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1. 发明申请

US20120214156A1 DEVICE INCLUDING A DISSOLVABLE STRUCTURE FOR FLOW CONTROL 审中-公开
标题翻译：包括用于流量控制的不溶性结构的装置
公开(公告)号：US20120214156A1
公开(公告)日：2012-08-23
申请号：US13403355
申请日：2012-02-23
申请人： Debjyoti BANERJEE , Konrad Faulstich , Aldrich N.K. Lau , Umberto Ulmanella , Jun Xie
发明人： Debjyoti BANERJEE , Konrad Faulstich , Aldrich N.K. Lau , Umberto Ulmanella , Jun Xie
IPC分类号： C12Q1/68 , B01L3/02 , G01N1/38
CPC分类号： F16K99/0001 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0415 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0661 , B01L2400/0677 , B01L2400/0683 , B01L2400/082 , B01L2400/084 , B01L2400/086 , F16K99/003 , F16K99/0036 , F16K99/0057 , F16K2099/0084 , Y10S422/901 , Y10T137/0318 , Y10T137/0324 , Y10T137/1624 , Y10T137/1812 , Y10T137/2191 , Y10T137/8376 , Y10T137/8593 , Y10T137/85978 , Y10T436/143333 , Y10T436/2575
摘要： A diagnostic device is provided that includes a plurality of retainment regions, with the retainment regions that are separated by at least one dissolvable barrier. The retainment regions can be interconnected through at least one fluid processing passageway. A retainment region can include a container such as a retainment region, well, chamber, or other receptacle, or a retainment region such as a surface on which the material is retained. The retainment regions can include a reaction retainment region, one or more reagent retainment regions, each containing unreacted reagents, and a sample retainment region. A pressure-actuated valve can be positioned in each fluid processing passageway interconnecting the one or more reagent retainment regions with the respective intermediate retainment regions interposed between each of the one or more reagent retainment regions and the reaction retainment region. The dissolvable barrier can be a fluid flow modulator in the at least one fluid processing passageway.
摘要翻译：提供了一种诊断装置，其包括多个保持区域，其中保留区域被至少一个可溶解屏障隔开。保持区域可以通过至少一个流体处理通道相互连接。保持区域可以包括诸如保持区域，孔，腔室或其它容器的容器，或诸如保持材料的表面的保持区域。保留区域可以包括反应保留区域，一个或多个试剂保留区域，每个含有未反应的试剂和样品保留区域。压力致动阀可以定位在每个流体处理通道中，其将一个或多个试剂保留区域与插入在一个或多个试剂保留区域中的每一个和反应保留区域之间的各个中间保留区域互连。可溶解屏障可以是至少一个流体处理通道中的流体流动调节器。

2. 发明申请

US20110114206A1 Fluid Processing Device Including Size-Changing Barrier 有权
标题翻译：包括尺寸变化屏障的流体处理装置
公开(公告)号：US20110114206A1
公开(公告)日：2011-05-19
申请号：US12945793
申请日：2010-11-12
申请人： Debjyoti Banerjee , Umberto Ulmanella , Konrad Faulstich , Aldrich N.K. Lau , Jun Xie
发明人： Debjyoti Banerjee , Umberto Ulmanella , Konrad Faulstich , Aldrich N.K. Lau , Jun Xie
IPC分类号： F15D1/00
CPC分类号： F16K99/0001 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0415 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0661 , B01L2400/0677 , B01L2400/0683 , B01L2400/082 , B01L2400/084 , B01L2400/086 , F16K99/003 , F16K99/0036 , F16K99/0057 , F16K2099/0084 , Y10S422/901 , Y10T137/0318 , Y10T137/0324 , Y10T137/1624 , Y10T137/1812 , Y10T137/2191 , Y10T137/8376 , Y10T137/8593 , Y10T137/85978 , Y10T436/143333 , Y10T436/2575
摘要： A diagnostic device is provided that includes a plurality of retainment regions interconnected through at least one fluid processing passageway or separated by at least one barrier. A fluid flow modulator can be provided in the fluid processing passageway if a fluid processing passageway is provided. The barrier and/or fluid flow modulator can comprise a polysaccharide, a derivative of a polysaccharide, or a combination thereof. For example, the barrier can comprise a chitosan material.
摘要翻译：提供了一种诊断装置，其包括通过至少一个流体处理通道互连或由至少一个屏障隔开的多个保持区域。如果提供流体处理通道，流体流动调节器可以设置在流体处理通道中。阻隔和/或流体流动调节器可以包含多糖，多糖的衍生物或其组合。例如，阻挡层可以包含壳聚糖材料。

