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1. 发明授权

US09442093B2 Tire metallic cable anomaly detection method and apparatus 有权
标题翻译：轮胎金属电缆异常检测方法及装置
公开(公告)号：US09442093B2
公开(公告)日：2016-09-13
申请号：US13260744
申请日：2010-03-31
申请人： Lee Brandon , Gene Edward DeAmicis , Frank E. Gramling , David Andrew Judd
发明人： Lee Brandon , Gene Edward DeAmicis , Frank E. Gramling , David Andrew Judd
IPC分类号： G01R33/06 , G01N27/82
CPC分类号： G01N27/82
摘要： Disclosed is an apparatus and methodology for detecting anomalies in cables within a tire structure. A plurality of magnetic field sensitive sensors are aligned within a magnetic field provided by a magnet. The alignment of sensors and magnet is such that flux lines from the magnet are generally parallel to the plane occupied by the magnetic sensors. A tire cable anomaly present between the magnetic field sensitive sensors produces a detectable difference in signals produced by the magnetic field sensitive sensors as a result of the formation of perpendicular flux patterns produced by the anomaly. A signal processing circuit receiving input signals from the sensors evaluates differences between the signals from each of the plurality of sensors by pairing the output signal from each sensor with the output signal from each of the others of the plurality of sensors and produces an output signal upon the differences meeting selected criteria. The output signal may include an externally measurable signal and/or may include a visual signal indicating presence of a tire anomaly.
摘要翻译：公开了一种用于检测轮胎结构内的电缆异常的装置和方法。多个磁场敏感传感器在由磁体提供的磁场内对准。传感器和磁体的对准使得来自磁体的磁通线通常平行于由磁性传感器占据的平面。存在于磁场敏感传感器之间的轮胎电缆异常由于由异常产生的垂直通量图形的形成而产生由磁场敏感传感器产生的信号的可检测差异。从传感器接收输入信号的信号处理电路通过将来自每个传感器的输出信号与来自多个传感器中的其他传感器的输出信号的输出信号进行配对来评估来自多个传感器中的每一个的信号之间的差异，并产生一个输出信号差异符合选定标准。输出信号可以包括可外部测量的信号和/或可以包括指示轮胎异常存在的视觉信号。

2. 发明授权

US09157834B2 High voltage probe apparatus and method for tire inner surface anomaly detection 有权
标题翻译：高压探头装置及轮胎内表面异常检测方法
公开(公告)号：US09157834B2
公开(公告)日：2015-10-13
申请号：US13822092
申请日：2010-09-14
申请人： Christian Albert Beccavin , Frank E. Gramling , David Andrew Judd , Bradley D. Schober
发明人： Christian Albert Beccavin , Frank E. Gramling , David Andrew Judd , Bradley D. Schober
IPC分类号： G01M17/02 , G01N27/20 , G01R31/12 , G01R31/02 , G01M3/40
CPC分类号： G01M17/02 , G01M3/40 , G01N27/20 , G01N27/205 , G01R31/022 , G01R31/1263
摘要： A tire testing apparatus and method for detecting anomalies in the surface of a tire is disclosed. A high voltage probe having a conductive spring electrode is placed adjacent a portion of a tire surface such that the conductive spring electrode is compressed against the surface of the tire. Relative motion is imparted between the high voltage probe and the surface of the tire. An electrical discharge occurs between the high voltage probe and a reference electrode at the location of an anomaly on the surface of the tire. The apparatus and method are configured to determine a precise azimuthal and radial position on the tire of the electrostatic discharge. The conductive spring electrode can have a length sufficient to ensure contact with a given point on the tire surface during a charge cycle for the high voltage probe at increased tire surface speeds.
摘要翻译：公开了一种用于检测轮胎表面的异常的轮胎试验装置和方法。具有导电弹簧电极的高电压探针被放置在轮胎表面的一部分附近，使得导电弹簧电极被压靠在轮胎的表面上。在高压探头和轮胎表面之间施加相对运动。在轮胎表面上的异常位置处，在高压探针与参考电极之间发生放电。该装置和方法被配置成确定轮胎上静电放电的精确方位角和径向位置。导电弹簧电极可以具有足够的长度，以确保在增加轮胎表面速度的高电压探针的充电循环期间与轮胎表面上的给定点接触。

