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1. 发明申请

US20120107371A1 STIMULI-RESPONSIVE SYSTEMS FOR CONTROLLED DRUG DELIVERY 有权
标题翻译：用于控制药物递送的刺激性系统
公开(公告)号：US20120107371A1
公开(公告)日：2012-05-03
申请号：US13301049
申请日：2011-11-21
申请人： Todd C. Zion , Andrey Zarur , Jackie Y. Ying
发明人： Todd C. Zion , Andrey Zarur , Jackie Y. Ying
IPC分类号： A61K38/28 , A61P5/48 , A61K9/14 , B82Y5/00
CPC分类号： A61K9/5161 , A61K9/06 , A61K9/5192 , A61K47/36 , A61K47/61 , Y02A50/473
摘要： A method of delivering a therapeutic agent by providing a cross-linked polymer encapsulating the therapeutic agent to a site in a patient. The degradation rate of the cross-linked polymer is correlated with a local concentration of an indicator, and the therapeutic agent is released as the cross-linked polymer degrades.
摘要翻译：通过将包封治疗剂的交联聚合物提供给患者的部位来递送治疗剂的方法。交联聚合物的降解速率与指示剂的局部浓度相关，并且随着交联聚合物降解，治疗剂释放。

2. 发明申请

US20050277187A1 Creation of shear in a reactor 审中-公开
标题翻译：在反应堆中产生剪切
公开(公告)号：US20050277187A1
公开(公告)日：2005-12-15
申请号：US11147416
申请日：2005-06-07
申请人： Timothy Johnson , Bernardo Aumond , Brian Benoit , George Vella , Seth Rodgers , Andrey Zarur
发明人： Timothy Johnson , Bernardo Aumond , Brian Benoit , George Vella , Seth Rodgers , Andrey Zarur
IPC分类号： B01F13/00 , B01F13/08 , B01J19/00 , B01L3/00 , C12M1/02 , C12M1/06 , C12M1/12
CPC分类号： B01F13/005 , B01F9/08 , B01F13/0052 , B01F13/0054 , B01F13/0055 , B01F13/0059 , B01F13/0098 , B01F13/0818 , B01F13/0827 , B01J2219/00488 , B01J2219/00605 , B01J2219/00621 , B01L3/5025 , B01L3/5027 , B01L3/50273 , B01L3/502746 , B01L2300/0877 , B01L2300/0887 , C12M23/16 , C12M23/24 , C12M35/04
摘要： An apparatus for performing a biological or biochemical reaction that, in certain embodiments, has the ability to apply shear stress to a component of a liquid sample and includes a biological or biochemical reactor comprising a container having a volume of less than about 2 mL and containing a liquid sample, and a shear-generating element, the shear-generating element being contained within the apparatus and constructed and arranged so that the entire shear-generating element moves along a selected path of motion intersecting a first location within the apparatus and a second location within the apparatus, with or without rotational movement is described. A method of applying shear stress to a component of a liquid sample that includes moving a liquid or gaseous shear-generating element within an apparatus along a selected path of motion to create a reproducible and controllable level of shear stress at a selected location within the liquid sample is also disclosed.
摘要翻译：一种用于进行生物或生物化学反应的装置，其在某些实施方案中具有向液体样品的组分施加剪切应力的能力，并且包括生物或生物化学反应器，其包含体积小于约2mL的容器并且含有液体样品和剪切产生元件，所述剪切产生元件被包含在所述设备内并被构造和布置成使得整个剪切产生元件沿着与所述设备内的第一位置相交的运动的选定路径移动，并且第二描述了具有或不具有旋转运动的装置内的位置。将剪切应力施加到液体样品的组分的方法，其包括沿着选定的运动路径移动装置内的液体或气体剪切产生元件，以在液体内的选定位置产生可再现和可控的剪切应力水平样品也被披露。

