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1. 发明授权

US11712053B2 Method for preparing an antimicrobial complex strain from kefir 有权
公开(公告)号：US11712053B2
公开(公告)日：2023-08-01
申请号：US17579432
申请日：2022-01-19
申请人： Amy Li , Li Wang , Youlian Zhao , Yuan Li
发明人： Jielong Liu
IPC分类号： A61K35/74 , A23L3/3571 , A23L19/00 , A01N63/20 , A23C9/127
CPC分类号： A23L3/3571 , A01N63/20 , A23C9/127 , A23L19/00 , A23V2002/00
摘要： The present disclosure relates to a method for preparing an antimicrobial complex strain from kefir, which includes: 1) providing and, optionally filtering, kefir or kefir whey; 2) introducing a fermentable sugar into the kefir or kefir whey, wherein based on the weight of the kefir or kefir whey, at least a saturation amount of said fermentable sugar is used, and allowing curd to gather at the top, so as to form a pre-fermentation composition; and 3) enabling the pre-fermentation composition to ferment until a microbial membrane that is capable of growth develops at the top and a whey liquid forms underneath, and the whey liquid demonstrates antimicrobial activity and has a pH of about 3.0, wherein during the fermentation, if needed, further adding said kefir or kefir whey and/or said fermentable sugar.

2. 外观设计

USD665025S1 Writing instrument 有权
公开(公告)号：USD665025S1
公开(公告)日：2012-08-07
申请号：US29388915
申请日：2011-04-04
申请人： Amy Li , James Bergman , Michael Albertini , Long Zhijun , Luo Qiang
设计人： Amy Li , James Bergman , Michael Albertini , Long Zhijun , Luo Qiang

3. 发明申请

US20220232862A1 METHOD FOR PREPARING AN ANTIMICROBIAL COMPLEX STRAIN FROM KEFIR 有权
公开(公告)号：US20220232862A1
公开(公告)日：2022-07-28
申请号：US17579432
申请日：2022-01-19
申请人： Amy LI , Li WANG , Youlian ZHAO , Yuan LI
发明人： Jielong LIU
IPC分类号： A23L3/3571 , A01N63/20 , A23C9/127 , A23L19/00
摘要： The present disclosure relates to a method for preparing an antimicrobial complex strain from kefir, which includes: 1) providing and, optionally filtering, kefir or kefir whey; 2) introducing a fermentable sugar into the kefir or kefir whey, wherein based on the weight of the kefir or kefir whey, at least a saturation amount of said fermentable sugar is used, and allowing curd to gather at the top, so as to form a pre-fermentation composition; and 3) enabling the pre-fermentation composition to ferment until a microbial membrane that is capable of growth develops at the top and a whey liquid forms underneath, and the whey liquid demonstrates antimicrobial activity and has a pH of about 3.0, wherein during the fermentation, if needed, further adding said kefir or kefir whey and/or said fermentable sugar.

4. 外观设计

USD508082S1 Writing instrument 失效
公开(公告)号：USD508082S1
公开(公告)日：2005-08-02
申请号：US29208901
申请日：2004-07-07
申请人： Charles E. Bain , Amy Li
设计人： Charles E. Bain , Amy Li

5. 外观设计

USD500520S1 Writing instrument 失效
公开(公告)号：USD500520S1
公开(公告)日：2005-01-04
申请号：US29190355
申请日：2003-09-16
申请人： Charles E. Bain , Amy Li
设计人： Charles E. Bain , Amy Li

6. 发明申请

US20200222466A1 ANTIMICROBIAL STRAIN COMPOSITION AND ITS PREPARATION METHOD 审中-公开
公开(公告)号：US20200222466A1
公开(公告)日：2020-07-16
申请号：US16732328
申请日：2020-01-01
申请人： Amy LI , Jielong LIU , Xia LIU , Li WANG
发明人： Jielong LIU , Xia LIU
IPC分类号： A61K35/20 , A61K31/70 , A61K35/747 , A61K35/57 , A61K36/87 , C12Q1/18 , A23L3/3463
摘要： Here disclosed is a method of preparing an antimicrobial strain composition from milk, a raw egg and a plant part, which includes the following steps: 1) providing a dairy composition comprising milk, a fermentable sugar, and edible starters from each of Lactobacillus, Bifidobacterium and Acetobacter, combining a first aliquot of the dairy composition (part A) with Rhizopus oryzae, Aspergillus niger and/or Aspergillus oryzae, and an edible starter from Saccharomyces, and conducting fermentation so as to enable the part A composition to substantially turn into a milk curd, 3) combining a second aliquot of the dairy composition (part B) with a raw egg, conducting fermentation so that eggshell substantially dissolves into the part B composition, making an opening on an eggshell membrane(s) without substantially affecting the construction of the eggshell membrane(s), and continuing fermentation of the part B composition until appearance of calcium particles on an inner surface of the eggshell membrane(s), 4) combining the part A composition obtained from step 2) and the part B composition obtained from step 3), and introducing thereinto the plant part and a fermentable sugar, so as to form an AB composition wherein casein is located on top of the AB composition, and 5) allowing the AB composition to ferment until a microbial membrane that is capable of growth develops on top of the AB composition and a liquid part forms underneath, and the liquid part is demonstrated anti-mould activity and has a pH≤about 3.0

