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1. 发明授权

US08457759B2 Systems and methods for adjusting electrical therapy based on impedance changes 有权
公开(公告)号：US08457759B2
公开(公告)日：2013-06-04
申请号：US13620519
申请日：2012-09-14
申请人： Jon Parker , Andre B. Walker , Udai Singh
发明人： Jon Parker , Andre B. Walker , Udai Singh
IPC分类号： A61N1/00
CPC分类号： A61N1/36139 , A61N1/0551 , A61N1/08 , A61N1/3605 , A61N1/36071 , A61N1/36142 , A61N2001/083
摘要： System and methods for adjusting electrical therapy based on impedance changes are disclosed herein. A method in accordance with a particular embodiment includes applying a therapeutic electrical signal to a patient via an implanted portion of a patient stimulation system that includes a signal delivery device in electrical communication with a target neural population of the patient. The electrical signal is delivered in accordance with a signal delivery parameter having a first value. Using the implanted portion of the patient stimulation system, a change in an impedance of an electrical circuit that includes the signal delivery device is detected. Based at least in part on the detected impedance change, the method can further include automatically adjusting the value of the signal delivery parameter from the first value to a second value different from the first, without human intervention.

2. 发明申请

US20130073007A1 SYSTEMS AND METHODS FOR ADJUSTING ELECTRICAL THERAPY BASED ON IMPEDANCE CHANGES 有权
公开(公告)号：US20130073007A1
公开(公告)日：2013-03-21
申请号：US13620519
申请日：2012-09-14
申请人： Jon Parker , Andre B. Walker , Udal Singh
发明人： Jon Parker , Andre B. Walker , Udal Singh
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61N1/0551 , A61N1/08 , A61N1/3605 , A61N1/36071 , A61N1/36142 , A61N2001/083
摘要： System and methods for adjusting electrical therapy based on impedance changes are disclosed herein. A method in accordance with a particular embodiment includes applying a therapeutic electrical signal to a patient via an implanted portion of a patient stimulation system that includes a signal delivery device in electrical communication with a target neural population of the patient. The electrical signal is delivered in accordance with a signal delivery parameter having a first value. Using the implanted portion of the patient stimulation system, a change in an impedance of an electrical circuit that includes the signal delivery device is detected. Based at least in part on the detected impedance change, the method can further include automatically adjusting the value of the signal delivery parameter from the first value to a second value different from the first, without human intervention.

3. 发明申请

US20130041425A1 SYSTEMS AND METHODS FOR PRODUCING ASYNCHRONOUS NEURAL RESPONSES TO TREAT PAIN AND/OR OTHER PATIENT CONDITIONS 有权
公开(公告)号：US20130041425A1
公开(公告)日：2013-02-14
申请号：US13544727
申请日：2012-07-09
申请人： Zi-Ping Fang , Anthony V. Caparso , Andre B. Walker
发明人： Zi-Ping Fang , Anthony V. Caparso , Andre B. Walker
IPC分类号： A61N1/34
CPC分类号： A61N1/36171 , A61N1/0551 , A61N1/36071 , A61N1/37247
摘要： Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal.

4. 发明申请

US20120209349A1 SELECTIVE HIGH FREQUENCY SPINAL CORD MODULATION FOR INHIBITING PAIN WITH REDUCED SIDE EFFECTS, AND ASSOCIATED SYSTEMS AND METHODS 有权
公开(公告)号：US20120209349A1
公开(公告)日：2012-08-16
申请号：US13447050
申请日：2012-04-13
申请人： Konstantinos Alataris , Andre B. Walker , Jon Parker , Yougandh Chitre , Sangsoo Wesley Park , James R. Thacker
发明人： Konstantinos Alataris , Andre B. Walker , Jon Parker , Yougandh Chitre , Sangsoo Wesley Park , James R. Thacker
IPC分类号： A61N1/34
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/0553 , A61N1/06 , A61N1/36021 , A61N1/3605 , A61N1/36157 , A61N1/36164 , A61N1/36167 , A61N1/36171 , A61N1/36175 , A61N1/36182 , A61N1/37235 , A61N1/37241 , A61N1/37247 , A61N1/37264 , A61N1/3787
摘要： Selective high-frequency spinal chord modulation for inhibiting pain with reduced side affects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal chord region to address low back pain without creating unwanted sensory and/or motor side affects. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications.