3. 发明申请

US20050106714A1 Rotatable reactor systems and methods 审中-公开
标题翻译：可旋转反应器系统和方法
公开(公告)号：US20050106714A1
公开(公告)日：2005-05-19
申请号：US10927789
申请日：2004-08-27
申请人： Andrey Zarur , Todd Basque , Derek Stevens , Nicholas Flannery , Seth Rodgers , A. Russo , Scott Miller , Ian MacGregor
发明人： Andrey Zarur , Todd Basque , Derek Stevens , Nicholas Flannery , Seth Rodgers , A. Russo , Scott Miller , Ian MacGregor
IPC分类号： B01L3/00 , C12M1/34 , C12M1/36 , C12Q1/02 , G01N21/47 , G01N21/63 , G01N21/64 , G01N21/77 , G01N33/50 , G01N33/543 , G01N33/84 , C12M3/00
CPC分类号： G01N33/84 , B01J2219/00317 , B01J2219/00704 , B01J2219/00743 , B01L3/5025 , B01L3/5027 , B01L3/502723 , B01L2200/0668 , B01L2200/12 , B01L2300/0654 , B01L2300/0861 , B01L2300/163 , B01L2300/1838 , B01L2400/046 , B01L2400/0487 , C12M23/16 , C12Q1/02 , G01N21/47 , G01N21/64 , G01N21/648 , G01N21/7703 , G01N33/5005 , G01N33/54373 , G01N2021/635
摘要： The present invention generally relates to chips, particularly microfluidic chips, that are rotatable and/or have a generally circular or rotationally symmetric geometry. The chips may be substantially planar in certain instances. In some cases, the chips of the invention can have more than one reaction site, which can, for example, contain cells. The reaction site can be very small, in some cases with a volume of less than about 1 ml. Reactions, transport, and/or other manipulations within the chip can be facilitated by rotating the chip, for example, at tens, hundreds or thousands of revolutions per minute (RPM). In some cases, data may also be written to and/or read from the chip. The chips of the invention can be used, for example, to move fluid from one portion of a chip to another, to concentrate and/or separate a mixture (e.g., a cell suspension), to lyse or fractionate a cell, or the like.
摘要翻译：本发明通常涉及可旋转和/或具有大致圆形或旋转对称几何形状的芯片，特别是微流体芯片。在某些情况下，芯片可能基本上是平面的。在一些情况下，本发明的芯片可以具有多于一个反应位点，其可以例如含有细胞。反应位点可以非常小，在一些情况下体积小于约1ml。芯片内的反应，运输和/或其他操作可以通过例如以数十，数百或数千转/分钟（RPM）旋转芯片来实现。在某些情况下，数据也可能被写入和/或从芯片读取。本发明的芯片可以用于例如将流体从芯片的一部分移动到另一部分，以浓缩和/或分离混合物（例如，细胞悬液），以将细胞裂解或分馏等。

4. 发明申请

US20070015276A1 Fluid transfer device 审中-公开
标题翻译：流体输送装置
公开(公告)号：US20070015276A1
公开(公告)日：2007-01-18
申请号：US11474050
申请日：2006-06-23
申请人： Sean LeBlanc , Ian MacGregor , Bernardo Aumond , George Vella , A. Russo , Seth Rodgers , Andrey Zarur
发明人： Sean LeBlanc , Ian MacGregor , Bernardo Aumond , George Vella , A. Russo , Seth Rodgers , Andrey Zarur
IPC分类号： C12M3/00 , A61M31/00
CPC分类号： B01L3/0275 , B01L2200/026 , B01L2200/027 , B01L2200/0689 , B01L2300/044 , B01L2300/0672 , B01L2300/0681
摘要： Fluid transfer devices described herein can include a body portion and a tip portion. A fluid pathway extends through the body and tip portions through which fluid may be transferred, for example, from a fluid-dispensing apparatus to a fluidic chamber of a microreactor. In some embodiments, the fluid transfer device is connected to the fluid-dispensing apparatus with an engaging element. The engaging element may be part of the body, and can enable the dispensing apparatus to repeatedly engage the body at one predetermined position. The body is capable of storing the fluid received from the dispensing apparatus. The tip portion may be formed of a rigid material (e.g., a metal), and/or may be configured to repeatedly pierce a septum without damaging either the tip or the body. Advantageously, in certain embodiments, the fluid transfer device can controllably transfer small volumes of fluid (e.g., 1 μL) with a high degree of accuracy.
摘要翻译：本文所述的流体输送装置可以包括主体部分和尖端部分。流体通道延伸穿过主体和尖端部分，流体可通过该尖端部分例如从流体分配装置传送到微反应器的流体室。在一些实施例中，流体输送装置用接合元件连接到流体分配装置。接合元件可以是主体的一部分，并且能够使得分配装置能够在一个预定位置反复地接合身体。身体能够存储从分配装置接收的流体。尖端部分可以由刚性材料（例如，金属）形成，和/或可以构造成反复刺穿隔膜而不损坏尖端或者身体。有利地，在某些实施方案中，流体转移装置可以高度准确地可控地传递小体积的流体（例如，1μl）。

