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1. 发明授权

US07041454B2 Genomic sequence of the purH gene and purH-related biallelic markers 失效
公开(公告)号：US07041454B2
公开(公告)日：2006-05-09
申请号：US10376893
申请日：2003-02-27
申请人： Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Annick Cohen-Akenine
发明人： Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Annick Cohen-Akenine
IPC分类号： C07H21/04 , C12Q1/68
CPC分类号： C12N9/10 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172 , G01N2500/10
摘要： The invention concerns the genomic sequence of the purH gene. The invention also concerns biallelic markers of a purH gene and the association established between these markers and cancer, particularly prostate cancer. The invention provides means to determine the predisposition of individuals to cancer as well as means for the diagnosis of cancer and for the prognosis/detection of an eventual treatment response to agents acting on cancer.

2. 发明授权

US07427482B2 Methods of assessing the risk for the development of sporadic prostate cancer 失效
标题翻译：评估散发性前列腺癌发展风险的方法
公开(公告)号：US07427482B2
公开(公告)日：2008-09-23
申请号：US11285466
申请日：2005-11-22
申请人： Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Annick Cohen-Akenine
发明人： Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Annick Cohen-Akenine
IPC分类号： C07H21/04 , C12Q1/68
CPC分类号： C12N9/10 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172 , G01N2500/10
摘要： The invention concerns the genomic sequence of the purH gene. The invention also concerns biallelic markers of a purH gene and the association established between these markers and cancer, particularly prostate cancer. The invention provides means to determine the predisposition of individuals to cancer as well as means for the diagnosis of cancer and for the prognosis/detection of an eventual treatment response to agents acting on cancer.
摘要翻译：本发明涉及purH基因的基因组序列。本发明还涉及purH基因的双重标记和这些标记与癌症之间建立的关联，特别是前列腺癌。本发明提供了确定个体对癌症的易感性以及用于诊断癌症的手段以及用于对作用于癌症的药剂的最终治疗反应的预后/检测的手段。

3. 发明申请

US20080168574A1 NOVEL BAP28 GENE AND PROTEIN 失效
标题翻译：新型BAP28基因和蛋白质
公开(公告)号：US20080168574A1
公开(公告)日：2008-07-10
申请号：US11776964
申请日：2007-07-12
申请人： Caroline Barry , Lydie Bougueleret , Ilya Chumakov , Annick Cohen-Akenine
发明人： Caroline Barry , Lydie Bougueleret , Ilya Chumakov , Annick Cohen-Akenine
IPC分类号： A01K67/027 , C07H21/04 , C40B40/06 , C12Q1/68 , C07K16/18 , C07K2/00 , C12N15/63 , C12N5/06
CPC分类号： C07K14/4702 , A01K2217/075 , C07K14/4748 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172
摘要： The present invention is directed to BAP28 polypeptides. BAP28 cDNA sequences encoding BAP28 polypeptides, to the genomic DNA sequence of the BAP28 gene as well as to regulatory regions located at the 5′- and 3′-ends of the BAP28 coding region. The invention also deals with antibodies directed specifically against such polypeptides that are useful as diagnostic reagents. The invention further encompasses biallelic markers of the BAP28 gene useful in genetic analysis. The invention concerns an association of the BAP28-related biallelic markers with prostate cancer. Therefore, the invention contemplates the diagnostic and treatment methods of prostate cancer.
摘要翻译：本发明针对BAP28多肽，编码BAP28多肽的BAP28 cDNA序列与BAP28基因的基因组DNA序列以及位于BAP28编码区的5'和3'端的调节区。本发明还涉及针对可用作诊断试剂的这种多肽的抗体。本发明还包括可用于遗传分析的BAP28基因的双重标记。本发明涉及BAP28相关双倍体标记物与前列腺癌的关联。因此，本发明考虑了前列腺癌的诊断和治疗方法。