5. 发明申请

US20120197369A1 SELECTIVE HIGH FREQUENCY SPINAL CORD MODULATION FOR INHIBITING PAIN WITH REDUCED SIDE EFFECTS, AND ASSOCIATED SYSTEMS AND METHODS 有权
公开(公告)号：US20120197369A1
公开(公告)日：2012-08-02
申请号：US13446944
申请日：2012-04-13
申请人： Konstantinos Alataris , Andre B. Walker , Jon Parker , Yougandh Chitre , Sangsoo Wesley Park , James R. Thacker
发明人： Konstantinos Alataris , Andre B. Walker , Jon Parker , Yougandh Chitre , Sangsoo Wesley Park , James R. Thacker
IPC分类号： A61N1/36
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/0553 , A61N1/06 , A61N1/36021 , A61N1/3605 , A61N1/36157 , A61N1/36164 , A61N1/36167 , A61N1/36171 , A61N1/36175 , A61N1/36182 , A61N1/37235 , A61N1/37241 , A61N1/37247 , A61N1/37264 , A61N1/3787
摘要： Selective high-frequency spinal chord modulation for inhibiting pain with reduced side affects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal chord region to address low back pain without creating unwanted sensory and/or motor side affects. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications.

6. 发明申请

US20120158093A1 SELECTIVE HIGH FREQUENCY SPINAL CORD MODULATION FOR INHIBITING PAIN WITH REDUCED SIDE EFFECTS, AND ASSOCIATED SYSTEMS AND METHODS 有权
标题翻译：用于抑制具有减少的副作用的疼痛的选择性高频脊柱调节以及相关系统和方法
公开(公告)号：US20120158093A1
公开(公告)日：2012-06-21
申请号：US13398693
申请日：2012-02-16
申请人： Konstantinos Alataris , Andre B. Walker , Jon Parker , Yougandh Chitre , Sangsoo Wesley Park , James R. Thacker
发明人： Konstantinos Alataris , Andre B. Walker , Jon Parker , Yougandh Chitre , Sangsoo Wesley Park , James R. Thacker
IPC分类号： A61N1/34 , A61N1/36
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/0553 , A61N1/06 , A61N1/36021 , A61N1/3605 , A61N1/36157 , A61N1/36164 , A61N1/36167 , A61N1/36171 , A61N1/36175 , A61N1/36182 , A61N1/37235 , A61N1/37241 , A61N1/37247 , A61N1/37264 , A61N1/3787
摘要： Selective high-frequency spinal chord modulation for inhibiting pain with reduced side affects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal chord region to address low back pain without creating unwanted sensory and/or motor side affects. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications.
摘要翻译：公开了选择性高频脊髓调制，用于抑制疼痛，减少副作用和相关系统和方法。在特定实施例中，可以将大约1.5KHz至大约50KHz范围内的高频调制施加到患者的脊弦区域以解决腰背痛而不产生不想要的感觉和/或运动副作用。在其他实施例中，根据类似参数的调制可以应用于其他脊柱或周边位置以解决其他指示。

7. 发明申请

US20120016439A1 DEVICES FOR CONTROLLING HIGH FREQUENCY SPINAL CORD MODULATION FOR INHIBITING PAIN, AND ASSOCIATED SYSTEMS AND METHODS, INCLUDING SIMPLIFIED CONTROLLERS 有权
标题翻译：用于控制用于抑制疼痛的高频脊柱调节装置，以及相关系统和方法，包括简化控制器
公开(公告)号：US20120016439A1
公开(公告)日：2012-01-19
申请号：US13245500
申请日：2011-09-26
申请人： Konstantinos Alataris , Andre B. Walker , James R. Thacker
发明人： Konstantinos Alataris , Andre B. Walker , James R. Thacker
IPC分类号： A61N1/372
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/0553 , A61N1/06 , A61N1/36021 , A61N1/3605 , A61N1/36157 , A61N1/36164 , A61N1/36167 , A61N1/36171 , A61N1/36175 , A61N1/36182 , A61N1/37235 , A61N1/37241 , A61N1/37247 , A61N1/37264 , A61N1/3787
摘要： Selective high-frequency spinal chord modulation for inhibiting pain with reduced side affects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal chord region to address low back pain without creating unwanted sensory and/or motor side affects. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications. In particular embodiments, aspects of the foregoing modulation therapies may be implemented by systems and devices that have simplified functionalities.
摘要翻译：公开了选择性高频脊髓调制，用于抑制疼痛，减少副作用和相关系统和方法。在特定实施例中，可以将大约1.5KHz至大约50KHz范围内的高频调制施加到患者的脊弦区域以解决腰背痛而不产生不想要的感觉和/或运动副作用。在其他实施例中，根据类似参数的调制可以应用于其他脊柱或周边位置以解决其他指示。在具体实施例中，前述调制疗法的方面可以由具有简化功能的系统和设备来实现。

