专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08137688B2 Hydroxyphenyl cross-linked macromolecular network and applications thereof 有权
标题翻译：羟基苯基交联大分子网络及其应用
公开(公告)号：US08137688B2
公开(公告)日：2012-03-20
申请号：US12380469
申请日：2009-02-27
申请人： Peter A. Zahos , Anthony Calabro , Aniq B. Darr , Richard A. Gross
发明人： Peter A. Zahos , Anthony Calabro , Aniq B. Darr , Richard A. Gross
IPC分类号： C08G63/91 , C08G65/48 , A61K31/775
CPC分类号： A61K31/775 , A61L27/20 , A61L27/50 , A61L27/52 , A61L2400/06 , A61L2430/38 , C08B37/0069 , C08B37/0072 , C08L5/08 , C08L2205/02 , C12P19/04 , C08L2666/26
摘要： A synthetic nucleus pulposus is provided that is useful in treatment of degenerative disc disease, augmentation of a degenerate disc, and alleviation of back pain. In an embodiment the synthetic nucleus pulposus comprises hyaluronan macromolecules that have been cross-linked via dihydroxyphenyl linkages. The synthetic nucleus pulposus restores or improves the water-retention capability of the disc. A method of treating an intervertebral disc with the cross-linked hyaluronan macromolecules is also provided. A method of regenerative therapy to address loss of cells of nucleus pulposus of an intervertebral disc based on treatment with the cross-linked hyaluronan macromolecules and mesenchymal stem cells is also provided.
摘要翻译：提供了一种合成髓核，可用于治疗退行性椎间盘疾病，增加退行性椎间盘，减轻背部疼痛。在一个实施方案中，合成髓核包含已经通过二羟基苯基键交联的透明质酸大分子。合成髓核恢复或提高椎间盘的保水能力。还提供了用交联的透明质酸大分子治疗椎间盘的方法。还提供了一种基于用交联透明质酸大分子和间充质干细胞治疗来解决椎间盘髓核的细胞损失的再生治疗方法。

2. 发明申请

US20050265959A1 Hydroxyphenyl cross-linked macromolecular network and applications thereof 有权
标题翻译：羟基苯基交联大分子网络及其应用
公开(公告)号：US20050265959A1
公开(公告)日：2005-12-01
申请号：US11198803
申请日：2005-08-05
申请人： Anthony Calabro , Richard Gross , Aniq Darr
发明人： Anthony Calabro , Richard Gross , Aniq Darr
IPC分类号： A61K31/74 , A61K31/765 , A61K47/34 , A61K47/36 , A61K47/42 , A61L27/14 , A61L27/52 , C08F261/02 , C08G63/48 , C08G63/81 , C08G63/91 , C08G73/02 , C08L71/00 , C12Q20060101
CPC分类号： A61L27/52 , A61K47/34 , A61K47/36 , A61K47/42 , A61L27/14 , C08G63/81 , C08G73/02 , C08J3/075 , C08L101/14
摘要： A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, such as artificial or synthetic cartilage. The network is made by first providing a polyamine or polycarboxylate macromolecule (having a plurality of amine or carboxylic acid groups respectively attached along the length of the molecule), reacting this macromolecule with a hydroxyphenyl compound having a free carboxylic acid group in the case of a polyamine or a free primary amine group in the case of a polycarboxylate, and substituting the hydroxyphenyl compound onto the macromolecule via a carbodiimide-mediated reaction pathway to provide a hydroxyphenyl-substituted macromolecule. This macromolecule is then linked to other such macromolecules via an enzyme catalyzed dimerization reaction between two hydroxyphenyl groups attached respectively to different macromolecules under metabolic conditions of temperature and pH. In a preferred embodiment, the macromolecular network is made up of tyramine-substituted hyaluronan molecules that are linked by dityramine bonds to provide a stable, coherent hydrogel with desired physical properties. A method of preparing such a network is also provided.
摘要翻译：提供二羟基苯基交联的大分子网络，其可用于人造或组织工程应用，例如人造或合成软骨。通过首先提供多胺或多羧酸盐大分子（沿着分子长度分别具有多个胺或羧酸基团）制备网络，使该高分子与具有游离羧酸基团的羟基苯基化合物反应多胺或游离的伯胺基，并且通过碳二亚胺介导的反应途径将羟基苯基化合物取代到大分子上以提供羟基苯基取代的大分子。然后通过在温度和pH值的代谢条件下分别连接到不同的大分子上的两个羟基苯基之间的酶催化的二聚反应将该大分子连接到其它这样的大分子。在优选的实施方案中，大分子网络由酪胺取代的透明质酸分子组成，其通过二苯胺键连接以提供具有所需物理性质的稳定的，连贯的水凝胶。还提供了一种制备这种网络的方法。