5. 发明申请

US20050026273A1 Reactor with memory component 审中-公开
标题翻译：具有内存组件的电抗器
公开(公告)号：US20050026273A1
公开(公告)日：2005-02-03
申请号：US10863636
申请日：2004-06-07
申请人： Andrey Zarur , Ian MacGregor , Todd Basque , Seth Rodgers , A. Russo , Sean Leblanc
发明人： Andrey Zarur , Ian MacGregor , Todd Basque , Seth Rodgers , A. Russo , Sean Leblanc
IPC分类号： B01J19/00 , B01L3/00 , C40B40/10 , C40B70/00 , G01N35/00 , C12M1/36
CPC分类号： B01L3/5027 , B01J19/0046 , B01J2219/0031 , B01J2219/00315 , B01J2219/00317 , B01J2219/00364 , B01J2219/00376 , B01J2219/00387 , B01J2219/00389 , B01J2219/00479 , B01J2219/00495 , B01J2219/00542 , B01J2219/00545 , B01J2219/00549 , B01J2219/00563 , B01J2219/00565 , B01J2219/00585 , B01J2219/00659 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00704 , B01J2219/00725 , B01J2219/00743 , B01L3/545 , B01L2300/021 , B01L2300/022 , B01L2300/024 , B01L2300/0806 , B01L2300/0816 , B01L2400/046 , C40B40/10 , C40B70/00 , G01N35/0099
摘要： The present invention provides techniques for conveniently and reliably storing and/or retrieving data associated with a chemical, biological, or biochemical chip, reactor, or reaction system. The data can pertain to the reactor; to chemical, biological, or biochemical species introduced into, taken from, or otherwise associated with the reactor; to conditions to which the reactor and/or some or all of its contents has been, is being, or will be exposed to, or the like. Various aspects of the present invention relate to memory and data storage components suitable for use in chips or other reaction systems. These components may include silicon integrated circuits, magnetic media, optical media, radio-frequency tags, smart cards, bar-codes and other kinds of data storage devices. The chip may contain a reaction site having a volume of less than about 2 ml. In some embodiments, the chip may be constructed in such a way as to be able to support a living cell. The chip may be used for imaging or analysis, or the chip may be used to facilitate a chemical or biological reaction, which may be light-sensitive or light-activated in certain cases. Other facilitated reactions may include the production and/or consumption of a chemical or biological species. In some embodiments, the chip may include more than one component or component type, and/or more than one reaction site.
摘要翻译：本发明提供了用于方便和可靠地存储和/或检索与化学，生物或生物化学芯片，反应器或反应系统相关的数据的技术。数据可以与反应堆有关; 化学，生物或生物化学物质引入，取自或以其他方式与反应器相关; 反应器和/或其一部分或全部内容物已经或将要暴露于或类似物的条件。本发明的各个方面涉及适用于芯片或其他反应系统的存储器和数据存储组件。这些组件可以包括硅集成电路，磁介质，光介质，射频标签，智能卡，条形码和其他种类的数据存储设备。芯片可以含有体积小于约2ml的反应位点。在一些实施例中，芯片可以以能够支撑活细胞的方式构造。该芯片可以用于成像或分析，或者芯片可以用于促进在某些情况下可能是光敏感或光激活的化学或生物反应。其他促进反应可能包括化学或生物物种的生产和/或消费。在一些实施方案中，芯片可以包括多于一种组分或组分类型和/或多于一个的反应位点。

