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1. 发明授权

US08722040B2 Site-activated binding systems that selectively increase the bioactivity of phenolic compounds at target sites 有权
标题翻译：选择性地增加酚类化合物在靶位点的生物活性的位点活化的结合体系
公开(公告)号：US08722040B2
公开(公告)日：2014-05-13
申请号：US13135124
申请日：2011-06-24
申请人： Alexander L. Huang , Gin Wu
发明人： Alexander L. Huang , Gin Wu
IPC分类号： A61K38/44
CPC分类号： A61K33/40 , A61K31/05 , A61K31/192 , A61K31/35 , A61K31/353 , A61K31/365 , A61K31/366 , A61K31/7032 , A61K36/185 , A61K36/22 , A61K36/82 , Y02A50/473 , Y02A50/481
摘要： The teachings provided herein generally relate to site-activated binding systems that selectively increase the bioactivity of phenolic compounds at target sites. More particularly, the systems taught here include a phenolic compound bound to a reactive oxygen species, wherein the phenolic compound and the reactive oxygen species react at a target area in the presence of an oxidoreductase enzyme.
摘要翻译：本文提供的教导通常涉及选择性地增加酚化合物在靶位点的生物活性的位点活化结合系统。更具体地说，本文中教导的系统包括与活性氧物质结合的酚类化合物，其中酚类化合物和活性氧在氧化还原酶存在下在目标区域反应。

2. 发明申请

US20120328711A1 Antimicrobial system for selective, site-activated binding at target sites 审中-公开
标题翻译：用于选择性，位点活化的目标位点结合的抗菌系统
公开(公告)号：US20120328711A1
公开(公告)日：2012-12-27
申请号：US13135128
申请日：2011-06-24
申请人： Alexander L. Huang , Gin Wu
发明人： Alexander L. Huang , Gin Wu
IPC分类号： A61K33/40 , A61P1/00 , A61P31/00 , A61P17/00
CPC分类号： A61K31/7024 , A61K31/353 , A61K33/40 , A61K2300/00
摘要： The teachings provided herein generally relate to site-activated binding systems that selectively increase the bioactivity of phenolic compounds at target sites. More particularly, the systems taught here include a phenolic compound bound to a reactive oxygen species, wherein the phenolic compound and the reactive oxygen species react at a target area in the presence of an oxidoreductase enzyme.
摘要翻译：本文提供的教导通常涉及选择性地增加酚化合物在靶位点的生物活性的位点活化结合系统。更具体地说，本文中教导的系统包括与活性氧物质结合的酚类化合物，其中酚类化合物和活性氧在氧化还原酶存在下在目标区域反应。

3. 发明申请

US20100158885A1 METHOD AND MATERIAL FOR SITE ACTIVATED COMPLEXING OF BIOLOGIC MOLECULES 有权
标题翻译：用于生物分子的活性复合物的方法和材料
公开(公告)号：US20100158885A1
公开(公告)日：2010-06-24
申请号：US12715270
申请日：2010-03-01
申请人： Alexander L. Huang , Gin Wu
发明人： Alexander L. Huang , Gin Wu
IPC分类号： A61K38/44 , A61K31/70 , A61K31/7032 , A61K31/37 , A61K31/352 , A61P1/12 , A61P31/00 , A61K31/715 , A61K36/00 , A61K31/05 , A01N31/08 , A01N43/16 , A01N43/02 , A01N61/00 , A01N43/04 , A61P17/02 , C07C39/04 , C07G1/00 , C07K2/00 , C12N1/00
CPC分类号： A61K36/82 , A01N59/00 , A01N65/08 , A23K20/111 , A23L33/105 , A61K31/05 , A61K31/122 , A61K33/40 , A61K36/185 , A61K36/22 , A61K38/44 , C07G1/00 , C07K1/1072 , A61K2300/00
摘要： Methods of and compositions for producing and using plant-based materials are provided. The methods include using biopolymers or their synthetic equivalents combined with a stable source of reactive oxygen species that when applied to or combined with a separate source of oxido-reducing enzyme or catalyst will cause the formation of an activated biopolymer with increased protein binding affinity and microbial control activities.
摘要翻译：提供了生产和使用植物材料的方法和组合物。这些方法包括使用生物聚合物或其合成当量与稳定的活性氧源组合，当应用于或与单独的氧化还原酶或催化剂的来源组合时，将引起具有增加的蛋白质结合亲和力和微生物的活化生物聚合物的形成控制活动。

