专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07759070B2 Conserved inner core lipopolysaccharide epitopes as multi-species vaccine candidates 失效
标题翻译：保守的内核脂多糖表位作为多种疫苗候选物
公开(公告)号：US07759070B2
公开(公告)日：2010-07-20
申请号：US11569093
申请日：2005-05-16
申请人： Andrew D. Cox , James C. Richards
发明人： Andrew D. Cox , James C. Richards
IPC分类号： A61K8/73 , A61K31/715 , G01N33/53
CPC分类号： C12N1/36 , A61K31/739 , A61K39/0208 , A61K39/05 , A61K39/102 , A61K47/646 , A61K2039/505 , A61K2039/522 , A61K2039/552 , A61K2039/6081 , A61K2039/70 , C07H3/06 , C07H13/04 , C07K16/1242 , C08B37/0003 , C08B37/006 , C12P19/04 , C12P19/44 , C12R1/01
摘要： A conserved inner-core oligosaccharide epitope expressed on the lipopolysaccharide (LPS) of a range of disease causing pathogenic bacterial isolates, including Actinobacillus pleuropneumoniae (Ap), Mannheimia haemolytica (Mh) and Pasteurella multocida (Pm), is disclosed. Construction of a mutant bacterial strain exclusively expressing the conserved inner core OS epitope as a terminally exposed structure has allowed the identification, production and isolation of an inner core LPS which is common to all three organisms. Further provided are associated vaccines, antibodies raised against the conserved LPS inner core and glycoconjugates comprising the LPS inner core linked to an immunogenic carrier.
摘要翻译：公开了在致病细菌分离物的一系列疾病的脂多糖（LPS）上表达的保守的内核寡糖表位，包括放线杆菌胸膜肺炎放线芽孢杆菌（Ap），溶血性马氏解毒血症（Mh）和多杀巴斯德氏菌（Pm））。构建仅表达保守的内核OS表位作为末端暴露结构的突变细菌菌株允许鉴定，产生和分离所有三种生物共同的内核LPS。还提供了相关疫苗，针对保守的LPS内核产生的抗体和包含与免疫原性载体连接的LPS内核的糖缀合物。

2. 发明申请

US20110307808A1 RENDERING INCOMPATIBLE CONTENT WITHIN A USER INTERFACE 审中-公开
标题翻译：在用户界面中渲染不相容的内容
公开(公告)号：US20110307808A1
公开(公告)日：2011-12-15
申请号：US12797869
申请日：2010-06-10
申请人： Daniel J. Giambalvo , Andrew D. Cox , Radu C. Margarint
发明人： Daniel J. Giambalvo , Andrew D. Cox , Radu C. Margarint
IPC分类号： G06F3/01
CPC分类号： G06F9/451
摘要： An increasing amount of the world's content resides on the web in a form targeted to web browser rendering. It may be advantageous to utilize this web content within non-web-based rich client applications because such rich client applications may provide robust features and/or interactions that web-based platforms lack. Unfortunately, integrating web content into non-web user interfaces may be a difficult task. Accordingly, one or more systems and/or techniques for rendering web content within a user interface are disclosed herein. In particular, a composition component may be configured to invoke one or more rendering components to generate rendered web content in a common format within a surface. The rendered web content may be provided to a user interface for display. An input component may be configured to invoke a rendering component to update rendered web content based upon interaction with rendered web content within the user interface.
摘要翻译：世界各地的内容越来越多地以Web浏览器呈现的形式存在于网络上。在非基于Web的富客户端应用程序中使用该Web内容可能是有利的，因为这样的富客户端应用可以提供基于web的平台缺乏的鲁棒特征和/或交互。不幸的是，将Web内容集成到非Web用户界面可能是一项艰巨的任务。因此，本文公开了用于在用户界面内呈现网络内容的一个或多个系统和/或技术。特别地，构图组件可以被配置为调用一个或多个渲染组件以在表面内以公共格式生成渲染的web内容。呈现的网页内容可以被提供给用户界面进行显示。输入组件可以被配置为基于与用户界面内的呈现的web内容的交互来调用呈现组件来更新呈现的web内容。

