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1. 发明申请

US20160002611A1 Methods and Apparatus for Cell-Free Microfluidic-Assisted Biosynthesis 审中-公开
标题翻译：无细胞微流体辅助生物合成的方法和装置
公开(公告)号：US20160002611A1
公开(公告)日：2016-01-07
申请号：US14735132
申请日：2015-06-09
申请人： Andreas Mershin , Vincent Noireaux , James Francis Pelletier , Neil A. Gershenfeld
发明人： Andreas Mershin , Vincent Noireaux , James Francis Pelletier , Neil A. Gershenfeld
IPC分类号： C12N9/10 , C12M1/00 , C12P1/00
CPC分类号： C12N9/1029 , C12M47/06 , C12M47/10 , C12P21/02 , C12Y203/01
摘要： A trans-disciplinary system for cell-free biosynthesis includes a cell-free transcription-translation (TX-TL) tool and modular, generalizable microfluidic architectures. Both components of the system are independently functional and are combinable into a cell-free biosynthesis platform. In the first component, modular plasmid libraries are used to program bacterial cell-free TX-TL systems. Each plasmid holds one gene or operon, and all the genes are controlled by the same promoter, so that the stoichiometry of enzyme synthesis is determined by the stoichiometry of plasmids in the reaction. In the second part, in order to facilitate high throughput mixing and matching of gene units from the modular plasmid libraries, a modular, reconfigurable, flexible, and scalable microfluidic architecture is employed. The microfluidic modules share common form factors and port/valve locations, so that a small set of module types, with multiple instances of each type interconnected in different geometries, allows simple reconfiguration to achieve different modes of operation.
摘要翻译：用于无细胞生物合成的跨学科系统包括无细胞转录转译（TX-TL）工具和模块化，可推广的微流体结构。系统的两个组分都是独立的功能，可组合成无细胞的生物合成平台。在第一个组分中，使用模块化质粒文库来编程细菌无细胞的TX-TL系统。每个质粒含有一个基因或操纵子，所有基因都由相同的启动子控制，因此酶合成的化学计量通过反应中质粒的化学计量来确定。在第二部分中，为了促进来自模块化质粒文库的基因单元的高通量混合和匹配，采用了模块化的，可重构的，灵活的和可扩展的微流体结构。微流体模块具有共同的形状因子和端口/阀位置，使得具有不同几何形状互连的每种类型的多个实例的一小组模块类型允许简单的重新配置以实现不同的操作模式。

2. 发明申请

US20150037890A1 Methods and Apparatus for Transplantation of Nucleic Acid Molecules 有权
标题翻译：用于移植核酸分子的方法和装置
公开(公告)号：US20150037890A1
公开(公告)日：2015-02-05
申请号：US14449106
申请日：2014-07-31
申请人： Andreas Mershin , James Pelletier , Neil Gershenfeld , John Glass , Elizabeth Strychalski
发明人： Andreas Mershin , James Pelletier , Neil Gershenfeld , John Glass , Elizabeth Strychalski
IPC分类号： C12N15/04 , C12M1/42 , C12N15/87
CPC分类号： C12M35/08 , C12N15/87
摘要： In exemplary implementations, transplantation of nucleic acids into cells occurs in microfluidic chambers. The nucleic acids may be large nucleic acid molecules with more than 100 kbp. In some cases, the microfluidic chambers have only one orifice that opens to a flow channel. In some cases, flow through a microfluidic chamber temporarily ceases due to closing one or more valves. Transplantation occurs during a period in which the contents of the chambers are shielded from shear forces. Diffusion, centrifugation, suction from a vacuum channel, or dead-end loading may be used to move cells or buffers into the chambers.
摘要翻译：在示例性实施方案中，将核酸移植到细胞中发生在微流体室中。核酸可以是大于100kbp的大核酸分子。在一些情况下，微流体室仅具有一个通向流动通道的孔口。在一些情况下，由于关闭一个或多个阀门，流过微流体室的流动暂时停止。移植发生在室内容物被剪切力屏蔽的期间。可以使用扩散，离心，真空通道抽吸或死端装载将细胞或缓冲液移动到腔室中。

