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1. 发明授权

US06528465B1 Viscosity enhanced ophthalmic solution, having a detergent action on contact lenses 有权
标题翻译：粘度增强的眼用溶液，对隐形眼镜具有洗涤剂作用
公开(公告)号：US06528465B1
公开(公告)日：2003-03-04
申请号：US09937513
申请日：2001-09-25
申请人： Amalio Cantoro
发明人： Amalio Cantoro
IPC分类号： C11D1722
CPC分类号： C11D1/008 , C11D1/66 , C11D3/0078 , C11D3/228 , C11D3/3707 , Y10S514/912
摘要： An ophthalmic solution with viscosity enhancing and detergent properties for contact lenses, comprising one or more physiologically acceptably viscosity enhancing agents in aqueous solution having a non-Newtonian rheological behaviour, and one or more physiologically acceptable non-ionic surfactants. The non-ionic surfactant may be selected among esters of fatty acids, sorbitan polyoxyethylates (i.e. polysorbates, such as “Tween”), or block copolymers polyoxyethylene-polyoxypropylene (i.e. poloxamers, such as “Pluronic”). The viscosity enhancing agent may be selected among hyaluronic acid or its salts with alkali or alkaline-earth metals, ethers or esters of cellulose, chitosans, gellans, alginates or carboxyvinyl polymers of the kind Carbopolol® (or carbomer).
摘要翻译：一种具有粘度增强和用于隐形眼镜的洗涤剂性质的眼用溶液，其包含具有非牛顿流变行为的水溶液中的一种或多种生理可接受的粘度增强剂和一种或多种生理上可接受的非离子表面活性剂。非离子表面活性剂可以选自脂肪酸，脱水山梨糖醇聚氧乙烯酸酯（即聚山梨醇酯，例如“吐温”）或嵌段共聚物聚氧乙烯 - 聚氧丙烯（即泊洛沙姆，例如“Pluronic”）的酯。粘度增强剂可以选自透明质酸或其盐与碱金属或碱土金属，纤维素的醚或酯，壳聚糖，凝胶凝胶，藻酸盐或卡波姆（卡波姆）类的羧基乙烯基聚合物。

2. 发明授权

US5770628A Ophthalmic preparation for use as artificial tear 失效
标题翻译：用作人造泪液的眼科制剂
公开(公告)号：US5770628A
公开(公告)日：1998-06-23
申请号：US505095
申请日：1995-07-21
申请人： Amalio Cantoro
发明人： Amalio Cantoro
IPC分类号： A61K9/08 , A61K9/00 , A61K31/715 , A61K31/728 , A61K33/06 , A61K33/14 , A61K33/42 , A61P27/02 , A61P27/04 , A61K31/74 , A01N59/26
CPC分类号： A61K9/0048 , Y10S514/915
摘要： Ophthalmic preparation for use as artificial tear containing hyaluronate as a viscosity thickener, preferably in the form of sodic salt and having a molecular weight of 500,000 to 4,000,000 daltons, at a concentration of 0.05 to 2% by weight, as well as the following minimum quantities of ionic species: 40 mmol/l sodium ion, 12 mmol/l potassium ion, 0.4 mmol/l calcium ion, 0.4 mmol/l magnesium ion, 50 mmol/l chloride ion, 7 mmol/l phosphate ion and, preferably, 0.7 mmol/l citrate ion. The formulation, which as an osmolarity of 140 to 280 mOsm/l, is useful for the treatment of keratoconjunctivitis sicca and may be administered whenever the use of artifical tears is advisable, e.g. for the treatment of eye irritations caused by environmental conditions or contact lenses.
摘要翻译：用作含有透明质酸盐作为粘度增稠剂的人造泪液的眼用制剂，优选为钠盐形式，分子量为500,000至4,000,000道尔顿，浓度为0.05至2重量％，以及以下最小量的离子物质：40mmol / l钠离子，12mmol / l钾离子，0.4mmol / l钙离子，0.4mmol / l镁离子，50mmol / l氯离子，7mmol / l磷酸根离子，优选0.7 mmol / l柠檬酸根离子。作为渗透摩尔浓度为140至280mOsm / l的制剂可用于治疗角结膜炎角膜炎，并且可以在使用人造眼泪时施用，例如，用于治疗由环境条件引起的眼睛刺激或隐形眼镜。

3. 发明授权

US5871772A Sodium hyaluronate viscous solutions for use as masking fluid in therapeutic photokeratectomy by means of excimer laser 失效
标题翻译：透明质酸钠溶液用于通过准分子激光治疗光疗治疗中的掩蔽液
公开(公告)号：US5871772A
公开(公告)日：1999-02-16
申请号：US570097
申请日：1995-12-11
申请人： Amalio Cantoro
发明人： Amalio Cantoro
IPC分类号： A61F9/007 , A61K31/728 , A61K33/42 , A61L31/00 , A61L31/04 , C08B37/08 , A61K31/715
CPC分类号： A61K33/42 , A61K31/728 , A61L31/042 , A61L2430/16
摘要： Sodium hyaluronate viscous aqueous solutions of molecular weight from 1,200,000 to 2,200,000 Daltons at concentrations from 0.10% to 0.40% by weight are proposed for use as masking fluid in therapeutic photokeratectomy by means of excimer laser (PTK), which realizes the ablation of superficial layers of corneal tissue for the elimination of unevenness and macula derived from different traumatic or pathological conditions. Preferably, the proposed solutions also contain one or more cationic species selected from the group consisting of sodium, potassium, calcium and magnesium ion and one or more anionic species selected from the group consisting of chloride, phosphate and citrate ion and, preferably, glucose. The solutions according to the invention wet the cornea and protect its areas which remain distressed after surgery, enabling the obtainment of uniform and smooth ablated surfaces. Further, they enable the execution of intraoperative corneal topographic tests.
摘要翻译：提出分子量为1,200,000至2,200,000道尔顿的透明质酸钠粘稠水溶液，浓度为0.10％至0.40％（重量），用于通过准分子激光（PTK）进行治疗性光切除术中的掩蔽液，其实现了表层的消融角膜组织用于消除源于不同外伤或病理状况的不均匀性和黄斑。优选地，所提出的溶液还含有一种或多种选自钠，钾，钙和镁离子的阳离子物质和一种或多种选自氯离子，磷酸盐和柠檬酸根离子，以及优选葡萄糖的阴离子种类。根据本发明的溶液润湿角膜并保护其在手术后保持痛苦的区域，使得能够获得均匀且平滑的烧蚀表面。此外，它们能够执行术中角膜地形测试。

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