3. 发明申请

US20110229513A1 LPS Based Vaccines 审中-公开
标题翻译：基于LPS的疫苗
公开(公告)号：US20110229513A1
公开(公告)日：2011-09-22
申请号：US13062299
申请日：2009-09-08
申请人： Andrew D. Cox , Frank St. Michael , James C. Richards , Richard E. Moxon
发明人： Andrew D. Cox , Frank St. Michael , James C. Richards , Richard E. Moxon
IPC分类号： A61K39/385 , C07K14/00 , C07K14/765 , C07K14/34 , C07K14/33 , C07K1/113 , C12P21/00 , A61P37/04 , A61P31/04
CPC分类号： A61K39/095 , A61K39/102 , A61K39/1045 , A61K2039/55566 , A61K2039/6037 , C08B37/0063
摘要： The removal of the glycosidic phosphate from the reducing end of the derived LPS molecule creates an aldehydo functionality which causes the formation of an immunologically dominant neo-epitope. Conjugation to the reducing end of a carbohydrate molecule following removal of the glycosidic phosphate traps the reducing glucosamine residue in an open-chain form which surprisingly was found to dominate the immune response. We therefore modified our conjugation strategy to avoid this open-chain form, by utilising the amino functionality created by the isolated amidase activity from Dictyostelium discoideum, concomitant with a unique blocking and un-blocking strategy to protect the immunologically important phosphoethanolamine inner core residue. These antigenic structures are useful in producing vaccines and compounds helpful in combating Gram-negative bacteria. Also described are specific structures of the carbohydrate molecules derived from a variety of Gram-negative bacteria, which when presented appropriately as a glycoconjugate will facilitate a functional immune response to the target core oligosaccharide region.
摘要翻译：从衍生的LPS分子的还原端去除糖苷磷酸形成醛官能团，其导致形成免疫优势的新表位。在除去糖苷磷酸盐后，与碳水化合物分子的还原末端的缀合物以开放链形式释放还原葡糖胺残基，令人惊讶地发现其主导免疫应答。因此，我们修改了我们的共轭策略，以避免这种开链形式，通过利用由盘基网柄菌分离的分离的酰胺酶活性产生的氨基功能，伴随着独特的阻断和非阻断策略来保护免疫重要的磷酸乙醇胺内核残基。这些抗原结构可用于生产有助于抗革兰氏阴性菌的疫苗和化合物。还描述了衍生自各种革兰氏阴性细菌的碳水化合物分子的特异性结构，当作为糖缀合物适当地呈现时，将促进对靶核心寡糖区域的功能性免疫应答。

4. 发明申请

US20110165163A1 IDENTIFICATION OF A CONSERVED INNER CORE OLIGOSACCHARIDE OF MORAXELLA CATARRHALIS LIPOPOLYSACCHARIDE AS A VACCINE ANTIGEN 有权
标题翻译：鉴定作为疫苗抗原的莫拉西拉卡罗来昔布脂多糖的内核寡核苷酸
公开(公告)号：US20110165163A1
公开(公告)日：2011-07-07
申请号：US13056165
申请日：2009-09-04
申请人： Andrew D. COX , James C. Richards
发明人： Andrew D. COX , James C. Richards
IPC分类号： A61K39/395 , C07H15/02 , A61P37/04 , A61P31/04
CPC分类号： C07K16/1214 , A61K39/1045 , A61K2039/505 , A61K2039/6087
摘要： There are disclosed herein antigenic structures useful in producing vaccines against and compounds helpful in combating diseases caused by the bacterium Moraxella catarrhalis. Disclosed are specific structures of the carbohydrate molecules derived from genetically engineered strains of Moraxella catarrhalis, which when presented appropriately to the immune system will facilitate a functional immune response to the target core oligosaccharide region.
摘要翻译：本文公开了可用于生产疫苗的抗原结构和有助于对抗由细菌莫拉氏杆菌引起的疾病的化合物。公开了衍生自卡介氏莫拉氏杆菌的遗传工程菌株的碳水化合物分子的特异性结构，当其适当地呈递给免疫系统时，将促进对目标核心寡糖区域的功能性免疫应答。

5. 发明授权

US08697092B2 Identification of a conserved inner core oligosaccharide of Moraxella catarrhalis lipopolysaccharide as a vaccine antigen 有权
标题翻译：鉴定作为疫苗抗原的卡他莫拉菌属多糖的保守内核寡糖
公开(公告)号：US08697092B2
公开(公告)日：2014-04-15
申请号：US13056165
申请日：2009-09-04
申请人： Andrew D. Cox , James C. Richards
发明人： Andrew D. Cox , James C. Richards
IPC分类号： A61K39/02 , A61K39/385 , A01N43/04 , C07H1/00
CPC分类号： C07K16/1214 , A61K39/1045 , A61K2039/505 , A61K2039/6087
摘要： There are disclosed herein antigenic structures useful in producing vaccines against and compounds helpful in combating diseases caused by the bacterium Moraxella catarrhalis. Disclosed are specific structures of the carbohydrate molecules derived from genetically engineered strains of Moraxella catarrhalis, which when presented appropriately to the immune system will facilitate a functional immune response to the target core oligosaccharide region.
摘要翻译：本文公开了可用于生产疫苗的抗原结构和有助于对抗由细菌莫拉氏杆菌引起的疾病的化合物。公开了衍生自卡介氏莫拉氏杆菌的遗传工程菌株的碳水化合物分子的特异性结构，当其适当地呈递给免疫系统时，将促进对目标核心寡糖区域的功能性免疫应答。

