the milligram or microgram quantities of compounds. Other embodiments of the invention encompass methods and devices for the rapid screening of the results of such experiments, as well as methods and devices for rapidly determining whether or not similarities exist among groups of samples in an array. Particular embodiments of the invention encompass methods and devices for the high-throughput preparation of different forms of compounds (e.g., different crystalline forms), for the discovery of new forms of old compounds, and for the discovery of new methods of producing such forms. Embodiments of the invention also allow for the high-throughput determination of how specific compounds or forms of compounds behave when exposed to other chemicals or environmental conditions.
摘要翻译：描述了允许高通量制备，处理和研究样品阵列的系统和方法，每个样品包含至少一种化合物。本发明的具体实施方案允许在由毫克或微克数量的化合物上的一种或多种化合物组成的样品上并行进行大量实验。本发明的其它实施例包括用于快速筛选这些实验的结果的方法和装置，以及用于快速确定阵列中的样品组之间是否存在相似性的方法和装置。本发明的具体实施方案包括用于高通量制备不同形式的化合物（例如不同结晶形式）的方法和装置，用于发现新形式的旧化合物，以及发现生产此类形式的新方法。本发明的实施方案还允许高通量测定当化合物或形式的化合物在暴露于其它化学物质或环境条件时的表现。

5. 发明授权

US4078410A Pulley splitting machine 失效
标题翻译：皮带轮分裂机
公开(公告)号：US4078410A
公开(公告)日：1978-03-14
申请号：US679260
申请日：1976-04-22
申请人： Anthony Lemmo
发明人： Anthony Lemmo
IPC分类号： B21H1/04 , B21D22/16
CPC分类号： B21H1/04 , Y10T29/49458
摘要： An apparatus for manufacturing split pulleys includes a frame and a spindle assembly supported by the frame and having an upper and lower spindle for supporting for rotation a blank to be split therebetween. The lower spindle includes a clamping mechanism having a screw means for drawing the upper spindle toward the lower spindle and the lower spindle toward the upper spindle to clamp the blank to be split therebetween. Bearing means are disposed between the frame and the spindle assembly for supporting the spindle assembly for rotation. The clamping means are operative to exert a clamping force between the upper and lower spindles which is isolated from the frame and the bearing means to clamp a blank therebetween. A pair of rotatable tools are provided each of which has an axis of rotation parallel to the axis of rotation of the spindle assembly and each of which is associated with a motor means to effect rotation of the tools. The tools are operable to move relative to the blank supported by the spindle assembly to effect sequential engagement between the tools and the peripheral edge of the blank to sequentially split and form the blank. Control means is provided for controlling the speed of the spindle to match the peripheral speed of the rotating blank supported by the spindle with the peripheral speed of the tool with which it is desired to engage the blank. The control means senses the speed of the first tool to be engaged with the rotating blank and controls the speed of the spindle in response to the speed of the first tool and subsequently senses the speed of the second tool to be engaged with the blank and controls the speed of the spindle in response to the speed of the second tool. The speed control of the peripheral speed of the tools and the rotating blank prevents skidding of the tools upon initial engagement of the blank with the tools.
摘要翻译：用于制造分体皮带轮的装置包括框架和由所述框架支撑的心轴组件，并且具有用于支撑待转动的坯件的上和下心轴。下主轴包括夹紧机构，该夹紧机构具有用于将上主轴朝向下主轴和下主轴朝向上主轴拉出的夹紧机构，以夹紧待分裂的坯料。轴承装置设置在框架和主轴组件之间，用于支撑主轴组件以进行旋转。夹紧装置可操作以在与框架和轴承装置隔离的上和下主轴之间施加夹紧力，以在其间夹紧坯料。提供了一对可旋转工具，每个可旋转工具具有平行于主轴组件的旋转轴线的旋转轴线，并且每个旋转工具与电动机装置相关联以实现工具的旋转。工具可操作以相对于由主轴组件支撑的坯件移动，以实现工具与坯件的周边边缘之间的顺序接合，以顺序地分离和形成坯料。提供控制装置用于控制主轴的速度以使由主轴支撑的旋转坯料的圆周速度与期望与坯料接合的工具的圆周速度相匹配。控制装置感测第一工具与旋转坯件接合的速度，并响应于第一工具的速度控制主轴的速度，随后感测到第二工具与坯件和控制件啮合的速度主轴响应于第二工具的速度的速度。刀具和旋转毛坯的圆周速度的速度控制可以防止在坯料与工具初始啮合时刀具的打滑。