3. 发明授权

US5551259A Adjustable ear clip 失效
标题翻译：可调式耳夹
公开(公告)号：US5551259A
公开(公告)日：1996-09-03
申请号：US437574
申请日：1995-05-09
申请人： Anthony Calabro
发明人： Anthony Calabro
IPC分类号： A44C7/00
CPC分类号： A44C7/006 , Y10T24/44504
摘要： An adjustable ear clip device for relieving pressure on the ear lobe of a wearer is provided. The adjustable ear clip includes a base member with a pair of spaced ears connected thereto. An angled stop plate is connected to the base plate and a mounting plate is connected to the angled stop plate to receive an ornamental member. An ear engaging member includes a pair of spring-biased arms for engaging the ears. A spring tongue is positioned between the arms and has a stop bolt aperture therethrough. A stop bolt is threaded through the spring tongue and engages with the angled stop plate to limit the travel of the ear engaging member toward the ornamental member.
摘要翻译：提供了用于缓解佩戴者耳垂上的压力的可调式耳夹装置。可调节的耳夹包括具有连接到其上的一对隔开的耳朵的基座构件。倾斜的止动板连接到基板，并且安装板连接到成角度的止动板以接收装饰构件。耳朵接合构件包括用于接合耳朵的一对弹簧偏压臂。弹簧舌片位于臂之间并且具有穿过其中的止动螺栓孔。止动螺栓穿过弹簧舌片并与成角度的止动板接合以限制耳朵接合构件朝向装饰构件的行进。

4. 发明申请

US20150032293A1 SYSTEM AND METHOD FOR REMOTE CONTROL OF UNMANNED VEHICLES 有权
标题翻译：远程控制无人机的系统和方法
公开(公告)号：US20150032293A1
公开(公告)日：2015-01-29
申请号：US14044136
申请日：2013-10-02
申请人： Trevor O'Neill , Samuel Reeves , Joshua Koplin , Anthony Calabro , Nathan Bivans , Erik de Brun , Scott Poff , Richard Derman
发明人： Trevor O'Neill , Samuel Reeves , Joshua Koplin , Anthony Calabro , Nathan Bivans , Erik de Brun , Scott Poff , Richard Derman
IPC分类号： B60W50/029 , B60W50/00 , B60W30/18
CPC分类号： G05D1/0276 , B25J13/006 , B60L11/1803 , B60L15/40 , B60W30/18 , B60W50/00 , B60W50/029 , B60W2050/0292 , B61L3/00 , B61L23/00 , B61L23/005 , B61L23/34 , F41H11/16 , G05B19/048 , G05B2219/23471 , G05D1/00 , G05D1/0022 , G05D1/0038 , G05D1/0077 , G05D1/0088 , G05D3/00 , G05D2201/0202 , H02P6/00 , Y10S901/01
摘要： An open architecture control system is provided that may be used for remote and semi-autonomous operation of commercial off the shelf (COTS) and custom robotic systems, platforms, and vehicles to enable safer neutralization of explosive hazards and other services. In order to effectively deal with rapidly evolving threats and highly variable operational environments, the control system is built using an open architecture and includes a high level of interoperability. The control system interfaces with a large range of robotic systems and vehicles, autonomy software packages, perception systems, and manipulation peripherals to enable prosecution of complex missions effectively. Because the control system is open and does not constrain the end user to a single robotics system, mobile platform, or peripheral hardware and software, the control system may be used to assist with a multitude of missions beyond explosive hazard detection and clearance.
摘要翻译：提供一种开放式架构控制系统，可用于远程和半自主运行商业现货（COTS）和定制机器人系统，平台和车辆，以更安全地中和爆炸危险和其他服务。为了有效应对快速变化的威胁和高度可变的操作环境，控制系统采用开放式架构构建，并具有高度的互操作性。控制系统与大范围的机器人系统和车辆，自主软件包，感知系统和操纵外围设备相接合，以有效地起诉复杂的任务。由于控制系统是开放式的并且不将最终用户限制在单个机器人系统，移动平台或外围硬件和软件上，所以可以使用控制系统来协助超出爆炸危险检测和清除的众多任务。

