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1. 发明授权

US07351821B2 Oxabispidine compounds useful in the treatment of cardiac arrhythmias 失效
标题翻译：可用于治疗心律失常的替比沙星化合物
公开(公告)号：US07351821B2
公开(公告)日：2008-04-01
申请号：US11640417
申请日：2006-12-18
申请人： Annika Björe , Magnus Björsne , David Cladingboel , Kurt-Jürgen Hoffmann , John Pavey , Fritiof Pontén , Gert Strandlund , Peder Svensson , Colin Thomson , Michael Wilsterman
发明人： Annika Björe , Magnus Björsne , David Cladingboel , Kurt-Jürgen Hoffmann , John Pavey , Fritiof Pontén , Gert Strandlund , Peder Svensson , Colin Thomson , Michael Wilsterman
IPC分类号： C07D265/36 , C07D498/02
CPC分类号： C07D498/08
摘要： There is provided compounds of formula I, wherein R1, R2, R3, R4, R41 to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.
摘要翻译：提供式I化合物，其中R 1，R 2，R 3，R 4，R 4，R 4， A，B和G具有描述中给出的含义，其可用于预防和治疗心律失常，特别是心房和室性心律失常。

2. 发明授权

US07217708B2 3,7-Diazabicyclo [3.3.1] formulations as anti-arrhythmic compounds 失效
标题翻译： 3,7-二氮杂双环[3.3.1]制剂作为抗心律失常化合物
公开(公告)号：US07217708B2
公开(公告)日：2007-05-15
申请号：US10474592
申请日：2002-04-12
申请人： Neil Barnwell , Annika Björe , Lal Cheema , David Cladingboel , Adam Herring , Karin Lövqvist
发明人： Neil Barnwell , Annika Björe , Lal Cheema , David Cladingboel , Adam Herring , Karin Lövqvist
IPC分类号： C07D498/08 , A61K31/5386
CPC分类号： C07D498/08
摘要： There is provided substantially crystalline forms of 4-({3-[7-(3,3-dimethyl-2-oxobutyl) -9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl]propyl}amino)benzo-nitrile; tert-butyl 2 -{7-[3-(4-cyanoanilino)propyl]-9-oxa-3,7-diazabicyclo-[3.3.1]non-3-yl}ethylcarbamate; tert-butyl 2-{7-[4-(4-cyanophenyl)butyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethylcarbamate; or tert-butyl 2-{7-[2S)-3-(4-cyanophenoxy)-2-hydroxypropyl]-9-oxa-3,7-diazabicyclo-[3.3.1]non-3-yl}ethylcarbamate and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of cardiac arhythmias.
摘要翻译：提供4 - （{3- [7-（3,3-二甲基-2-氧代丁基）-9-氧杂-3,7-二氮杂双环[3.3.1]壬-3-基]丙基} 氨基）苯并 - 腈; 2- {7- [3-（4-氰基苯胺基）丙基] -9-氧杂-3,7-二氮杂双环[3.3.1]壬-3-基}乙基氨基甲酸叔丁酯; 2- {7- [4-（4-氰基苯基）丁基] -9-氧杂-3,7-二氮杂双环[3.3.1]壬-3-基}乙基氨基甲酸叔丁酯; 或2- {7- [2S）-3-（4-氰基苯氧基）-2-羟丙基] -9-氧杂-3,7-二氮杂双环[3.3.1]壬-3-基}乙基氨基甲酸叔丁酯和药学上其可接受的盐，其可用于治疗心律失常。

3. 发明授权

US06492382B1 Dried or frozen pharmaceutical preparation containing a class III antiarrhythmic compound 失效
标题翻译：含有III类抗心律失常药物的干燥或冷冻药物制剂
公开(公告)号：US06492382B1
公开(公告)日：2002-12-10
申请号：US09423200
申请日：1999-11-03
申请人： Annika Björe , Anna-Karin Granath
发明人： Annika Björe , Anna-Karin Granath
IPC分类号： A61K31439
CPC分类号： C07D471/08 , A61K9/19 , A61K31/439 , Y10S514/821
摘要： The present invention relates to dried preparations containing a class III antiarrhythmic compound in the form of a crystalline or amorphous salt or any combination thereof, where the counterion is selected from pharmaceutically acceptable water-soluble organic or inorganic acids. The present invention also relates to frozen preparations containing a class III antiarrhythmic compound in the form of a salt solution, where the counterion is selected from pharmaceutically acceptable water-soluble organic or inorganic acids. Preferred preparations contain a salt of the compound 3,7-diazabicyclo[3.3.1]-nonane-3-carboxylic acid, 7-[(2S)-3-(4-cyanophenoxy)-2-hydroxypropyl]-1,1-dimethylethyl ester (Compound A). Further aspects of the present invention include salts of Compound A per se, processes for preparing the preparations, as well as use of the preparations for prophylaxis and/or treatment of cardiac arrhytmia.
摘要翻译：本发明涉及含有结晶或无定形盐或其任何组合形式的III类抗心律失常化合物的干燥制剂，其中抗衡离子选自药学上可接受的水溶性有机酸或无机酸。本发明还涉及含有盐溶液形式的III类抗心律失常化合物的冷冻制剂，其中抗衡离子选自药学上可接受的水溶性有机酸或无机酸。优选的制剂含有化合物3,7-二氮杂双环[3.3.1] - 壬烷-3-羧酸，7 - [（2S）-3-（4-氰基苯氧基）-2-羟丙基] 二甲基乙基酯（化合物A）。本发明的其它方面包括化合物A本身的盐，制备方法，以及用于预防和/或治疗心脏性心律的制剂。