3. 发明申请

US20130174657A1 TIRE INNER LINER ANOMALY PROBE GROUNDING APPARATUS AND METHOD 有权
标题翻译：轮胎内衬异常探头接地装置和方法
公开(公告)号：US20130174657A1
公开(公告)日：2013-07-11
申请号：US13822097
申请日：2010-09-14
申请人： Christian Albert Beccavin , Frank E. Gramling , David Andrew Judd , Bradley D. Schober
发明人： Christian Albert Beccavin , Frank E. Gramling , David Andrew Judd , Bradley D. Schober
IPC分类号： G01M17/02
CPC分类号： G01M17/02
摘要： An apparatus and method for high voltage discharge testing of a tire is disclosed. In particular embodiments, a high voltage probe is maintained against the surface of a tire. The high voltage probe is energized and relative motion is provided between the surface of the tire and the high voltage probe. At the presence of an anomaly that penetrates the insulating material of the tire surface, an electrical discharge will occur between the conductive spring electrode and a reference electrode. The reference electrode is positioned adjacent the bead portion of the tire such that the electrical discharge will travel from the high voltage probe through the anomaly in the surface of the tire to one or more carcass plies in the tire. The carcass plies will carry the electrical discharge to the bead portion of the tire, where the electrical discharge will pass to the reference electrode.
摘要翻译：公开了一种用于轮胎的高压放电测试的装置和方法。在具体实施例中，高压探针保持抵靠轮胎的表面。高压探头通电，轮胎表面和高压探头之间提供相对运动。在存在穿透轮胎表面的绝缘材料的异常的情况下，在导电弹簧电极和参考电极之间将发生放电。参考电极定位成与轮胎的胎圈部分相邻，使得放电将从高压探针行进通过轮胎表面中的异常到轮胎中的一个或多个胎体帘布层。胎体帘布层将放电到轮胎的胎圈部分，其中放电将通过参考电极。

4. 发明申请

US20080064717A1 Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme 审中-公开
标题翻译：二酰基甘油的抑制剂O-酰基转移酶1型酶
公开(公告)号：US20080064717A1
公开(公告)日：2008-03-13
申请号：US11749952
申请日：2007-05-17
申请人： Rajesh Iyengar , Gang Zhao , Jennifer Freeman , Ju Gao , Andrew Judd , Philip Kym , John Lynch , Mathew Mulhern , Andrew Souers
发明人： Rajesh Iyengar , Gang Zhao , Jennifer Freeman , Ju Gao , Andrew Judd , Philip Kym , John Lynch , Mathew Mulhern , Andrew Souers
IPC分类号： A61K31/4402 , A61K31/17 , A61K31/19 , A61P3/00 , C07C61/06 , C07D471/04 , C07D213/46 , C07C275/28 , A61P1/16 , A61K31/4375
CPC分类号： C07C335/22 , C07C229/46 , C07C275/30 , C07C275/32 , C07C275/38 , C07C279/28 , C07C2601/08 , C07C2601/14 , C07D213/55 , C07D213/75 , C07D277/30 , C07D333/22 , C07D333/36 , C07D401/04 , C07D401/12 , C07D409/12 , C07D409/14
摘要： The present invention relates to compounds of formula (I): wherein R1, R3, X, Q, Z, A, 9, m, and n are defined herein Pharmaceutical compositions and methods for treating DGAT-1 related diseases or conditions are also disclosed.
摘要翻译：本发明涉及式（I）化合物：其中R 1，R 3，X，Q，Z，A，9，m和n如本文所定义还公开了治疗DGAT-1相关疾病或病症的药物组合物和方法。