5. 发明申请

US20090274678A1 Compositions and methods to treat urinary incontinence 有权
标题翻译：治疗尿失禁的组成和方法
公开(公告)号：US20090274678A1
公开(公告)日：2009-11-05
申请号：US12387256
申请日：2009-04-30
申请人： Anthony Calabro , Aniq B. Darr , Firouz Daneshgari
发明人： Anthony Calabro , Aniq B. Darr , Firouz Daneshgari
IPC分类号： A61K38/44 , A61K38/39 , A61P13/00 , A61K33/40
CPC分类号： A61K38/39 , A61L31/044 , A61L2400/06
摘要： A method is disclosed for treatment of urinary incontinence. The method includes the steps of providing to a person or animal, in the vicinity of a pubo-urethral ligament of the person or animal, a composition including collagen macromolecules that have hydroxyphenyl side groups substituted thereon, which are reacted to form dihydroxyphenyl linkages. In an embodiment, the collagen macromolecules are gelatin macromolecules. In another embodiment, the hydroxyphenyl side groups are tyramine side groups and the dihydroxyphenyl linkages are dityramine linkages. The composition can be injected into a space between a urethra and a pubis of the person or animal wherein the pubo-urethral ligament is disposed in the space. The method is advantageous, for example, based on being minimally invasive.
摘要翻译：公开了一种治疗尿失禁的方法。该方法包括以下步骤：向人或动物在人或动物的尿道韧带附近提供包含其上被羟基苯基侧基取代的胶原大分子的组合物，其被反应以形成二羟基苯基键。在一个实施方案中，胶原大分子是明胶大分子。在另一个实施方案中，羟基苯基侧基是酪胺侧基，二羟基苯基键是二联苯胺键。组合物可以注射到尿道和人或动物的耻骨之间的空间中，其中尿道 - 尿道韧带设置在该空间中。该方法是有利的，例如，基于微创。

6. 发明申请

US20090204227A1 Molecular enhancement of extracellular matrix and methods of use 有权
标题翻译：细胞外基质的分子增强和使用方法
公开(公告)号：US20090204227A1
公开(公告)日：2009-08-13
申请号：US12378296
申请日：2009-02-13
申请人： Kathleen Anne Derwin , Joseph Patrick Iannotti , LiKang Chin , Anthony Calabro
发明人： Kathleen Anne Derwin , Joseph Patrick Iannotti , LiKang Chin , Anthony Calabro
IPC分类号： A61F2/02 , A61B17/08
CPC分类号： A61F2/08 , A61B17/1146 , A61L27/3633 , A61L27/48 , C08L89/00 , C08L5/08
摘要： A composition comprising a human- or animal-derived extracellular matrix and a macromolecular network which is prepared ex vivo is provided that is useful in the repair of a tissue injury, particularly in repair of tears or gaps between a tendon and a bone, such as in a rotator cuff tear. In an embodiment, the composition comprises a human- or animal-derived extracellular matrix having impregnated therein a macromolecular network of hyaluronan macromolecules that have been cross-linked via dihydroxyphenyl linkages, so that the cross-linked network is interlocked within the extracellular matrix. The resulting HA-incorporated extracellular matrix can be supplied in the form of a patch to reinforce a tissue repair or cover a tissue defect.
摘要翻译：提供了包含人或动物衍生的细胞外基质和离体制备的大分子网络的组合物，其可用于修复组织损伤，特别是修复腱和骨之间的泪液或间隙，例如在肩袖撕裂。在一个实施方案中，组合物包含其中浸渍有通过二羟基苯基键交联的透明质酸大分子的大分子网络的人或动物衍生的细胞外基质，使得交联网络在细胞外基质内互锁。所得到的HA结合的细胞外基质可以以补片的形式提供，以加强组织修复或覆盖组织缺损。