4. 发明申请

US20090018549A1 APPARATUS FOR OCCLUDING BODY LUMENS 有权
公开(公告)号：US20090018549A1
公开(公告)日：2009-01-15
申请号：US11777522
申请日：2007-07-13
申请人： Rupesh Desai , Alexander L. Huang , Steven Yee
发明人： Rupesh Desai , Alexander L. Huang , Steven Yee
IPC分类号： A61B17/22
CPC分类号： A61B17/12022 , A61B17/12099 , A61B17/12131
摘要： A luminal occlusion device comprises a tension member, an elongate shaft, and a flat film having an axial receptacle which is received over a distal portion of the tension member. The flat film has proximal and distal ends which are attached to the distal ends of the tension member and the elongate shaft, respectively. Thus, distal advancement of the tension member relative to the shaft will cause the flat film to assume a low profile configuration, while proximal retraction of the tension member relative to the elongate shaft will cause the flat film to assume a foreshortened, compacted configuration. The film usually includes one or more radioopaque markers which help shape the compacted film.

5. 发明授权

US07195629B2 Methods and systems for focused bipolar tissue ablation 有权
标题翻译：聚焦双极组织消融的方法和系统
公开(公告)号：US07195629B2
公开(公告)日：2007-03-27
申请号：US10643635
申请日：2003-08-18
申请人： Robert S. Behl , Morton Grosser , Alexander L. Huang
发明人： Robert S. Behl , Morton Grosser , Alexander L. Huang
IPC分类号： A61B18/18
CPC分类号： A61B18/1477 , A61B2018/0016 , A61B2018/00577 , A61B2018/143 , A61B2018/1432 , A61B2018/1467
摘要： Large tissue regions are treated using pairs of electrode arrays. The electrode arrays may be concave and disposed in tissue so that their concave portions are opposed to each other. Axial conductors may be provided extending from the arrays and toward each other in order to increase the heating of tissues lying along the axis between the deployed electrode arrays. By properly spacing the electrode arrays apart and selecting the diameters of the arrays, desired volumes of tissue may be treated, typically with a bipolar, radiofrequency current.
摘要翻译：使用成对的电极阵列处理大的组织区域。电极阵列可以是凹形的并且设置在组织中，使得它们的凹部彼此相对。可以提供轴向导体从阵列延伸并且朝彼此延伸，以便增加沿着部署的电极阵列之间的轴线的组织的加热。通过将电极阵列分开适当地间隔并选择阵列的直径，可以通常使用双极射频电流来处理所需体积的组织。