3. 发明授权

US09834747B2 Methods and apparatus for transplantation of nucleic acid molecules 有权
公开(公告)号：US09834747B2
公开(公告)日：2017-12-05
申请号：US14449106
申请日：2014-07-31
申请人： Andreas Mershin , James Pelletier , Neil Gershenfeld , John Glass , Elizabeth Strychalski
发明人： Andreas Mershin , James Pelletier , Neil Gershenfeld , John Glass , Elizabeth Strychalski
IPC分类号： C12N15/04 , C12M1/42 , C12N15/87
CPC分类号： C12M35/08 , C12N15/87
摘要： In exemplary implementations, transplantation of nucleic acids into cells occurs in microfluidic chambers. The nucleic acids may be large nucleic acid molecules with more than 100 kbp. In some cases, the microfluidic chambers have only one orifice that opens to a flow channel. In some cases, flow through a microfluidic chamber temporarily ceases due to closing one or more valves. Transplantation occurs during a period in which the contents of the chambers are shielded from shear forces. Diffusion, centrifugation, suction from a vacuum channel, or dead-end loading may be used to move cells or buffers into the chambers.

4. 发明授权

US09714941B2 Bio-sensing nanodevice 有权
公开(公告)号：US09714941B2
公开(公告)日：2017-07-25
申请号：US12183916
申请日：2008-07-31
申请人： Shuguang Zhang , Andreas Mershin , Liselotte Kaiser , Brian Cook , Johanna F. Graveland-Bikker , Manu Prakash , David Kong , Yael Maguire
发明人： Shuguang Zhang , Andreas Mershin , Liselotte Kaiser , Brian Cook , Johanna F. Graveland-Bikker , Manu Prakash , David Kong , Yael Maguire
IPC分类号： G01N33/543
CPC分类号： G01N33/54366 , G01N2333/726
摘要： The invention provides a bio-sensing nanodevice comprising: a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—on a support, a real time receptor-ligand binding detection method, an odorant delivery system and an odorant recognition program. The biologically-derived G-protein coupled receptor can be stabilized on nanotechnology using surfactant peptide. The said nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.

5. 发明授权

US08748111B2 Multiplexed olfactory receptor-based microsurface plasmon polariton detector 有权
标题翻译：基于多重嗅觉受体的微表面等离子体激元检测器
公开(公告)号：US08748111B2
公开(公告)日：2014-06-10
申请号：US13015851
申请日：2011-01-28
申请人： Andreas Mershin , Brian Cook , Liselotte Kaiser , Johanna F. Bikker , Yoshikatsu Miura , Daisuke Niwa , Dai Ohnishi , Atsushi Tazuke , Shuguang Zhang
发明人： Andreas Mershin , Brian Cook , Liselotte Kaiser , Johanna F. Bikker , Yoshikatsu Miura , Daisuke Niwa , Dai Ohnishi , Atsushi Tazuke , Shuguang Zhang
IPC分类号： G01N33/53 , C07K2/00 , B82Y30/00 , G01N33/00 , G01N21/55
CPC分类号： G01N21/553 , B82Y30/00 , C07K2/00 , G01N21/554 , G01N33/0031 , G01N2201/06113 , G01N2201/08
摘要： The invention provides a bio-sensing nanodevice comprising: a stabilized G-protein coupled receptor on a support, a real time receptor-ligand binding detection method, a test composition delivery system and a test composition recognition program. The G-protein coupled receptor can be stabilized using surfactant peptide. The nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized G-protein coupled receptor immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.
摘要翻译：本发明提供了一种生物感测纳米装置，其包括：载体上的稳定的G-蛋白偶联受体，实时受体 - 配体结合检测方法，测试组合物递送系统和测试组合物识别程序。 G蛋白偶联受体可以使用表面活性肽稳定。纳米器件提供更大的表面积，以提高气味检测的精度和灵敏度。本发明进一步提供了一种微流控芯片，其含有固定在载体上的稳定化的G蛋白偶联受体，并且被布置在至少二维微阵列系统中。本发明还提供了一种递送加臭剂的方法，其包括在复杂微流体网络中操作气泡的步骤，其中气泡在携带各种气体样品的微流体通道中移动到芯片上的精确位置。本发明还提供了制备hOR17-4嗅觉受体的方法。

