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1. 发明授权

US06326167B1 TktA from Streptococcus pneumoniae 失效
标题翻译： TktA来自肺炎链球菌
公开(公告)号：US06326167B1
公开(公告)日：2001-12-04
申请号：US09298724
申请日：1999-04-23
申请人： Alison F Chalker , Sauli J Haataja , David W Holden , David J Holmes , Karen A Ingraham , Gee W Lau , Andrea Marra , Michael A Lonetto , Damien McDevitt , Jennifer Ray , Jun Yu
发明人： Alison F Chalker , Sauli J Haataja , David W Holden , David J Holmes , Karen A Ingraham , Gee W Lau , Andrea Marra , Michael A Lonetto , Damien McDevitt , Jennifer Ray , Jun Yu
IPC分类号： C07H2104
CPC分类号： C07K16/40
摘要： The invention provides tktA polypeptides and polynucleotides encoding tktA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tktA polypeptides and polynucleotides to screen for antibacterial compounds and for the detection of Streptococcus pneumoniae.
摘要翻译：本发明提供tktA多肽和编码tktA多肽的多核苷酸以及通过重组技术产生此类多肽的方法。还提供了利用tktA多肽和多核苷酸筛选抗菌化合物和检测肺炎链球菌的方法。

2. 发明申请

US20050095643A1 Method of generating conditionally expressed mutant cells using expressible antisense sequences 审中-公开
标题翻译：使用可表达的反义序列产生有条件表达的突变细胞的方法
公开(公告)号：US20050095643A1
公开(公告)日：2005-05-05
申请号：US11017379
申请日：2004-12-20
申请人： Andrea Marra , Martin Rosenberg , Yinduo Ji
发明人： Andrea Marra , Martin Rosenberg , Yinduo Ji
IPC分类号： A01K67/027 , C12N1/21 , C12Q1/68 , C12N15/85
CPC分类号： A01K67/027 , C12Q1/6897
摘要： The present invention provides a method for determining pathogen sensitivity to varying levels of reduction of a gene product using an expression vector system having a promoter that is essentially off in vitro and turns on selectively during the infection process in vivo. Genes and gene products identified by this method as essential to growth of infection of a selected pathogen are also provided. In addition, therapeutic compositions designed to target genes identified by this method are provided.
摘要翻译：本发明提供了一种使用具有在体外基本上关闭的启动子并且在体内感染过程中选择性导通的表达载体系统来确定对不同水平的基因产物的病原体敏感性的方法。还提供了通过该方法鉴定的对所选病原体的感染生长至关重要的基因和基因产物。另外，提供了旨在靶向通过该方法鉴定的基因的治疗组合物。

3. 发明授权

US6162619A Sensor histidine kinase of streptococcus pneumoniae 失效
标题翻译：传染性肺炎支原体组氨酸激酶
公开(公告)号：US6162619A
公开(公告)日：2000-12-19
申请号：US81686
申请日：1998-05-20
申请人： Sanjoy Biswas , Alexander Bryant , Yigong Ge , David John Holmes , Karen A Ingraham , Deborah Dee Jaworski , Andrea Marra , Lisa Kathleen Shilling , John P. Throup , Min Wang , Nicola Gail Wallis , Magdalena Zalacain
发明人： Sanjoy Biswas , Alexander Bryant , Yigong Ge , David John Holmes , Karen A Ingraham , Deborah Dee Jaworski , Andrea Marra , Lisa Kathleen Shilling , John P. Throup , Min Wang , Nicola Gail Wallis , Magdalena Zalacain
IPC分类号： C12N9/12 , C12N15/31 , C07H21/00 , C12N15/52 , C12N15/62 , C12N15/63
CPC分类号： C12N9/1205
摘要： The invention provides Histidine kinase polypeptides and polynucleotides encoding Histidine kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Histidine kinase polypeptides to screen for antibacterial compounds.
摘要翻译：本发明提供组氨酸激酶多肽和编码组氨酸激酶多肽的多核苷酸以及通过重组技术产生此类多肽的方法。还提供了利用组氨酸激酶多肽筛选抗菌化合物的方法。

4. 发明申请

US20080285283A1 Spiral Shaped, with Jointed Rigid Arms, Foldable Lamp 审中-公开
标题翻译：螺旋形，带有连接的刚性臂，折叠灯
公开(公告)号：US20080285283A1
公开(公告)日：2008-11-20
申请号：US10586468
申请日：2005-01-18
申请人： Claudio Marra , Andrea Marra
发明人： Claudio Marra , Andrea Marra
IPC分类号： F21S2/00 , F21V19/00
CPC分类号： F21V21/32 , F21V21/28 , F21V27/00
摘要： The present invention concerns a lamp with jointed rigid arms forming, in the folded position, a spiral shape, that can be a circular spiral or a polygonal spiral: see FIG. 1A, 2, 12, 13, 14, 15, 16. The arms are joined one another by means of joints, see FIG. 3, housed and locked inside the arms, and that consist of cylindrical hinges provided with brakes having an adjustable braking moment, see FIGS. 3, 4 and 5. This allows to turn at will the arms one another and to keep them still in the wanted position. The joints have a pass through hole inside, see FIGS. 3, 7 and 8, to permit the passing of the electric wires or of the optical fibres.
摘要翻译：本发明涉及一种具有连接的刚性臂的灯，在折叠位置处形成螺旋形，其可以是圆形螺旋形或多边形螺旋形。 1 A，2，12，13，14，15，16。臂通过接头彼此连接，参见图3。 3，容纳并锁定在臂内部，并且由具有可调制动力矩的制动器的圆柱形铰链组成，见图1和图2。 3，4和5。这样就可以将武器相互转动，并保持他们仍然在想要的位置。接头在内部具有通孔，见图1和图2。如图3，图7和图8所示，允许电线或光纤的通过。

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