6. 发明申请

US20070020662A1 COMPUTERIZED CONTROL OF HIGH-THROUGHPUT EXPERIMENTAL PROCESSING AND DIGITAL ANALYSIS OF COMPARATIVE SAMPLES FOR A COMPOUND OF INTEREST 审中-公开
标题翻译：高效率实验处理的计算机控制和用于化合物的比较样品的数字分析
公开(公告)号：US20070020662A1
公开(公告)日：2007-01-25
申请号：US11467061
申请日：2006-08-24
申请人： Michael Cima , Douglas Levinson , Donovan Chin , Christopher McNulty , Christopher Moore , Anthony Lemmo , Javier Gonzalez-Zugasti , Alasdair Johnson , Hongming Chen , Orn Almarsson
发明人： Michael Cima , Douglas Levinson , Donovan Chin , Christopher McNulty , Christopher Moore , Anthony Lemmo , Javier Gonzalez-Zugasti , Alasdair Johnson , Hongming Chen , Orn Almarsson
IPC分类号： C12Q1/68 , G01N33/53 , G06F19/00
CPC分类号： G16C20/60 , B01J2219/007 , B01J2219/00756 , G16B15/00 , G16B35/00 , G16B40/00
摘要： The present invention relates to computer-controlled automated high-throughput systems and/or computer-program products to design, prepare, process, and analyze a large number of samples having experimental formulations each containing a compound of interest formulated with differing component combinations and varying concentrations and component identities. The computer-controlled methods of the present invention allow determination of the effects of additional or inactive components, such as excipients, carriers, enhancers, adhesives, additives, and the like, on the compound of interest, such as pharmaceuticals. The invention thus encompasses the computer systems, computer methods, and computer-program products for computer-controlled automated high-throughput testing of pharmaceutical compositions or formulations in order to determine the overall optimal composition or formulation for an intended use or purpose.
摘要翻译：本发明涉及计算机控制的自动化高通量系统和/或计算机程序产品，用于设计，制备，处理和分析大量具有实验制剂的样品，每个试样含有不同成分组合配制的感兴趣的化合物，浓度和组分特征。本发明的计算机控制方法允许确定附加或不活泼组分如赋形剂，载体，增强剂，粘合剂，添加剂等对目标化合物如药物的作用。因此，本发明包括计算机系统，计算机方法和用于药物组合物或制剂的计算机控制的自动化高通量测试的计算机程序产品，以便为预期用途或目的确定总体最佳组成或配方。

7. 发明申请

US20050191614A1 High-throughput formation, identification and analysis of diverse solid forms 审中-公开
标题翻译：高通量形成，识别和分析各种固体形式
公开(公告)号：US20050191614A1
公开(公告)日：2005-09-01
申请号：US11051698
申请日：2005-01-31
申请人： Michael Cima , Douglas Levinson , Anthony Lemmo , Nicholas Galakatos , David Putnam
发明人： Michael Cima , Douglas Levinson , Anthony Lemmo , Nicholas Galakatos , David Putnam
IPC分类号： G01N23/04 , B01J19/00 , B01L3/00 , C07B61/00 , C07B63/00 , C07C227/42 , C07C229/08 , C12Q1/00 , C30B7/00 , C40B30/04 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , G01N1/28 , G01N1/36 , G01N13/14 , G01N13/16 , G01N21/03 , G01N21/23 , G01N21/35 , G01N21/65 , G01N23/20 , G01N23/225 , G01N24/08 , G01N33/15 , G01N33/48 , G01N33/50 , G01N33/68 , G01N37/00 , G06F19/00
CPC分类号： C40B30/04 , B01J19/0046 , B01J2219/00315 , B01J2219/00351 , B01J2219/00479 , B01J2219/00495 , B01J2219/00585 , B01J2219/00587 , B01J2219/00659 , B01J2219/00702 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/00756 , B01L3/5085 , B82Y30/00 , C30B7/00 , C30B29/58 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , G01N21/23 , G01N33/6845
摘要： The invention concerns arrays of solid-forms of substances, such as compounds and rapid-screening methods therefor to identify solid-forms, particularly of pharmaceuticals, with enhanced properties. Such properties include improved bioavailability, solubility, stability, delivery, and processing and manufacturing characteristics. The invention relates to a practical and cost-effective method to rapidly screen hundreds to thousands of samples in parallel. The invention further provides methods for determining the conditions and/or ranges of conditions required to produce crystals with desired compositions, particle sizes, habits, or polymorphic forms. In a further aspect, the invention provides high-throughput methods to identify sets of conditions and/or combinations of components compatible with particular solid-forms, for example, conditions and/or components that are compatible with advantageous polymorphs of a particular pharmaceutical.
摘要翻译：本发明涉及固体形式的物质阵列，例如化合物及其快速筛选方法，用于鉴定具有增强性质的固体形式，特别是药物。这些性质包括提高的生物利用度，溶解度，稳定性，递送以及加工和制造特性。本发明涉及一种用于并行快速筛选数百到数千个样本的实用且具有成本效益的方法。本发明还提供了用于确定产生具有所需组成，粒度，习惯或多晶形式的晶体所需条件和/或范围的方法。在另一方面，本发明提供了高通量方法来鉴定与特定固体形式相容的条件组合和/或组合，例如与特定药物的有利多晶型物相容的条件和/或组分。