3. 发明申请

US20100206731A1 DEVICES AND METHODS FOR OPTOELECTRONIC MANIPULATION OF SMALL PARTICLES 有权
标题翻译：用于光电子操作小颗粒的装置和方法
公开(公告)号：US20100206731A1
公开(公告)日：2010-08-19
申请号：US12702137
申请日：2010-02-08
申请人： Aldrich N.K. Lau , Joon Mo Yang , Huan L. Phan , Steven W. Sherwood , Hans A. Fuernkranz
发明人： Aldrich N.K. Lau , Joon Mo Yang , Huan L. Phan , Steven W. Sherwood , Hans A. Fuernkranz
IPC分类号： B03C11/00
CPC分类号： B03C5/026 , B03C5/005 , B03C5/028 , C07K1/26 , G01N27/305
摘要： A method for sorting cells in a biological sample comprising a first type of cells and a second type of cells may comprise introducing the biological sample into a chamber comprising a first surface and a second surface, wherein the first surface is associated with a transparent electrode and the second surface is associated with a photoconductive portion of an electrode. The method may further comprise moving incident light and the photoconductive portion relative to one another so as to illuminate regions of the photoconductive portion and modulate an electric field in the chamber in proximity to the illuminated regions. The method may further comprise separating the first type of cells from the second type of cells in the chamber via dielectrophoretic movement of the first type of cells and the second type of cells caused by the modulated electric field, wherein a dielectrophoretic characteristic of at least one of the first type of cells and the second type of cells has been modified.
摘要翻译：用于分选生物样品中包含第一类型细胞和第二类型细胞的细胞的方法可以包括将生物样品引入包含第一表面和第二表面的室中，其中第一表面与透明电极相关联，第二表面与电极的光电导部分相关联。该方法还可以包括相对于彼此移动入射光和光电导部分，以照射光电导部分的区域并且调制在邻近照明区域的室中的电场。该方法还可以包括通过由调制电场引起的第一类型的细胞和第二类型的细胞的介电电泳运动，将第一类型的细胞与腔室中的第二类型的细胞分离，其中至少一种的介电电泳特性的第一类型的细胞和第二类型的细胞已被修改。

4. 发明申请

US20100196912A1 Polyelectrolyte-Coated Size-Exclusion Ion-Exchange Particles 审中-公开
公开(公告)号：US20100196912A1
公开(公告)日：2010-08-05
申请号：US12757888
申请日：2010-04-09
申请人： Michael P. Harrold , Aldrich N.K. Lau , Ben F. Johnson , Gilbert P. Amparo , Frank W. Mercer
发明人： Michael P. Harrold , Aldrich N.K. Lau , Ben F. Johnson , Gilbert P. Amparo , Frank W. Mercer
IPC分类号： C12Q1/68 , C07H1/06 , C09K3/00 , G01N27/26
CPC分类号： C12Q1/6869 , B01D15/34 , B01J13/10 , B01J13/22 , B01J47/018 , B01J47/04 , C12Q1/6806 , C12Q2527/125 , C12Q2565/631 , C12Q2565/125 , C12Q2563/113
摘要： A polyelectrolyte-coated particle, devices for using the particle, methods for using the particle for separating PCR reaction products and/or DNA sequencing reaction products, and compositions for coating the particle are provided.

