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1. 发明授权

US06808522B2 Microchip devices for delivery of molecules and methods of fabrication thereof 有权
标题翻译：用于递送分子的Microchip器件及其制造方法
公开(公告)号：US06808522B2
公开(公告)日：2004-10-26
申请号：US09727858
申请日：2000-12-01
申请人： Amy C. Richards , John T. Santini, Jr. , Michael J. Cima , Robert S. Langer
发明人： Amy C. Richards , John T. Santini, Jr. , Michael J. Cima , Robert S. Langer
IPC分类号： A16K922
CPC分类号： A61K9/0097 , A61K9/0009 , A61K9/0024 , Y10T436/25
摘要： Methods of manufacturing microchip devices are provided for controlled release of molecules, such as drugs. Methods include compression molding and casting, alone or in combination with microfabrication techniques. In preferred embodiments, devices are made by (1) filling a die with a polymer powder; (2) compressing the powder to form a polymer preform; (3) thermal compression molding the preform to form a substrate in a mold having a plurality of protrusions that form reservoirs in the substrate; and (4) filling the reservoirs with a release system comprising the molecules to be released. Alternatively, ceramic devices are formed by casting the substrate from a ceramic powder or a slurry using a mold having protrusions that form reservoirs in the substrate. Control over the release rate and time of the molecules from the reservoirs of the microchip device is provided by incorporating release systems and/or reservoir caps.
摘要翻译：提供制造微芯片器件的方法用于控制释放诸如药物之类的分子。方法包括压塑和铸造，单独或与微细加工技术组合。在优选实施例中，装置通过（1）用聚合物粉末填充模具制成; （2）压缩粉末以形成聚合物预成型体; （3）热压缩成型预成型件以在具有在基板中形成储存器的多个突起的模具中形成基板; 和（4）用包含要释放的分子的释放系统填充储存器。或者，通过使用具有在基板中形成储存器的突起的模具从陶瓷粉末或浆料浇铸基材来形成陶瓷装置。通过结合释放系统和/或储存器盖来控制来自微芯片装置的储存器的分子的释放速率和时间。

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