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1. 发明授权

US6164845A Processing photographic material 失效
标题翻译：加工照相材料
公开(公告)号：US6164845A
公开(公告)日：2000-12-26
申请号：US167939
申请日：1998-10-06
申请人： Anthony Earle , Andrew Sewell , Sheridan Vincent
发明人： Anthony Earle , Andrew Sewell , Sheridan Vincent
IPC分类号： G03D3/06 , G03D13/00
CPC分类号： G03D3/065
摘要： Processing of photographic material is carried out by sensing the quantity of material passing through a processor and supplying replenishment solution in accordance therewith. The level of solution in the processing tanks is also sensed during processing, and a second solution is supplied in the event that the level falls below a predetermined value. The second solution is less concentrated than the normal replenishment solution, thereby to maintain the chemical activity of the tank closer to its required, seasoned state. Furthermore, by controlling the solution levels during processing, less replenishment solution need be added during normal replenishment, thus minimizing the amount of solutions needed.
摘要翻译：照相材料的处理是通过感测通过处理器的材料的数量并根据其提供补充溶液来进行的。在处理期间也检测处理槽中的溶液水平，并且在水平低于预定值的情况下提供第二溶液。第二种溶液比正常的补充溶液浓缩得少，从而保持罐体的化学活性更接近所需的调味状态。此外，通过在处理过程中控制溶液浓度，在正常补充期间需要添加较少的补充溶液，从而最小化所需溶液的量。

2. 发明申请

US20090264456A1 COMPOSTIONS AND METHODS FOR PREVENTING AND/OR TREATING DISORDERS ASOCIATED WITH CEPHALIC PAIN 有权
标题翻译：用于预防和/或治疗与CEPHALIC PAIN相关的疾病的组合物和方法
公开(公告)号：US20090264456A1
公开(公告)日：2009-10-22
申请号：US12408438
申请日：2009-03-20
申请人： Richard Andrew Sewell
发明人： Richard Andrew Sewell
IPC分类号： A61K31/48 , C07D457/06 , A61P25/00
CPC分类号： A61K31/48 , A61J1/14 , A61K31/4045 , A61K33/00 , C07D457/06
摘要： Compounds, e.g., of formula (I) and (Ia), pharmaceutical compositions comprising the compounds and methods of using the compounds and pharmaceutical compositions for treating pain disorders, e.g., disorders associated with cephalic pain, are provided.
摘要翻译：提供了例如式（I）和（Ia）的化合物，包含该化合物的药物组合物和使用该化合物的方法和用于治疗疼痛障碍的药物组合物，例如与头痛相关的病症。

3. 发明申请

US20070191278A1 CD8 AS AN INHIBITOR OF THE CELLULAR IMMUNE SYSTEM 审中-公开
标题翻译： CD8作为细胞免疫系统的抑制剂
公开(公告)号：US20070191278A1
公开(公告)日：2007-08-16
申请号：US11696301
申请日：2007-04-04
申请人： Bent Jakobsen , George Gao , Ulrich Gerth , Andrew Sewell
发明人： Bent Jakobsen , George Gao , Ulrich Gerth , Andrew Sewell
IPC分类号： A61K38/17
CPC分类号： C07K14/70517 , A61K38/00 , C07K2319/00
摘要： This invention is directed to a method for inhibiting cytotoxic T lymphocyte (CTL) activity in which soluble CD8 is used as the inhibitor. The invention is further directed to soluble forms of the CD8 molecule which can be administered to a patient. The method of this invention is particularly useful for immunosuppressive therapy in which inhibition of CTL activity is desirable, for example, in patients undergoing transplantation.
摘要翻译：本发明涉及一种抑制细胞毒性T淋巴细胞（CTL）活性的方法，其中使用可溶性CD8作为抑制剂。本发明还涉及可以给予患者的CD8分子的可溶形式。本发明的方法特别适用于抑制CTL活性的免疫抑制治疗，例如在接受移植的患者中。