8. 发明授权

US10806259B2 Lounge chair with ergonomic features 有权
公开(公告)号：US10806259B2
公开(公告)日：2020-10-20
申请号：US16300074
申请日：2017-05-10
申请人： Anthony Lemmo
发明人： Anthony Lemmo
IPC分类号： A47C4/00 , A47C4/20 , A47C17/64 , A47C1/024 , A47C3/04 , A47C4/28 , A47C1/03 , A47C1/14 , A47C7/62
摘要： A lounge chair includes a frame including an upper body section, and a lower body section, a support section and support material. The upper body section is operatively coupled to the lower body section to pivot between a plurality of angular positions. The upper body section includes an aperture extending through the support material to receive the face of an individual when lying in a supine position. The lower body section is operatively coupled to the support section with an anterior tilt. The lounge chair includes armrests which pivot incrementally between a plurality of angular positions in a direction transverse, parallel or both transverse and parallel to a plane of a side member of the lower body section.

9. 发明申请

US20190150619A1 LOUNGE CHAIR WITH ERGONOMIC FEATURES 审中-公开
公开(公告)号：US20190150619A1
公开(公告)日：2019-05-23
申请号：US16300074
申请日：2017-05-10
申请人： Anthony Lemmo
发明人： Anthony Lemmo
IPC分类号： A47C1/024 , A47C4/28 , A47C1/03 , A47C1/14
CPC分类号： A47C1/024 , A47C1/03 , A47C1/143 , A47C3/04 , A47C4/28 , A47C7/62 , A47C7/624
摘要： A lounge chair includes a frame including an upper body section, and a lower body section, a support section and support material. The upper body section is operatively coupled to the lower body section to pivot between a plurality of angular positions. The upper body section includes an aperture extending through the support material to receive the face of an individual when lying in a supine position. The lower body section is operatively coupled to the support section with an anterior tilt. The lounge chair includes armrests which pivot incrementally between a plurality of angular positions in a direction transverse, parallel or both transverse and parallel to a plane of a side member of the lower body section.

10. 发明授权

US07449342B2 Methods of manipulating small amounts of solids 失效
标题翻译：操作少量固体的方法
公开(公告)号：US07449342B2
公开(公告)日：2008-11-11
申请号：US10700146
申请日：2003-11-03
申请人： Nathan Kane , Michael Cima , Javier Gonzalez-Zugasti , Jeanie Cherng , Anthony Lemmo , J. Richard Gyory
发明人： Nathan Kane , Michael Cima , Javier Gonzalez-Zugasti , Jeanie Cherng , Anthony Lemmo , J. Richard Gyory
IPC分类号： G01N1/10 , B65H5/00
CPC分类号： B01F3/18 , B01F7/00258 , B01F7/18 , B01F11/0065 , B01F13/0059 , B01F13/0272 , B01F13/08 , B01L3/0217 , B01L2200/0657 , G01F11/021 , G01F11/10 , G01F11/18 , G01G19/00 , G01N1/286 , G01N1/36 , G01N35/0099 , G01N2001/368 , Y10T436/2575
摘要： The invention relates to methods and apparatuses for manipulating small amounts of solids. Specific embodiments of the invention are particularly suited for the automated transfer of small amounts of solids. In one embodiment, a uniform powder bed is lightly compressed into plugs of powder and dispensed. In another embodiment, the solid is placed in a liquid carrier to form a slurry, dispensed, and the liquid component is subsequently removed. In yet another embodiment, solids are manipulated using adhesive surfaces.
摘要翻译：本发明涉及用于操作少量固体的方法和装置。本发明的具体实施方案特别适用于少量固体的自动转移。在一个实施方案中，将均匀的粉末床轻轻压缩成粉末塞并分配。在另一个实施方案中，将固体置于液体载体中以形成浆液，分配，随后除去液体组分。在另一个实施方案中，使用粘合剂表面操纵固体。

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