7. 发明授权

US10898521B2 Antimicrobial strain composition and its preparation method 有权
公开(公告)号：US10898521B2
公开(公告)日：2021-01-26
申请号：US16732328
申请日：2020-01-01
申请人： Amy Li , Jielong Liu , Xia Liu , Li Wang
发明人： Jielong Liu , Xia Liu
IPC分类号： A61K35/20 , A23L3/3463 , A61K31/70 , A61K35/57 , A61K35/747 , A61K36/87 , C12Q1/18
摘要： Here disclosed is a method of preparing an antimicrobial strain composition from milk, a raw egg and a plant part, which includes the following steps: 1) providing a dairy composition comprising milk, a fermentable sugar, and edible starters from each of Lactobacillus, Bifidobacterium and Acetobacter, combining a first aliquot of the dairy composition (part A) with Rhizopus oryzae, Aspergillus niger and/or Aspergillus oryzae, and an edible starter from Saccharomyces, and conducting fermentation so as to enable the part A composition to substantially turn into a milk curd, 3) combining a second aliquot of the dairy composition (part B) with a raw egg, conducting fermentation so that eggshell substantially dissolves into the part B composition, making an opening on an eggshell membrane(s) without substantially affecting the construction of the eggshell membrane(s), and continuing fermentation of the part B composition until appearance of calcium particles on an inner surface of the eggshell membrane(s), 4) combining the part A composition obtained from step 2) and the part B composition obtained from step 3), and introducing thereinto the plant part and a fermentable sugar, so as to form an AB composition wherein casein is located on top of the AB composition, and 5) allowing the AB composition to ferment until a microbial membrane that is capable of growth develops on top of the AB composition and a liquid part forms underneath, and the liquid part is demonstrated anti-mould activity and has a pH≤about 3.0.

8. 发明申请

US20130177577A1 NLRC5 AS A TARGET TO INTERVENE MHC CLASS 1-MEDIATED IMMUNE RESPONSES 审中-公开
标题翻译： NLRC5作为干预MHC类别1介导的免疫应答的目标
公开(公告)号：US20130177577A1
公开(公告)日：2013-07-11
申请号：US13808729
申请日：2011-07-12
申请人： Koichi S. Kobayashi , Torsten B. Meissner , Amy Li
发明人： Koichi S. Kobayashi , Torsten B. Meissner , Amy Li
IPC分类号： A61K48/00 , A61K45/06 , A61K36/00 , A61K35/12 , A61K38/02 , A61K35/66
CPC分类号： A61K48/00 , A61K35/12 , A61K35/66 , A61K36/00 , A61K38/02 , A61K45/06 , C07K14/4702 , C12N15/1138 , C12N2310/14
摘要： A method to modulate MHC class I gene expression by modulating NLRC5 expression and/or NLRC5 activity in a subject is provided. The method comprises administering to the subject a compound HLA-A HLA-B that modulates NLRC5 expression and/or NLRC5 activity in an amount effective to modulates MHC class I gene expression. Also described is a screen for compounds that modulate NLRC5 expression. Candidate compounds are tested for their ability to modulate NLRC5 expression.
摘要翻译：提供了通过调节受试者中的NLRC5表达和/或NLRC5活性来调节MHC I类基因表达的方法。该方法包括向受试者施用以有效调节MHC I类基因表达的量调节NLRC5表达和/或NLRC5活性的化合物HLA-A HLA-B。还描述了调节NLRC5表达的化合物的筛选。测试候选化合物调节NLRC5表达的能力。

9. 外观设计

USD679326S1 Writing instrument 有权
公开(公告)号：USD679326S1
公开(公告)日：2013-04-02
申请号：US29426109
申请日：2012-06-29
申请人： Amy Li , James Bergman , Michael Albertini , Zhijun Long , Qiang Luo
设计人： Amy Li , James Bergman , Michael Albertini , Zhijun Long , Qiang Luo

10. 外观设计

USD501511S1 Clip for a writing instrument 失效
标题翻译：剪辑一个书写工具
公开(公告)号：USD501511S1
公开(公告)日：2005-02-01
申请号：US29208908
申请日：2004-07-07
申请人： Charles E. Bain , Amy Li
设计人： Charles E. Bain , Amy Li

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