7. 发明申请

US20090143766A1 Hydroxyphenyl cross-linked macromolecular network and applications thereof 有权
标题翻译：羟基苯基交联大分子网络及其应用
公开(公告)号：US20090143766A1
公开(公告)日：2009-06-04
申请号：US12320613
申请日：2009-01-29
申请人： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukumachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
发明人： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukumachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
IPC分类号： A61M37/00 , A61L27/52
CPC分类号： C08B37/0072 , A61K47/6903 , C08G73/02 , C08H1/00 , C08J3/24 , C08J3/246 , C12N5/0068 , C12N5/0655 , C12N2533/30
摘要： A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.
摘要翻译：提供了可用于人造组织和组织工程应用的二羟基苯基交联的大分子网络，特别是提供用于各种组织类型的合成大分子网络。特别地，描述人造或合成软骨，声带材料，玻璃体材料，软组织材料和二尖瓣材料。在一个实施方案中，网络由酪胺取代和交联的透明质酸分子组成，其中通过可以在体内进行的过氧化物酶介导的二联胺连接来实现交联。二联苯键提供具有所需物理性质的稳定的，一致的透明质酸基水凝胶。

8. 发明授权

US07368502B2 Hydroxyphenyl cross-linked macromolecular network and applications thereof 有权
标题翻译：羟基苯基交联大分子网络及其应用
公开(公告)号：US07368502B2
公开(公告)日：2008-05-06
申请号：US11198803
申请日：2005-08-05
申请人： Anthony Calabro , Richard A. Gross , Aniq B. Darr
发明人： Anthony Calabro , Richard A. Gross , Aniq B. Darr
IPC分类号： C08L89/00 , C08G63/48
CPC分类号： A61L27/52 , A61K47/34 , A61K47/36 , A61K47/42 , A61L27/14 , C08G63/81 , C08G73/02 , C08J3/075 , C08L101/14
摘要： A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, such as artificial or synthetic cartilage. The network is made by first providing a polyamine or polycarboxylate macromolecule (having a plurality of amine or carboxylic acid groups respectively attached along the length of the molecule), reacting this macromolecule with a hydroxyphenyl compound having a free carboxylic acid group in the case of a polyamine or a free primary amine group in the case of a polycarboxylate, and substituting the hydroxyphenyl compound onto the macromolecule via a carbodiimide-mediated reaction pathway to provide a hydroxyphenyl-substituted macromolecule. This macromolecule is then linked to other such macromolecules via an enzyme catalyzed dimerization reaction between two hydroxyphenyl groups attached respectively to different macromolecules under metabolic conditions of temperature and pH. In a preferred embodiment, the macromolecular network is made up of tyramine-substituted hyaluronan molecules that are linked by dityramine bonds to provide a stable, coherent hydrogel with desired physical properties. A method of preparing such a network is also provided.
摘要翻译：提供二羟基苯基交联的大分子网络，其可用于人造或组织工程应用，例如人造或合成软骨。通过首先提供多胺或多羧酸盐大分子（沿着分子长度分别具有多个胺或羧酸基团）制备网络，使该高分子与具有游离羧酸基团的羟基苯基化合物反应多胺或游离的伯胺基，并且通过碳二亚胺介导的反应途径将羟基苯基化合物取代到大分子上以提供羟基苯基取代的大分子。然后通过在温度和pH值的代谢条件下分别连接到不同大分子上的两个羟基苯基之间的酶催化的二聚反应将该大分子连接到其它这样的大分子。在优选的实施方案中，大分子网络由酪胺取代的透明质酸分子组成，其通过二苯胺键连接以提供具有所需物理性质的稳定的，连贯的水凝胶。还提供了一种制备这种网络的方法。