6. 发明授权

US08734867B2 Antibacterial having an extract of pomegranate combined with hydrogen peroxide 有权
标题翻译：具有石榴提取物与过氧化氢结合的抗菌剂
公开(公告)号：US08734867B2
公开(公告)日：2014-05-27
申请号：US12317638
申请日：2008-12-23
申请人： Alexander L. Huang , Gin Wu
发明人： Alexander L. Huang , Gin Wu
IPC分类号： A61K36/00
CPC分类号： A61K33/40 , A01N59/00 , A01N2300/00 , A61K31/05 , A61K36/00 , A61K36/185 , A61K36/82 , A61K2300/00 , A01N25/08 , A01N25/22 , A01N65/08 , A01N65/20 , A01N65/40 , A01N65/42 , A01N65/44
摘要： The present invention is directed to a method and a composition for producing and using a plant-based biocidal solution. The plant-based biocidal solution contains a bioactive material and a plant-based substance formed from the cellular material of a plant. The plant-based substance is capable of binding to the bioactive material. In some embodiments, the bioactive material is hydrogen peroxide. The hydrogen peroxide can be added exogenously or generated endogenously. In accordance with further embodiments, the plant-based biocidal solution can be applied to a target, thereby impairing the target. In some embodiments, the target can be a pathogen. In accordance with another embodiment, the plant-based substance of the plant-based biocidal solution can form a microscopic cluster, a complex, or an aggregate for providing sufficient bioactive material to overcome the defense mechanism of the target.
摘要翻译：本发明涉及一种用于生产和使用植物性杀生物溶液的方法和组合物。基于植物的杀生物溶液含有生物活性物质和由植物的细胞材料形成的基于植物的物质。植物性物质能够结合生物活性物质。在一些实施方案中，生物活性物质是过氧化氢。过氧化氢可以外源添加或内生生成。根据进一步的实施方案，可以将基于植物的杀生物溶液施用于靶，从而损害靶。在一些实施方案中，靶可以是病原体。根据另一个实施方案，基于植物的杀生物溶液的基于植物的物质可以形成微观簇，复合物或聚集体，以提供足够的生物活性物质来克服靶的防御机制。

7. 发明授权

US08722116B2 Treating a bacteria-induced gastric disorder with a mixture having pomegranate and hydrogen peroxide 有权
标题翻译：用石榴和过氧化氢的混合物治疗细菌诱导的胃病
公开(公告)号：US08722116B2
公开(公告)日：2014-05-13
申请号：US12868634
申请日：2010-08-25
申请人： Alexander L. Huang , Gin Wu
发明人： Alexander L. Huang , Gin Wu
IPC分类号： A61K36/00
CPC分类号： A61K33/40 , A01N59/00 , A01N2300/00 , A61K31/05 , A61K36/00 , A61K36/185 , A61K36/82 , A61K2300/00 , A01N25/08 , A01N25/22 , A01N65/08 , A01N65/20 , A01N65/40 , A01N65/42 , A01N65/44
摘要： The present invention is directed to a method and a composition for producing and using a plant-based biocidal solution. The plant-based biocidal solution contains a bioactive material and a plant-based substance formed from the cellular material of a plant. The plant-based substance is capable of binding to the bioactive material. In some embodiments, the bioactive material is hydrogen peroxide. The hydrogen peroxide can be added exogenously or generated endogenously. In accordance with further embodiments, the plant-based biocidal solution can be applied to a target, thereby impairing the target. In some embodiments, the target can be a pathogen. In accordance with another embodiment, the plant-based substance of the plant-based biocidal solution can form a microscopic cluster, a complex, or an aggregate for providing sufficient bioactive material to overcome the defense mechanism of the target.
摘要翻译：本发明涉及一种用于生产和使用植物性杀生物溶液的方法和组合物。基于植物的杀生物溶液含有生物活性物质和由植物的细胞材料形成的基于植物的物质。植物性物质能够结合生物活性物质。在一些实施方案中，生物活性物质是过氧化氢。过氧化氢可以外源添加或内生生成。根据进一步的实施方案，可以将基于植物的杀生物溶液施用于靶，从而损害靶。在一些实施方案中，靶可以是病原体。根据另一个实施方案，基于植物的杀生物溶液的基于植物的物质可以形成微观簇，复合物或聚集体，以提供足够的生物活性物质来克服靶的防御机制。