4. 发明申请

US20050158788A1 Methods, software and apparati for identifying genomic regions harboring a gene associated with a detectable trait 审中-公开
标题翻译：方法，软件和装置，用于鉴定携带可检测性状相关基因的基因组区域
公开(公告)号：US20050158788A1
公开(公告)日：2005-07-21
申请号：US11048148
申请日：2005-02-01
申请人： Nicholas Schork , Laurent Essioux , Annick Cohen-Akenine , Marta Blumenfeld , Daniel Cohen
发明人： Nicholas Schork , Laurent Essioux , Annick Cohen-Akenine , Marta Blumenfeld , Daniel Cohen
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/68 , G01N33/566 , G06F17/30 , G06F19/18 , G06F19/22 , G06F19/24 , G06F19/00 , G01N33/48 , G01N33/50
CPC分类号： C12Q1/6827 , G16B20/00 , G16B30/00 , G16B40/00
摘要： The present invention relates to methods, software, and apparati for determining whether a genomic region harbors a gene associated with a detectable trait. In one embodiment, the present invention relates to a method of confirming that a genomic region harbors a gene associated with a detectable trait comprising the steps of identifying a candidate genomic region suspected of harboring the gene associated with the detectable trait, constructing a trait-associated distribution of association values using the biallelic markers in the candidate genomic region, identifying a plurality of biallelic markers in random genomic regions which are not suspected of harboring the gene associated with the detectable trait, constructing a random distribution of association values using the biallelic markers in the random genomic regions, comparing the trait-associated distribution of association values to the random distribution of association values, and determining whether the trait-associated distribution of association values and the random distribution of association values are significantly different from one another. In other embodiments, the present invention comprises software for performing the above method and devices comprising the software in a retrievable form.
摘要翻译：本发明涉及用于确定基因组区域是否包含与可检测特征相关的基因的方法，软件和装置。在一个实施方案中，本发明涉及一种确认基因组区域包含与可检测性状相关的基因的方法，其包括以下步骤：鉴定疑似携带可检测性状相关基因的候选基因组区域，构建与性状相关在候选基因组区域中使用双重标记的关联值的分布，鉴定不怀疑携带与可检测性状相关的基因的随机基因组区域中的多个双重标记，使用双重标记物建立关联值的随机分布随机基因组区域，将关联值的性状相关分布与关联值的随机分布进行比较，以及确定关联值的性状相关分布和关联值的随机分布是否彼此显着不同。在其他实施例中，本发明包括用于执行上述方法的软件和包括可检索形式的软件的装置。

5. 发明授权

US06544737B1 Genomic sequence of the purH gene and purH-related biallelic markers 失效
公开(公告)号：US06544737B1
公开(公告)日：2003-04-08
申请号：US09536059
申请日：2000-03-23
申请人： Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Annick Cohen-Akenine
发明人： Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Annick Cohen-Akenine
IPC分类号： C12Q168
CPC分类号： C12N9/10 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172 , G01N2500/10
摘要： The invention concerns the genomic sequence of the purH gene. The invention also concerns biallelic markers of a purH gene and the association established between these markers and cancer, particularly prostate cancer. The invention provides means to determine the predisposition of individuals to cancer as well as means for the diagnosis of cancer and for the prognosis/detection of an eventual treatment response to agents acting on cancer.

6. 发明申请

US20060040304A1 Biallelic markers related to genes involved in drug metabolism 审中-公开
公开(公告)号：US20060040304A1
公开(公告)日：2006-02-23
申请号：US11204311
申请日：2005-08-15
申请人： Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Annick Cohen-Akenine
发明人： Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Annick Cohen-Akenine
IPC分类号： C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/6888 , C12Q1/6827 , C12Q1/6876 , C12Q2600/158
摘要： The invention provides polynucleotides including biallelic markers derived from genes involved in the biotransformation of xenobiotics such as drugs and from genomic regions flanking those genes. Primers hybridizing to regions flanking these biallelic markers are also provided. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype.