6. 发明申请

US20150362469A1 Methods and Apparatus for Artificial Olfaction 有权
标题翻译：人工嗅觉的方法和装置
公开(公告)号：US20150362469A1
公开(公告)日：2015-12-17
申请号：US14815574
申请日：2015-07-31
申请人： Andreas Mershin , Asmamaw Wassie , Yael Maguire , David Kong , Shuguang Zhang , Patrick Moran , Karolina Corin
发明人： Andreas Mershin , Asmamaw Wassie , Yael Maguire , David Kong , Shuguang Zhang , Patrick Moran , Karolina Corin
IPC分类号： G01N33/00
CPC分类号： G01N33/0031 , G01N27/00
摘要： In exemplary implementations of this invention, an electronic olfactor determines whether a scent being tested matches the scent of a positive control. The electronic olfactor can perform this scent matching even in a changing olfactory environment, and even if the positive control scent is a combination of hundreds or thousands of different odorants. No prior training is needed, and no attempt is made to identify a single odorant that is unambiguously responsible for a scent. Instead, a computer compares the total scent pattern of a positive control sample with the total scent pattern of a test sample, across a sweep of many permutations of electrical inputs to scent sensors, to try to find any condition under which the total scent patterns do not match. If such a condition cannot be found, then the computer declares a match between the test and target scents.
摘要翻译：在本发明的示例性实施方案中，电子嗅觉元件确定被测试的香味是否与阳性对照的香味相匹配。电子嗅觉剂即使在不断变化的嗅觉环境中也可以进行这种气味的匹配，即使阳性对照气味是数百种或数千种不同气味剂的组合。不需要进行任何先前的培训，也没有尝试确定一个明确负责香味的单一加臭剂。相反，计算机将阳性对照样品的总气味模式与测试样品的总气味模式进行比较，以扫描多次电气输入到气味传感器的排列，以尝试找到总气味图案的任何条件不匹配。如果找不到这样的条件，那么计算机会声明测试和目标气味之间的匹配。

7. 发明申请

US20110169507A1 METHODS AND APPARATUS FOR THE DETERMINATION OF MOISTURE CONTENT 审中-公开
标题翻译：测定水分含量的方法和装置
公开(公告)号：US20110169507A1
公开(公告)日：2011-07-14
申请号：US12987037
申请日：2011-01-07
申请人： Andreas Mershin , Stella J. Karavas , Yiannis G. Karavas , Chris J. Lagadinos , Patrick J. Moran
发明人： Andreas Mershin , Stella J. Karavas , Yiannis G. Karavas , Chris J. Lagadinos , Patrick J. Moran
IPC分类号： G01R27/04
CPC分类号： G01N22/04 , G01N33/0098
摘要： Methods and apparatus for determining water content in a bulk heterogeneous material using electromagnetic radiation. A radiation source and a radiation receiver are positioned such that the material to be measured is located between them. As the radiation signal is transmitted from the source to the receiver, the signal experiences a path loss due, at least in part to the presence of the material located between the source and the receiver. The path loss in the transmitted signal, when recorded over time may be used to determine the water content of the material.
摘要翻译：使用电磁辐射测定大块异质材料中含水量的方法和装置。辐射源和辐射接收器被定位成使得待测量的材料位于它们之间。当辐射信号从源发射到接收机时，信号经历路径损耗，至少部分地由于位于源和接收机之间的材料的存在。随时间记录的传输信号中的路径损耗可用于确定材料的含水量。

8. 发明申请

US20090156427A1 Bio-Sensing Nanodevice 有权
标题翻译：生物传感纳米技术
公开(公告)号：US20090156427A1
公开(公告)日：2009-06-18
申请号：US12183916
申请日：2008-07-31
申请人： Shuguang Zhang , Andreas Mershin , Liselotte Kaiser , Brian Cook , Johanna F. Graveland-Bikker , Manu Prakash , David Kong , Yael Maguire
发明人： Shuguang Zhang , Andreas Mershin , Liselotte Kaiser , Brian Cook , Johanna F. Graveland-Bikker , Manu Prakash , David Kong , Yael Maguire
IPC分类号： C40B30/10 , B01J19/00 , C40B40/10 , C40B60/12 , C40B30/00 , C12P21/00
CPC分类号： G01N33/54366 , G01N2333/726
摘要： The invention provides a bio-sensing nanodevice comprising: a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—on a support, a real time receptor-ligand binding detection method, an odorant delivery system and an odorant recognition program. The biologically-derived G-protein coupled receptor can be stabilized on nanotechnology using surfactant peptide. The said nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.
摘要翻译：本发明提供一种生物感测纳米装置，其包括：稳定的生物衍生的G蛋白偶联受体 - 支持物上的嗅觉受体，实时受体 - 配体结合检测方法，加味剂递送系统和气味识别程序。生物衍生的G蛋白偶联受体可以使用表面活性剂肽在纳米技术上稳定。所述纳米器件提供更大的表面积，以提高气味检测的精度和灵敏度。本发明进一步提供了一种微流控芯片，其包含稳定的生物衍生的G蛋白偶联受体 - 嗅觉受体 - 固定在载体上，并且布置在至少二维微阵列系统中。本发明还提供了一种递送加臭剂的方法，其包括在复杂微流体网络中操作气泡的步骤，其中气泡在携带各种气体样品的微流体通道中移动到芯片上的精确位置。本发明还提供了制备hOR17-4嗅觉受体的方法。