4. 发明授权

US07928225B2 Oxabispidine compounds for the treatment of cardiac arrhythmias 有权
标题翻译：用于治疗心律失常的替比泊星化合物
公开(公告)号：US07928225B2
公开(公告)日：2011-04-19
申请号：US11917195
申请日：2006-06-12
申请人： Annika Björe , David Cladingboel , Gareth Ensor , Adam Herring , Johan Kajanus , Robert Lundqvist , Christina Olsson , Carl-Gustav Sigfridsson , Gert Strandlund
发明人： Annika Björe , David Cladingboel , Gareth Ensor , Adam Herring , Johan Kajanus , Robert Lundqvist , Christina Olsson , Carl-Gustav Sigfridsson , Gert Strandlund
IPC分类号： C07D265/36 , C07D498/02 , A61K31/535
CPC分类号： C07D498/08 , C07C255/54 , C07C309/73
摘要： There is provided compounds of formula I, wherein R1, R2, R3, R41 to R46, X, Y and Z have meanings given in the description, which compounds are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.
摘要翻译：提供式I化合物，其中R 1，R 2，R 3，R 41至R 46，X，Y和Z具有描述中给出的含义，哪些化合物可用于预防和治疗心律失常，特别是心房和心室心律失常

5. 发明授权

US07772229B2 Oxabispidine compounds useful in the treatment of cardiac arrhythmias 失效
标题翻译：可用于治疗心律失常的替比沙星化合物
公开(公告)号：US07772229B2
公开(公告)日：2010-08-10
申请号：US11385833
申请日：2006-03-22
申请人： Annika Björe , Magnus Björsne , Kurt-Jürgen Hoffmann , Fritiof Pontėn , Gert Strandlund , Peder Svensson , Michael Wilsterman
发明人： Annika Björe , Magnus Björsne , Kurt-Jürgen Hoffmann , Fritiof Pontėn , Gert Strandlund , Peder Svensson , Michael Wilsterman
IPC分类号： A61K31/535 , C07D265/36
CPC分类号： C07D498/08
摘要： There is provided compounds of formula I, wherein R1, R2, R3, R4, R41 to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.
摘要翻译：提供式I化合物，其中R 1，R 2，R 3，R 4，R 41至R 46，A，B和G具有描述中给出的含义，其可用于预防和治疗心律失常，特别是心房和室性心律失常。

6. 发明授权

US06559143B1 Oxabispidine compounds useful in the treatment of cardiac arrhyythmias 失效
标题翻译：可用于治疗心律失常的Oxabispidine化合物
公开(公告)号：US06559143B1
公开(公告)日：2003-05-06
申请号：US09688251
申请日：2000-10-16
申请人： Annika Björe , Magnus Björsne , Kurt-Jürgen Hoffmann , Fritiof Pontén , Gert Strandlund , Peder Svensson , Michael Wilsterman
发明人： Annika Björe , Magnus Björsne , Kurt-Jürgen Hoffmann , Fritiof Pontén , Gert Strandlund , Peder Svensson , Michael Wilsterman
IPC分类号： A61K31535
CPC分类号： C07D498/08
摘要： There is provided compounds of formula I, wherein R1, R2, R3, R4, R41 to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.
摘要翻译：提供式I化合物，其中R 1，R 2，R 3，R 4，R 41至R 46，A，B和G具有描述中给出的含义，其可用于预防和治疗心律失常，特别是心房和室性心律失常。

7. 发明授权

US06291475B1 Bispidine antiarrhythmic compounds 失效
标题翻译：二甲苯抗心律失常药
公开(公告)号：US06291475B1
公开(公告)日：2001-09-18
申请号：US09214756
申请日：1999-01-12
申请人： Christer Alstermark , Annika Björe , Magnus Björsne , Marianne Frantsi , Torbjörn Halvarsson , Kurt-Jürgen Hoffmann , Eva-Lotte Lindstedt , Magnus Polla , Gert Strandlund
发明人： Christer Alstermark , Annika Björe , Magnus Björsne , Marianne Frantsi , Torbjörn Halvarsson , Kurt-Jürgen Hoffmann , Eva-Lotte Lindstedt , Magnus Polla , Gert Strandlund
IPC分类号： A61K31439
CPC分类号： C07D471/08
摘要： There is provided a compound of formula I, wherein R1, R2, R9, R10, R11, R12, X, A and B have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.
摘要翻译：提供式I化合物，其中R 1，R 2，R 9，R 10，R 11，R 12，X，A和B具有在描述中给出的含义，其可用于预防和治疗心律失常，特别是心房和室性心律失常。

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