9. 发明授权

US08658593B2 Treatment of extracellular matrix to reduce inflammation 有权
标题翻译：细胞外基质的治疗以减少炎症
公开(公告)号：US08658593B2
公开(公告)日：2014-02-25
申请号：US13489974
申请日：2012-06-06
申请人： Anthony Calabro , Mark Lauer , Vincent Hascall
发明人： Anthony Calabro , Mark Lauer , Vincent Hascall
IPC分类号： A61K47/00 , A61P19/00 , A61P29/00
CPC分类号： A61K31/728 , A61K38/1709 , A61K38/191 , A61K2300/00
摘要： Pharmaceutical compositions are provided. The compositions comprise a compound comprising the hyaluronan-containing structure A-(low molecular weight hyaluronan domain)-B. The compositions also comprise a pharmaceutically acceptable excipient. A is hydrogen, a substituent that does not comprise a binding site for tumor necrosis factor stimulated gene-6 (“TSG-6”) protein, a substituent that interferes with binding of TSG-6 protein immediately adjacent thereto, or chondroitin. B is hydroxyl, a substituent that does not comprise a binding site for TSG-6 protein, a substituent that interferes with binding of TSG-6 protein immediately adjacent thereto, or chondroitin. The composition is suitable for administration by injection, inhalation, topical rub, or ingestion. Also disclosed are methods and kits for treating a site of inflammation in an individual in need thereof and for decreasing heavy chain modification of pathological hyaluronan at a site of inflammation in an individual in need thereof based on administering the compounds or the compositions.
摘要翻译：提供药物组合物。组合物包含含有透明质酸的结构A-（低分子量透明质酸结构域）-B的化合物。组合物还包含药学上可接受的赋形剂。 A是氢，不包含肿瘤坏死因子刺激的基因-6（“TSG-6”）蛋白的结合位点的取代基，干扰与其相邻的TSG-6蛋白的结合的取代基或软骨素。 B是羟基，不包含TSG-6蛋白的结合位点，干扰与其紧邻的TSG-6蛋白的结合的取代基或软骨素的取代基。该组合物适用于通过注射，吸入，局部擦拭或摄入进行给药。还公开了用于治疗有需要的个体的炎症部位的方法和试剂盒，并且基于施用化合物或组合物，减少有需要的个体的炎症部位的病理性透明质酸的重链修饰。

10. 发明授权

US07465766B2 Hydroxyphenyl cross-linked macromolecular network and applications thereof 有权
标题翻译：羟基苯基交联大分子网络及其应用
公开(公告)号：US07465766B2
公开(公告)日：2008-12-16
申请号：US11176544
申请日：2005-07-07
申请人： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
发明人： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
IPC分类号： C08L89/00 , C08G63/48
CPC分类号： C08B37/0072 , A61K47/6903 , C08G73/02 , C08H1/00 , C08J3/24 , C08J3/246 , C12N5/0068 , C12N5/0655 , C12N2533/30
摘要： A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic, implantable tissue matrix material for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.
摘要翻译：提供了可用于人造组织和组织工程应用的二羟基苯基交联的大分子网络，特别是提供用于各种组织类型的合成的，可植入的组织基质材料。特别地，描述人造或合成软骨，声带材料，玻璃体材料，软组织材料和二尖瓣材料。在一个实施方案中，网络由酪胺取代和交联的透明质酸分子组成，其中通过可以在体内进行的过氧化物酶介导的二联胺连接来实现交联。二联苯键提供具有所需物理性质的稳定的，一致的透明质酸基水凝胶。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式