5. 发明申请

US20090023189A1 APPARATUS AND METHODS FOR PREPARATION OF SUBTANTIALLY UNIFORM EMULSIONS CONTAINING A PARTICLE 审中-公开
标题翻译：用于制备含有颗粒的亚基均匀乳液的装置和方法
公开(公告)号：US20090023189A1
公开(公告)日：2009-01-22
申请号：US12119475
申请日：2008-05-12
申请人： Aldrich N.K. Lau , Jonathan M. Cassel , John A. Bridgham
发明人： Aldrich N.K. Lau , Jonathan M. Cassel , John A. Bridgham
IPC分类号： C12P19/34 , C12M1/40
CPC分类号： B01F3/0807 , B01F5/0475 , B01F5/0476 , B01F5/0485 , B01F13/0059
摘要： Methods and systems for forming water-in-oil emulsions are described. For example, an apparatus is described which includes: a first compartment containing a plurality of particles dispersed in an aqueous phase; a second compartment containing an oil phase; a porous layer separating the first and second compartments; and a device for applying pressure to the first compartment. A method is described which includes: moving an oil phase relative to a surface of a porous layer while simultaneously forcing an aqueous composition comprising particles through the porous layer and into the flowing dispersion medium thereby forming droplets of the aqueous composition containing particles dispersed in the oil phase. The aqueous composition can include one or more nucleic acid templates and reagents for amplifying the nucleic acids such as PCR reagents. A porous partition is described comprising a first and second major surfaces and at least two straight through pores comprising a cross sectional shape selected from a polygon, an oval, an oblong, a dumbbell, a bowtie and irregular shapes thereof. Aqueous droplets containing an oligonucleotide attached to a particle and reagents can be used as a microreactor for nucleic acid amplification.
摘要翻译：描述了用于形成油包水乳液的方法和系统。例如，描述了一种装置，其包括：包含分散在水相中的多个颗粒的第一隔室; 含有油相的第二隔室; 分离第一和第二隔室的多孔层; 以及用于向第一隔室施加压力的装置。描述了一种方法，其包括：相对于多孔层的表面移动油相，同时迫使包含颗粒的水性组合物通过多孔层并进入流动分散介质中，由此形成含有分散在油中的颗粒的含水组合物的液滴相。水性组合物可以包括用于扩增核酸如PCR试剂的一种或多种核酸模板和试剂。描述了一种多孔分隔件，其包括第一和第二主表面和至少两个直通孔，其包括选自多边形，椭圆形，长方形，哑铃，弓形和不规则形状的横截面形状。含有与粒子连接的寡核苷酸的水滴和试剂可用作核酸扩增的微反应器。

6. 发明申请

US20080293127A1 Method to Render Pressure Sensitive Adhesive Compatible with Polymerase Chain Reaction Systems 审中-公开
标题翻译：兼容聚合酶链反应体系的压敏粘合剂的方法
公开(公告)号：US20080293127A1
公开(公告)日：2008-11-27
申请号：US11752243
申请日：2007-05-22
申请人： Yuh-Min Chiang , Aldrich N.K. Lau
发明人： Yuh-Min Chiang , Aldrich N.K. Lau
IPC分类号： C08J3/00 , C12M1/00
CPC分类号： C09J5/00 , B01L3/50851 , B01L2200/0689 , B01L2200/12 , B01L2200/141 , B01L2300/044 , B01L2300/0829 , C09J2205/302
摘要： A method for substantially eliminating a cross-linking element of a pressure sensitive adhesive by heating the pressure sensitive adhesive at a temperature of at least 180° C. for a period of time required to thermally decompose the cross-linking element of the pressure sensitive adhesive.
摘要翻译：一种基本上消除压敏粘合剂的交联元件的方法，该方法是在压敏粘合剂的至少180℃的温度下加热压敏粘合剂的交联元件所需的时间。