6. 发明申请

US20090275115A1 MICROREACTOR 审中-公开
公开(公告)号：US20090275115A1
公开(公告)日：2009-11-05
申请号：US12347579
申请日：2008-12-31
申请人： Andrey Zarur Jury , Mark D. Angelino
发明人： Andrey Zarur Jury , Mark D. Angelino
IPC分类号： C12M3/00
CPC分类号： B01F13/0064 , B01F5/0256 , B01F5/061 , B01F5/0646 , B01F5/0647 , B01F13/0094 , B01F15/00935 , B01F2005/0621 , B01J19/0093 , B01J2219/00783 , B01J2219/00828 , B01J2219/00835 , B01J2219/00862 , B01J2219/00871 , B01J2219/00873 , B01J2219/00889 , B01J2219/00907 , B01J2219/00957 , B01J2219/00961 , B01J2219/00963 , B01J2219/00966 , C12M23/16
摘要： Chemical and biological reactors, including microreactors, are provided. Exemplary reactors include a plurality of reactors operable in parallel, where each reactor has a small volume and, together, the reactors produce a large volume of product. Reaction systems can include mixing chambers, heating/dispersion units, reaction chambers, and separation units. Components of the reactors can be readily formed from a variety of materials. For example, they can be etched from silicon. Components are connectable to and separable from each other to form a variety of types of reactors, and the reactors can be attachable to and separable from each other to add significant flexibility in parallel and/or series reactor operation.
摘要翻译：提供化学和生物反应堆，包括微反应器。示例性反应器包括可并行操作的多个反应器，其中每个反应器具有小体积，并且一起反应器产生大体积的产物。反应系统可以包括混合室，加热/分散单元，反应室和分离单元。反应器的组分可以容易地由各种材料形成。例如，它们可以从硅上蚀刻。组件可彼此连接并可分离以形成各种类型的反应器，并且反应器可以彼此附接和分离，以在并联和/或串联反应器操作中增加显着的灵活性。

7. 发明授权

US07485454B1 Microreactor 失效
标题翻译：微反应器
公开(公告)号：US07485454B1
公开(公告)日：2009-02-03
申请号：US09707852
申请日：2000-11-07
申请人： Andrey Zarur Jury , Mark D. Angelino
发明人： Andrey Zarur Jury , Mark D. Angelino
IPC分类号： C12M1/12
CPC分类号： B01F13/0064 , B01F5/0256 , B01F5/061 , B01F5/0646 , B01F5/0647 , B01F13/0094 , B01F15/00935 , B01F2005/0621 , B01J19/0093 , B01J2219/00783 , B01J2219/00828 , B01J2219/00835 , B01J2219/00862 , B01J2219/00871 , B01J2219/00873 , B01J2219/00889 , B01J2219/00907 , B01J2219/00957 , B01J2219/00961 , B01J2219/00963 , B01J2219/00966 , C12M23/16
摘要： Chemical and biological reactors, including microreactors, are provided. Exemplary reactors include a plurality of reactors operable in parallel, where each reactor has a small volume and, together, the reactors produce a large volume of product. Reaction systems can include mixing chambers, heating/dispersion units, reaction chambers, and separation units. Components of the reactors can be readily formed from a variety of materials. For example, they can be etched from silicon. Components are connectable to and separable from each other to form a variety of types of reactors, and the reactors can be attachable to and separable from each other to add significant flexibility in parallel and/or series reactor operation.
摘要翻译：提供化学和生物反应堆，包括微反应器。示例性反应器包括可并行操作的多个反应器，其中每个反应器具有小体积，并且一起反应器产生大体积的产物。反应系统可以包括混合室，加热/分散单元，反应室和分离单元。反应器的组分可以容易地由各种材料形成。例如，它们可以从硅上蚀刻。组件可彼此连接并可分离以形成各种类型的反应器，并且反应器可以彼此附接和分离，以在并联和/或串联反应器操作中增加显着的灵活性。

8. 发明申请

US20070099292A1 Reactor systems having a light-interacting component 审中-公开
标题翻译：具有光相互作用组分的反应器系统
公开(公告)号：US20070099292A1
公开(公告)日：2007-05-03
申请号：US11584343
申请日：2006-10-20
申请人： Scott Miller , Sean LeBlanc , Seth Rodgers , Andrey Zarur
发明人： Scott Miller , Sean LeBlanc , Seth Rodgers , Andrey Zarur
IPC分类号： C12M1/34
CPC分类号： B01L3/502715 , B01L2200/025 , B01L2300/0654 , B01L2300/0829 , B01L2300/0887 , B01L2300/12 , B01L2400/046 , G01N2021/0346
摘要： Various aspects of the present invention relate to light-interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like. If waveguides are used, they may be fashioned out of any material able to transmit light to or from the reaction site. The chip may contain a reaction site having a volume of less than about 1 ml. In some embodiments, the chip may be constructed in such a way as to be able to support a living cell. The chip may be used for imaging or analysis, or the chip may be used to facilitate a chemical or biological reaction, which may be light-sensitive or light-activated in certain cases. Other facilitated reactions may include the production or consumption of a chemical or biological species. In some embodiments, the chip may include more than one component or component type, or more than one reaction site.
摘要翻译：本发明的各个方面涉及适用于芯片和其它反应器系统的光相互作用组件。这些组件可以包括波导，光纤，光源，光电检测器，光学元件等。如果使用波导，则它们可以从能够将光透射到反应位点的任何材料形成。芯片可以含有体积小于约1ml的反应位点。在一些实施例中，芯片可以以能够支撑活细胞的方式构造。该芯片可以用于成像或分析，或者芯片可以用于促进在某些情况下可能是光敏感或光激活的化学或生物反应。其他促进反应可能包括化学或生物物种的生产或消费。在一些实施方案中，芯片可以包括多于一种组分或组分类型，或多于一个反应位点。