9. 发明授权

US09140677B2 Methods and apparatus for artificial olfaction 有权
标题翻译：人造嗅觉的方法和装置
公开(公告)号：US09140677B2
公开(公告)日：2015-09-22
申请号：US13966169
申请日：2013-08-13
申请人： Andreas Mershin , Asmamaw Wassie , Yael Maguire , David Kong , Shuguang Zhang , Patrick Moran , Karolina Corin
发明人： Andreas Mershin , Asmamaw Wassie , Yael Maguire , David Kong , Shuguang Zhang , Patrick Moran , Karolina Corin
IPC分类号： G01N33/00 , G01N27/00
CPC分类号： G01N33/0031 , G01N27/00
摘要： In exemplary implementations of this invention, an electronic olfactor determines whether a scent being tested matches the scent of a positive control. The electronic olfactor can perform this scent matching even in a changing olfactory environment, and even if the positive control scent is a combination of hundreds or thousands of different odorants. No prior training is needed, and no attempt is made to identify a single odorant that is unambiguously responsible for a scent. Instead, a computer compares the total scent pattern of a positive control sample with the total scent pattern of a test sample, across a sweep of many permutations of electrical inputs to scent sensors, to try to find any condition under which the total scent patterns do not match. If such a condition cannot be found, then the computer declares a match between the test and target scents.
摘要翻译：在本发明的示例性实施方案中，电子嗅觉元件确定被测试的香味是否与阳性对照的香味相匹配。电子嗅觉剂即使在不断变化的嗅觉环境中也可以进行这种气味的匹配，即使阳性对照气味是数百种或数千种不同气味剂的组合。不需要进行任何先前的培训，也没有尝试确定一个明确负责香味的单一加臭剂。相反，计算机将阳性对照样品的总香味图案与测试样品的总香味图案进行比较，以扫描许多排列的电气输入到香味传感器，以尝试找到任何条件，在这些条件下总香味图案不匹配。如果找不到这样的条件，那么计算机会声明测试和目标气味之间的匹配。

10. 发明授权

US08796544B2 Bio-sensitized solar cells (BSSC) 有权
标题翻译：生物敏化太阳能电池（BSSC）
公开(公告)号：US08796544B2
公开(公告)日：2014-08-05
申请号：US11639372
申请日：2006-12-14
申请人： Andreas Mershin , Brian Cook , Shuguang Zhang
发明人： Andreas Mershin , Brian Cook , Shuguang Zhang
IPC分类号： H01G9/20 , H01L51/42
CPC分类号： H01G9/2027 , B82Y10/00 , B82Y30/00 , H01G9/204 , H01G9/2059 , H01L51/0093 , Y02E10/542 , Y02E10/549
摘要： The present invention provides a wet or dry bio-sensitized photoelectric conversion device (photodetector or photovoltaic) comprising: a stabilized biologically-derived sensitizer, such as a stablilized photosystem I (PS-I), deposited on nanowires, semiconductor material, electrodes and a support. The nanowires provide a greater surface area of the light absorption layer for better energy conversion efficiency and are chosen such as to complement the absorption spectrum of the sensitizer and protect the sensitizer from photobleaching.
摘要翻译：本发明提供一种湿或干生物敏化光电转换装置（光电检测器或光伏），其包括：稳定的生物衍生的敏化剂，例如沉积在纳米线，半导体材料，电极上的稳定的光系统I（PS-1）支持。纳米线提供更大的光吸收层的表面积以获得更好的能量转换效率，并且被选择为补充敏化剂的吸收光谱并保护敏化剂免受漂白。

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