7. 发明申请

US20130153421A1 GRAFT COPOLYMERS, THEIR PREPARATION AND USE IN CAPILLARY ELECTROPHORESIS 审中-公开
标题翻译： GRAFT共聚物，其在毛细管电泳中的制备和用途
公开(公告)号：US20130153421A1
公开(公告)日：2013-06-20
申请号：US13613729
申请日：2012-09-13
申请人： Aldrich N.K. LAU
发明人： Aldrich N.K. LAU
IPC分类号： C08F267/10 , G01N27/447
CPC分类号： C08L51/003 , C08F2/32 , C08F120/54 , C08F120/56 , C08F220/54 , C08F265/10 , C08F267/10 , C08L33/24 , C08L33/26 , C12Q1/6806 , G01N27/44747 , G01N27/44791 , C08F220/52 , C08L2666/24 , C08L2666/04 , C08L2666/02 , C08F220/56
摘要： The invention relates to graft copolymers, their preparation, and compositions, such as electrophoresis separation media, containing the same; also to ultra-high molecular weight poly(N,N-dimethylacrylamide) (“poly(DMA)”) polymers, their preparation, and compositions, such as electrophoresis separation media, containing the same; and more particularly to supports, such as capillaries, containing these polymers and methods for separating biomolecules, especially polynucleotides, using capillary electrophoresis. The graft copolymers can be prepared by, e.g., grafting polyacrylamide units onto a poly(DMA) backbone. Separation media comprising such graft copolymers or ultra-high molecular weight poly(DMA) polymers yield superior performance in the analysis and separation of biomolecules by capillary electrophoresis.
摘要翻译：本发明涉及接枝共聚物，它们的制备方法和组合物，例如含有它们的电泳分离介质; 也可以是超高分子量聚（N，N-二甲基丙烯酰胺）（“聚（DMA）”）聚合物，它们的制备方法和组合物，例如含有它们的电泳分离介质; 更具体地涉及含有这些聚合物的载体，例如毛细管，以及使用毛细管电泳分离生物分子，特别是多核苷酸的方法。接枝共聚物可以通过例如将聚丙烯酰胺单元接枝到聚（DMA）主链上来制备。包含这种接枝共聚物或超高分子量聚（DMA）聚合物的分离介质通过毛细管电泳在生物分子的分析和分离中产生优异的性能。

8. 发明申请

US20110085168A1 Luminescence Reference Standards 有权
标题翻译：发光参考标准
公开(公告)号：US20110085168A1
公开(公告)日：2011-04-14
申请号：US12813389
申请日：2010-06-10
申请人： J. Michael Phillips , Aldrich N.K. Lau , Mark F. Oldham , Kevin S. Bodner , Steven J. Boege , Donald R. Sandell , David H. Tracy
发明人： J. Michael Phillips , Aldrich N.K. Lau , Mark F. Oldham , Kevin S. Bodner , Steven J. Boege , Donald R. Sandell , David H. Tracy
IPC分类号： G01J1/10 , G01B11/00 , B82Y99/00
CPC分类号： G01N21/278 , B82Y15/00 , G01J1/10 , G01N21/01 , G01N21/4785 , G01N21/6452 , G01N21/76 , G01N2201/06113 , G01N2201/0612 , G01N2201/062 , G01N2201/0691 , G01N2201/0697 , Y10S977/943 , Y10S977/949
摘要： The present teachings provide for systems, and components thereof, for detecting and/or analyzing light. These systems can include, among others, optical reference standards utilizing luminophores, such as nanocrystals, for calibrating, validating, and/or monitoring light-detection systems, before, during, and/or after sample analysis.
摘要翻译：本教导提供了用于检测和/或分析光的系统及其组件。这些系统尤其可以包括在样品分析之前，期间和/或之后利用发光体（例如纳米晶体）用于校准，验证和/或监测光检测系统的光学参考标准。