8. 发明申请

US20100274326A1 SELECTIVE HIGH FREQUENCY SPINAL CORD MODULATION FOR INHIBITING PAIN WITH REDUCED SIDE EFFECTS, AND ASSOCIATED SYSTEMS AND METHODS, INCLUDING IMPLANTABLE PATIENT LEADS 审中-公开
标题翻译：选择性高频脊柱调节用于抑制具有减少的副作用的疼痛，以及相关系统和方法，包括可植入患者领导
公开(公告)号：US20100274326A1
公开(公告)日：2010-10-28
申请号：US12765805
申请日：2010-04-22
申请人： Yougandh Chitre , James R. Thacker , Andre B. Walker , Konstantinos Alataris
发明人： Yougandh Chitre , James R. Thacker , Andre B. Walker , Konstantinos Alataris
IPC分类号： A61N1/36
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/0553 , A61N1/06 , A61N1/36021 , A61N1/3605 , A61N1/36157 , A61N1/36164 , A61N1/36167 , A61N1/36171 , A61N1/36175 , A61N1/36182 , A61N1/37235 , A61N1/37241 , A61N1/37247 , A61N1/37264 , A61N1/3787
摘要： Selective high-frequency spinal chord modulation for inhibiting pain with reduced side affects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal chord region to address low back pain without creating unwanted sensory and/or motor side affects. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications.
摘要翻译：公开了选择性高频脊髓调制，用于抑制疼痛，减少副作用和相关系统和方法。在特定实施例中，可以将大约1.5KHz至大约50KHz范围内的高频调制施加到患者的脊弦区域以解决腰背痛而不产生不想要的感觉和/或运动副作用。在其他实施例中，根据类似参数的调制可以应用于其他脊柱或周边位置以解决其他指示。

9. 发明授权

US5428252A Power supply interruption detection and response system for a microcontroller 失效
标题翻译：微控制器的电源中断检测和响应系统
公开(公告)号：US5428252A
公开(公告)日：1995-06-27
申请号：US817465
申请日：1992-01-03
申请人： Andre B. Walker , Victor So
发明人： Andre B. Walker , Victor So
IPC分类号： G06F1/30 , G11C5/14 , H02J9/06 , H02J9/00 , G11C14/00
CPC分类号： G11C5/141 , G06F1/30 , H02J9/061 , Y10T307/615
摘要： A microcontroller power management system wherein the voltage of a power supply is monitored and the microcontroller central processing unit ("CPU") receives an interrupt signal when the supply voltage falls below a predetermined level. The CPU monitors the duration of the low voltage condition and switches into a sleep mode, after storing any data in its registers that are not maintained in the sleep mode, when that duration exceeds a fixed limit that indicates more than a temporary power glitch is being experienced. If only a short power glitch, the CPU continues normal operation. A large capacitor connected to the power supply input to the microcontroller provides enough energy for the microcontroller to operate normally during short glitches and to operate in a sleep mode for a considerable time, thereby maintaining data in CMOS static RAM until power is restored. This is particularly useful for battery operated systems, responding to both a low battery voltage condition and to a complete loss of power during battery replacement.
摘要翻译：一种微处理器电源管理系统，其中监视电源的电压，并且当电源电压低于预定电平时，微控制器中央处理单元（“CPU”）接收中断信号。在将任何数据存储在不保持在睡眠模式的寄存器中时，CPU将监视低电压状态的持续时间并切换到休眠模式，当该持续时间超过指示超过临时电源故障的固定限制时有经验的。如果只有短暂的电源故障，CPU会继续正常运行。连接到微控制器的电源输入的大电容器提供足够的能量，以使微控制器在短时间毛刺期间正常工作并在睡眠模式下工作相当长的时间，从而在电源恢复之前保持CMOS静态RAM中的数据。这对于电池供电的系统特别有用，对电池电压低的条件和电池更换期间电源的完全损失做出回应。

10. 发明授权

US08712533B2 Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods 有权
公开(公告)号：US08712533B2
公开(公告)日：2014-04-29
申请号：US12765747
申请日：2010-04-22
申请人： Konstantinos Alataris , Andre B. Walker , Jon Parker , Yougandh Chitre , Sangsoo Wesley Park , James R. Thacker
发明人： Konstantinos Alataris , Andre B. Walker , Jon Parker , Yougandh Chitre , Sangsoo Wesley Park , James R. Thacker
IPC分类号： A61N1/18 , A61N1/36 , A61N1/06 , A61N1/05
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/0553 , A61N1/06 , A61N1/36021 , A61N1/3605 , A61N1/36157 , A61N1/36164 , A61N1/36167 , A61N1/36171 , A61N1/36175 , A61N1/36182 , A61N1/37235 , A61N1/37241 , A61N1/37247 , A61N1/37264 , A61N1/3787
摘要： Selective high-frequency spinal cord modulation for inhibiting pain with reduced side effects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal cord region to address low back pain without creating unwanted sensory and/or motor side effects. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications.

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