5. 发明申请

US20050137187A1 Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor 审中-公开
标题翻译：黑色素浓缩激素对黑色素浓缩激素受体的拮抗作用
公开(公告)号：US20050137187A1
公开(公告)日：2005-06-23
申请号：US10744571
申请日：2003-12-23
申请人： Andrew Souers , Christine Collins , Ju Gao , Andrew Judd , Philip Kym , Mathew Mulhern , Hing Sham , Dariusz Wodka
发明人： Andrew Souers , Christine Collins , Ju Gao , Andrew Judd , Philip Kym , Mathew Mulhern , Hing Sham , Dariusz Wodka
IPC分类号： A61K31/416 , A61K31/454 , A61K31/55 , C07D231/56 , C07D401/06 , C07D403/06 , C07D405/12 , C07D491/10 , C07D43/02
CPC分类号： C07D401/06 , A61K31/416 , A61K31/454 , A61K31/55 , C07D231/56 , C07D403/06 , C07D405/12 , C07D491/10
摘要： The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.
摘要翻译：本发明涉及黑色素浓缩激素（MCH）通过黑色素浓缩激素受体的作用的拮抗作用，其可用于预防或治疗进食障碍，体重增加，肥胖，生殖和性行为异常，甲状腺激素分泌，利尿和水/电解质体内平衡，感觉加工，记忆，睡眠，唤醒，焦虑，抑郁，癫痫发作，神经变性和精神疾病。

6. 发明授权

US08910511B2 Tire inner liner anomaly probe grounding apparatus and method 有权
标题翻译：轮胎内衬异径探头接地装置及方法
公开(公告)号：US08910511B2
公开(公告)日：2014-12-16
申请号：US13822097
申请日：2010-09-14
申请人： Christian Albert Beccavin , Frank E. Gramling , David Andrew Judd , Bradley D. Schober
发明人： Christian Albert Beccavin , Frank E. Gramling , David Andrew Judd , Bradley D. Schober
IPC分类号： G01M17/02
CPC分类号： G01M17/02
摘要： An apparatus and method for high voltage discharge testing of a tire is disclosed. In particular embodiments, a high voltage probe is maintained against the surface of a tire. The high voltage probe is energized and relative motion is provided between the surface of the tire and the high voltage probe. At the presence of an anomaly that penetrates the insulating material of the tire surface, an electrical discharge will occur between the conductive spring electrode and a reference electrode. The reference electrode is positioned adjacent the bead portion of the tire such that the electrical discharge will travel from the high voltage probe through the anomaly in the surface of the tire to one or more carcass plies in the tire. The carcass plies will carry the electrical discharge to the bead portion of the tire, where the electrical discharge will pass to the reference electrode.
摘要翻译：公开了一种用于轮胎的高压放电测试的装置和方法。在具体实施例中，高压探针保持抵靠轮胎的表面。高压探头通电，轮胎表面和高压探头之间提供相对运动。在存在穿透轮胎表面的绝缘材料的异常的情况下，在导电弹簧电极和参考电极之间将发生放电。参考电极定位成与轮胎的胎圈部分相邻，使得放电将从高压探针行进通过轮胎表面中的异常到轮胎中的一个或多个胎体帘布层。胎体帘布层将放电到轮胎的胎圈部分，其中放电将通过参考电极。

7. 发明申请

US20050187387A1 Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor 审中-公开
标题翻译：黑色素浓缩激素对黑色素浓缩激素受体的拮抗作用
公开(公告)号：US20050187387A1
公开(公告)日：2005-08-25
申请号：US10787694
申请日：2004-02-25
申请人： John Lynch , Christine Collins , Jennifer Freeman , Ju Gao , Rajesh Iyengar , Andrew Judd , Philip Kym , Mathew Mulhern , Hing Sham , Andrew Souers , Gang Zhao
发明人： John Lynch , Christine Collins , Jennifer Freeman , Ju Gao , Rajesh Iyengar , Andrew Judd , Philip Kym , Mathew Mulhern , Hing Sham , Andrew Souers , Gang Zhao
IPC分类号： B32B27/02 , C07D401/12 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14
CPC分类号： C07D405/12 , C07D401/12 , C07D405/14 , C07D413/14 , C07D417/14
摘要： The present invention is directed to compounds of formula (I), which antagonize of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.
摘要翻译：本发明涉及通过黑色素浓缩激素受体拮抗黑色素浓缩激素（MCH）的作用的式（I）化合物，其可用于预防或治疗进食障碍，体重增加，肥胖症，异常生殖和性行为，甲状腺激素分泌，利尿和水/电解质体内平衡，感觉加工，记忆，睡眠，觉醒，焦虑，抑郁，癫痫发作，神经变性和精神疾病。