9. 发明申请

US20050032204A1 Microreactor architecture and methods 审中-公开
标题翻译：微反应器结构和方法
公开(公告)号：US20050032204A1
公开(公告)日：2005-02-10
申请号：US10664067
申请日：2003-09-16
申请人： Seth Rodgers , Andrey Zarur , A. Russo , Sean Leblanc , Xinyu Li , Howard Schreyer
发明人： Seth Rodgers , Andrey Zarur , A. Russo , Sean Leblanc , Xinyu Li , Howard Schreyer
IPC分类号： C12M1/34 , C12Q1/20
CPC分类号： B01L3/5027 , B01L2200/028 , B01L2300/0874 , B01L2300/0877 , B01L2300/0887 , B01L2400/046
摘要： The present invention generally relates to chemical, biological, and/or biochemical reactor chips and other reaction systems such as microreactor systems, as well as systems and methods for constructing and using such devices. In one aspect, a chip or other reaction system may be constructed so as to promote cell growth within it. In certain embodiments, the chips or other reaction systems of the invention include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In one aspect of the invention, a chip is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO2 concentration, O2 concentration, relative humidity, pH, etc. associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In another aspect, the present invention is directed to materials and systems having humidity and/or gas control, for example, for use with a chip. Such materials may have high oxygen permeability and/or low water vapor permeability. The present invention, in still another aspect, generally relates to light-interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.
摘要翻译：本发明一般涉及化学，生物和/或生化反应堆芯片和其他反应系统，例如微反应器系统，以及用于构建和使用这些装置的系统和方法。在一个方面，可以构建芯片或其它反应系统，以促进细胞内的细胞生长。在某些实施方案中，本发明的芯片或其它反应体系包括一个或多个反应位点。反应位点可以非常小，例如，体积小于约1ml。在本发明的一个方面，芯片能够检测，测量和/或控制与一个或多个反应位点相关联的环境因素例如温度，压力，CO 2浓度，O 2浓度，相对湿度，pH等，通过使用一个或多个传感器，致动器，处理器和/或控制系统。在另一方面，本发明涉及具有例如用于芯片的湿度和/或气体控制的材料和系统。这样的材料可以具有高氧渗透性和/或低水蒸汽渗透性。在另一方面，本发明通常涉及适用于芯片和其它反应器系统的光相互作用组分。这些组件可以包括波导，光纤，光源，光电检测器，光学元件等。

10. 发明授权

US06413489B1 Synthesis of nanometer-sized particles by reverse micelle mediated techniques 失效
公开(公告)号：US06413489B1
公开(公告)日：2002-07-02
申请号：US09060733
申请日：1998-04-15
申请人： Jackie Y. Ying , Andrey Zarur
发明人： Jackie Y. Ying , Andrey Zarur
IPC分类号： C01F716
CPC分类号： B82Y30/00 , B01J13/0056 , B01J23/02 , B01J23/10 , B01J23/34 , B01J35/002 , B01J35/1019 , B01J35/1023 , B01J35/1061 , B01J37/033 , C01B13/328 , C01F7/168 , C01P2002/01 , C01P2002/34 , C01P2004/03 , C01P2004/32 , C01P2004/52 , C01P2004/62 , C01P2004/64 , C01P2006/12 , C01P2006/13 , C01P2006/14 , C01P2006/16 , C04B35/195 , C04B35/624
摘要： The present invention relates to a method of producing particles having a particle size of less than 100 nm and surface areas of at least 20 m2/g where the particles are free from agglomeration. The method involves synthesizing the particles within an emulsion having a 1-40% water content to form reverse micelles. In particular, the particles formed are metal oxide particles. The particles can be used to oxidize hydrocarbons, particularly methane.

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