6. 发明申请

US20110173564A1 EXTENDING VIEW FUNCTIONALITY OF APPLICATION 审中-公开
标题翻译：扩展查看应用程序的功能
公开(公告)号：US20110173564A1
公开(公告)日：2011-07-14
申请号：US12687123
申请日：2010-01-13
申请人： Radu C. Margarint , Andrew D. Cox , Gary W. Flake , Karim T. Farouki , Alan K. Wu
发明人： Radu C. Margarint , Andrew D. Cox , Gary W. Flake , Karim T. Farouki , Alan K. Wu
IPC分类号： G06F3/048
CPC分类号： G06F3/04855 , G06F9/451 , G06F2203/04805 , G06F2203/04806
摘要： The viewing functionality of an application may be extended by use of an adapter. An application is instantiated, and the application may provide a view box that contains a scrolling feature as part of its interface. The adapter uses the application “behind the scenes” to collect information in a way that is not visible to the user. Mouse gestures may be defined to perform various viewing functions such as zooming. The adapter intercepts these gestures in the window that the user uses to interact with the application, and interprets the gestures as specific view commands (such as zoom). Based on the commands (or, possibly, in anticipation of commands that have not yet been issued), the adapter uses the application to collect content. The application then scales the content appropriately, puts the scaled content in a document, and overlays the document on top of the view box.
摘要翻译：可以通过使用适配器来扩展应用程序的查看功能。应用程序被实例化，并且应用程序可以提供包含作为其界面的一部分的滚动特征的视图框。适配器使用应用程序“幕后”以用户不可见的方式收集信息。可以定义鼠标手势以执行各种查看功能，例如缩放。适配器在用户用于与应用程序交互的窗口中拦截这些手势，并将手势解释为特定视图命令（如缩放）。基于命令（或可能预期尚未发布的命令），适配器使用应用程序来收集内容。应用程序然后适当地缩放内容，将缩放的内容放在文档中，并将文档叠加在视图框的顶部。

7. 发明申请

US20100015175A1 Vaccine 有权
标题翻译：疫苗
公开(公告)号：US20100015175A1
公开(公告)日：2010-01-21
申请号：US12508683
申请日：2009-07-24
申请人： Joyce S. Plested , Michael P. Jennings , Margaret Anne Gidney , Andrew D. Cox , James C. Richards , E. Richard Moxon
发明人： Joyce S. Plested , Michael P. Jennings , Margaret Anne Gidney , Andrew D. Cox , James C. Richards , E. Richard Moxon
IPC分类号： A61K39/095 , A61K39/385
CPC分类号： A61K39/385 , A61K39/095 , A61K39/40 , A61K2039/505 , A61K2039/53 , C07K14/22 , C07K16/1217 , C07K2317/76
摘要： The invention relates to a vaccine for the treatment of disease caused by Neisseria, the vaccine including one or more immunogenic components for Neisseria serogroups, as well as antibodies to the immunogenic components and methods of preventing and treating Neisseria infections. The immunogens are based on elements of the inner core lipopolysaccharide.
摘要翻译：本发明涉及用于治疗由奈瑟氏球菌引起的疾病的疫苗，该疫苗包括奈瑟氏球菌血清群的一种或多种免疫原性成分，以及针对免疫原性成分的抗体以及预防和治疗奈瑟氏球菌感染的方法。免疫原基于内核脂多糖的元件。

8. 发明申请

US20100016560A1 Vaccine 有权
公开(公告)号：US20100016560A1
公开(公告)日：2010-01-21
申请号：US12508691
申请日：2009-07-24
申请人： Joyce S. Plested , Michael P. Jennings , Margaret Ann J. Gidney , Andrew D. Cox , James C. Richards , E. Richard Moxon
发明人： Joyce S. Plested , Michael P. Jennings , Margaret Ann J. Gidney , Andrew D. Cox , James C. Richards , E. Richard Moxon
IPC分类号： C07K16/12
CPC分类号： A61K39/385 , A61K39/095 , A61K39/40 , A61K2039/505 , A61K2039/53 , C07K14/22 , C07K16/1217 , C07K2317/76
摘要： The invention relates to a vaccine for the treatment of disease caused by Neisseria, the vaccine including one or more immunogenic components for Neisseria serogroups, as well as antibodies to the immunogenic components and methods of preventing and treating Neisseria infections. The immunogens are based on elements of the inner core lipopolysaccharide.

9. 发明申请

US20100010211A1 Vaccine 失效
公开(公告)号：US20100010211A1
公开(公告)日：2010-01-14
申请号：US12508673
申请日：2009-07-24
申请人： Joyce S. Plested , Michael P. Jennings , Margaret Anne Gidney , Andrew D. Cox , James C. Richards , E. Richard Moxon
发明人： Joyce S. Plested , Michael P. Jennings , Margaret Anne Gidney , Andrew D. Cox , James C. Richards , E. Richard Moxon
IPC分类号： C07H3/00
CPC分类号： A61K39/385 , A61K39/095 , A61K39/40 , A61K2039/505 , A61K2039/53 , C07K14/22 , C07K16/1217 , C07K2317/76
摘要： The invention relates to a vaccine for the treatment of disease caused by Neisseria, the vaccine including one or more immunogenic components for Neisseria serogroups, as well as antibodies to the immunogenic components and methods of preventing and treating Neisseria infections. The immunogens are based on elements of the inner core lipopolysaccharide.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式