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1. 发明申请

US20070059316A1 Singlet oxygen photosensitizers activated by target binding enhancing the selectivity of targeted pdt agents 审中-公开
标题翻译：通过靶结合活化的单线态氧光敏剂增强靶向pdt试剂的选择性
公开(公告)号：US20070059316A1
公开(公告)日：2007-03-15
申请号：US10517569
申请日：2004-09-23
申请人： Alexander Pallenberg , James Chen
发明人： Alexander Pallenberg , James Chen
IPC分类号： A61K39/395 , A61K38/40 , A61K31/58 , A61K31/715 , C07D487/22 , C07K16/46 , C07K14/80
CPC分类号： A61K49/0021 , A61K41/0057 , A61K41/0071 , A61K41/0076 , A61K49/005
摘要： Provided herein are conjugates, kits, articles of manufacture and methods for detection, diagnosis and treatment by photodynamic therapy of certain undesired biological substrate targets, including, but not limited to bacteria, viruses, and other pathogenic microorganisms, tumors and hyperproliferative tissue. In particular, the conjugates provided include a fluorophore or photosensitizer linked to a targeting moiety and a quenching agent in such a way that activation of the fluorophore or the photosensitizer is quenched unless the targeting moiety is bound to a target, whereupon the quenching agent dissociates or moves away from the photosensitizer, enabling activation of the photosensitizer upon irradiation with light of a suitable wavelength.
摘要翻译：本文提供了缀合物，试剂盒，制品和用于通过光动力学治疗某些不期望的生物底物靶（包括但不限于细菌，病毒和其它病原微生物，肿瘤和过度增生组织）进行检测，诊断和治疗的方法。特别地，提供的缀合物包括与靶向部分和猝灭剂连接的荧光团或光敏剂，使得荧光团或光敏剂的活化被淬灭，除非靶向部分结合到靶上，随后猝灭剂解离或远离光敏剂，能够在用合适波长的光照射时激活光敏剂。

2. 发明申请

US20060067889A1 Singlet oxygen photosensitizers activated by target binding enhancing the selectivity of targeted PDT agents 审中-公开
标题翻译：通过靶结合活化的单线态氧光敏剂增强靶向PDT剂的选择性
公开(公告)号：US20060067889A1
公开(公告)日：2006-03-30
申请号：US10951037
申请日：2004-09-27
申请人： Alexander Pallenberg , James Chen
发明人： Alexander Pallenberg , James Chen
IPC分类号： A61K49/00 , A61K39/395 , A61K31/555 , C07K16/46
CPC分类号： A61K49/0036 , A61K31/555 , A61K41/0057 , A61K41/0071 , A61K41/0076 , A61K49/0054 , C09B47/00
摘要： Provided herein are conjugates, kits, articles of manufacture and methods for detection, diagnosis and treatment by photodynamic therapy of certain undesired biological substrate targets, including, but not limited to bacteria, viruses, and other pathogenic microorganisms, tumors and hyperproliferative tissue. In particular, the conjugates provided include a fluorophore or photosensitizer linked to a targeting moiety and a quenching agent in such a way that activation of the fluorophore or the photosensitizer is quenched unless the targeting moiety is bound to a target, whereupon the quenching agent dissociates or moves away from the photosensitizer, enabling activation of the photosensitizer upon irradiation with light of a suitable wavelength.
摘要翻译：本文提供了缀合物，试剂盒，制品和用于通过光动力学治疗某些不期望的生物底物靶（包括但不限于细菌，病毒和其它病原微生物，肿瘤和过度增生组织）进行检测，诊断和治疗的方法。特别地，提供的缀合物包括与靶向部分和猝灭剂连接的荧光团或光敏剂，使得荧光团或光敏剂的活化被淬灭，除非靶向部分结合到靶上，随后猝灭剂解离或远离光敏剂，能够在用合适波长的光照射时激活光敏剂。

3. 发明申请

US20080021210A1 COMPOSITIONS AND METHODS OF MAKING A PHOTOACTIVE AGENT 有权
标题翻译：制备光合剂的组合物和方法
公开(公告)号：US20080021210A1
公开(公告)日：2008-01-24
申请号：US11772024
申请日：2007-06-29
申请人： Leon Xu , Alexander Pallenberg
发明人： Leon Xu , Alexander Pallenberg
IPC分类号： C07D491/22
CPC分类号： C07D491/22
摘要： An improved two stage reaction process for production of mono-L-aspartyl chlorin e6. In a first stage, the activation reaction between chlorin e6 and a carbodiimide produces a previously unknown anhydride in an activation reaction product. This reaction product is purified to remove a significant proportion of the precursors of di-L-aspartyl chlorin e6. The purified activation reaction product contains a higher concentration of the previously unknown anhydride. This purified reaction product is used in a second stage: a coupling reaction of the purified activation reaction product with aspartate. The coupling reaction produces a coupling reaction product that has significantly reduced di-L-aspartyl chlorin e6 concentration. This reduced di-L-aspartyl chlorin e6 concentration facilitates purification of mono-L-aspartyl chlorin e6 from the coupling reaction mixture.
摘要翻译：改进的用于生产单-L-天冬氨酰二氢卟酚的二级反应方法。在第一阶段，二氢卟酚和碳二亚胺之间的活化反应在活化反应产物中产生以前未知的酸酐。将该反应产物纯化以除去相当大比例的二-L-天冬氨酰二氢卟酚e前体的前体。纯化的活化反应产物含有较高浓度的先前未知的酸酐。该纯化的反应产物用于第二阶段：纯化的活化反应产物与天冬氨酸的偶联反应。偶联反应产生显着降低二-L-天冬氨酰二氢卟吩e6浓度的偶联反应产物。这种减少的二-L-天冬氨酰二氢卟吩e6浓度有助于从偶联反应混合物中纯化单-L-天冬氨酰二ine素e6。

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