4. 发明授权

US08859579B2 Compostions and methods for preventing and/or treating disorders associated with cephalic pain 有权
标题翻译：用于预防和/或治疗与头痛有关的疾病的组合物和方法
公开(公告)号：US08859579B2
公开(公告)日：2014-10-14
申请号：US12408438
申请日：2009-03-20
申请人： Richard Andrew Sewell
发明人： Richard Andrew Sewell
IPC分类号： A61K31/44 , C07D457/00
CPC分类号： A61K31/48 , A61J1/14 , A61K31/4045 , A61K33/00 , C07D457/06
摘要： Compounds, e.g., of formula (I) and (Ia), pharmaceutical compositions comprising the compounds and methods of using the compounds and pharmaceutical compositions for treating pain disorders, e.g., disorders associated with cephalic pain, are provided.
摘要翻译：提供了例如式（I）和（Ia）的化合物，包含该化合物的药物组合物和使用该化合物的方法和用于治疗疼痛障碍的药物组合物，例如与头痛相关的病症。

5. 发明申请

US20070031442A1 Method and compositions for boosting immune response 审中-公开
标题翻译：用于增强免疫反应的方法和组合物
公开(公告)号：US20070031442A1
公开(公告)日：2007-02-08
申请号：US10545580
申请日：2004-02-17
申请人： Andrew Sewell
发明人： Andrew Sewell
IPC分类号： A61K39/00 , C07H21/04 , C12P21/06 , C07K14/74 , C07K14/16
CPC分类号： C07K14/70539 , A61K2039/55516
摘要： An antigen presenting molecule is capable of increasing sensitivity of a cytotoxic T lymphocyte to an antigen by interaction with a T cell receptor and CD8 coreceptor thereon, when the antigen presentation molecule displays an increased avidity for the CD8, compared to the molecule encoded by SEQ ID NO. 1 in vivo. Levels of avidity of the molecule for CD8 in excess of the pMHC I/TCR interaction result in the molecule being a pan activator for MHC Class I specific cytotoxic T cells.
摘要翻译：抗原呈递分子能够通过与其上的T细胞受体和CD8共同受体的相互作用增强细胞毒性T淋巴细胞对抗原的敏感性，当抗原呈递分子显示针对CD8的增加的亲合力时，与由SEQ ID 没有。 1在体内。超过pMHC I / TCR相互作用的CD8分子的亲合力水平导致该分子是MHC I类特异性细胞毒性T细胞的泛激活物。

6. 发明申请

US20150118327A1 COMPOSITIONS AND METHODS FOR PREVENTING AND/OR TREATING DISORDERS ASSOCIATED WITH CEPHALIC PAIN 审中-公开
标题翻译：用于预防和/或治疗与腹膜炎相关的疾病的组合物和方法
公开(公告)号：US20150118327A1
公开(公告)日：2015-04-30
申请号：US14510386
申请日：2014-10-09
申请人： Richard Andrew Sewell
发明人： Richard Andrew Sewell
IPC分类号： A61K31/48 , A61K31/4045 , A61J1/14 , A61K33/00
CPC分类号： A61K31/48 , A61J1/14 , A61K31/4045 , A61K33/00 , C07D457/06
摘要： Compounds, e.g., of formula (I) and (Ia), pharmaceutical compositions comprising the compounds and methods of using the compounds and pharmaceutical compositions for treating pain disorders, e.g., disorders associated with cephalic pain, are provided.
摘要翻译：提供了例如式（I）和（Ia）的化合物，包含该化合物的药物组合物和使用该化合物的方法以及用于治疗疼痛障碍的药物组合物，例如与头痛相关的病症。

7. 发明申请

US20070105822A1 Novel uses of known drugs 审中-公开
标题翻译：小说使用已知药物
公开(公告)号：US20070105822A1
公开(公告)日：2007-05-10
申请号：US10580658
申请日：2004-11-29
申请人： Andrew Sewell
发明人： Andrew Sewell
IPC分类号： A61K31/663 , A61K31/401 , A61K31/675 , A61K31/366 , A61K31/22
CPC分类号： A61K31/336 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/663 , A61K2300/00
摘要： Statins are able to block the mevalonate pathway at an early stage, preventing build up of isopentenyl pyrophosphate by nitrogen containing bisphosphonates by blocking the pathway further downstream, with medicaments containing statins being administered at an appropriate time being able to thereby prevent the build up of IPP, which has been found to activate γδ T cells and cause the acute phase response associated with the nitrogen containing bisphosphonates.
摘要翻译：他汀类药物能够在早期阻断甲羟戊酸途径，通过阻止下游途径阻止含氮二磷酸的异戊烯基焦磷酸盐的积累，在适当的时间给予含有他汀类药物，从而可以防止IPP的积聚已被发现激活Gammadelta T细胞并引起与含氮二膦酸盐相关的急性期反应。

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