7. 发明授权

US06291182B1 Methods, software and apparati for identifying genomic regions harboring a gene associated with a detectable trait 失效
标题翻译：方法，软件和装置，用于鉴定携带可检测性状相关基因的基因组区域
公开(公告)号：US06291182B1
公开(公告)日：2001-09-18
申请号：US09438016
申请日：1999-11-10
申请人： Nicholas J. Schork , Laurent Essioux , Annick Cohen-Akenine , Marta Blumenfeld , Daniel Cohen
发明人： Nicholas J. Schork , Laurent Essioux , Annick Cohen-Akenine , Marta Blumenfeld , Daniel Cohen
IPC分类号： C12Q168
CPC分类号： G06F19/18 , C12Q1/6827 , G06F19/22 , G06F19/24
摘要： The present invention relates to methods, software, and apparati for determining whether a genomic region harbors a gene associated with a detectable trait. In one embodiment, the present invention relates to a method of confirming that a genomic region harbors a gene associated with a detectable trait comprising the steps of identifying a candidate genomic region suspected of harboring the gene associated with the detectable trait, constructing a trait-associated distribution of association values using the biallelic markers in the candidate genomic region, identifying a plurality of biallelic markers in random genomic regions which are not suspected of harboring the gene associated with the detectable trait, constructing a random distribution of association values using the biallelic markers in the random genomic regions, comparing the trait-associated distribution of association values to the random distribution of association values, and determining whether the trait-associated distribution of association values and the random distribution of association values are significantly different from one another. In other embodiments, the present invention comprises software for performing the above method and devices comprising the software in a retrievable form.
摘要翻译：本发明涉及用于确定基因组区域是否包含与可检测特征相关的基因的方法，软件和装置。在一个实施方案中，本发明涉及一种确认基因组区域包含与可检测性状相关的基因的方法，其包括以下步骤：鉴定疑似携带可检测性状相关基因的候选基因组区域，构建与性状相关在候选基因组区域中使用双重标记的关联值的分布，鉴定不怀疑携带与可检测性状相关的基因的随机基因组区域中的多个双重标记，使用双重标记物建立关联值的随机分布随机基因组区域，将关联值的性状相关分布与关联值的随机分布进行比较，以及确定关联值的性状相关分布和关联值的随机分布是否彼此显着不同。在其他实施例中，本发明包括用于执行上述方法的软件和包括可检索形式的软件的装置。

8. 发明授权

US07998671B2 Methods of detecting prostate cancer using BAP28-related biallelic markers 失效
标题翻译：使用BAP28相关双标记检测前列腺癌的方法
公开(公告)号：US07998671B2
公开(公告)日：2011-08-16
申请号：US11776964
申请日：2007-07-12
申请人： Caroline Barry , Lydie Bougueleret , Ilya Chumakov , Annick Cohen-Akenine
发明人： Caroline Barry , Lydie Bougueleret , Ilya Chumakov , Annick Cohen-Akenine
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C07K14/4702 , A01K2217/075 , C07K14/4748 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172
摘要： The present invention is directed to BAP28 polypeptides. BAP28 cDNA sequences encoding BAP28 polypeptides, to the genomic DNA sequence of the BAP28 gene as well as to regulatory regions located at the 5′- and 3′-ends of the BAP28 coding region. The invention also deals with antibodies directed specifically against such polypeptides that are useful as diagnostic reagents. The invention further encompasses biallelic markers of the BAP28 gene useful in genetic analysis. The invention concerns an association of the BAP28-related biallelic markers with prostate cancer. Therefore, the invention contemplates the diagnostic and treatment methods of prostate cancer.
摘要翻译：本发明针对BAP28多肽，编码BAP28多肽的BAP28 cDNA序列与BAP28基因的基因组DNA序列以及位于BAP28编码区的5'和3'端的调节区。本发明还涉及针对可用作诊断试剂的这种多肽的抗体。本发明还包括可用于遗传分析的BAP28基因的双重标记。本发明涉及BAP28相关双倍体标记物与前列腺癌的关联。因此，本发明考虑了前列腺癌的诊断和治疗方法。

9. 发明申请

US20060073512A1 Genomic sequence of the purH gene and purH-related biallelic markers 失效
公开(公告)号：US20060073512A1
公开(公告)日：2006-04-06
申请号：US11285466
申请日：2005-11-22
申请人： Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Annick Cohen-Akenine
发明人： Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Annick Cohen-Akenine
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12N9/10 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172 , G01N2500/10
摘要： The invention concerns the genomic sequence of the purH gene. The invention also concerns biallelic markers of a purH gene and the association established between these markers and cancer, particularly prostate cancer. The invention provides means to determine the predisposition of individuals to cancer as well as means for the diagnosis of cancer and for the prognosis/detection of an eventual treatment response to agents acting on cancer.

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