9. 发明申请

US20100187111A1 Graft Copolymers, Their Preparation And Use in Capillary Electrophoresis 有权
标题翻译：接枝共聚物，其在毛细管电泳中的制备和应用
公开(公告)号：US20100187111A1
公开(公告)日：2010-07-29
申请号：US12565590
申请日：2009-09-23
申请人： Aldrich N.K. LAU
发明人： Aldrich N.K. LAU
IPC分类号： B01D59/42
CPC分类号： C08L51/003 , C08F2/32 , C08F120/54 , C08F120/56 , C08F220/54 , C08F265/10 , C08F267/10 , C08L33/24 , C08L33/26 , C12Q1/6806 , G01N27/44747 , G01N27/44791 , C08F220/52 , C08L2666/24 , C08L2666/04 , C08L2666/02 , C08F220/56
摘要： The invention relates to graft copolymers, their preparation, and compositions, such as electrophoresis separation media, containing the same; also to ultra-high molecular weight poly(N,N-dimethylacrylamide) (“poly(DMA)”) polymers, their preparation, and compositions, such as electrophoresis separation media, containing the same; and more particularly to supports, such as capillaries, containing these polymers and methods for separating biomolecules, especially polynucleotides, using capillary electrophoresis. The graft copolymers can be prepared by, e.g., grafting polyacrylamide units onto a poly(DMA) backbone. Separation media comprising such graft copolymers or ultra-high molecular weight poly(DMA) polymers yield superior performance in the analysis and separation of biomolecules by capillary electrophoresis.
摘要翻译：本发明涉及接枝共聚物，它们的制备方法和组合物，例如含有它们的电泳分离介质; 也可以使用超高分子量聚（N，N-二甲基丙烯酰胺）（“聚（DMA）”）聚合物，它们的制备方法和组合物，例如含有它们的电泳分离介质; 更具体地涉及含有这些聚合物的载体，例如毛细管，以及使用毛细管电泳分离生物分子，特别是多核苷酸的方法。接枝共聚物可以通过例如将聚丙烯酰胺单元接枝到聚（DMA）主链上来制备。包含这种接枝共聚物或超高分子量聚（DMA）聚合物的分离介质通过毛细管电泳在生物分子的分析和分离中产生优异的性能。

10. 发明申请

US20090233327A1 Surface Modification in a Manipulation Chamber 审中-公开
标题翻译：操纵室中的表面改性
公开(公告)号：US20090233327A1
公开(公告)日：2009-09-17
申请号：US12398140
申请日：2009-03-04
申请人： Aldrich N.K. Lau , Huan L. Phan
发明人： Aldrich N.K. Lau , Huan L. Phan
IPC分类号： C12Q1/02 , B05D5/12 , B05D3/00
CPC分类号： G01N27/305 , B03C11/00 , C07K1/26
摘要： A device for manipulating biological material, the device including at least one electrode and a photoconductive material configured to receive the biological material; and a light source configured to illuminate the photoconductive material so as to modulate an electric field, wherein the electric field is configured to manipulate the biological material; wherein a surface of the at least one electrode and/or the photoconductive material is modified with at least one of a carboxylic moiety, an amino moiety, a poly(ethylene glycol) moiety, a polymer of (poly(ethylene oxide) methyl ether) acrylate, a poly(2-hydroxyethyl (meth)acrylate), a poly(N-vinylpyrrolidone), a poly(N-vinylformamide), a poly(N-vinylformamide) derivative, a poly((meth)acrylamide), and a poly((meth)acrylamide) derivative. Methods for manipulating biological material are also disclosed.
摘要翻译：一种用于操纵生物材料的装置，该装置包括至少一个电极和被配置为容纳生物材料的光导材料; 以及光源，被配置为照亮所述光电导材料以调制电场，其中所述电场被配置为操纵所述生物材料; 其中所述至少一个电极和/或光电导材料的表面用羧基部分，氨基部分，聚（乙二醇）部分，（聚（环氧乙烷）甲基醚）的聚合物，丙烯酸酯，聚（甲基）丙烯酸2-羟乙酯），聚（N-乙烯基吡咯烷酮），聚（N-乙烯基甲酰胺），聚（N-乙烯基甲酰胺）衍生物，聚（（甲基）丙烯酰胺）聚（（甲基）丙烯酰胺）衍生物。还公开了用于操作生物材料的方法。

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