8. 发明授权

US08475489B2 Apparatus for occluding body lumens 有权
标题翻译：用于阻塞体腔的装置
公开(公告)号：US08475489B2
公开(公告)日：2013-07-02
申请号：US12041241
申请日：2008-03-03
申请人： Rupesh Desai , Alexander L. Huang , Steven Yee , Jennifer Hodor
发明人： Rupesh Desai , Alexander L. Huang , Steven Yee , Jennifer Hodor
IPC分类号： A61M29/00
CPC分类号： A61B17/12131 , A61B17/12022 , A61B17/12099 , A61B17/1214 , A61B17/22 , A61B17/221 , A61B2017/00867 , A61B2017/1205 , A61B2017/22054 , A61B2017/22067 , A61B2017/22084 , A61B2017/2217
摘要： A luminal occlusion device comprises a tension member, an elongate shaft, and a flat film having an axial receptacle which is received over a distal portion of the tension member. The flat film has proximal and distal ends which are attached to the distal ends of the tension member and the elongate shaft, respectively. Thus, distal advancement of the tension member relative to the shaft will cause the flat film to assume a low profile configuration, while proximal retraction of the tension member relative to the elongate shaft will cause the flat film to assume a foreshortened, compacted configuration. The film usually includes one or more radioopaque markers which help shape the compacted film.
摘要翻译：管腔闭塞装置包括张力构件，细长轴和具有轴承座的扁平膜，所述轴向容纳件容纳在所述张力构件的远侧部分上。平膜具有近端和远端，它们分别附接到张紧构件和细长轴的远端。因此，张力构件相对于轴的远侧前进将导致平膜呈现低轮廓构型，而张紧构件相对于细长轴的近端缩回将导致平膜呈现缩短的压实构型。该膜通常包括一个或多个不透射线的标记，其有助于形成压实膜。

9. 发明申请

US20120328710A1 Selective, site-activated binding of toxins at target sites 有权
标题翻译：选择性，位点活化的毒素在靶位点的结合
公开(公告)号：US20120328710A1
公开(公告)日：2012-12-27
申请号：US13135125
申请日：2011-06-24
申请人： Alexander L. Huang , Gin Wu
发明人： Alexander L. Huang , Gin Wu
IPC分类号： A61K33/40 , A61P1/00 , A61P39/02 , A61P17/00
CPC分类号： A61K36/00 , A61K31/353 , A61K31/7024 , A61K33/40 , A61K36/185 , A61K36/82 , A61K2300/00
摘要： The teachings provided herein generally relate to site-activated binding systems that selectively increase the bioactivity of phenolic compounds at target sites. More particularly, the systems taught here include a phenolic compound bound to a reactive oxygen species, wherein the phenolic compound and the reactive oxygen species react at a target area in the presence of an oxidoreductase enzyme.
摘要翻译：本文提供的教导通常涉及选择性地增加酚化合物在靶位点的生物活性的位点活化结合系统。更具体地说，本文中教导的系统包括与活性氧物质结合的酚类化合物，其中酚类化合物和活性氧在氧化还原酶存在下在目标区域反应。

10. 发明申请

US20120016357A1 METHODS AND SYSTEMS FOR FOCUSED BIPOLAR TISSUE ABLATION 有权
公开(公告)号：US20120016357A1
公开(公告)日：2012-01-19
申请号：US13239071
申请日：2011-09-21
申请人： Robert S. Behl , Morton Grosser , Alexander L. Huang
发明人： Robert S. Behl , Morton Grosser , Alexander L. Huang
IPC分类号： A61B18/18
CPC分类号： A61B18/1477 , A61B2018/0016 , A61B2018/00577 , A61B2018/143 , A61B2018/1432 , A61B2018/1467
摘要： Large tissue regions are treated using pairs of electrode arrays. The electrode arrays may be concave and disposed in tissue so that their concave portions are opposed to each other. Axial conductors may be provided extending from the arrays and toward each other in order to increase the heating of tissues lying along the axis between the deployed electrode arrays. By properly spacing the electrode arrays apart and selecting the diameters of the arrays, desired volumes of tissue may be treated, typically with a bipolar, radiofrequency current.

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