8. 发明申请

US20050187279A1 Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor 有权
公开(公告)号：US20050187279A1
公开(公告)日：2005-08-25
申请号：US11020464
申请日：2004-12-22
申请人： Andrew Souers , Christine Collins , Ju Gao , Andrew Judd , Philip Kym , Mathew Mulhern , Hing Sham , Dariusz Wodka
发明人： Andrew Souers , Christine Collins , Ju Gao , Andrew Judd , Philip Kym , Mathew Mulhern , Hing Sham , Dariusz Wodka
IPC分类号： C07D231/56 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/06 , C07D491/10 , A61K31/416
CPC分类号： C07D403/06 , C07D231/56 , C07D401/06 , C07D403/04 , C07D405/06 , C07D491/10
摘要： The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.

9. 发明申请

US20050137243A1 Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor 审中-公开
公开(公告)号：US20050137243A1
公开(公告)日：2005-06-23
申请号：US10744188
申请日：2003-12-23
申请人： Andrew Souers , Christine Collins , Ju Gao , Andrew Judd , Philip Kym , Mathew Mulhern , Hing Sham , Anil Vasudevan , Dariusz Wodka
发明人： Andrew Souers , Christine Collins , Ju Gao , Andrew Judd , Philip Kym , Mathew Mulhern , Hing Sham , Anil Vasudevan , Dariusz Wodka
IPC分类号： C07D231/56 , C07D401/04 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , A61K31/416
CPC分类号： C07D413/12 , C07D231/56 , C07D401/04 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.

10. 发明申请

US20130162265A1 HIGH VOLTAGE PROBE APPARATUS AND METHOD FOR TIRE INNER SURFACE ANOMALY DETECTION 有权
标题翻译：用于轮胎内表面异常检测的高电压探针装置和方法
公开(公告)号：US20130162265A1
公开(公告)日：2013-06-27
申请号：US13822092
申请日：2010-09-14
申请人： Christian Albert Beccavin , Frank E. Gramling , David Andrew Judd , Bradley D. Schober
发明人： Christian Albert Beccavin , Frank E. Gramling , David Andrew Judd , Bradley D. Schober
IPC分类号： G01N27/20
CPC分类号： G01M17/02 , G01M3/40 , G01N27/20 , G01N27/205 , G01R31/022 , G01R31/1263
摘要： A tire testing apparatus and method for detecting anomalies in the surface of a tire is disclosed. A high voltage probe having a conductive spring electrode is placed adjacent a portion of a tire surface such that the conductive spring electrode is compressed against the surface of the tire. Relative motion is imparted between the high voltage probe and the surface of the tire. An electrical discharge occurs between the high voltage probe and a reference electrode at the location of an anomaly on the surface of the tire. The apparatus and method are configured to determine a precise azimuthal and radial position on the tire of the electrostatic discharge. The conductive spring electrode can have a length sufficient to ensure contact with a given point on the tire surface during a charge cycle for the high voltage probe at increased tire surface speeds.
摘要翻译：公开了一种用于检测轮胎表面的异常的轮胎试验装置和方法。具有导电弹簧电极的高电压探针被放置在轮胎表面的一部分附近，使得导电弹簧电极被压靠在轮胎的表面上。在高压探头和轮胎表面之间施加相对运动。在轮胎表面上的异常位置处，在高压探针与参考电极之间发生放电。该装置和方法被配置成确定轮胎上静电放电的精确方位角和径向位置。导电弹簧电极可以具有足够的长度，以确保在增加轮胎表面速度的高电压探针的充电循环期间与轮胎表面上的给定点接触。

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